Regulator of Calcineurin 1 in Periodontal Disease by Ulrike Peters, Eleni Solominidou, Yüksel Korkmaz, Stefan Rüttermann, Astrid Klocke, Thomas Frank Flemmig, Thomas Beikler

“…During an acute infection, however, rcan1 seems to be upregulated in endothelial cells, indicating a modulating role in immune homeostasis of periodontal tissues.…”
Get full text

Impaired Glucose Metabolism Is Associated with Visit-to-Visit Blood Pressure Variability in Participants without Cardiovascular Disease by Nobuo Sasaki, Ryoji Ozono, Saeko Fujiwara, Ryo Maeda, Yasuki Kihara

“…In participants without CVD, impaired glucose metabolism may modulate visit-to-visit BP variability.…”
Get full text

The evolutionary dynamics of plastic foraging and its ecological consequences: a resource-consumer model by Ledru, Léo, Garnier, Jimmy, Guillot, Océane, Faou, Erwan, Noûs, Camille, Ibanez, Sébastien

“…Yet little is known about the ecological conditions that favor the evolution of PF, and how the evolutionary dynamics of PF may modulate its effects on community stability. In order to address these questions, we constructed an eco-evolutionary model in which resource and consumer niche traits underwent evolutionary diversification. …”
Get full text

The Lyn/RUVBL1 Complex Promotes Colorectal Cancer Liver Metastasis by Regulating Arachidonic Acid Metabolism Through Chromatin Remodeling by Zhenyu Zhang, Yina Gao, Yuanyuan Qian, Bowen Wei, Kexin Jiang, Zhiwei Sun, Feifan Zhang, Mingming Yang, Salem Baldi, Xiaoqi Yu, Yunfei Zuo, Shuangyi Ren

“…Then, it is found that COX2 is regulated by the transcription factor FOXA1. Lyn/RUVBL1 modulates AA metabolism by regulating the chromatin accessibility of FOXA1. …”
Get full text

Tripartite organization of brain state dynamics underlying spoken narrative comprehension by Lanfang Liu, Jiahao Jiang, Hehui Li, Guosheng Ding

“…The three states are selectively modulated by the acoustic, word-level semantic, and clause-level semantic properties of the narrative. …”
Get full text

Seasonal recurrence and modular assembly of an Arctic pelagic marine microbiome by Taylor Priest, Ellen Oldenburg, Ovidiu Popa, Bledina Dede, Katja Metfies, Wilken-Jon von Appen, Sinhué Torres-Valdés, Christina Bienhold, Bernhard M. Fuchs, Rudolf Amann, Antje Boetius, Matthias Wietz

“…Specifically, we identified five temporal microbiome modules whose succession within each annual cycle represents a transition across different ecological states. …”
Get full text

Monocyte Chemotactic Protein 1-Induced Protein 1 Is Highly Expressed in Inflammatory Bowel Disease and Negatively Regulates Neutrophil Activities by Jian Lin, Gengfeng Li, Chunjin Xu, Huiying Lu, Cui Zhang, Zhi Pang, Zhanju Liu

“…MG-132 may partially modulate the function of neutrophils via the induction of MCPIP-1. …”
Get full text

Chromatin accessibility and differentially expressed genes profiling in large yellow croaker (Larimichthys crocea) head kidney cells following iridovirus infection by Chaowei Song, Ying Huang, Fang Han, Zhiyong Wang, Zhiyong Wang

“…CUT&Tag results revealed that AP-1 was significantly enriched in the open chromatin regions of cytokine genes, with Batf potentially regulating the cytokine genes LIF and CLCF1.DiscussionThese findings suggest that AP-1 may play a crucial role in the defense response against viral infection by modulating inflammatory cytokines and contributing to cellular inflammatory responses. …”
Get full text

Functional resting state connectivity is differentially associated with IL-6 and TNF-α in depression and in healthy controls by Christian N. Schmitz, Gebhard Sammer, Elena Neumann, Carlo Blecker, Gerhard Gründer, Hana Adolphi, Eva Kathrin Lamadé, Bruno Pedraz-Petrozzi

“…In human studies, inflammation has been shown to act as a critical disease modifier, promoting susceptibility to depression and modulating specific endophenotypes of depression. However, there is scant documentation of how inflammatory processes are associated with neural activity in patients with depression. …”
Get full text

