In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…Colorectal cancer (CRC) is a multifactorial disease driven by genetic and epigenetic alterations that modulate specific metabolic pathways. Despite the availability of effective treatments like 5-fluorouracil (5-FU), pharmacological therapy for CRC still faces significant challenges, including drug resistance, toxicity, and limited specificity. …”
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Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model by Qiong Liang, Qiqing Lin, Yueyong Li, Weigui Luo, Xia Huang, Yujie Jiang, Chunyan Qin, Jin Nong, Xiang Chen, Suren Rao Sooranna, Liao Pinhu

“…Although it is clear that TGF-β1 can modulate the expression of the extracellular matrix (ECM) through intracellular signaling molecules such as Smad3, its role as a therapeutic target against ARDS remains unknown. …”
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Comparative Study of Maximum Power Point Tracking Techniques for Photovoltaic Systems by Fernando Lessa Tofoli, Dênis de Castro Pereira, Wesley Josias de Paula

“…Besides, MPP tracking (MPPT) is desirable in both grid-connected and stand-alone photovoltaic systems because the solar irradiance and temperature change throughout the day, as well as along seasons and geographical conditions, also leading to the modification of the I×V (current versus voltage) and P×V (power versus voltage) curves of the PV module. MPPT is also justified by the relatively high cost of the energy generated by PV systems if compared with other sources. …”
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Multi-level representation learning via ConvNeXt-based network for unaligned cross-view matching by Fangli Guan, Nan Zhao, Zhixiang Fang, Ling Jiang, Jianhui Zhang, Yue Yu, Haosheng Huang

“…In addition, the features of different branches are aggregated through the multilevel feature fusion module to prepare for cross-view matching. Finally, we created a new hybrid loss function to better limit these features and assist in mining crucial data regarding global features. …”
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The Role of the Gastrointestinal Microbiota in Parkinson’s Disease by Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco, Enrico Celestino Nista, Veronica Ojetti, Antonio Gasbarrini

“…Conclusions: The potential to modulate gut microbiota through probiotics, prebiotics, and synbiotics; fecal microbiota transplantation; and antibiotics represents a promising frontier for innovative PD treatments. …”
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Decitabine Increases the Transcription of <i>RIG-I</i> Gene to Suppress the Replication of Feline Calicivirus and Canine Influenza Virus by Shaotang Ye, Zhen Wang, Aolei Chen, Ying Chen, Gaoming Lou, Qingmei Xie, Gang Lu, Shoujun Li

“…Decitabine has been proven to modulate gene expression through its demethylating effect. …”
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Dominant Modes of Tropospheric Ozone Variation over East Asia from GOME Observations by Yi Liu, Yuli Zhang, Yong Wang, Chuanxi Liu, Zhaonan Cai, Paul Konopka, Rolf Müller

“…The principal component of EOF1 (PC1) suggested that photochemical ozone production together with Brewer-Dobson circulation and subtropical westerly jet plays important roles in modulating the seasonal variation of the TOVMR; ozone-rich air produced by photochemical processes was transported from the stratosphere to the troposphere by BD circulation and this ozone-rich air was then blocked by the subtropical westerly jet and accumulated north of the jet. …”
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L-arabinose alleviates constipation through gastrointestinal peptide，gut microbiota，and Phlpp2 of gastrointestinal rhythms in rats by Ting Gong, Linzheng Liao, Yong Tang, Weiwei Liu, Ling Yao, Zhen Wu, Jianmei Li, Fulai Bai, Qian Zhang, Liling Tang

“…It also improved gastric, liver, and kidney function, while modulating key gastrointestinal peptides, including motilin (MTL), substance P (SP), vasoactive intestinal peptide (VIP), acetylcholinesterase (AchE), endothelin-1 (ET-1), serotonin (5-HT), somatostatin (SS), gastrin (Gas), and nitric oxide (NO). …”
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Porphyromonas gingivalis affects neutrophil pro-inflammatory activities by Agnieszka Zimny, Alicja Płonczyńska, Alicja Płonczyńska, Wiktor Jakubowski, Natalia Zubrzycka, Natalia Zubrzycka, Jan Potempa, Jan Potempa, Maja Sochalska

