Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the induction of dendritic cells, cell adhesion molecules, death receptors, and tumour-associated antigens, effectively transforming the tumour into an individualised vaccine. …”
Get full text

Audio classification using grasshopper‐ride optimization algorithm‐based support vector machine by Suryabhan Pratap Singh, Umesh Chandra Jaiswal

“…The robust classification using the proposed grasshopper‐ride optimization algorithm‐based support vector machine (G‐ROA‐based SVM) uses the features, such as multiple kernel Mel frequency cepstral coefficients, spectral flux, spectral kurtosis, and delta‐amplitude modulation spectrogram. The proposed G‐ROA is the integration of ROA and grasshopper optimization algorithm in tuning the optimal weights of SVM and also, the kernel function in SVM is modified using the Gaussian radial basis function, Gaussian kernel, and polynomial kernels. …”
Get full text

Compressive Sensing Based Bayesian Sparse Channel Estimation for OFDM Communication Systems: High Performance and Low Complexity by Guan Gui, Li Xu, Lin Shan, Fumiyuki Adachi

“…In orthogonal frequency division modulation (OFDM) communication systems, channel state information (CSI) is required at receiver due to the fact that frequency-selective fading channel leads to disgusting intersymbol interference (ISI) over data transmission. …”
Get full text

Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals by Ghyda Murad Hashim, Mehdi Shahgolzari, Kathleen Hefferon, Afagh Yavari, Srividhya Venkataraman

“…Several studies have proved that natural plant polyphenols, such as flavonoids, lignans, phenolic acids, alkaloids, phenylpropanoids, isoprenoids, terpenes, and stilbenes, could be used in anticancer prophylaxis and therapeutics by recruitment of mechanisms inclusive of antioxidant and anti-inflammatory activities and modulation of several molecular events associated with carcinogenesis. …”
Get full text

Modeling, Assessment, and Design of Porous Cells Based on Schwartz Primitive Surface for Bone Scaffolds by Rita Ambu, Anna Eva Morabito

“…In this paper a triply periodic minimal surface (TPMS), the Schwarz’s Primitive surface (P-surface), has been considered as scaffold unit cell and conveniently parameterized in order to investigate the effect of modulation of analytical parameters on the P-cell geometry and on its properties. …”
Get full text

G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells by Matthew Vassey, Rininta Firdaus, Akhmed Aslam, Lee M. Wheldon, Neil J. Oldfield, Dlawer A. A. Ala’Aldeen, Karl G. Wooldridge

“…These changes in cell cycle control proteins are coincident with cellular responses including inhibition of cell migration and a G1 cell cycle arrest. Modulation of the cell cycle of host cells is likely to contribute to the pathogenesis of meningococcal disease.…”
Get full text

Lipoxins and Annexin-1: Resolution of Inflammation and Regulation of Phagocytosis of Apoptotic Cells by Michael Scannell, Paola Maderna

“…In this article, we will review the recognition and signaling mechanisms involved in the phagocytosis of apoptotic cells as well as the role of endogenous compounds that play a relevant role in the modulation of inflammation. The first of these endogenous local mediators to be described are lipoxins (LXs). …”
Get full text

The Role of Angiotensin Antagonism in Coronary Plaque Regression: Insights from the Glagovian Model by Abdul H. Alkatiri, Doni Firman, Amir A. Alkatiri, Paskalis I. Suryajaya, Albert Sudharsono

“…On this review, we aim to present the basic mechanism on the role of RAAS in plaque modulation and its arterial remodeling aspect, which is then integrated with the clinical evidence based on the available intravascular ultrasonography (IVUS) studies on coronary arteries.…”
Get full text

Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice by Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser

“…Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. …”
Get full text

Microbial Changes in Subgingival Plaque and Polymicrobial Intracellular Flora in Buccal Cells after Fixed Orthodontic Appliance Therapy: A Preliminary Study by Caterina Montaldo, Matteo Erriu, Francesca Maria Giovanna Pili, Carla Peluffo, Annalisa Nucaro, Germano Orrù, Gloria Denotti

“…The presence of inadequate oral hygiene was considered as a modulation variable for microbial colonization. Statistical analysis was performed by Fisher’s exact test, ANOVA, and Pearson correlation. …”
Get full text

Marine Diterpenoids as Potential Anti-Inflammatory Agents by Yisett González, Daniel Torres-Mendoza, Gillian E. Jones, Patricia L. Fernandez

