Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components by Malena Herrera Lopez, Matías Bertone Arolfo, Mónica Remedi, Laura Gastaldi, Carlos Wilson, Gonzalo G. Guendulain, Danilo Ceschin, Andrés Cardozo Gizzi, Alfredo Cáceres, Ana Lis Moyano

“…This transcription factor modulates both neural differentiation and pluripotency. …”
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Automated Zebrafish Spine Scoring System Based on Instance Segmentation by Wen-Hsin Chen, Tien-Ying Kuo, Yu-Jen Wei, Cheng-Jung Ho, Ming-der Lin, Huan Chen, Wen-Ying Lin

“…Our method was designed using Mask R-CNN as the instance segmentation backbone, enhanced with a mask enhancement module and a small object preprocessing approach to strengthen its detection abilities. …”
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FoodMicroDB: A microbiome database for composition and time‐series research in food by Yahui Li, Hujie Lyu, Haifei Yang, Zhicheng Ju, Chuang Ma, Huiyu Hou, Yao Wang, Yuanping Zhou, Yunyun Gao, Junbo Yang, Shanshan Xu, Defeng Bai, Hao Luo, Salsabeel Yousuf, Tianyuan Zhang, Jiani Xun, Meiyin Zeng, Heyuan Qi, Tong Chen, Yong‐Xin Liu

“…It also includes advanced modules for microbial abundance analysis, cross‐host abundance comparison, and cross‐food analysis. …”
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InP/Si₃N₄ Hybrid Integrated Lasers for RF Local Oscillator Signal Generation in Satellite Payloads by Jessica César-Cuello, Alberto Zarzuelo, Robinson C. Guzmán, Charoula Mitsolidou, Ilka Visscher, Roelof B. Timens, Paulus W. L. Van Dijk, Chris G. H. Roeloffzen, Luis González, José Manuel Delgado Mendinueta, Guillermo Carpintero

“…This paper presents an integrated tunable hybrid multi-laser module designed to simultaneously generate multiple radiofrequency (RF) local oscillator (LO) signals through optical heterodyning. …”
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RevCAR-mediated T-cell response against PD-L1-expressing cells turns suppression into activation by Eugenia Crespo, Liliana R. Loureiro, Antonia Stammberger, Lydia Hoffmann, Nicole Berndt, Anja Hoffmann, Claudia Dagostino, Karla E. G. Soto, Luise Rupp, Claudia Arndt, Martin Schneider, Claudia R. Ball, Michael Bachmann, Marc Schmitz, Anja Feldmann

“…Our findings suggest that RevCAR-mediated targeting of PD-L1 could be a promising therapeutic approach for modulating the TME and improving solid tumor treatment.…”
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A DAG Scheduling Scheme on Heterogeneous Computing Systems Using Tuple-Based Chemical Reaction Optimization by Yuyi Jiang, Zhiqing Shao, Yi Guo

“…A complex computing problem can be solved efficiently on a system with multiple computing nodes by dividing its implementation code into several parallel processing modules or tasks that can be formulated as directed acyclic graph (DAG) problems. …”
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Seepage Analysis on the Surface Layer of Multistage Filled Slope with Rainfall Infiltration by Bingxiang Yuan, Zengrui Cai, Mengmeng Lu, Jianbing Lv, Zhilei Su, Zuqing Zhao

“…Based on the theory of rainfall infiltration, the surface infiltration model of multilevel filled slope was established by using the SEEP/W module of GeoStudio. The changes of the volumetric water content (VWC) and pore water pressure (PWP) in the surface of the slope during the rainfall infiltration were analyzed, and the influence of the change of the rainfall conditions on the VWC and PWP was considered. …”
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Effect of Common Buffers and Heterocyclic Ligands on the Binding of Cu(II) at the Multimetal Binding Site in Human Serum Albumin by Magdalena Sokołowska, Krystyna Pawlas, Wojciech Bal

“…These results indicate that metal binding properties of MBS can be modulated directly and indirectly by small molecules.…”
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Microbial biogeography along a 2578 km transect on the East Antarctic Plateau by Victor Parro, María Ángeles Lezcano, Mercedes Moreno-Paz, Alfonso F. Davila, Armando Azua-Bustos, Miriam García-Villadangos, Jacek Wierzchos, Miguel Ángel Fernández-Martínez, Ramón Larramendi, Hilo Moreno, Ignacio Oficialdegui, Manuel Olivera, Miguel Redondo-Nieto, Pedro Mustieles-del-Ser, Mariusz Potocki, Paul Andrew Mayewski, Sergi González-Herrero, Ana Justel, Antonio Quesada

