Microcephaly protein ANKLE2 promotes Zika virus replication by Adam T. Fishburn, Cole J. Florio, Thomas N. Klaessens, Brian Prince, Neil A. B. Adia, Nicholas J. Lopez, Nitin Sai Beesabathuni, Sydney S. Becker, Liubov Cherkashchenko, Sophia T. Haggard Arcé, Vivian Hoang, Traci N. Shiu, R. Blake Richardson, Matthew J. Evans, Claudia Rückert, Priya S. Shah

“…This decrease in virus replication is coupled with a moderate increase in innate immune activation. Using microscopy, we observe dysregulated formation of virus-induced endoplasmic reticulum rearrangements in ANKLE2 knockout cells. …”
Get full text

GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth by Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Michael G Rosenblum, Brian Aguirre, Cheng-Hsiang Lu, Anubhav Chandla, Nidhi Kejriwal, Lucia Liu, Ann M Chan, SuYin Kok, Sergio Duarte, David Casero, Madhuri Wadehra

“…Ex vivo stability at 37°C indicated a half-life exceeding 96 hours while in vivo PK indicated a biexponential plasma clearance, with a moderate initial clearance (t1/2α=18.4 hours) and a much slower terminal clearance rate (t1/2β=73.1 hours). …”
Get full text

Relationship between triglyceride glucose-body mass index baselines and variation with future cardiovascular diseases risk in the middle-aged and elderly individuals by Junpeng Qiao, Xueyu Chen, Jinhong Pang, Haicheng Fei, Zhang Liu, Fang Cheng, Qiaoqiao Chen, Yingying Zhao, Fengxue Shi, Hongying Jia, Hongying Jia, Weiwei Chi, Weiwei Chi

“…After adjusting for potential confounding factors, compared to participants with consistently low TyG-BMI levels, those with moderate TyG-BMI levels and a slowly increasing trend had an HR of 1.27 (95% CI 1.10-1.47), while those with the highest TyG-BMI levels and a slowly decreasing trend had an HR of 1.52 (95% CI 1.26-1.83).ConclusionMaterial changes in the TyG-BMI are independently associated with the risk of CVDs in middle-aged and elderly individuals. …”
Get full text

COVID-19 and HIV: Clinical Outcomes and Inflammatory Markers in a Cohort from a Reference Hospital in Rio de Janeiro, Brazil by Nathalia Beatriz Ramos de Sá, Karine Venegas Macieira, Mariana Rosa Inacio Coelho, Milena Neira Goulart, Marcelo Ribeiro-Alves, Leonardo Azevedo da Silva Rosadas, Kim Mattos Geraldo, Maria Pia Diniz Ribeiro, Sandra Wagner Cardoso, Beatriz Grinsztejn, Valdiléa G. Veloso, Andressa da Silva Cazote, Dalziza Victalina de Almeida, Carmem Beatriz Wagner Giacoia-Gripp, Fernanda Heloise Côrtes, Mariza Gonçalves Morgado

“…Critical COVID-19 cases showed higher levels of inflammatory markers (Bilirubin, D-dimer, PCR, and urea, as well as IL-8, IL-10, TNF-α, INF-α, IL-1β, IL-17A, IL-23, IL-6) than moderate and severe groups. The COVID/PLWH group had lower CD4 counts (64 cells/mm³) and cytokine levels than other COVID-19 patients. …”
Get full text

Mitigation of soil salinity by biochar and halophytes by Qiang Xu, Yibin Xu, Hanji Xia, Han Han, Mingsi Li, Ping Gong, Chunxia Wang, Yufang Li, Pengfei Li, Hongguang Liu

“…However, excessive biochar applications may hinder surface soil desalination and pose risks of secondary salinization. Thus, a moderate biochar application rate of 45 Mg/ha is recommended for effective water retention and salt suppression in saline wastelands.…”
Get full text

A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With D... by Kim SJ, Yoo WS, Kwon LH, Kim RB, Yoon HJ, Yoon KC

