Design of Interface ASIC with Power-Saving Switches for Capacitive Accelerometers by Juncheng Cai, Yongbin Cai, Xiangyu Li, Shanshan Wang, Xiaowei Zhang, Xinpeng Di, Pengjun Wang

“…The proposed interface circuit, based on switched-capacitor modulation technology, incorporates a low-noise charge amplifier, sample-and-hold circuit, integrator, and clock divider circuit. …”
Get full text

Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats by Yan-Hong Zhou, Jie-Ping Yu, Yi-Fei Liu, Xiao-Jun Teng, Mei Ming, Peng Lv, Ping An, Shi-Quan Liu, Hong-Gang Yu

“…We concluded that the probable mechanisms of EGB ameliorated inflammatory injury in TNBS-induced colitis in rats by its modulation of inflammatory mediators and antioxidation.…”
Get full text

Acyl-CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic-Associated Steatohepatitis by Elisa Pasini, Cristina Baciu, Marc Angeli, Bianca Arendt, Diogo Pellegrina, Jüri Reimand, Keyur Patel, George Tomlinson, Mohammad T. Mazhab-Jafari, Lakshmi P. Kotra, Sandra Fischer, Johane P. Allard, Atul Humar, Mamatha Bhat

“…These results suggest that ACOT1 contributes to the transition from steatosis to MASH through modulation of glycerophospholipid accumulation and its potential as a novel therapeutic target in MASH. …”
Get full text

Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells by Huang Shuaishuai, Tuergong Gulimire, Zhu Hangjie, Wang Xue, Weng Guobin, Ren Yu

“…Collectively, these findings suggest that NCTD might activate JNK and ERK signaling pathways, consequently inducing apoptosis and G2/M arrest through the modulation of related proteins. This study provided evidence that NCTD is a promising therapeutic drug for the treatment of RCC.…”
Get full text

Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-te... by Alan B. Dogan, Spencer R. Marsh, Rachel J. Tschetter, Claire E. Beard, Md R. Amin, L. Jane Jourdan, Robert G. Gourdie

“…Abstract Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. …”
Get full text

The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities by Hajed Obaid A. Alharbi, Mohammad Alshebremi, Ali Yousif Babiker, Arshad Husain Rahmani

“…It has been reported to have a wide range of health benefits including hepatoprotective, antidiabetic, anti-obesity, neuroprotective, cardioprotective, wound healing, antimicrobial, and immunomodulatory effects, achieved through the modulation of various biological activities. Additionally, numerous in vitro and in vivo studies have shown that quercetin’s efficacies in cancer management involve inhibiting cell signaling pathways, such as inflammation, cell cycle, and angiogenesis, activating cell signaling pathways including tumor suppressor genes, and inducing apoptosis. …”
Get full text

CDMA/OTFS Sensing Outperforms Pure OTFS at the Same Communication Throughput by Hugo Hawkins, Chao Xu, Lie-Liang Yang, Lajos Hanzo

“…The results demonstrate that Zadoff-Chu Dl-CDMA/OTFS and DD-CDMA/OTFS consistently outperform pure OTFS sensing, whilst maintaining a similar communication performance at the same throughput. The extra modulation complexity of CDMA/OTFS is similar to that of other OTFS multi-user methodologies, but the demodulation complexity of CDMA/OTFS is lower than that of some other OTFS multi-user methodologies. …”
Get full text

Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways by Ersilia Nigro, Fabio Perrotta, Rita Polito, Vito D’Agnano, Filippo Scialò, Andrea Bianco, Aurora Daniele

“…In addition, the role of the main biological processes that may connect metabolic alterations to SARS-CoV-2 infection such as hyperglycemia, immune system deregulation, ACE-2 receptor modulation, and inflammatory response is described. …”
Get full text

Imaging the Brainstem Raphe in Medication-Overuse Headache: Pathophysiological Insights and Implications for Personalized Care by Annika Mall, Christine Klötzer, Luise Bartsch, Johanna Ruhnau, Sebastian Strauß, Robert Fleischmann

“…It is characterized by both pain modulation and addiction-like mechanisms involving the brainstem raphe, a region critical to serotonergic signaling. …”
Get full text

Targeted Neuromodulation of Abnormal Interhemispheric Connectivity to Promote Neural Plasticity and Recovery of Arm Function after Stroke: A Randomized Crossover Clinical Trial Stu... by Michael R. Borich, Steven L. Wolf, Andrew Q. Tan, Jacqueline A. Palmer

“…This clinical trial aims to characterize ihPAS-induced modulation of interhemispheric connectivity and the effect on motor skill performance and learning in chronic stroke survivors. …”
Get full text

Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity by Salome’ V. Ibba, Mohamed A. Ghonim, Kusma Pyakurel, Matthew R. Lammi, Anil Mishra, A. Hamid Boulares

“…Our study suggests that the amount of iNOS and NO are critical determinants in the modulation of AHR by selective iNOS inhibitors and renews the potential of iNOS as a therapeutic target for asthma.…”
Get full text

An Inverse Correlation of Serum Fibroblast Growth Factor 19 with Abdominal Pain and Inflammatory Markers in Patients with Ulcerative Colitis by Magdalena Panek-Jeziorna, Agata Mulak

“…Bile acids (BA) play an important role in the modulation of numerous gut functions. Fibroblast growth factor 19 (FGF19) is the ileal hormone regulating BA homeostasis. …”
Get full text

A New Digital to Analog Converter Based on Low-Offset Bandgap Reference by Jinpeng Qiu, Tong Liu, Xubin Chen, Yongheng Shang, Jiongjiong Mo, Zhiyu Wang, Hua Chen, Jiarui Liu, Jingjing Lv, Faxin Yu

“…This paper presents a new 12-bit digital to analog converter (DAC) circuit based on a low-offset bandgap reference (BGR) circuit with two cascade transistor structure and two self-contained feedback low-offset operational amplifiers to reduce the effects of offset operational amplifier voltage effect on the reference voltage, PMOS current-mirror mismatch, and its channel modulation. A Start-Up circuit with self-bias current architecture and multipoint voltage monitoring is employed to keep the BGR circuit working properly. …”
Get full text

Piezoresistive Cantilever Microprobe with Integrated Actuator for Contact Resonance Imaging by Tianran Ma, Michael Fahrbach, Erwin Peiner

“…Moreover, a new substrate contact has been added in the new design for an AC voltage supply for the Wheatstone bridge to reduce parasitic signal influence via the EAM (Electromechanical Amplitude Modulation) in our homemade CRI system. Measurements on a bulk Al sample show the expected force dependence of the CR frequency. …”
Get full text

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration by Minkoo Seo, Jin-Chul Kim, Hyung-Ki Kim, Eun wook Choi, Suyeong Jeong, Ki Chang Nam, Mihue Jang

“…Remarkably, we identified round vesicles derived from DaMSC-CM, with an average diameter of ~120 nm that were associated with hair follicle formation, suggesting that secretory vesicles may act as paracrine mediators for modulation of local cellular responses. In addition, these secretory vesicles could regulate the expression of Wnt-3a, Wnt-10b, and lymphoid enhancer-binding factor-1 (LEF-1), which are related to tissue renewal. …”
Get full text

High-resolution X-ray phase-contrast tomography of human placenta with different wavefront markers by Sara Savatović, Davis Laundon, Fabio De Marco, Mirko Riedel, Jörg U. Hammel, Madleen Busse, Murielle Salomé, Lorella Pascolo, Irene Zanette, Rohan M. Lewis, Julia Herzen, Pierre Thibault

“…Both MBI datasets are processed with the Unified Modulated Pattern Analysis (UMPA) model, a pattern-matching algorithm. …”
Get full text

Impact of Experimental Tonic Pain on Corrective Motor Responses to Mechanical Perturbations by Elodie Traverse, Clémentine Brun, Émilie Harnois, Catherine Mercier

“…The observation of a muscle-specific modulation using a cutaneous pain model highlights the fact that the impacts of pain on the motor system are not only driven by the need to unload structures from which the nociceptive signal is arising.…”
Get full text

IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses by Junfeng Zhu, Fangli Yang, Lixuan Sang, Jingbo Zhai, Xiaoqing Zhang, Dan Yue, Shengjun Li, Yan Li, Changlong Lu, Xun Sun

“…Interleukin- (IL-) 33, a member of the IL-1 cytokine family, is an important modulator of the immune system associated with several immune-mediated diseases. …”
Get full text

Tidally Distorted Stars Are Triaxial Pulsators by Jim Fuller, Saul Rappaport, Rahul Jayaraman, Don Kurtz, Gerald Handler

“…Quadrupole modes have similar but slightly more complex behavior. This amplitude modulation allows for mode identification, which can potentially enable detailed asteroseismic analyses of tidally tilted pulsators. …”
Get full text

Nonlinear vibration analysis of a 3DOF double pendulum system near resonance by Asmaa Amer, W. Zhang, T.S. Amer, H. Li

“…These solutions are ascertained by contrasting them with numerical solutions (NS) that are derived utilizing the fourth-order Runge-Kutta algorithm (RKA-4). The modulation equations are constructed, and the principal external resonance cases are scrutinized concurrently based on the solvability constraints. …”
Get full text