Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…Seventy-two dogs with mild-to-moderate pneumonia were randomly assigned to one of three groups: AB4, placebo, or Chuanxinlian injection (CXL). …”
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Phytochemical Analysis, Antioxidant Activity, Antimicrobial Activity, and Cytotoxicity of Chaptalia nutans Leaves by Letiele Bruck de Souza, Amanda Leitão Gindri, Thainara de Andrade Fortes, Thais Felli Kubiça, Jefferson Enderle, Rafael Roehrs, Sidnei Moura e Silva, Vanusa Manfredini, Elton Luís Gasparotto Denardin

“…DPPH (345.41 ± 5.35 μg/mL) and FRAP (379.98 ± 39.25 μM FeSO4/mg sample) show to extract of C. nutans leaves an intermediate value, indicating moderate antioxidant activity of the extract. Antibacterial results revealed only a positive result (antimicrobial activity) for the hexane fraction which significantly inhibited the microorganisms E. epidermidis, C. tropicalis, C. glabrata, and C. krusei at a concentration of 1000 μg/mL. …”
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Characterizing local forest structural complexity based on multi-platform and -sensor derived indicators by Patrick Kacic, Ursula Gessner, Christopher R. Hakkenberg, Stefanie Holzwarth, Jörg Müller, Kerstin Pierick, Dominik Seidel, Frank Thonfeld, Michele Torresani, Claudia Kuenzer

“…Remotely sensed observations comprise in-situ measurements (mobile and terrestrial laser scanning), as well as spaceborne observations from various sensors (including Sentinel-1 radar, Sentinel-2 multispectral, and GEDI lidar). We found moderate to strong inter-platform correlations among structural complexity metrics (|r| >= 0.6) between mobile laser scanning (box dimension, canopy cover), terrestrial laser scanning (canopy openness index), Sentinel-1 (VH, cross-polarized backscatter), Sentinel-2 (NMDI, Normalized Multi-band Drought Index), and GEDI (total canopy cover). …”
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Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…Results: The extracts of I. bolusiana and I. crassipes exhibited moderate inhibitory activity against α-amylase with an inhibitory percentage range of 10.72 – 30.08 %. …”
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Spinal cord demyelination predicts neurological deterioration in patients with mild degenerative cervical myelopathy by Jefferson R Wilson, David Anderson, Stephan Duplessis, Julien Cohen-Adad, David W Cadotte, Nathan Evaniew, Jacques Bouchard, Michael Craig, Abdul Al-Shawwa, Kalum Ost, Steve Casha, W Bradley Jacobs, Saswati Tripathy, Peter Lewkonia, Fred Nicholls, Alex Soroceanu, Ganesh Swamy, Kenneth C Thomas, Michael MH Yang, Nicholas Dea

“…Key predictors included MT ratio (demyelination) above the MCCL in the dorsal and ventral funiculi and moderate tingling in the arm, shoulder or hand. qMRI metrics significantly improved predictive performance compared to models using only clinical (bal. acc=68.1%) or imaging data (bal. acc=57.4%).Conclusions Reduced myelin content in the dorsal and ventral funiculi above the site of compression, combined with sensory deficits in the hands and gait/balance disturbances, predicts 6-month neurological deterioration in mild DCM and may warrant early surgical intervention.…”
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A Metapopulation Model to Assess Water Management Impacts on the Threatened Australian Lungfish, <i>Neoceratodus forsteri</i> by Charles R. Todd, Andrew J. McDougall, Scott M. C. Raymond, Robin Hale, Timothy R. Brown, John D. Koehn, Henry F. Wootton, Steven G. Brooks, Adrian M. Kitchingman, Tom Espinoza, Benjamin G. Fanson, Peter K. Kind, Sharon M. Marshall, David T. Roberts

“…., 1.2% decline) and a moderate decline in the overall metapopulation (e.g., 22.3% decline). …”
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Heart disease in pregnancy and adverse outcomes: an umbrella review by Jiani Zhang, Jiani Zhang, Yuxin Ren, Yuxin Ren, Bingjie Li, Qi Cao, Qi Cao, Xiaodong Wang, Xiaodong Wang, Haiyan Yu, Haiyan Yu

“…The overall AMSTAR 2 confidence rating for the included meta-analyses and systematic reviews was moderate. The majority (55.3%) of the evidence evaluated by GRADE was of low quality, while the remaining outcomes were categorized as having “very low”-quality evidence.ConclusionCurrent evidence links heart disease during pregnancy to adverse maternal outcomes, including death and cardiac, pulmonary, and cerebrovascular events, as well as increased mortality risk for offspring. …”
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Exploring socio-economic inequalities in mental healthcare utilization in adults with self-reported psychological distress: a survey-registry linked cohort design by J. J. Muwonge, C. Dalman, B. Burström, B. Jablonska, A-C. Hollander