“…We included 60 adults with moderate to severe DED and divided them into two groups. …”
Get full text

Association between non-insulin-based insulin resistance indicators and frailty progression: a national cohort study and mendelian randomization analysis by Hui Tian, Yong-meng Li, Cheng-qiang Wang, Guo-qiang Chen, Ying Lian

“…Results Three FI trajectories including low-stable frailty, moderate-increasing frailty, and accelerated rising frailty were identified. …”
Get full text

Genetic status assessment and future development forecast for an isolated giant panda population by Jiabin Liu, Jiaojiao Yu, Wenlei Bi, Mingxia Fu, Xiang Yu, Rong Hou, Xinqiang Song, Rui Ma, Yanshan Zhou, Zusheng Li, Hong Yang, Wei Wu, Jiang Gu, Chong Huang, Long Zhang, Xiaodong Gu, Haijun Gu, Daode Yang, Dunwu Qi

“…Although the Daxiangling population is small, it has moderate genetic diversity, suggesting potential adaptability. …”
Get full text

Fatty Acids of Erythrocyte Membranes and Blood Serum as Possible Predictors of Exacerbation in Patients with Inflammatory Bowel Diseases by M. V. Kruchinina, M. F. Osipenko, A. I. Valuyskikh, E. Yu. Valuiskikh, I. O. Svetlova

“…Over a period of 6–12 months, 24 patients (mean age — 38.2 ± 4.4 years) with IBD with of moderate and mild severity of the disease were examined, of which 10 patients had ulcerative colitis, 10 — Crohn’s disease, 4 — unclassified colitis: the first examination was in the acute stage, the second was in the remission stage. …”
Get full text

Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance by Alexandre Díaz-Pons, Sergio Castaño-Castaño, Víctor Ortiz-García de la Foz, Ángel Yorca-Ruiz, Carlos Martínez-Asensi, Eva Munarriz-Cuezva, Rosa Ayesa-Arriola

“…Some correlations between cytokine levels and NBAS performance showed moderate associations. Conclusions: These findings highlight the need for ongoing neurodevelopmental monitoring of infants born during the COVID-19 pandemic. …”
Get full text

Prevalence, Risk Factors, and Coinfection of Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis among Primary School Children in Biase, Southern Nigeria by Kenneth Nnamdi Opara, Eteye Udobong Wilson, Clement Ameh Yaro, Luay Alkazmi, Nsima Ibanga Udoidung, Friday Maduka Chikezie, Bassey Eyibio Bassey, Gaber El-Saber Batiha

“…Although the degree of infection is quite low or moderate, there is a need to intensify and sustain control measures such as provision of sustainable clean water supply, health education intervention, and chemotherapy.…”
Get full text

Gestational weight gain and increased risk of cesarean delivery across body mass index categoriesAJOG Global Reports at a Glance by Pearl A. McElfish, PhD, Britni L. Ayers, PhD, Nicola L. Hawley, PhD, Aaron Caldwell, PhD, Austin Porter, DrPh, Michael D. Macechko, MD, Donya Watson, MD, Jennifer A. Callaghan-Koru, PhD, James P. Selig, PhD, Jennifer A. Andersen, PhD, Nirvana Manning, MD, Lanita White, PharmD, Enrique Gomez-Pomar, MD, Clare C. Brown, PhD

“…Among women with a healthy prepregnancy body mass index, the risk of cesarean delivery decreased with appropriate weight gain, suggesting a potential protective effect of moderate weight gain for individuals with a healthy prepregnancy body mass index. …”
Get full text

Toxoplasma gondii in dromedary camels (Camelus dromedarius) in Egypt: a comparative seroepidemiological study in Upper and Lower Egypt by Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy, Nady Khairy Elbarbary, David Cano-Terriza, David Cano-Terriza, Tomás Fajardo, Nada Oudah Albalawi, Débora Jiménez-Martín, Marwa M. I. Ghallab, Ahmed Gareh, Refaat Ras, Refaat Ras, Isabelle Villena, Sabry A. S. Sadek, Hajar AlQadeeb, Hind Alzaylaee, Sonia Almería, Ignacio García-Bocanegra, Ignacio García-Bocanegra