“…The anti-inflammatory activity of marine diterpenoids has been attributed to the inhibition of Nuclear Factor-κB activation and to the modulation of arachidonic acid metabolism. However, more research is necessary to describe the mechanisms of action of these secondary metabolites. …”
Get full text

Observational Evidence for the Origin of Repetitive Chorus Emissions by Xinliang Gao, Rui Chen, Quanming Lu, Lunjin Chen, Huayue Chen, Xueyi Wang

“…Its repetitive nature directly causes the rapid modulation of pulsating aurora in the upper atmosphere and microburst in the ionosphere, but its origin remains a decades‐old puzzle. …”
Get full text

Adaptive Fringe Projection for 3D Shape Measurement with Large Reflectivity Variations by Using Image Fusion and Predicted Search by Wei Feng, Shaojing Tang, Xiaodong Zhao, Guodong Sun, Daxing Zhao

“…Compared with the traditional structured light measurement methods, our method can decrease the number of projected and captured images with higher modulation and better contrast. In addition, the measurement process only needs two prior steps and avoids hardware complexity, which is more convenient to apply to the industry.…”
Get full text

An electro-optically tunable arrayed waveguide grating fabricated on thin film lithium niobate by Zhe Wang, Zhiwei Fang, Yiran Zhu, Jian Liu, Lang Gao, Jianping Yu, Haisu Zhang, Min Wang, Ya Cheng

“…The monolithically integrated microelectrodes are designed for waveguide phase modulation and wavelength tuning. Experiments show that the fabricated electro-optically controlled TFLN AWG has a channel spacing of 200 GHz and a wavelength tuning efficiency of 10 pm/V.…”
Get full text

Quality of Vision after Deep Anterior Lamellar Keratoplasty (Fluid Dissection) Compared to Penetrating Keratoplasty for the Treatment of Keratoconus by Islam Mahmoud Hamdi, Momen Mahmoud Hamdi

“…All aberrations, point spread functions (PSF), and the modulation transfer function (MTF) were not statistically different between groups (P>0.05). …”
Get full text

An Inductive Link-Based Wireless Power Transfer System for Biomedical Applications by M. A. Adeeb, A. B. Islam, M. R. Haider, F. S. Tulip, M. N. Ericson, S. K. Islam

“…The backward data communication unit transmits the data to an outside reader using FSK modulation scheme via the inductive link. To demonstrate the operation of the inductive link, a board-level design has been implemented with high link efficiency. …”
Get full text

Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses by Tamana Eskandari, Yasamin Eivazzadeh, Fatemeh Khaleghinia, Fatemeh Kashi, Valentyn Oksenych, Dariush Haghmorad

“…Traditionally, research on the adaptive immune system has focused on protein antigens, but emerging evidence has underscored the essential role of lipid antigens in immune modulation. Lipid antigens are presented by CD1 molecules and activate invariant natural killer T (iNKT) cells and group 1 CD1-restricted T cells, whereby they impact immune responses to pathogens and tumors. …”
Get full text

Statistical Recognition of OAM States in Free-Space Optical System by Qinnan Zhu, Guowei Yang, Zhiyu Yuan, Meihua Bi, Xuefang Zhou, Miao Hu

“…The orbital angular momentum (OAM) states are used for OAM modulation and OAM multiplexing in free-space optical (FSO) communication systems to enhance the transmission quality and capacity. …”
Get full text

Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders by Mi Eun Kim, Jun Sik Lee

“…Immunomodulators, gene and RNA-based therapeutics, and stem cell methods have all shown promise for more specific and effective interventions. Additionally, the modulation of metabolic states and gut microbiota has emerged as a novel strategy to regulate neuroinflammation. …”
Get full text

Purine but Not Pyrimidine De Novo Nucleotide Biosynthesis Inhibitors Strongly Enhance the Antiviral Effect of Corresponding Nucleobases Against Dengue Virus by Laurent F. Bonnac, Christine D. Dreis, Madhu Rai, Robert J. Geraghty

“…Our study revealed that while a strong potentiation of purine nucleobases by purine de novo nucleotide biosynthesis inhibitors was observed, the pyrimidine nucleobases were not potentiated by pyrimidine de novo nucleotide biosynthesis inhibitors, possibly highlighting a significant difference between the modulation of purine versus pyrimidine de novo pathways and their impact on nucleobase potentiation. …”
Get full text