Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice by Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo

“…Because PCSK9 is mainly expressed in the liver and modulates lipid uptake through low-density lipoprotein receptor family members, the present study aimed to elucidate the effect of conditional knockdown of hepatic PCSK9 on hyperlipidemia-induced inflammation and the underlying mechanisms of action.MethodsPCSK9flox/flox mice were bred with ALB-Cre+ mice to obtain hepatic PCSK9(−/−), PCSK9(+/−), and PCSK9(+/+) mice. …”
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CRYβB2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line by Amr A. Waly, London Harper, Jodie M. Fleming, Lindsey M. Costantini

“…RNA sequencing analysis indicated that CRYβB2 overexpression modulated cell-cell adhesion and extracellular matrix organization pathways, which are critical to invasion of cancer cells. …”
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Multiomics Integrated Analysis Identifies SLC24A2 as a Potential Link between Type 2 Diabetes and Cancer by Qin Bian, Haijun Li, Xiaoyi Wang, Tingting Liang, Kai Zhang

“…Moreover, a total of 3719 overlapped DEGs were divided into 8 functional modules. Grey module negatively correlated with T2D and FPG and was markedly involved in ribosome biogenesis. …”
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Weakly Supervised Nuclei Segmentation with Point-Guided Attention and Self-Supervised Pseudo-Labeling by Yapeng Mo, Lijiang Chen, Lingfeng Zhang, Qi Zhao

“…The generated center points are utilized by the segmentation module to facilitate the effective separation of adjacent nuclei. …”
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Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective by Wenhao Liao, Jing Wang, Yuchen Li

“…In Phase II, NPs modulate multiple pathways and mediators regulating gastric mucosal cell cycle, apoptosis, autophagy, and angiogenesis to reverse gastric precancerous lesions. …”
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Cross-Supervised LiDAR-Camera Fusion for 3D Object Detection by Chao Jie Zuo, Cao Yu Gu, Yi Kun Guo, Xiao Dong Miao

“…The latter utilizes three sub-attention modules with different roles to achieve cross-modal interaction within the same space, effectively reducing semantic loss. …”
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Enhancing Underwater Video from Consecutive Frames While Preserving Temporal Consistency by Kai Hu, Yuancheng Meng, Zichen Liao, Lei Tang, Xiaoling Ye

“…In addition, to address the limitations of traditional U-Net models in handling complex multiscale feature fusion, this study proposes a novel underwater feature fusion module. By applying both max pooling and average pooling, this module separately extracts local and global features. …”
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High-entropy assisted capacitive energy storage in relaxor ferroelectrics by chemical short-range order by Tongxin Wei, Jinzhu Zou, Xuefan Zhou, Miao Song, Yan Zhang, Cewen Nan, Yuanhua Lin, Dou Zhang

“…Although high entropy relaxor ferroelectric exhibited enormous potential in functional materials, the chemical short-range order, which is a common phenomenon in high entropy alloys to modulate performances, have been paid less attention here. …”
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Upregulating Nonneuronal Cholinergic Activity Decreases TNF Release from Lipopolysaccharide-Stimulated RAW264.7 Cells by Yi Lv, Sen Hu, Jiangyang Lu, Ning Dong, Qian Liu, Minghua Du, Huiping Zhang

“…We assumed that nonneuronal cholinergic system existing in macrophages could modulate inflammation through autocrine ACh and expressed α7nAChR on the cells. …”
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RETRACTED: LncRNA CCAT2 promotes the proliferation and metastasis of colorectal cancer through activation of the ERK and Wnt signaling pathways by regulating GNB2 expression by Jinhai Tian, Xu Cao, Zongying Jiang, Jia Wang, Wan Fan, Shaoting Zhang, Sien Zhao, Jianmin Sun

“…Conclusion CCAT2 plays a crucial role in CRC progression by modulating the ERK and Wnt signaling pathways through its interaction with GNB2. …”
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The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease by Shiyuan Wang, Yan Huang, Cili Zhou, Huangan Wu, Jimeng Zhao, Luyi Wu, Min Zhao, Fang Zhang, Huirong Liu

“…During the endoplasmic reticulum stress response, miR-665, miR-375, and miR-150 modulate autophagy by regulating the unfolded protein response, which may play an important role in IBD intestinal fibrosis. …”
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Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children by Yali Zhang, Yali Zhang, Yingying Xu, Yingying Xu, Ling Hu, Ling Hu, Xiaomei Wang

