Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover tr... by Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

“…Methods A randomized blinded crossover trial was conducted to compare the efficacy and safety of low-dose quadruple antihypertensives (irbesartan 75 mg + metoprolol 23.75 mg + amlodipine 2.5 mg + indapamide 1.25 mg) with standard-dose dual antihypertensives (irbesartan 150 mg + amlodipine 5 mg), both in a single pill, in the initial treatment of patients with mild to moderate hypertension. Patients were randomly assigned in a 1:1 ratio to two crossover sequences. …”
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β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese by Mayuka Nakajima, Michihiro Hosojima, Koichi Tabeta, Sayuri Miyauchi, Miki Yamada-Hara, Naoki Takahashi, Haruna Miyazawa, Yumi Matsuda-Matsukawa, Keisuke Sato, Noriko Sugita, Yasutaka Komatsu, Tomomi Ishikawa, Kazuhiro Akiishi, Kazuhisa Yamazaki, Kiminori Kato, Akihiko Saito, Hiromasa Yoshie

“…Based on the findings, β2-microglobulin (β2-MG) and neutrophil gelatinase-associated lipocalin (NGAL) were selected for comparison and multivariate regression analysis, and the Kruskal–Wallis test followed by Bonferroni correction was used to identify differences in their concentrations between the three periodontitis groups (severe, moderate, and no/mild periodontitis). Results. β2-MG and NGAL exhibited a significant correlation with clinical parameters of periodontitis. …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…Staining was semi-quantitatively scored, and overexpression was defined as moderate to strong positivity. The prognostic impact was assessed by correlating protein expression with patient survival. …”
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Urethra-sparing prostate cancer radiotherapy: Current practices and future insights from an international survey by Jennifer Le Guévelou, Paul Sargos, Piet Ost, Filippo Alongi, Stefano Arcangeli, Alejandro Berlin, Pierre Blanchard, Anna Bruynzeel, Olivier Chapet, Alan Dal Pra, Robert T. Dess, Matthias Guckenberger, Andrew Loblaw, Amar U. Kishan, Barbara Alicja Jereczek-Fossa, David Pasquier, Mohamed Shelan, Shankar Siva, Alison C. Tree, Costantinos Zamboglou, Stephane Supiot, Vedang Murthy, Thomas Zilli

“…Most experts would not apply specific dose constraints to the urethra for either conventional or moderate hypofractionation regimens. When delivering stereotactic body radiotherapy (SBRT), urethra-sparing with dose hotspot limitation (urethra steering) is recommended by 70 % of the experts, in particular when combined with focal boosting (91 %). …”
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Pegilated interferon alpha 2b «Pegaltevir» chronic hepatitis C treatment (randomized clinical trial) by Marina V. Mayevskaya, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda, V. T. Ivashkin

“…Pegaltevir® and PegIntron® treatment groups were comparable safety profile, adverse events were expected, mainly of mild and moderate severity. Conclusion. The hypothesis of identical efficacy of the Russian drug Pegaltevir® tested in the protocol in comparison to PegIntron® was correct and proved. …”
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Effect of high-voltage electrostatic field salting on the quality of salt-reduced Yi ye Cheng golden pomfret by Chunbei Chen, Zefu Wang, Ziliang Gao, Xiaosi Chen, Shuai Wei, Qiuyu Xia, Qinxiu Sun, Yantao Yin, Yang Liu, Shucheng Liu

“…Lipid and protein oxidation increased with the voltage (P < 0.05), which may account for the changes in water retention, texture and flavor. Therefore, moderate HVEF treatment had a positive effect on the quality. …”
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基于现行标准实施后市售一级大豆油品质分析 "Quality analysis of commercially available grade 1 soybean oils after the national standard revision" by 陈焱1，王翔宇1，尤梦圆1，刘芯羽1，李晓龙1，孙承国2，王风艳2 " CHEN Yan1, WANG Xiangyu1, YOU Mengyuan1, LIU Xinyu1, LI Xiaolong1, SUN Chengguo2,WANG Fengyan1"

“…In summary, soybean oil manufacturers should adhere to the principle of moderate processing, retaining the nutrients and reducing the generation of hazardous substances as far as possible while ensuring that the product quality meets the required standards. …”
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Impact of bedroom light exposure on glucose metabolic markers and the role of circadian-dependent meal timing: A population-based cross-sectional study by Qi Li, Yu-xiang Xu, Xiu-zhen Lu, Yu-ting Shen, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Xin Chen, Ying Sun

