Are patients with stage III non-small cell lung cancer treated with chemoradiotherapy at risk for cardiac events? Results from a retrospective cohort study by Juliette Degens, D De Ruysscher, Ruud Houben, Bastiaan Kietselaer, Gerben Bootsma, Lizza Hendriks, Ellen Huijbers, Annemie Schols, Anne-Marie C Dingemans

“…Long-term data on mild to moderately severe cardiac events as underlying cause of dyspnoea in patients with stage III NSCLC are lacking. …”
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Impact of centrifugal therapeutic plasma exchange on platelet counts in patients with neurological autoimmune diseases by GAO Qingmei, ZHU Xinfang, WANG Yuan, ZHONG Yao, ZHANG Qi, XIA Rong

“…Spearman's correlation analysis indicated that platelet loss did not correlate with the duration of TPE (ρ=0.037), the age of the patient (ρ=0.015), or the volume of the single replacement fluid (ρ=0.034), P>0.05, weakly correlated with the number of TPE sessions (ρ=0.017), and moderately correlated with the PLT counts before TPEs (ρ=0.446). …”
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Beclin-1 as a potential prognostic marker in correlation with E-cadherin in oral lichen planus and oral squamous cell carcinoma: an immunohistochemical analysis by Heba N. Shalash, Radwa R. Hussein, Fatma Seragel-Deen

“…They were classified into three groups (20 each) as follows: group 1: the negative control group; group 2: comprised OLP cases, subdivided into two groups (10 each): group 2A, the erosive type and group 2B, the nonerosive type and group 3: comprised the OSCC cases, subdivided into two groups (10 each): group 3A, well-differentiated OSCC and group 3B, moderately differentiated OSCC. Immunohistochemistry was utilized to assess the expression levels of both Beclin-1, as a marker of autophagy and E-cadherin, as a marker of invasiveness and aggressiveness, to validate the malignant transformation potential. …”
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Sustainability of regional Antarctic ice sheets under late Eocene seasonal atmospheric conditions by D. H. A. Vermeulen, M. L. J. Baatsen, A. S. von der Heydt

“…Paradoxically, this atmospheric regime – particularly its coastal precipitation in winter – appears to be necessary for the sustenance of the moderately sized regional ice sheets we imposed on the continent, contrary to our assumption that these ice sheets would disrupt the atmospheric regime. …”
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Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults by Hao Shu, Gangyu Ding, Xiaona Xu, Xuerong Huang, Ruqian He

“…The primary aim of this study was to investigate the association between CSF sTREM1 levels and longitudinal changes in hippocampal volumes, and to determine if this relationship is moderated by cognitive status.MethodsWe included 576 participants, comprising 152 cognitively unimpaired (CU) and 424 cognitively impaired (CI) individuals. …”
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Agricultural land use conflict identification and land degradation risk analysis from the perspective of spatial matching in the Ili River Valley by DONG Guanglong, WANG Jue, WANG Han, CHENG Weiya, LIU Zheng, ZHANG Wenxin

“…The actual land use in this region exceeded the appropriate range of natural land use determined by natural resource endowments, and the spatial mismatch of agricultural resources was obvious. (3) The soil erosion insensitive area in the Ili River Valley was the most widely distributed, covering an area of 44442.46 km², accounting for 67.14% of the total study area, and widely distributed in the flat and open plain area of the Ili River Valley. The moderately sensitive, highly sensitive, and extremely sensitive areas were 3811.25, 3692.74, and 2683.44 km², respectively, which are mainly distributed in the northern part of Khorgos City, the southern part of Zhaosu County, and the northern part of Nilek County. (4) The high land degradation risk area covered 4200.92 km², accounting for 20.95% of the agricultural land use conflict area and 7.63% of the Ili River Valley, mainly distributed in the north, middle, and south Tianshan Mountains with rugged terrain and harsh natural environment making it suitable for woodland or mixed forest and grass. …”
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Optical coherence tomography angiography reveals abnormal retinal vascular density and perfusion in patients with X-linked adrenoleukodystrophy: a cross-sectional study by Lujie Zhang, Yongqiu Yu, Ting Liu, Chongyi Li, Liang Tan, Shuiqian Wen