“…We investigated inequalities in MHC use among adults in Stockholm County (Sweden), and whether inequalities were moderated by self-reported psychological distress. …”
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Incidence of constrained condylar and hinged knee implants and mid- to long-term survivorship: a register-based study from the Nordic Arthroplasty Register Association (NARA) by Jake von Hintze, Ville Ponkilainen, Annette W-Dahl, Nils P Hailer, Ove Furnes, Anne M Fenstad, Mona Badawy, Alma B Pedersen, Martin Lindberg-Larsen, Mika J Niemeläinen, Keijo Mäkelä, Antti Eskelinen

“…Results: The incidence of CCK and RHK implants increased significantly in Finland, while it was moderate in Denmark, Norway, and Sweden. With revision for any reason as the endpoint the 15-year K–M cumulative revision risk for RHK was 13.6% (CI 10.4–16.7) and for CCK it was 11.3% (CI 9.1–13.5). …”
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Artificial intelligence conversational agents in mental health: Patients see potential, but prefer humans in the loop by Hyein S. Lee, Hyein S. Lee, Colton Wright, Julia Ferranto, Jessica Buttimer, Clare E. Palmer, Andrew Welchman, Kathleen M. Mazor, Kimberly A. Fisher, David Smelson, Laurel O’Connor, Laurel O’Connor, Nisha Fahey, Nisha Fahey, Apurv Soni, Apurv Soni, Apurv Soni

“…This study aimed to fill the gap by exploring patients’ perceptions and acceptability of AI conversational agents in mental healthcare.MethodsAdults with self-reported mild to moderate anxiety were recruited from the UMass Memorial Health system. …”
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Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study by Gautam Mehta, Rajiv Jalan, Matteo Rosselli, James Maurice, Stewart Macdonald, Alexandra Cronberg, Tanya Khera-Butler, Colin Sumpter, Safa Al-Khatib, Anjly Jain, Christos Charalambous, Amir Gander, Cynthia Ju, Talay Hakan, Roy Sherwood, Devaki Nair, Kevin P Moore

“…No significant changes from baseline in primary or secondary outcomes were noted in the control group.Conclusion These findings demonstrate that abstinence from alcohol in moderate–heavy drinkers improves insulin resistance, weight, BP and cancer-related growth factors. …”
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Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin by Baoguo Shen, Seiji Wada, Tomohiro Sugihara, Takashi Nagata, Haruka Nishioka, Emi Kawano-Yamashita, Takeaki Ozawa, Mitsumasa Koyanagi, Akihisa Terakita

“…Photoresponse analyses of the PP1 cells using gene-knockdown larvae revealed Arr3a-involved quick inactivation was switched to Sagb-involved moderate inactivation depending on increased light intensity. …”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…According to CHD complexity, five (28%) patients had mild, six (33%) moderate, and seven (38%) great defects. Patients with CHD scored significantly higher in the Euro quality of life visual analogue scale (7.83 ± 1.4 vs. 7.14 ± 1.6, <i>p</i> = 0.012) and lower in the Beck Depression Inventory-II (12.3 ± 10.9 vs. 18.1 ± 12.1, <i>p</i> = 0.003) post-program than pre-intervention. …”
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Psychological counselling interventions to improve perceived quality of life and counter anxiety and depression in pulmonary-arterial-hypertension patients: A clinical trial by Emilia TARANTINO, Pietro CRESCENZO, Maria CAMPOBASSO, Francesca D’ALESSANDRO, Paola ARGIENTO, Emanuele ROMEO, Stefano GHIO, Patrizio VITULO, Francesco PARISI, Massimiliano MULÈ, Carlo ALBERA, Carmine Dario VIZZA, Michele D’ALTO

“…Results: A sample of 50 patients with a PAH diagnosis was evaluated; among them 6% had mild PAH, 66% moderate PAH, and 28% severe PAH. The majority (53%) did not receive psychological counselling. …”
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Characterization of RAP Signal Patterns, Temporal Relationships, and Artifact Profiles Derived from Intracranial Pressure Sensors in Acute Traumatic Neural Injury by Abrar Islam, Amanjyot Singh Sainbhi, Kevin Y. Stein, Nuray Vakitbilir, Alwyn Gomez, Noah Silvaggio, Tobias Bergmann, Mansoor Hayat, Logan Froese, Frederick A. Zeiler