“…Importantly, circadian-dependent meal timing may have potentially moderate effects on these associations. Keeping bedroom darkness at night and adhering to early eating pattern may be important public health strategies to reduce the risk of glucose metabolism disorders.…”
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Spirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function—FEEL Trial Results by Maria Emília Figueiredo Teixeira, Weimar Kunz Sebba Barroso, Andréa Araújo Brandão, Ana Luiza Lima Sousa, Roberto Esporcatte, Mário Henrique Elesbão de Borba, Ana Clara Neri Ávila Baleeiro, Beatriz Caldas Gonçalves, Enzo Inumaru, Enzo Mata de Sousa, Giovana Barros Leal, Henrique Soares de Araújo Pereira Farias, Juliana Alves de Souza, Lure Emilly Barreto da Silva, Matheus Canguçu de Paiva Queiroz, Frederico Rafael Moreira, Priscila Valverde de Oliveira Vitorino, John Eikelboom, Álvaro Avezum

“…Objectives: To evaluate whether a spirituality-based intervention, compared to a control group, can reduce blood pressure (BP) and improve endothelial function after 12 weeks in patients with mild or moderate hypertension (HTN). Methods: Open randomized controlled trial of adults with stage I or II hypertension. …”
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Ground-based Characterization of (98943) Torifune 2001 CC21, the Target of the Hayabusa2# Space Mission by Marcel M. Popescu, Eri Tatsumi, Javier Licandro, Miguel R. Alarcon, Javier Rodríguez Rodríguez, Miquel Serra-Ricart, Julia de León, Joaquín Fernandez Martin, David Morate, Gabriel N. Simion, Bogdan Alexandru Dumitru, Daniel Nicolae Berteşteanu, George Pantelimon Prodan, Masatoshi Hirabayashi

“…The spectral data indicate a surface affected by moderate space weathering effects.…”
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La flore sauvage du boulevard Dr Henri-Henrot à Reims/Durocortorum : approche carpologique de l’environnement du site et des productions de denrées végétales by Véronique Matterne, Clémence Pagnoux

“…The index average measuring the sensitivity to nitrogen supply for 40 of the 49 taxa growing preferentially in grasslands is 5, a value indicative of mesophilic species, i.e. those species which are satisfied with a moderate or intermittent supply of nutrients, but the index oscillates between 1 and 8 on a scale of 9. …”
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Prevalence of abnormal bone mineral density and its influencing factors among adult residents in Jiangsu province: a cross-sectional survey by Weihao WANG, Huijing HE, Yaoda HU, Xingming CHEN, Tan XU, Ji TU, Ang LI, Binbin LIN, Qihang LIU, Zhiming LU, Tianshu XI, Haibo HUANG, Da XU, Zhili CHEN, Zichao WANG, Guangliang SHAN

“…Age ≥ 60 years, hypertension, and menopause were risk factors for abnormal BMD in female adults, whereas high school education and moderate physical work were protective factors. ConclusionsThe prevalence of abnormal BMD in adult residents of Jiangsu province is relatively low, and the prevalence of abnormal BMD is higher in male adult residents than in female adult residents. …”
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Olanzapine for young PEople with aNorexia nervosa (OPEN): results of a feasibility study by Olena Said, Dominic Stringer, Ece Sengun Filiz, Hiba Mutwalli, Sevgi Bektas, Melahat Nur Akkese, Vanessa Kellermann, Katie Ireland, Elizabeth Tyrrell-Bunge, Demelza Beishon-Murley, Joel W. T. Khor, Lee Allman, Joanna Barker, Nicus Kotze, Ben Carter, Mima Simic, Dilveer Singh Sually, Jessica Bentley, Allan H. Young, Sloane Madden, Sarah Byford, Sabine Landau, Vanessa Lawrence, Janet Treasure, Ulrike Schmidt, Dasha Nicholls, Hubertus Himmerich

“…Abstract Background Despite the availability of evidence-based treatments for anorexia nervosa (AN), remission rates are moderate, and mortality is high. Olanzapine is used as adjunct therapy for AN in case of insufficient response to first-line treatments, even though the evidence is limited. …”
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Utilizing a Wireless Radar Framework in Combination With Deep Learning Approaches to Evaluate Obstructive Sleep Apnea Severity in Home-Setting Environments by Lee KT, Liu WT, Lin YC, Chen Z, Ho YH, Huang YW, Tsai ZL, Hsu CW, Yeh SM, Lin HY, Majumdar A, Chen YL, Kuan YC, Lee KY, Feng PH, Chen KY, Kang JH, Lee HC, Ho SC, Tsai CY

