Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…The findings arising from the Delphi process provide valuable insights into the unmet needs in the management of moderate-to-severe ulcerative colitis from the clinician’s perspective, while emphasising the benefits of therapeutic individualization and suggesting areas that need additional study with the aim of optimising the treatment of patients with ulcerative colitis.…”
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Genome-wide association study and genomic prediction of root system architecture traits in Sorghum (Sorghum bicolor (L.) Moench) at the seedling stage by Muluken Enyew, Mulatu Geleta, Kassahun Tesfaye, Amare Seyoum, Tileye Feyissa, Admas Alemu, Cecilia Hammenhag, Anders S. Carlsson

“…The genomic prediction accuracy estimated for the studied traits using five Bayesian models ranged from 0.30 to 0.63 while it ranged from 0.35 to 0.60 when the RR-BLUP model was used. The observed moderate to high prediction accuracy for each trait suggests that genomic selection could be a feasible approach to sorghum RSA-targeted selection and breeding. …”
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External validation and revision of the Lafontaine criteria for unstable distal radius fractures: a retrospective study by Pornpanit Dissaneewate, Phatklao Thanavirun, Yanin Tangjaroenpaisan, Kantapon Dissaneewate

“…The updated criteria using age group (< 56 years, 56–74 years, and > 74 years), associated ulnar fractures, and initial radial shortening > 3 mm was found to have moderate discrimination; however, further research is warranted to improve the prediction and measurement reliability of fracture instability.…”
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Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response by Binfeng He, Mingdong Hu, Zhihui Liang, Qianli Ma, Yunhai Zi, Zhiwei Dong, Qi Li, Yongjun Luo, Guisheng Qian, Liang Guo, Kexiong Lin, Zhenyu Liu, Guansong Wang

“…Subjects (n=288) in 20 clusters were diagnosed with mild or moderate HADAS on the third day of the study. We randomly allocated 20 clusters of subjects (1 : 1) to receive SPCs or a placebo for 7 weeks, and they were then followed up to the 14th week. …”
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Purification, Preliminary Structural Characterization, and In Vitro Inhibitory Effect on Digestive Enzymes by β-Glucan from Qingke (Tibetan Hulless Barley) by Jialiang Hu, Yue Wu, Huifang Xie, Wanyin Shi, Zhiyuan Chen, Dan Jiang, Hui Hu, Xiangwei Zheng, Jian Xu, Yuejun Yang, Yuancai Liu

“…The β-glucan presented a relatively strong inhibitory activity on α-glucosidase, moderate inhibition on invertase, and a weak inhibition on α-amylase, whereas it did not inhibit lipase. …”
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Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging by Hugo Helbert, Winnie Deuther-Conrad, Michel de Haan, Barbara Wenzel, Gert Luurtsema, Wiktor Szymanski, Peter Brust, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga

“…Conclusion (-)-2-methylspirobenzovesamicol was identified as a potent and selective VAChT ligand, with moderate to low affinity for σ receptors, and its racemate was radiolabeled in good radiochemical yields with Carbon-11. …”
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Comparing the Accuracy and Reliability of Detecting the Intensity of Spinal Inflammation on STIR Sequence with Apparent Diffusion Coefficient Values in Axial Spondyloarthritis by Ho Yin Chung, Tommy Tsang Cheung, Vince Wing Hang Lau, Kam Ho Lee, Florence King Pui Chan

“…Inter-reader agreements were slight to moderate (kappa = 0.07–0.45). Reliability substantially improved when only the lowest and highest 25th percentiles of ADC values were included (kappa = 0.17–0.75). …”
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Influence of Secondary Inorganic Aerosol on the Concentrations of PM2.5 and PM0.1 during Air Pollution Episodes in Hanoi, Vietnam by Nguyen-Quoc Dat, Bich-Thuy Ly, Trung-Dung Nghiem, Thu-Thi Hien Nguyen, Kazuhiko Sekiguchi, Truong-Thi Huyen, Thai-Ha Vinh, Le-Quang Tien