“…Among the 52 patients, the expanded disability status score (EDSS) was moderately negatively correlated with the vascular density (p = 0.001) and perfusion area (p = 0.002) in the peripheral ring superior quadrant of the macular SVC. …”
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Seroprevalence of anti-ToxoplasmaIgG among the human population in Indonesia: a systematic review and meta-analysis by Taufik Mulya Perdana, Alfin Harjuno Dwiputro, Stefanie Kusuma, Artha Maressa Theodora Simanjuntak, Frengki Prabowo Saputro Wijayanto

“…Publication year, sample size, and RoB were identified as non-significant moderators. Seroprevalence did not correlate with annual precipitation. …”
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Coronary Atherosclerotic Plaque Vulnerability Rather than Stenosis Predisposes to Non-ST Elevation Acute Coronary Syndromes by Mohamed Laimoud, Farouk Faris, Helmy Elghawaby

“…Non-ST elevation acute coronary syndromes (NSTE-ACS) may arise from moderately stenosed atherosclerotic lesions that suddenly undergo transformation to vulnerable plaques complicated by rupture and thrombosis. …”
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The Groundwater Geochemistry and the Human Health Risk Assessment of Drinking Water in an Area with a High Prevalence of Chronic Kidney Disease of Unknown Etiology (CKDu), Sri Lank... by W. S. M. Botheju, J. A. Liyanage, S. D. P. Kannangara

“…The hardness values in the CKDu prevalent site indicated “moderately hard water,” while the non-CKDu area indicated the “soft water.” …”
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Effects of chronic exposure of specific water quality parameters in poultry drinking water on dietary amino acid digestibility and early broiler performance by Rabin Raut, Biswajit Kumar Biswas, Thyneice Taylor-Bowden, Agnes Kilonzo-Nthenge, Bharat Pokharel, Tom Tabler, Samuel N. Nahashon, Pramir Maharjan

“…Four treatment groups were created based on water source and water quality types: i) municipal water source (MW); ii) well/underground water source with moderately higher levels of Ca, SO4–, and Mn (WW); iii) high-pH (>8) water (HPH); and iv) high-TDS water (>3000 ppm) (HTDS). …”
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Low body mass index as a predictor of sputum culture conversion and treatment outcomes among patients receiving treatment for multidrug-resistant tuberculosis in Lesotho by Lawrence Oyewusi, Chengbo Zeng, KJ Seung, Stephanie Mpinda, Mikanda Kunda, Carole D Mitnick, Makelele Kanu, Meseret Tamirat, Joalane Makaka, Mabatloung Mofolo, Refiloe Maime, Llang Maama, Ninza Senyo, Bamidele Oguntoyinbo, Lwayi Mayombo, Molly F Franke

“…Low BMI was associated with a lower frequency of culture conversion at six months among those who were not living with HIV (relative risk [RR]: 0.50 [95% CI: 0.21, 0.79]); this association was attenuated among those living with HIV (RR: 0.88 [95% CI: 0.68, 1.23]). A low BMI was moderately associated with a lower frequency of treatment success (RR = 0.89 [95% CI: 0.77, 1.03]), regardless of HIV status. …”
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Molecular cytogenetic characteristics of new spring bread wheat introgressive lines resistant to stem rust by O. A. Baranova, I. G. Adonina, S. N. Sibikeev

“…Evaluation of introgression lines in the field for resistance to the Ug99 race (TTKSK) showed that four lines were immune, two were resistant, three were moderately resistant, and one had an intermediate type of response to infection. …”
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Indications, Surgical Technique and Outcomes of Laparoscopic Splenectomy: A Retrospective Descriptive Study from Srinagar, India by Mushtaq Chalkoo, Mudasir Habib, Ashiq Hussain Raina, Firdous Hamid, Sajad Nazir Malla, Imtiyaz Ahmad Malik