“…Data point to geochemical and bacterial geographic distribution that correlate with wind trajectory and speed, modulated by local gathering and recirculation of microorganisms through snow drifting. …”
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PAI-1: An Integrator of Cell Signaling and Migration by Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins

“…These events appear distinct from the original function of uPA/PAI-1 as modulators of the plasmin-based proteolytic cascade. …”
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Dynamic Spectrum Sensing Under Crash and Byzantine Failure Environments for Distributed Convergence in Cognitive Radio Networks by Ali Mustafa, Muhammad Najam Ul Islam, Salman Ahmed

“…The proposed algorithm is investigated under crash and Byzantine failure environments to study their behavior and efficiency for consensus. Energy detector module is modeled for each cooperating SU in cognitive radio network for sensing the presence of PU in a dedicated spectrum. …”
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Porous Cellulose Beads Fabricated from Regenerated Cellulose as Potential Drug Delivery Carriers by Lee Ken Voon, Suh Cem Pang, Suk Fun Chin

“…The loading capacity and efficiency of curcumin onto CBs could be enhanced via the optimization of curcumin solution concentration and the morphological characteristics of CBs, whereas the release kinetic profiles of curcumin from CBs could be modulated by varying the mean diameter of CBs. Optimized CBs derived from regenerated cellulose of paper wastes are potentially useful as cost-effective drug delivery carriers.…”
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Role of Lactate in Inflammatory Processes: Friend or Foe by Carolina Manosalva, John Quiroga, John Quiroga, Alejandra I. Hidalgo, Pablo Alarcón, Nicolás Ansoleaga, Nicolás Ansoleaga, María Angélica Hidalgo, Rafael Agustín Burgos

“…Additionally, various targets, including post-translational modifications, G-protein coupled receptor and transcription factor activation such as NF-κB and HIF-1, allow lactate to modulate signaling pathways that control the expression of cytokines, chemokines, adhesion molecules, and several enzymes associated with immune response and metabolism. …”
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Adipokines regulate the development and progression of MASLD through organellar oxidative stress by Ke Zhao, Heng Zhang, Wenyu Ding, Xiaoshuai Yu, Yanli Hou, Xihong Liu, Xinhua Li, Xiaolei Wang

“…Human adipose tissue, an integral endocrine organ, secretes an array of adipokines that are modulated by dietary patterns and lifestyle choices. …”
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Enhancing cybersecurity incident response: AI-driven optimization for strengthened advanced persistent threat detection by Gauhar Ali, Sajid Shah, Mohammed ElAffendi

“…This study proposes six event detection modules to identify 14 different types of malicious behavior using Splunk. …”
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Deep-Learning-Based Bughole Detection for Concrete Surface Image by Gang Yao, Fujia Wei, Yang Yang, Yujia Sun

“…A deep convolutional neural network for detecting bugholes on concrete surfaces was developed, by adding the inception modules into the traditional convolution network structure to solve the problem of the relatively small size of input image (28 × 28 pixels) and the limited number of labeled examples in training set (less than 10 K). …”
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Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spina... by Mary J. Eaton, Eva Widerström-Noga, Stacey Quintero Wolfe

“…Transplant of cells which make biologic agents that can modulate the sensory and motor responses after spinal cord injury (SCI) would be useful to treat pain and paralysis. …”
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A Computer Vision-Based Framework for Snow Removal Operation Routing by Mohamed Karaa, Hakim Ghazzai, Yehia Massoud, Lokman Sboui

“…As a result, more efficient snow removal operation can be achieved by optimizing the trajectories of trucks based on the computer vision module outputs.…”
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Development and Assessment of an Online, Asynchronous State-Specific Pharmacy Law Continuing Education Program for Multistate Pharmacy Jurisprudence Examination Preparation by Apryl Peddi, Lauren Caldas, Evan Sisson, Sofia Yousufzai, Laura Frankart

“…The course is divided into six modules, aligned with MJPE competency statements. …”
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Understanding the Immune System and Biospecimen-Based Response in Glioblastoma: A Practical Guide to Utilizing Signal Redundancy for Biomarker and Immune Signature Discovery by Luke R. Jackson, Anna Erickson, Kevin Camphausen, Andra V. Krauze

“…However, there are gaps in the understanding of the intricate interactions between GBM and the peripheral immune system and how these interactions change with standard and immune-modulating treatments. The key to understanding the true nature of these interactions is through multi-omic analysis of tumor progression and treatment response. …”
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