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4701
Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity
Published 2025-02-01“…DNA-damaging therapies also modulate cyDNA stimulation capacity, with radiation inducing larger cyDNA sizes and increased mitochondrial DNA content. …”
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4702
Photovoltaic High-Frequency Pulse Charger for Lead-Acid Battery under Maximum Power Point Tracking
Published 2013-01-01“…Maximum energy transfer between the PV module and a boost current converter (BCC) is modeled to maximize the charging energy for LAB under different solar insolation. …”
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4703
Deciphering consciousness: The role of corticothalamocortical interactions in general anesthesia
Published 2025-02-01“…Emerging evidence highlights the critical role of corticothalamocortical circuits, which are involved in higher cognitive functions, in controlling arousal states and modulating transitions between different conscious states during anesthesia. …”
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4704
Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration
Published 2025-01-01“…Moreover, Ru-hydroxide can effectively sustain stem cell viability and osteogenic differentiation in elevated ROS environments, modulating the inflammatory microenvironment during bone tissue regeneration in male mice. …”
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4705
Antitumor Responses of Invariant Natural Killer T Cells
Published 2015-01-01“…Next, we delineate the mechanisms by which iNKT cells influence and modulate the activity of other immune cells to directly or indirectly affect tumor growth. …”
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4706
Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application
Published 2025-01-01“…Ketone bodies (KBs), which are generated during lipid metabolism, are fundamental bioactive molecules that can be modulated to satisfy the escalating metabolic needs of cancer cells. …”
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4707
Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling
Published 2012-09-01“…A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. …”
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4708
The Role of Protein Modifications of T-Bet in Cytokine Production and Differentiation of T Helper Cells
Published 2014-01-01“…T-Bet simultaneously modulates IL-2 and Th2 cytokines in an IFN-γ-independent manner, resulting in an attenuation of Th2 cell development. …”
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4709
Infusing Oral Health Care into Nursing Curriculum: Addressing Preventive Health in Aging and Disability
Published 2012-01-01“…This descriptive study reports on the interdisciplinary development, implementation, and testing of an oral health module that was included and infused into a graduate nursing curriculum in a three-phase plan. …”
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4710
Electrical Stimulation of the Ear, Head, Cranial Nerve, or Cortex for the Treatment of Tinnitus: A Scoping Review
Published 2016-01-01“…Neurostimulation therapies should modulate neural activity to deliver a permanent reduction in tinnitus percept by driving the neuroplastic changes necessary to interrupt abnormal levels of oscillatory cortical activity and restore typical levels of activity. …”
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4711
Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis
Published 2018-01-01“…We will also discuss the most recent strategies in modulating the inflammatory microenvironment that have an impact on neutrophil function which may provide alternative novel therapies for RA.…”
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4712
Numerical Simulation Study on Directional Solidification of DD5 Nickel-Based Single-Crystal Turbine Blades
Published 2024-12-01“…Two models with a wax module tree structure were employed for directional solidification simulation. …”
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4713
Estimation of Continental-Basin-Scale Sublimation in the Lena River Basin, Siberia
Published 2015-01-01“…We found that the ratio of sublimation to snowfall in forests was around 26% and that interannual variation of sublimation modulated spring river runoff.…”
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4714
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse
Published 2025-01-01“…In a mouse model of APAP-induced injury, peripherally injected cryopreserved hAAMs reduced liver necrosis, modulated inflammatory responses, and enhanced liver regeneration. hAAMs were effective even when administered after the therapeutic window for NAC. …”
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4715
Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview
Published 2025-01-01“…We present a review of the methodology and the preliminary outcomes of the pioneering studies exploring intracranial biomarker detection and closed-loop neuromodulation to modulate high-symptom severity states in neuropsychiatric disorders. …”
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4716
Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice
Published 2021-05-01“…Overall, YB improved function and prevented MetS by modulating the gut microbiota and alleviating oxidative stress.…”
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4717
Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse
Published 2016-01-01“…Additionally, we observed that Oprm1−/− mice act as less attractive social partners than wild types, which suggests that social motivation can be modulated by the stimulus employed. This experiment supports previous findings suggesting that early social environmental stimulation has profound and long-term beneficial effects, encouraging the use of nonpharmacological interventions for the treatment of social defects in neurodevelopmental diseases.…”
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4718
Research on Fault Diagnosis of Ship Propulsion System Based on Improved Residual Network
Published 2025-01-01“…Lastly, a residual network, which includes a Squeeze-and-Excitation module, is engineered to boost the identification of crucial fault characteristics. …”
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4719
CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation
Published 2025-01-01“…Additionally, natural products such as flavonoids and glycosides, by modulating circRNA-miRNA-mRNA networks, offer promising therapeutic strategies. …”
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4720
Secure software development: leveraging application call graphs to detect security vulnerabilities
Published 2025-01-01“…The extracted information undergoes strict evaluation against the anticipated function call sequence in the relevant cryptographic module to identify and localize potential security issues. …”
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