“…RAP remains largely unexplored in cases of moderate to severe acute traumatic neural injury (also known as traumatic brain injury (TBI)). …”
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Pengaruh Pemberian Kopi Instan Oral Terhadap Kadar Asam Urat pada Tikus Wistar by Fauzan Arisyi Koto, Husnil Kadri, Zelly Dia Rofinda

“…Control was not treat with coffee, treatment 1 were given low dose of coffee equivalent to 3 cups (0,39 mg/3 ml), treatment 2 were given moderate dose of coffee equivalent to 6 cups (0,78 mg/ 3ml), treatment 3 were given high dose of coffee equivalent to 10 cups (1,3 mg/ 3ml) for 4 weeks (28 days). …”
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Prevalence of myopia and refractive parameters among children and adolescents in Hi-tech District of Chengdu City by Xiaoqin Wang, Liuzhi Zeng, Yiping Xian, Mei Xin, Qingqing Shan, Weiye Li, Lixia Lv, Yifeng Liu, Rui Zhang, Kejian Song, Xixi Tian, Han Guo, Changjiang Yan, Chunyan Li, Xueni Luo, Honglin Luo, Ling Yang, Jun Luo, Zejun Chen

“…Mild myopia was the most common (24.47%), followed by moderate (10.77%) and severe myopia (2.91%). The mean SER were −1.72 ± 1.57 D in 2021, −1.32 ± 1.51 D in 2022, and −1.42 ± 1.36 D in 2023 (P &lt; 0.001). …”
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Parasitic Zoonoses in Humans and Their Dogs from a Rural Community of Tropical Mexico by Antonio Ortega-Pacheco, Juan F. J. Torres-Acosta, Alejandro Alzina-López, Eduardo Gutiérrez-Blanco, Manuel E. Bolio-González, Armando J. Aguilar-Caballero, Roger I. Rodríguez-Vivas, Edwin Gutiérrez-Ruiz, Karla Y. Acosta-Viana, Eugenia Guzmán-Marín, Alberto Rosado-Aguilar, Matilde Jiménez-Coello

“…From the total of blood samples taken from dogs, 87 (97.6%) were seropositive to T. gondii; only 52 viable fecal samples were collected from dogs of which 46.2% had the presence of gastrointestinal parasites with low to moderate intensity; from those, 12% had the presence of T. canis. …”
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The FIT FIRST 10 dose-response study: evaluation of implementation outcomes by Sofie Koch, Sofie Koch, Caroline Eckert, Nikos Ntoumanis, Nikos Ntoumanis, Nikos Ntoumanis, Cecilie Thøgersen-Ntoumani, Cecilie Thøgersen-Ntoumani, Cecilie Thøgersen-Ntoumani, Chiara Cimenti, Chiara Cimenti, Malte Nejst Larsen, Peter Krustrup, Peter Krustrup, Lars Breum Skov Christiansen, Lars Breum Skov Christiansen

“…Teachers (n = 32) in both groups rated FF10 moderately acceptable, appropriate, and feasible (3.5–4.0 out of a potential maximum of 5). …”
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Optimizing Muscle Performance in Young Soccer Players: Exploring the Impact of Resisted Sprint Training and Its Relationship with Distance Covered by Felipe Hermosilla-Palma, Juan Francisco Loro-Ferrer, Pablo Merino-Muñoz, Nicolás Gómez-Álvarez, Rodrigo Zacca, Hugo Cerda-Kohler, Ciro Brito, Jorge Pérez-Contreras, Moacyr Portes-Junior, Esteban Aedo-Muñoz

“…Time-dependent differences were observed in all groups for peak force (PF) (<i>p</i> < 0.001; η²p = 0.62), time to PF (TPF) (<i>p</i> < 0.001; η²p = 0.53), impulse at 50 (<i>p</i> < 0.001; η²p = 0.57), 100 (<i>p</i> < 0.001; η²p = 0.60), and 200 ms (<i>p</i> < 0.001; η²p = 0.67) in IMTP; jump height by impulse-momentum (<i>p</i> < 0.001; η²p = 0.64), rate of force development (<i>p</i> = 0.04; η²p = 0.14), yielding impulse (<i>p</i> < 0.001; η²p = 0.49), and concentric impulse (<i>p</i> = 0.01; η²p = 0.19) in CMJ; time (<i>p</i> < 0.001; η²p = 0.46) in 505 m; and average speed in linear sprint (<i>p</i> = 0.003; η²p = 0.36), with moderate to large effect sizes, regardless of the distance covered. …”
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