“…Probiotics have recently emerged as promising agents for modulating intestinal microecology and have gained considerable attention in clinical research on preventing and treating RRTIs in children. …”
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Synthetic Microbial Communities Enhance Pepper Growth and Root Morphology by Regulating Rhizosphere Microbial Communities by Tian You, Qiumei Liu, Meng Chen, Siyu Tang, Lijun Ou, Dejun Li

“…However, few studies have been conducted to enhance pepper growth via modulating rhizosphere microbial communities by SynCom application. …”
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LMF-Net: A Learnable Multimodal Fusion Network for Semantic Segmentation of Remote Sensing Data by Jihao Li, Wenkai Zhang, Weihang Zhang, Ruixue Zhou, Chongyang Li, Boyuan Tong, Xian Sun, Kun Fu

“…Then, to further harness the cross-modal collaborative embeddings/features, we elaborate two learnable fusion modules, learnable embedding fusion and learnable feature fusion. …”
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Diffused Multi-scale Generative Adversarial Network for low-dose PET images reconstruction by Xiang Yu, Daoyan Hu, Qiong Yao, Yu Fu, Yan Zhong, Jing Wang, Mei Tian, Hong Zhang

“…Methods The proposed method includes two modules: the diffusion generator and the u-net discriminator. …”
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Leverage of lysozyme dietary supplementation on gut health, hematological, antioxidant, and immune parameters in different plumage-colors Japanese quails by Ibrahim A. Elkhaiat, Seham El-Kassas, Safaa E Abdo, Karima El-Naggar, Haitham K. Shalaby, Reyad Y. Nofal, Mayada R. Farag, Mahmoud M. Azzam, Antonia Lestingi

“…These effects were linked with marked modulations of SOD, CAT, GPX, andIL-1βgene expression levels in both quail varieties. …”
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Enhancing Remote Sensing Semantic Segmentation Accuracy and Efficiency Through Transformer and Knowledge Distillation by Kang Zheng, Yu Chen, Jingrong Wang, Zhifei Liu, Shuai Bao, Jiao Zhan, Nan Shen

“…It incorporates a feature refinement module to optimize the transformer's feature learning, and a feature fusion module to effectively merge CNN and transformer features, preventing the insufficient learning of local features by the transformer. …”
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Transcriptome and weighted gene co-expression network analysis of jujube (Ziziphus jujuba Mill.) fruit reveal putative genes involved in proanthocyanin biosynthesis and regulation by Wenqiang Wang, Yunfeng Pu, Hao Wen, Dengyang Lu, Min Yan, Minzhe Liu, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…A weighted gene co-expression network analysis (WGCNA) was performed, and a network module including 1620 genes highly correlated with content of Pas and catechin was established. …”
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immun... by Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We made the following findings: (1) LIUS upregulates proinflammatory IGs and downregulates metastasis genes in cancer cells, and LIUS upregulates adaptive immunity pathways but inhibits danger-sensing and inflammation pathways and promote tolerogenic differentiation in bone marrow (BM) cells. (2) LIUS upregulates IGs encoded for proteins localized in the cytoplasm, extracellular space, and others, but downregulates IG proteins localized in nuclear and plasma membranes, and LIUS downregulates phosphatases. (3) LIUS-modulated IGs act partially via several important pathways of reactive oxygen species (ROS), reverse signaling of immune checkpoint receptors B7-H4 and BTNL2, inflammatory cytokines, and static or oscillatory shear stress and heat generation, among which ROS is a dominant mechanism. (4) LIUS upregulates trained immunity enzymes in lymphoma cells and downregulates trained immunity enzymes and presumably establishes trained tolerance in BM cells. (5) LIUS modulates chromatin long-range interactions to differentially regulate IGs expression in cancer cells and noncancer cells. …”
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Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKα/β/NF-κB Signaling Axis by Rahul Gupta, Dipanjan Roy, Arijit Ghosh, Yasmin Begum, Dipanjan Ghosh, Snehasikta Swarnakar

“…Furthermore, MBZ induced G2/M cell cycle arrest by modulating Cyclin B1, CDC25C, and WEE1. Also, it triggered apoptosis by disrupting mitochondrial membrane potential. …”
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