“…Additionally, Youden’s index was used to establish cutoff thresholds for the bRDITIB, followed by multiclass classification and outcome comparisons.Results: A strong correlation (ρ = 0.87) and high agreement (93.88% within the 95% confidence interval; 138/147) between the AHI and bRDITIB were identified. The moderate-to-severe OSA model achieved 83.67% accuracy (with a bRDITIB cutoff of 21.19 events/h), and the severe OSA model demonstrated 93.21% accuracy (with a bRDITIB cutoff of 28.14 events/h). …”
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Application of indigenous zinc-solubilizing bacteria in biofertilizers to enhance zinc nutrition of rice grains in inceptisols paddy fields by E. Pratiwi, P. Lestari, Y. Nugraha, W. Hartatik, Z. Susanti, I.G.M. Subiksa, A. Kasno, T.A. Adriany, Y.S. Fatma, A.F. Nababan, A.A. Rivaie

“…In terms of zinc content in grains, the rice variety Inpago 13 Fortiz exhibited a notable increase compared to the Inpari IR Nutrizinc variety, with levels of 40.3 milligrams per kilogram as opposed to 34.1 milligrams per kilogram.CONCLUSION: the utilization of a native combination of carefully chosen zinc-solubilizing bacterial strains could augment the productivity, zinc concentration, and absorption in rice grains of various varieties in a paddy field with Inceptisols soil type, characterized by a moderate to high overall zinc content and limited zinc accessibility. …”
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Long-Term Evaluation of GCOM-C/SGLI Reflectance and Water Quality Products: Variability Among JAXA G-Portal and JASMES by Salem Ibrahim Salem, Mitsuhiro Toratani, Hiroto Higa, SeungHyun Son, Eko Siswanto, Joji Ishizaka

“…The Global Change Observation Mission-Climate (GCOM-C) satellite, launched in December 2017, is equipped with the Second-generation Global Imager (SGLI) sensor, featuring a moderate spatial resolution of 250 m and 19 spectral bands, including the unique 380 nm band. …”
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Mitral Valve Repair by Irbaz Hameed, MD, Adham Ahmed, BS, Christina Waldron, BS, Percy T. Algarate, MD, Michal Kawczynski, MD, Maurish Fatima, MBBS, BS, Amnah Alhazmi, MBBS, Samantha Colon, BS, Alexandria Brackett, MA, MLIS, Samuel Heuts, MD, PhD, Peyman Sardari Nia, MD, PhD, Mario Gaudino, MD, PhD, Vinay Badhwar, MD, Arnar Geirsson, MD

“…The primary outcomes were long-term survival, freedom from reoperation, and freedom from recurrent mitral regurgitation (moderate-severe). A novel meta-analytic volume-outcome approach using reconstructed Kaplan-Meier-derived individual patient data from the original studies was used. …”
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Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts by Jagadeesh Puvvula, Wei-Ting Hwang, Lawrence McCandless, Changchun Xie, Joseph M. Braun, Ann M. Vuong, Youssef Oulhote, Enrique F. Schisterman, Russell T. Shinohara, Linda Booij, Maryse F. Bouchard, Kristin Linn, Michael M. Borghese, Jean R. Seguin, Angelika Zidek, Christine Till, William Fraser, Kimberly Yolton, Kim M. Cecil, Jillian Ashley-Martin, Tye E. Arbuckle, Bruce Lanphear, Aimin Chen

“…Although statistical significance was not attained for child sex as an effect modifier, our stratified analysis unveiled a moderate divergence in association trends. We noted a marginal inverse trend between the chemical biomarker mixture and cognitive scores [Full-Scale Intelligence Quotient (FSIQ) &amp; Performance Intelligence Quotient (PIQ)] among males. …”
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Characteristics of cardiopulmonary exercise capacity in adults with different degrees of obesity by Shukun Deng, Shengrui Mei, Qunyan Zhou, Wenjun Zhi, Wenjun Wu, Junyan Cai, Peng Yuan

“…They were categorized into five groups based on their body mass index (BMI): the control group (18.5 ≤ BMI &lt; 24 kg/m2, n = 28), the overweight group (24.0 ≤ BMI &lt; 28 kg/m2, n = 48), the mild obesity group (28 ≤ BMI &lt; 35 kg/m2, n = 75), the moderate obesity group (35.0 ≤ BMI &lt; 40 kg/m2, n = 47), and the severe obesity group (BMI ≥ 40 kg/m2, n = 33). …”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…Solicited local and systemic reactogenicity was mostly mild to moderate in severity. The heterologous prime-boost regimen was immunogenic, including induction of durable antibody responses which peaked as early as two weeks and persisted up to one year after each vaccination. …”
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