Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer by Jingyang Li, Di Zhang, Shaohui Wang, Peng Yu, Jiayi Sun, Yi Zhang, Xianli Meng, Juan Li, Li Xiang

“…However, previous studies have not determined if baicalein exerts proapoptotic effects by modulating the metabolic pathways. Objective: To investigate if baicalein induces apoptosis in lung cancer cells by modulating the glutamine-mTOR metabolic pathway. …”
Get full text

LURAP1L-AS1 long noncoding RNA promotes breast cancer progression and associates with poor prognosis by Radhakrishnan Vishnubalaji, Dania Awata, Nehad M. Alajez

“…Through a custom siRNA library screen targeting TNBC-associated lncRNAs in MDA-MB-231 and BT-549 TNBC cell models, we identified LURAP1L-AS1 as a key modulator of TNBC progression. Survival analysis of TNBC patients demonstrated a significant association between elevated LURAP1L-AS1 expression and poor clinical outcomes.LURAP1L-AS1 knockdown significantly impaired colony formation and organoid growth of TNBC models, associated with increased apoptosis thus highlighting its role in promoting tumorigenicity. …”
Get full text

MASFNet: Multi-level attention and spatial sampling fusion network for pine wilt disease trees detection by Dong Ren, Meng Li, Ziyu Hong, Li Liu, Jingfeng Huang, Hang Sun, Shun Ren, Pan Sao, Wenbin Wang, Jingcheng Zhang

“…Specifically, we designed a Multi-level Attention (MLAttention) module aimed at capturing features through an expanded receptive field to help the model distinguish between the background and the objects of interest. …”
Get full text

Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Emily R. Stevenson, Crystal E. Uvalle, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus

“…Rather, if present in sufficient concentrations, LXA4 and other mono- and poly-hydroxylated unsaturated fatty acids synthesized by macrophages would be readily oxidized to electrophilic α,β-unsaturated ketone products that modulate the redox-sensitive cysteine proteome via G-protein coupled receptor-independent mechanisms.…”
Get full text

Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning by Tao Zhou, Can Zhu, Wei Zhang, Qiongfang Wu, Mingqiang Deng, Zhiwei Jiang, Longfei Peng, Hao Geng, Zhouting Tuo, Zhouting Tuo, Ci Zou

“…Key genes within the module were revealed using weighted gene co-expression network analysis (WGCNA). …”
Get full text

Treatment of uterine fibroid: focus on endometrial receptivity. A pilot randomized prospective study by Yulia E. Dobrokhotova, Irina A. Lapina, Valeriia M. Gomzikova, Yury А. Sorokin, Eleonora T. Khatagova, Ayshan R. Allakhverdieva, Mariya A. Olkhovskaya

“…Group 1 (n=24) included patients with UF who were treated with a selective progesterone receptor modulator, mifepristone 50 mg per day, and group 2 (n=21) – with gonadotropin-releasing hormone agonist triptorelin acetate 3.75 mg once every 28 days for 3 months. …”
Get full text

Implementasi Algoritma Mickey 2.0 untuk Mengamankan Komunikasi Data pada Perangkat Bluetooth Low Energy by Amelia Dwi Rochani, Ari Kusyanti, Fariz Andri Bakhtiar

“… Kondisi Internet of Things saat ini yang cenderung tanpa menggunakan fitur keamanan dapat menjadi tantangan untuk realisasi Internet of things terutama di bidang privasi dan kerahasiaan data, khususnya pada modul sensorik berdaya rendah yaitu Bluetooth Low Energy. …”
Get full text

Visual hermeneutics as a tool to introduce empathy and core physician attributes in doctor-patient relationship for first-year medical undergraduate students by Sushma Prabhath, Uma Kulkarni, Vani Lakshmi R., Bikash Patra, Eshwari K., Divya Arvind Prabhu, Kirtana R. Nayak

“…Doctor-patient relationship is one of the modules taught in first year as part of mandatory AETCOM (Attitude, Ethics, and Communication) course in the undergraduate Indian medical curriculum. …”
Get full text