“…Relative humidity, pressure, temperature, and radiation had a good correlation with SIA of PM0.1 and a moderate correlation with PM0.1. Concentration-weighted trajectory analysis demonstrated that PM2.5 and SIA levels were also influenced by long-range transportation from the upper areas. …”
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Assessment of occupational hazards in midwifery setting and impact of occupational stress and job satisfaction on midwives’ quality of work-life: multicenter study in IRAN by Nasibeh Sharifi, Azita Fathnezhad-Kazemi, Nazanin Rezaei, Masoumeh Yaralizadeh, Zahra PourMohammad

“…The preliminary results showed that the mean scores for job stress, job satisfaction, and quality of work life were 232.35 (high), 41.09 (moderate), and 95.34, respectively. In the regression model, job satisfaction, age, and work experience were significantly associated with quality of work life, with job satisfaction having the strongest influence (β = 0.376, P < 0.0013). …”
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Patient perspectives on stress after ICU and a short primary care based psychological intervention – results from a qualitative sub‑study of the PICTURE trial by Antina Beutel, Linda Sanftenberg, Chris M. Friemel, Robert Philipp Kosilek, Maggie Schauer, Thomas Elbert, Ulf-Dietrich Reips, Tomke Schubert, Sabine Gehrke-Beck, Konrad Schmidt, Jochen Gensichen, for the PICTURE study group

“…In view of chronification and the lack of specific follow-up treatment options for these patients and the long waiting times for psychotherapy, the implementation of low-threshold treatment options by GPs appears to be ideally suited to closing this gap in care, particularly for patients with mild to moderate symptoms of a post-traumatic stress disorder. …”
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Environmental vulnerability characteristics in an active swarm region by A.V.H. Simanjuntak, U Muksin, A. Arifullah, K. Lythgoe, Y. Asnawi, M. Sinambela, S. Rizal, S. Wei

“…Cluster III features moderate values of amplification and seismic vulnerability and therefore needs attention before future infrastructure development. …”
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Assessing Nutritional Knowledge and Physical Health Among Football Players: A Pilot Study from Three Sports Clubs in Western Romania by Gabriel Roberto Marconi, Brigitte Osser, Gyongyi Osser, Caius Calin Miuța, Csongor Toth, Viorel Petru Ardelean, Anca Dicu, Corina Dalia Toderescu, Laura Ioana Bondar

“…Supplement use was moderately correlated with alcohol consumption (<i>ρ</i> = 0.548, <i>p</i> < 0.001) and weakly correlated with smoking (<i>ρ</i> = 0.348, <i>p</i> = 0.007). …”
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Psychometric properties of the Spanish version of the hospital anxiety and depression scale in cancer patients by Ana L. Vilela-Estrada, Ana L. Vilela-Estrada, David Villarreal-Zegarra, Anthony Copez-Lonzoy, Loida Esenarro-Valencia, Loida Esenarro-Valencia, Loida Esenarro-Valencia, José C. Sánchez-Ramírez, José C. Sánchez-Ramírez, Fernando Lamas-Delgado, Fernando Lamas-Delgado, Fernando Lamas-Delgado, Juan Ambrosio-Melgarejo, C. Mahony Reategui-Rivera, Joseph Finkelstein

“…The HADS demonstrates invariance with respect to sex and years of education. It shows a moderate correlation with the Beck Anxiety Inventory and the Beck Depression Inventory. …”
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Natural Concurrent Infections with Black Spot Disease and Multiple Bacteriosis in Farmed Nile Tilapia in Central Kenya by Daniel W. Wanja, Paul G. Mbuthia, Robert M. Waruiru, Lilly C. Bebora, Helena A. Ngowi

“…Furthermore, a thick fibrous capsule around the metacercaria, black pigment melanomacrophages, and moderate muscle atrophy were observed. The most prevalent bacteria isolated were Aeromonas, Enterobacter cloacae, Klebsiella pneumoniae, and Micrococcus luteus. …”
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Sources analysis and risk assessment of heavy metals in soil in a polymetallic mining area in southeastern Hubei based on Monte Carlo simulation by Jing Wang, Bo Wang, Qibin Zhao, Jinnan Cao, Xiao Xiao, Di Zhao, Zhenya Chen, Di Wu