“…Introduction: Laparoscopic splenectomy has become the preferred approach because it offers several advantages over traditional open surgery, including smaller incisions, decreased postoperative pain, reduced blood loss and shorter hospital stays. For mild to moderately enlarged spleens, it has become the procedure of choice. …”
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The relationship between negative psychological state and quality of life among cardiovascular disease patients in China: the masking effect of abnormal dietary behavior by QingNing Chang, QingNing Chang, HaiBo Ma, Can Zhang, Xin Li, YiBo Wu, LiNa Ha

“…The purpose of this study was to construct a moderated mediation model to explore the roles of abnormal dietary behavior and family health in the mechanism through which depression/anxiety influences Quality of life (QoL) in patients with cardiovascular disease.MethodsA field survey was conducted in China and ultimately included 730 patients with cardiovascular disease aged 20–60 years. …”
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Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review by Lauren M Henry, Morkeh Blay-Tofey, Clara E Haeffner, Cassandra N Raymond, Elizabeth Tandilashvili, Nancy Terry, Miryam Kiderman, Olivia Metcalf, Melissa A Brotman, Silvia Lopez-Guzman

“…We will conduct meta-analyses for the distal and proximal outcomes conditional upon sufficient homogeneity in subgroups. Moderation (conditional upon sufficient heterogeneity of outcomes) and mediation (ie, whether changes in proximal outcomes mediate the relation between JITAIs and distal outcomes) will be conducted as appropriate. …”
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Role of IgM testing in the diagnosis and post-treatment follow-up of syphilis: a prospective cohort study by Tania Crucitti, Irith De Baetselier, Hilde Smet, Kara K Osbak, Achilleas Tsoumanis, Marjan Van Esbroek, Chris R Kenyon

“…The IgM EIAs and IgM LIA agreed from fairly to moderately (Cohen’s kappa (κ): 0.36 (EU EIA); κ: 0.53 (MI EIA); κ: 0.40 (MI LIA)) with the diagnosis of syphilis.Conclusions IgM detection was not a sensitive method to diagnose syphilis and was even poorer in the diagnosis of syphilis repeat infections.…”
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Asthma and obesity increase inflammatory markers in children by Harshita Shailesh, Safa Noor, Lena Hayati, Antonisamy Belavendra, Nicholas Van Panhuys, Abdul Badi Abou-Samra, Stefan Worgall, Ibrahim Janahi, Ibrahim Janahi

“…However, the interaction did not result in a synergistic or additive impact on cytokines, indicating a moderating effect of obesity on inflammation in pediatric asthma.ConclusionBoth asthma and overweight/obesity were independently associated with increased expression of pro-inflammatory cytokines and decreased expression of anti-inflammatory cytokine in children. …”
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Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin by Bayazit Yunusbayev, Anna Bogdanova, Nadezhda Nadyrchenko, Lavrentii Danilov, Viktor Bogdanov, Grigory Sergeev, Radick Altinbaev, Fanil Bilalov, Milyausha Yunusbaeva

“…While our findings hardly support overt dysbiosis in the large intestine, the observed microbial changes correlate with moderately elevated calprotectin, albeit at levels not enough to diagnose ongoing inflammation. …”
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Use of Imaging Modalities in Real Life: Impact on Visual Acuity Outcomes of Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration in Germany by Joachim Wachtlin, Georg Spital, Steffen Schmitz-Valckenberg, Sandra Liakopoulos, Jessica Vögeler, Bettina Müller, Focke Ziemssen, Ocean study group

“…Subgroups according to the number of OCT examinations (≤4, rarely OCT examined; 5–8, moderately OCT examined; ≥8, well monitored) were associated with different treatment frequencies and outcomes: Rarely OCT-examined patients had received a median of 4 injections (range: 1–19) at 24 months; well-monitored patients had received a median of 8 injections (range: 1–21) at 24 months. …”
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