Nicotinamide Mononucleotide Restores NAD⁺ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells by Mehboob Ahmed, Umair Riaz, Haimiao Lv, Muhammad Amjad, Sohail Ahmed, Shaokat Ali, Muhammad Usman Ghani, Guohua Hua, Liguo Yang

“…Nicotinamide mononucleotide (NMN) is an important precursor of NAD⁺ and has gained attention for its potential to modulate cellular metabolism, redox homeostasis, and mitigate inflammation. …”
Get full text

Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins by Mindaugas Urba, Jurgita Skieceviciene, Dainius Janciauskas, Laimas Jonaitis, Limas Kupcinskas, Matteo Fassan, Massimo Rugge, Juozas Kupcinskas

“…The progression of Helicobacter pylori-associated gastritis towards atrophic gastritis is modulated by host-related and environmental factors. …”
Get full text

Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…Additionally, it exhibits the ability to enhance myocardial energy metabolism flexibility through modulating metabolites and key enzymes associated with the fatty acid metabolic pathway. …”
Get full text

Solid medical waste management practices and awareness in COVID-19 screening stations by S.E. Alzghoul, O.A. Smadi, T. Almomani, M.B. Alzghoul, O.M. Al-Bataineh

“…Furthermore, the results of the third module revealed that the private sector fails to successfully execute national and international procedures, with the most significant negative responses among other categories.CONCLUSION: It was concluded that Jordan's solid waste collection and disposal methods were effectively implemented, which might aid in the virus eradication. …”
Get full text

User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project by Pascal Raszke, Godwin Denk Giebel, Carina Abels, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Silke Mreyen, Nina Timmesfeld, Marianne Tokic, Frank Martin Brunkhorst, Nikola Blase

“…The scoping review has been concluded and the qualitative modules have been subjected to analysis. The start of the survey, including the DCE, was at the end of July 2024. …”
Get full text

Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers by Yuyun Zhong, Ruiqi Wang, Zijie Huang, Zhaoting Hu, Bin Peng, Bin Chen, Liyue Sun

“…ABSTRACT Background SET domain‐containing protein 4 (SETD4) is a histone methyltransferase that has been shown to modulate cell proliferation, differentiation, and inflammatory responses by regulating histone H4 trimethylation (H4K20me3). …”
Get full text

Separating snow and ice melt using water stable isotopes and glacio-hydrological modelling: towards improving the application of isotope analyses in highly glacierized catchments by T. Müller, T. Müller, M. Fischer, M. Fischer, S. N. Lane, B. Schaefli, B. Schaefli, B. Schaefli

“…The runoff generation and transfer module relies on a combined routing and reservoir approach and is calibrated based on measured streamflow and isotopic data.…”
Get full text

Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

“…It also downregulated mGluR5 and modulated the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits: GluA1 was downregulated, inhibiting long-term potentiation, while GluA2 and GluA3 were upregulated in the nigrostriatal pathway in PD animal models. …”
Get full text

Global Fault-Tolerant Control of Underactuated Aerial Vehicles with Redundant Actuators by Yushu Yu, Yiqun Dong

“…The entire proposed fault-tolerant control algorithm contains a baseline controller, the fault detection and isolation scheme, and the controller reconstruction module. A robust parameter identification method is designed to identify the torque and thrust generated by the actuators. …”
Get full text

Design, Fabrication, and Comparative Study of Electronically Tunable Active Filters by Umesh Kumar, P. Bhushan Mital

“…The circuit is suitable for use as a tunable universal filtering module and can be easily digitally programmed.…”
Get full text

ENGINEERING TEACHER'S PEDAGOGICAL MASTERY: WAYS TO IMPROVE by F. T. Shageeva

“…The program consists of several modules aimed at the improving engineering teacher's pedagogical mastery.…”
Get full text

Les Rois mages. Iconographie et art monumental dans l’espace féodal (xe-xiie siècle) by Mathieu Beaud

“…Being abstract universal figures, the Three Kings constitute a clear picture of the notion of social group, modulated according to various unifying consciences, from the most basic unit to Christian Holism.…”
Get full text