“…Additionally, although gingipains played a role in modulating the IL-8-dependent inflammatory response of human neutrophils, they did not affect the expression levels of pro-inflammatory cytokines TNF-α and IL-6.…”
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Transcriptome Analysis of Long Noncoding RNAs in Toll-Like Receptor 3-Activated Mesenchymal Stem Cells by Shihua Wang, Xiaoxia Li, Robert Chunhua Zhao

“…Recently, toll-like receptors (TLR) have been shown to modulate MSC functions; however, the underlying molecular mechanisms are poorly understood. …”
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Efficient Hyperspectral Video Reconstruction via Dual-Channel DMD Encoding by Mingming Ma, Yi Niu, Dahua Gao, Fu Li, Guangming Shi

“…However, the reliance on spatial light modulators for coding reduces optical efficiency, while complex recovery algorithms hinder real-time reconstruction. …”
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Energy-related contaminants in subterranean waterbodies: The role of geocolloids on facilitated and hindered transport by Mustafa E.S. Akbulut, Younjin Min

“…This article critically reviews contemporary studies on the influence of aqueous geocolloids in modulating the transport kinetics of energy-related contaminants within subterranean hydrological systems. …”
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The NaBH4 Reduction and pH Effects on the Optical Property of Bismuth Vanadate by Riapanitra Anung, Julian Haryanto Michael, Setyaningtyas Tien, Riyani Kapti, Nur Handayani Santi

“…Optical absorption data using a UV-visible diffuse reflectance spectrophotometer showed that the reduction process increases the maximum absorption edge to 575 nm and reduces the band gap energy to 2.78 eV at high pH. Furthermore, modulating pH during synthesis allowed tuning of the electronic structure and surface states of BiVO₄, which significantly impacts the photocatalytic efficiency. …”
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Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet by Frederick Wasinski, Reury F. P. Bacurau, Milton R. Moraes, Anderson S. Haro, Pedro M. M. Moraes-Vieira, Gabriel R. Estrela, Edgar J. Paredes-Gamero, Carlos C. Barros, Sandro S. Almeida, Niels O. S. Câmara, Ronaldo C. Araujo

“…Together, these data demonstrated that exercise and caloric restriction modulate resident immune cells in adipose tissues differently in spite of an equivalent body weight reduction. …”
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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…To advance urban carbon neutrality efforts, future research should integrate these findings into practical tools, such as enhanced modules in landscape performance platforms. These modules should allow for lifecycle assessments that account for design, construction, and maintenance phases, thus supporting real-time monitoring and optimization. …”
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Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…This article provides a detailed review of the multiple roles of hypoxia-inducible factor-1α in the pathogenesis of diabetic kidney disease, including: regulating angiogenesis, increasing the expression of erythropoietin, modulating oxidative stress through the PI3K/AKT and HIF-1α/HO-1 pathways, promoting inflammatory cell infiltration and the release of inflammatory factors to induce inflammatory responses, facilitating epithelial-mesenchymal transition, pathological angiogenesis, and promoting the release of fibrotic factors, ultimately leading to renal fibrosis. …”
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The Effects of GABAergic System under Cerebral Ischemia: Spotlight on Cognitive Function by Juan Li, Luting Chen, Feng Guo, Xiaohua Han

“…Furthermore, exogenous cell transplantation, which improves cognition by modulating the GABAergic system, will also be described in this review to bring new insight and strategy on solving cognitive deficits caused by cerebral ischemia.…”
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A generic self-learning emotional framework for machines by Alberto Hernández-Marcos, Eduardo Ros

“…Abstract In nature, intelligent living beings have developed emotions to modulate their behavior as a fundamental evolutionary advantage. …”
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Morphology and properties of hollow fiber membrane prepared under different air gap lengths by AIDA ISMA MOHAMAD IDRIS, Syeda Hina Iqbal, Rozita Omar, Hazmin Mansor

“…The fabrication of hollow fibre membrane modules is affected by many spinning variables, including polymer composition, bath temperature, bore fluid ratio, fibre take-up velocity, and air gap length, resulting in varying properties. …”
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