Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Aci... by Olga Gordeeva, Sergey Khaydukov

“…Thus, this study demonstrates that a differentiation strategy that modulates prodifferentiation and antiproliferative signaling in ES cells may be effective for eliminating tumorigenic cells and may represent a valuable tool for the development of safe stem cell therapeutics.…”
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Efficacy of melatonin treatment in a cystic fibrosis mouse model of airway infection by Kristen R. Schaefer, Sara Rogers, Zachary Faber, Thomas J. Kelley

“…Abstract Approaches to mitigate the severity of infections and of immune responses are still needed for the treatment of cystic fibrosis (CF) even with the success of highly effective modulator therapies. Previous studies identified reduced levels of melatonin in a CF mouse model related to circadian rhythm dysregulation. …”
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The effects of haloperidol on motor vigour and movement fusion during sequential reaching. by Sebastian Sporn, Joseph M Galea

“…The neurotransmitter dopamine plays a central role in the processing of reward signals and has been implicated to modulate motor vigour and regulate movement fusion. …”
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A Lightweight Person Detector for Surveillance Footage Based on YOLOv8n by Qicheng Wang, Guoqiang Feng, Zongzhe Li

“…This model balances high accuracy with low computational cost and parameter size. First, the MSBlock module was introduced into YOLOv8n. Then, a series of modifications were made to the MSBlock structure. …”
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Polyamines Interaction with Gaseous Signaling Molecules for Resilience Against Drought and Heat Stress in Plants by Nidhi, Noushina Iqbal, Nafees A. Khan

“…Moreover, a comprehensive analysis of physiological, biochemical, and molecular approaches demonstrates that their interaction activates key stress-responsive pathways, enhances antioxidant systems, and modulates gene expression. These combined effects contribute to improved drought and heat tolerance in plants. …”
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Regulation and Roles of Urocortins in the Vascular System by Kazunori Kageyama, Ken Teui, Naoki Tamasawa, Toshihiro Suda

“…Ucns are important and unique modulators of vascular smooth muscle cells and act directly or indirectly as autocrine and paracrine factors in the vascular system.…”
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Multi-omics and machine learning-driven CD8+ T cell heterogeneity score for head and neck squamous cell carcinoma by Di He, Zhan Yang, Tian Zhang, Yaxian Luo, Lianjie Peng, Jiatao Yan, Tao Qiu, Jingyu Zhang, Luying Qin, Zhichao Liu, Mouyuan Sun

“…Single-cell analysis of HNSCC tissues and peripheral blood, along with spatial transcriptome analysis, revealed that OLR1 predominantly functions in macrophages, modulating the immune microenvironment of HNSCC. The expression level of OLR1 may serve as a predictive marker for immunotherapy responses. …”
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Inaudible airborne ultrasound affects emotional states in the olfactory bulbectomized rat depression model by Tsugumi Yamauchi, Kou Takahashi, Toshinori Yoshioka, Daisuke Yamada, Yoshio Nakano, Satoka Kasai, Satoshi Iriyama, Kazumi Yoshizawa, Shoichi Nishino, Satoru Miyazaki, Akiyoshi Saitoh

“…Abstract Recently, exposure to sounds with ultrasound (US) components has been shown to modulate brain activity. However, the effects of US on emotional states remain poorly understood. …”
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Long Noncoding RNA uc001pwg.1 Is Downregulated in Neointima in Arteriovenous Fistulas and Mediates the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Lei Lv, Haozhe Qi, Xiangjiang Guo, Qihong Ni, Zezhen Yan, Lan Zhang

“…This study represents the first effort of identifying a novel candidate lncRNA for modulating the function of iPSC-ECs, which may facilitate the improvement of stem cell-based therapies for AVF failure.…”
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Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation of gut microbiota by Ruting Zhong, Lanbin Chen, Yuanyuan Liu, Shouxia Xie, Sumei Li, Bin Liu, Chao Zhao