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…Many PPARγ ligands are under investigation as potential therapies for human diseases. These ligands modulate multiple cellular pathways via both PPARγ-dependent and PPARγ-independent mechanisms. …”
Get full text

A dendritic hexamer acceptor enables 19.4% efficiency with exceptional stability in organic solar cells by Tao Jia, Tao Lin, Yang Yang, Lunbi Wu, Huimin Cai, Zesheng Zhang, Kangfeng Lin, Yulong Hai, Yongmin Luo, Ruijie Ma, Yao Li, Top Archie Dela Peña, Sha Liu, Jie Zhang, Chunchen Liu, Junwu Chen, Jiaying Wu, Shengjian Liu, Fei Huang

“…The dendritic acceptor Six-IC exhibits modulated crystallinity and miscibility with the donor, thus better morphology performance compared to its monomer, DTC8. …”
Get full text

Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry by Aline Menezes, Yara Martins, Fábio Nogueira, Denise De Abreu Pereira, Katia Carneiro

“…These results suggest that iHDAC inhibitors may modulate or suppress tumor behavior growth by targeting ECM proteins’ secretion rather than directly inhibiting angiogenesis.…”
Get full text

Comparison of Real-Time Methods Demonstrating the Effects of Reduced Glutathione on Olfactory Neuroblasts by Alain Géloën, Emmanuelle Berger

“…Results support the hypothesis that excreted GSH could modulate disulfide bound-dependent integrin conformations involved in neurogenesis and/or neuronal plasticity. …”
Get full text

Ontogeny and function of the intestinal epithelial and innate immune cells during early development of chicks: to explore in ovo immunomodulatory nutrition by Habtamu Ayalew, Changchun Xu, Assefa Adane, Astrid Lissette Barreto Sanchez, Siman Li, Jing Wang, Shugeng Wu, Kai Qiu, Guanghai Qi, Haijun Zhang

“…Thus, summarizing the ontogeny and function of IECs, innate immunity systems, and interaction mechanisms of in ovo feeding of bioactive substances could provide baseline information for designing targeted in ovo feeding interventions to modulate cell waise specific innate immune systems.…”
Get full text

LotusSQL: SQL Engine for High-Performance Big Data Systems by Xiaohan Li, Bowen Yu, Guanyu Feng, Haojie Wang, Wenguang Chen

“…In recent years, Apache Spark has become the de facto standard for big data processing. SparkSQL is a module offering support for relational analysis on Spark with Structured Query Language (SQL). …”
Get full text

Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites by Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K. Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L. Merchant, Craig J. McClain, Huang-Ge Zhang

“…Our findings reveal a previously unknown mechanistic impact of PNP on human tumor immunotherapy by modulating gut bacterial metabolic pathways.…”
Get full text

CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production by Emily E. O’Driscoll, Sakshi Arora, Jonathan F. Lang, Beverly L. Davidson, Ophir Shalem

“…Specifically, we performed a CRISPR-based genome-wide knockout (KO) screen in human embryonic kidney (HEK) 293 cells using an antibody specific to intact AAV2 capsids coupled with flow cytometry to identify genes that modulate rAAV production. We discovered that the KO of a group of heparan sulfate biosynthesis genes previously implicated in rAAV infectivity decreased rAAV production. …”
Get full text

A Modular and Scalable Approach to Hybrid Battery and Converter Integration for Full-Electric Waterborne Transport by Ramon Lopez-Erauskin, Argiñe Alacano, Aitor Lizeaga, Giuseppe Guidi, Olve Mo, Amaia Lopez-de-Heredia, Mikel Alzuri

“…This real-time capability has been validated, and related results are presented in this paper, showing a synchronization accuracy below 200 ns between two modules and a stable control at a cycle time of 400 µs. …”
Get full text

Modified SWAT Model for Agricultural Watershed in Karst Area of Southwest China by Junfeng Dai, Linyan Pan, Yan Deng, Zupeng Wan, Rui Xia

“…This study aims to refine the delineation of hydrological response units within the SWAT model by combining geomorphological classification and to enhance the model with an epikarst zone hydrological process module, exploring the accuracy improvement of SWAT model simulations in karst regions of Southwest China. …”
Get full text

Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells by Debora Dessì, Giacomo Fais, Paolo Follesa, Giorgia Sarais

“…Our findings reveal that Myrtus extract significantly protects against 6-OHDA-induced cytotoxicity, reduces ROS levels, and modulates the expression of key stress-related genes, underscoring its potential as a neuroprotective agent. …”
Get full text