Improved CenterNet for Accurate and Fast Fitting Object Detection by Huimin He, Qionglan Na, Dan Su, Kai Zhao, Jing Lou, Yixi Yang

“…In addition, the lightweight receptive field enhancement module is proposed for the deep layer features to further enhance the characterization power of global features and generate more accurate heatmaps. …”
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CSTN: A cross-region crop mapping method integrating self-training and contrastive domain adaptation by Shuwen Peng, Liqiang Zhang, Rongchang Xie, Ying Qu

“…The interpretability of the model is demonstrated through an in-depth analysis of feature map visualizations, attention map visualizations, and the effectiveness of the modules. This study provides a robust method for enhancing large-scale crop mapping and facilitating more accurate and timely agricultural practices.…”
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Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products by Jing Long, Hengzhou Lai, Yuqing Huang, Fengming You, Yifang Jiang, Qixuan Kuang

“…Future research should leverage emerging technologies to further elucidate the composition and interactions within the bone marrow microenvironment, as well as the specific pathways through which natural products modulate hematopoietic dysfunction.…”
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Relationship between Dyskerin Expression and Telomerase Activity in Human Breast Cancer by Lorenzo Montanaro, Maria Calienni, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Stefano Pileri, Davide Treré, Massimo Derenzini

“…In conclusion, our results indicated that, beside its effect on ribosome biogenesis, the levels of dyskerin in cancer cells modulate telomerase activity through the regulation of TERC levels, independently of TERT expression. …”
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In vitro studies on the immunomodulatory effects of fulvic acid extract from palm oil empty fruit bunch (OPEFB) by Dimarwanita Firda, Mariya Silmi, Nur Annisa Dewi Fitria, Latisya Silva, Faramitha Yora, Goenadi Didiek Hadjar

“…With an increasing need for sustainable natural therapies, FA has shown promise in treating degenerative diseases by modulating immune responses. The research focused on assessing the immunomodulatory effects of FA by analysing its impact on cytokine production. …”
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Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities by Anna Hernández-Aguilera, Anna Rull, Esther Rodríguez-Gallego, Marta Riera-Borrull, Fedra Luciano-Mateo, Jordi Camps, Javier A. Menéndez, Jorge Joven

“…Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.…”
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Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer by Chao Wang, Zihao You, Guoqing Zhou, Juanjuan Dong, Sihao Tong, Guoping Sun

“…Moreover, it was uncovered that AG retarded Nrf2/HO-1/GPX4 activation. Additionally, AG modulated PTC cell viability and stimulated ferroptosis. …”
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Electrocardiographic changes induced by temperature variations in newly hatched Aperema (Rhinoclemmys punctularia, Daudin, 1801) by Deise de Lima Cardoso, Deise de Lima Cardoso, Brenda Stefany dos Santos Braga, Brenda Stefany dos Santos Braga, Daniella Bastos de Araújo, Clarissa Araújo da Paz, Luciana Eiró-Quirino, Thaysa de Sousa Reis, Luana Vasconcelos de Souza, Rayllan da Cunha Ferreira, Gabriela Brito Barbosa, Raíssa Vieira de Souza, Yris da Silva Deiga, Maria Klara Otake Hamoy, Diva Anelie de Araújo Guimarães, Diva Anelie de Araújo Guimarães, Moisés Hamoy

“…Therefore, we demonstrated through the electrocardiographic patterns observed during the experiment that a reduction in the ambient temperature to which Rhinoclemmys punctularia are exposed can modulate the conductivity and automaticity of cardiac cells, subsequently leading to a decrease in heart rate.…”
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Pentoxifylline inhibits the fibrogenic activity of pleural effusions and transforming growth factor-β by P. Entzian, M. Schlaak, U. Seitzer, Y. Acil, M. Ernst, P. Zabel

“…Further, we were interested in finding out how TGF-β effects on fibroblast growth could be modulated. We found that pentoxifylline is able to inhibit both fibroblast proliferation and collagen synthesis independently of the stimulus. …”
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Trogocytosis-mediated immune evasion in the tumor microenvironment by Jeonghyun Kim, Soyeon Park, Jungseo Kim, Yewon Kim, Hong Min Yoon, Bima Rexa Rayhan, Jaekwang Jeong, Alfred L. M. Bothwell, Jae Hun Shin

“…Additionally, trogocytosis enables the acquisition of immune-regulatory molecules, such as CTLA-4 and Tim3, in recipient cells, thereby modulating their anti-tumor immunity. Concurrently, donor cells undergo plasma membrane loss, and substantial loss can trigger trogocytosis-mediated cell death, termed trogoptosis. …”
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RNA modifications in cancer by Han Wu, Shi Chen, Xiang Li, Yuyang Li, He Shi, Yiwen Qing, Bohe Shi, Yifei Tang, Zhuoyi Yan, Yang Hao, Dongxu Wang, Weiwei Liu