“…Additionally, aloin treatment inhibited the protein expression of c-Jun N-terminal kinases and activated that of IRS1/PI3K/Akt in the liver. Moreover, aloin modulated the bacterial community in the gut by raising the abundance of Bacteroidota and reducing the richness of Firmicutes, Proteobacteria, and Actinobacteriota. …”
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Using Internet of things technology to construct an integrated intelligent sensing environment for long-term care service by Lun-Ping Hung, Nan-Chen Hsieh, Li-Ju Lin, Zong-Jie Wu

“…This study uses a medical-grade Internet of Things module that can calculate the environmental values with edge computing to generate different levels of alarms by combining the index-weighted moving average method to dynamically calculate the optimal threshold value for the environment. …”
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Pro- and Anti-Inflammatory Cytokines Release in Mice Injected with Crotalus durissus terrificus Venom by A. Hernández Cruz, S. Garcia-Jimenez, R. Zucatelli Mendonça, V. L. Petricevich

“…In conclusion, the observation that Cdt affects the production of pro- and anti-inflammatory cytokines provides further evidence for the role played by Cdt in modulating pro/anti-inflammatory cytokine balance.…”
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Microbiome turnover during offspring development varies with maternal care, but not moult, in a hemimetabolous insect by Cheutin, Marie-Charlotte, Boucicot, Manon, Meunier, Joël

“…Here, we investigated whether and how moulting affects the microbiome of a hemimetabolous insect, and whether maternal care can modulate these effects. We reared European earwig juveniles with or without mothers and used 16S rRNA metabarcoding to analyse the prokaryotic fraction of the core microbiome of eggs, recently and old moulted individuals at four developmental stages and the resulting adults. …”
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Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report by Amedeo Minichino, Francesco Saverio Bersani, Francesco Spagnoli, Alessandra Corrado, Francesco De Michele, Wanda Katharina Calò, Martina Primavera, Baoran Yang, Laura Bernabei, Francesco Macrì, Lucilla Vergnani, Massimo Biondi, Roberto Delle Chiaie

“…As both prefrontal cortex and cerebellum may play a role in regulating sleep processes, concomitant cathodal (inhibitory) stimulation of cerebellum and anodal (excitatory) stimulation of DLPFC may have the potential to modulate prefrontal-thalamic-cerebellar circuits leading to improvements of sleep quality.…”
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Local Region Frequency Guided Dynamic Inconsistency Network for Deepfake Video Detection by Pengfei Yue, Beijing Chen, Zhangjie Fu

“…The network includes two parts: Global SpatioTemporal Network (GSTN) and Local Region Frequency Guided Module (LRFGM). The GSTN is responsible for capturing the dynamic information of the entire face, while the LRFGM focuses on extracting the frequency dynamic information of the eyes and mouth. …”
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Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging by Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C. Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong, Jie Zhuang, Xinglu Huang

“…RNA-sequencing analysis highlight the crucial role of these nanozymes in modulating superoxide anions-, hydrogen peroxide- and mitochondrial functions-relevant genes in IR injured cardiac tissue. …”
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Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis by Dixin Cui, Hongyu Li, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng, Yachuan Zhou

“…In addition, the trophic modulations of MSCs exert anti-inflammatory and immunomodulatory effects under aberrant conditions. …”
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Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1 by Nana Li, Haibo Du, Rui Ren, Yanfei Wang, Zhigang Xu

“…Alternative splicing plays a pivotal role in modulating the function of eukaryotic proteins. In the inner ear, many genes undergo alternative splicing, and errors in this process lead to hearing loss. …”
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FMCW-based contactless heart rate monitoring by Zhanjun Hao, Yifei Gao, Yangyang Tang, Yue Wang, Kai Fan, Fenfang Li

“…Therefore, this study utilized frequency-modulated continuous wave (FMCW) radar for heart rate monitoring. …”
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The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression by E. Czarnowska, D. Domal-Kwiatkowska, E. Reichman-Warmusz, J. B. Bierla, A. Sowinska, A. Ratajska, K. Goral-Radziszewska, R. Wojnicz

“…Thus, there is limited time window for therapy modulating cardiac metabolism and protecting cardiomyocyte structure in failing heart.…”
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