“…The main findings are as follows: (1) Among the heavy metals present in the soil, copper (Cu) has the highest average concentration at 278.54 mg/kg, followed by zinc (Zn) at 161.16 mg/kg, chromium (Cr) at 75.23 mg/kg, nickel (Ni) at 30.38 mg/kg, arsenic (As) at 22.53 mg/kg, cadmium (Cd) at 0.76 mg/kg, and mercury (Hg) at 0.14 mg/kg; (2) The distribution of heavy metal concentrations exhibits significant regional variations, with the spatial pattern of pollution indicating that TLS is more affected than JLS, as evidenced by the Pollution Load Index (PLI) values; (3) Three potential sources of heavy metals were identified: natural sources, anthropogenic activities (including industrial production and agricultural practices), and atmospheric deposition (both dry and wet); (4) While severe contamination levels of specific metals such as copper and cadmium are observed in JLS and TLS soils, the overall contamination is mild, suggesting complex contamination dynamics; (5) Cadmium poses a moderate to high ecological risk, being the most sensitive factor in the comprehensive ecological risk assessment with a contribution rate of 65.2 %; (6) The concentrations of heavy metals in the soil present certain health risks, with children being more vulnerable than adults. …”
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A systematic review and meta-analysis of randomized controlled trials for physical activity among colorectal cancer survivors: directions for future research by Jiayu Mao, Xiaoke Qiu, Yi Zhang, Can Wang, Xueli Yang, Qiuping Li

“…In addition, research evidence suggests that daily as the frequency (Z = 4.28, p < 0.001), Moderate-to-vigorous physical activity (MVPA) as the intensity (Z = 2.29, p = 0.022), aerobic combined with resistance exercise as the type of PA (Z = 4.19, p < 0.001) is appropriate for increasing total PA levels in CRC survivors. …”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Against the clinical diagnosis of proven or probable IFDs, the findings show that the LFA system produced a high specificity of 99.4 % while the sensitivity was only moderate at 47.8 % due to the difficulty of extracting fungal DNA from blood samples. …”
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Prospective cohort study investigating frequency and risk factors for acute pain 1 day after refractive surgery by Anat Galor, Jodi Lapidus, Winston Chamberlain, Elyana Vittoria Tessa Locatelli, Jason Betz, Brooke M Harkness, Maricarmen Perez-Blanco, Steven J Everist, Siting Chen, Richard Stutzman, Afshan Nanji, Sue A Aicher

“…Factors that were associated with pain 1 day after surgery included Hispanic ethnicity (adjusted relative risk (aRR) 1.42, 95% CI 1.21 to 1.68, p&lt;0.001) and the presence of eye pain presurgery (aRR 1.10, 95% CI 1.02 to 1.18, p=0.02).Conclusion A majority of individuals report moderate or greater pain within 24 hours of refractive surgery. …”
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Characterisation of coastal reef fish assemblages across an estuarine-urbanisation gradient using underwater visual census and environmental DNA metabarcoding by Yu-De Pei, Joseph Heard, Wenqian Xu, Shara K.K. Leung, Charmaine C.M. Yung, Alex S.J. Wyatt

“…However, there were only moderate changes in the fish community regionally overall. …”
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Position Paper by Canadian Dental Sleep Medicine Professionals Regarding the Role of Different Health Care Professionals in Managing Obstructive Sleep Apnea and Snoring with Oral A... by Luc Gauthier, Fernanda Almeida, Patrick Arcache, Catherine Ashton-McGregor, David Côté, Helen Driver, Kathleen Ferguson, Gilles Lavigne, Philippe Martin, Jean-François Masse, Florence Morisson, Jeffrey Pancer, Charles Samuels, Maurice Schachter, Frédéric Sériès, Glendon Sullivan

“…OAs offer an effective, first-line treatment option for patients with mild to moderate OSA who prefer an OA to continuous positive airway pressure (CPAP) therapy, or for severe OSA patients who cannot tolerate CPAP, are inappropriate candidates for CPAP or who have failed CPAP treatment attempts. …”
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