“…These modifications are regulated by proteins that write, erase, and read RNA and modulate RNA stability, splicing, translation, and degradation. …”
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Enterococcus faecium HDRsEf1 Protects the Intestinal Epithelium and Attenuates ETEC-Induced IL-8 Secretion in Enterocytes by Zhongyuan Tian, Xiaofang Liu, Ran Dai, Yuncai Xiao, Xiliang Wang, Dingren Bi, Deshi Shi

“…Moreover, Ef1 and its cell-free supernatant (S-Ef1) modulate IL-8 released by IPEC-J2 cells. Ef1 and its cell-free supernatant showed the potential to protect enterocytes from an acute inflammatory response. …”
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TRACE assessment of density wave instability onset with void reactivity feedback under natural circulation by Paul Hurley, Yang Liu, Tomasz Kozlowski, Juliana P. Duarte

“…Experiments performed at the Karlstein Thermal Hydraulic Test Facility (KATHY) have reproduced the reactivity feedback mechanism in BWRs under ATWS conditions. Using a neutronics module simulator, the KATHY facility was able to provide data on the effect of different neutronic parameters on DWO onset. …”
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A Novel Approach of Impulsive Signal Extraction for Early Fault Detection of Rolling Element Bearing by Hu Aijun, Lin Jianfeng, Sun Shangfei, Xiang Ling

“…The fault signals of rolling element bearing are often characterized by the presence of periodic impulses, which are modulated high-frequency harmonic components. The features of early fault in rolling bearing are very weak, which are often masked by background noise. …”
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FE-YOLO: An Efficient Deep Learning Model Based on Feature-Enhanced YOLOv7 for Microalgae Identification and Detection by Gege Ding, Yuhang Shi, Zhenquan Liu, Yanjuan Wang, Zhixuan Yao, Dan Zhou, Xuexiu Zhu, Yiqin Li

“…Firstly, the feature extraction capability was enhanced by integrating the CAGS (Coordinate Attention Group Shuffle Convolution) attention module into the Neck section. Secondly, the SIoU (SCYLLA-IoU) algorithm was employed to replace the CIoU (Complete IoU) loss function in the original model, addressing the issues of unstable convergence. …”
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Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis by Madonna R. Peter, Mirjana Jerkic, Valentin Sotov, David N. Douda, Daniela S. Ardelean, Niousha Ghamami, Flavia Lakschevitz, Meraj A. Khan, Susan J. Robertson, Michael Glogauer, Dana J. Philpott, Nades Palaniyar, Michelle Letarte

“…We also demonstrate dysregulated expression of BMPER and follistatin, which are extracellular regulators of the TGF-β superfamily that modulate angiogenesis and inflammation. Heightened colonic levels of the neutrophil chemoattractant and proangiogenic factor, CXCL1, were also observed in DSS-treated Eng+/− mice. …”
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The TIR Domain Containing Locus of Enterococcus faecalis Is Predominant among Urinary Tract Infection Isolates and Downregulates Host Inflammatory Response by Thomas Daniel Kraemer, Orlando Daniel Quintanar Haro, Eugen Domann, Trinad Chakraborty, Svetlin Tchatalbachev

“…When transiently expressed in cultured eukaryotic cells, TcpF caused suppression of TLR2-dependent NF-κB activation suggesting for TcpF a role as a factor in E. faecalis that benefits colonization by modulating the host’s immune responses.…”
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Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice by Gengshu Wu, Liyan Zhang, Tete Li, Gary Lopaschuk, Dennis E. Vance, René L. Jacobs

“…The aim of this study was to evaluate if choline supply could also modulate obesity and insulin resistance caused by a genetic defect. …”
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Biomolecular condensates: Formation mechanisms, biological functions, and therapeutic targets by Xin Niu, Lei Zhang, Yuchen Wu, Zhi Zong, Bin Wang, Jisheng Liu, Long Zhang, Fangfang Zhou

“…Recently, a series of pathological and physiological processes have been found associated with the dysfunction of condensates, and a range of targets and methods have been demonstrated to modulate the formation of these condensates. A more extensive description of biomolecular condensates is urgently needed for the development of novel therapies. …”
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Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers by Feng Hao, Zhang Yan, Luo Shen, Wang Hui, Qiu Ling, Yang Xiaoyu, Jiang Hua

“…Methods We integrated single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to explore immune regulation in OC and CC, focusing on the PI3K/AKT pathway and FLT3 as key modulators. Seurat and Harmony were employed for batch correction and dimensionality reduction. …”
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