“…Our results provide evidence of moderate, widespread, and heterogeneous spatial distribution of T. gondii among camel populations in Egypt, which might have important implications for animal and public health in that country. …”
Get full text

Mixture density networks for re-constructing historical ocean-color products over inland and coastal waters: demonstration and validation by Sundarabalan V. Balasubramanian, Ryan E. O’Shea, Ryan E. O’Shea, Arun M. Saranathan, Arun M. Saranathan, Christopher C. Begeman, Christopher C. Begeman, Daniela Gurlin, Caren Binding, Claudia Giardino, Michelle C. Tomlinson, Krista Alikas, Kersti Kangro, Moritz K. Lehmann, Moritz K. Lehmann, Lisa Reed

“…The heritage missions include the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard Aqua and Terra, the Environmental Satellite (Envisat) Medium Resolution Imaging Spectrometer (MERIS), and the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-orbiting Partnership (Suomi NPP). …”
Get full text

Arbovirus vectors of epidemiological concern in the Americas: A scoping review of entomological studies on Zika, dengue and chikungunya virus vectors. by Reilly Jones, Manisha A Kulkarni, Thomas M V Davidson, RADAM-LAC Research Team, Benoit Talbot

“…However, all three viruses are associated with moderate to severe health consequences in a small proportion of cases. …”
Get full text

POPULATION STRUCTURE OF LEAF PATHOGENS OF COMMON SPRING WHEAT IN THE WEST ASIAN REGIONS OF RUSSIA AND NORTH KAZAKHSTAN IN 2017 by E. I. Gultyaeva, N. M. Kovalenko, V. P. Shamanin, V. A. Tyunin, E. R. Shreyder, E. L. Shaydayuk, А. I. Morgunov

“…There was a high genetic similarity in virulence and phenotypic composition between the Omsk and the North Kazakhstani population as well as between the Omsk and the Chelyabinsk population and a moderate similarity between the Chelyabinsk and the North Kazakhstani population. …”
Get full text

Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer by Kurt VerCauteren, Abigail Feuka, Michael Lavelle, Michael Glow, Keely Kohen, Patrick Ryan, Tony Aderman, Anthony Duffiney, Mitchell Palmer, Paola M. Boggiatto, Carly Kanipe, Hayden Hamby, Emily Ruell, Melinda Cosgrove, Michael Vanderklok, Nathan Snow, Kim M. Pepin, Henry Campa

“…Consumption, still images, and video data were analyzed to assess uptake of vaccine DUs by deer.Results and discussionVaccine DUs were deployed in 2024 at 11 agricultural sites on private land which had previously demonstrated moderate to high deer activity and at all but two sites >50% of distributed vaccine DU’s were consumed, with 100% consumed at two sites. …”
Get full text

A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…All treatment-emergent adverse events were transient, non-dose dependent, and graded mild to moderate in severity. Nebulization was well-tolerated and completed in an average of 6 min. …”
Get full text

Protocol of the TransformUs SecondaryTeachers’ perceptions of the program reach, effectiveness,adoption, implementation and maintenance schools program: a type II hybrid implementa... by Harriet Koorts, Anna Timperio, Jo Salmon, David Revalds Lubans, Gavin Abbott, Nicola D Ridgers, Natalie Lander, Ana María Contardo Ayala, Emiliano Mazzoli

“…Implementation levels will be classified as low, moderate or high based on the extent of intervention delivery. …”
Get full text

Conocimientos, práctica y actitudes hacia la salud oral entre matronas de España by Yolanda Martínez-Beneyto, Andrea Poza Pascual, Cristina Carazo, Clara Serna-Muñoz, Amparo Pérez-Silva, Antonio José Ortiz-Ruiz

“…Conclusions: Midwives had moderate knowledge about oral health during pregnancy and in infants, which improved significantly after the educational intervention. …”
Get full text