Do doctors in dispensing practices with a financial conflict of interest prescribe more expensive drugs? A cross-sectional analysis of English primary care prescribing data by Ben Goldacre, Carl Reynolds, Anna Powell-Smith, Alex J Walker, Tom A Yates, Richard Croker, Liam Smeeth

“…Total cost savings were modelled by applying the mean cost per dose from non-dispensing practices to the number of doses prescribed in dispensing practices.Results Dispensing practices were more likely to prescribe high-cost drugs across all classes: statins adjusted OR 1.51 (95% CI 1.49 to 1.53, p<0.0001), PPIs OR 1.11 (95% CI 1.09 to 1.13, p<0.0001), ACEi OR 2.58 (95% CI 2.46 to 2.70, p<0.0001), ARB OR 5.11 (95% CI 5.02 to 5.20, p<0.0001). …”
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L’africanisation de l’Église évangélique au Maroc : revitalisation d’une institution religieuse et dynamiques d’individualisation by Bernard Coyault

“…La cohabitation dans une même structure d’identités religieuses hétérogènes produit parfois tensions et malentendus. Les modèles d’organisation, les référents théologiques et les pratiques observables témoignent de ce pluralisme en tension. …”
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The role of the behavioral immune system in the expression of short and long-term orientation in young Chilean men during the COVID-19 pandemic by Oriana Figueroa, Pablo Polo, Daniel Torrico-Bazoberry, Gabriela Fajardo, Carlos Rodríguez-Sickert, Nohelia Valenzuela, Abigail Arenas, Paula Pavez, Montserrat Belinchon, Gabriela Valdebenito, José Antonio Muñoz-Reyes

“…To test our predictions, we fitted general linear models. Results Results point to a significant decrease in long-term mating orientation in paired and single men, but only when compared with the pandemic face-to-face study. …”
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Cognitive function differs across healthy lifestyle behavior profiles: a 10-year population-based prospective cohort study by Huixiu Hu, Yajie Zhao, Di Guo, Ying Deng, Huanhuan Luo, Yuqing Hao, Chao Sun, Kang Yu

“…The resultant profiles, were then used to further explore associations with cognitive function using cox proportional hazard regression and linear mixed models. Results: During a 10-year follow-up period, 2017 (37.5%) out of 5381 participants developed cognitive impairment. …”
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An interlaboratory comparison to quantify oxidative potential measurement in aerosol particles: challenges and recommendations for harmonisation by P. A. Dominutti, J.-L. Jaffrezo, A. Marsal, T. Mhadhbi, R. Elazzouzi, C. Rak, F. Cavalli, J.-P. Putaud, A. Bougiatioti, N. Mihalopoulos, N. Mihalopoulos, D. Paraskevopoulou, I. Mudway, I. Mudway, A. Nenes, A. Nenes, K. R. Daellenbach, C. Banach, S. J. Campbell, H. Cigánková, D. Contini, G. Evans, M. Georgopoulou, M. Ghanem, D. A. Glencross, D. A. Glencross, M. R. Guascito, M. R. Guascito, H. Herrmann, S. Iram, M. Jovanović, M. Jovašević-Stojanović, M. Kalberer, I. M. Kooter, S. E. Paulson, A. Patel, A. Patel, A. Patel, E. Perdrix, M. C. Pietrogrande, P. Mikuška, J.-J. Sauvain, K. Seitanidi, P. Shahpoury, E. J. d. S. Souza, S. Steimer, S. Steimer, S. Stevanovic, G. Suarez, P. S. G. Subramanian, B. Utinger, M. F. van Os, V. Verma, X. Wang, R. J. Weber, Y. Yang, X. Querol, G. Hoek, R. M. Harrison, R. M. Harrison, G. Uzu

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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…C2C12 myotube nutrition-deprivation and mice tail suspension models were established. Subsequently, the diameter of C2C12 myotubes, Soleus mass, cross-sectional area (CSA) of muscle fibers, and grip strength in mice were assessed to investigate the impact of hBMSC-EVs on muscle atrophy. …”
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Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors by Enzo G. Plaitano, Enzo G. Plaitano, Daniel McNeish, Sophia M. Bartels, Sophia M. Bartels, Kathleen Bell, Jesse Dallery, Michael Grabinski, Michaela Kiernan, Hannah A. Lavoie, Hannah A. Lavoie, Shea M. Lemley, Michael R. Lowe, David P. MacKinnon, Stephen A. Metcalf, Stephen A. Metcalf, Lisa Onken, Judith J. Prochaska, Cady Lauren Sand, Cady Lauren Sand, Emily A. Scherer, Luke E. Stoeckel, Haiyi Xie, Lisa A. Marsch

“…Bayesian dynamic mediation models were used to examine moment-to-moment mediation effects between momentary self-regulation subscales, medical regimen adherence, and behavioral outcomes.ResultsIn the binge eating disorder sample, the perseverance [β1 = 0.17, 95% CI = (0.06, 0.45)] and emotion regulation [β1 = 0.12, 95% CI = (0.03, 0.27)] targets of momentary self-regulation positively predicted Laddr adherence on the following day, and higher Laddr adherence was subsequently a positive predictor of steps taken the same day for both perseverance [β2 = 0.335, 95% CI = (0.030, 0.717)] and emotion regulation [β2 = 0.389, 95% CI = (0.080, 0.738)]. …”
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Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China’s two-child policy by SiQin Xiu, Li Tang, Chengjie Qin, Di Tian, Yuhong Chen, Lingling Gu, Liu Yang, Yuhao Sun, Xinghui Liu, Yonghong Lin, Yumei Wang

“…Logistic regression modeling, incorporating restricted cubic spline (RCS), was used to assess association between IPI and adverse perinatal outcomes, including full-term low birthweight (LBW), preterm birth (PTB), small-for-gestational age (SGA) and adverse neonatal composite (very low birthweight, very preterm birth, severe neonatal asphyxia or death). …”
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Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…Cox proportional hazards models with 1:1 propensity score (PS) matching were used to estimate the risk, with results calibrated using negative control outcomes. …”
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The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study by Fausto Negri, Luca Boeri, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Giuseppe Fallara, Eugenio Ventimiglia, Luigi Candela, Alessia d’Arma, Francesco Montorsi, Andrea Salonia

“…Descriptive statistics and logistic regression models tested association between FSH and InhB values. …”

Relationship between triglyceride glucose-body mass index baselines and variation with future cardiovascular diseases risk in the middle-aged and elderly individuals by Junpeng Qiao, Xueyu Chen, Jinhong Pang, Haicheng Fei, Zhang Liu, Fang Cheng, Qiaoqiao Chen, Yingying Zhao, Fengxue Shi, Hongying Jia, Hongying Jia, Weiwei Chi, Weiwei Chi

“…We used Cox proportional hazards models to evaluate the relationship between baseline quartiles of the TyG-BMI index and its variability with CVDs and their subtypes.ResultsAmong the 7,072 participants (mean age of 59.1 ± 9.3 years), 3330 (47%) were male. …”
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Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Jan-Hendrik Bockmann, Lena Allweiss, Annika Volmari, David da Fonseca Araújo, Matin Kohsar, Anastasia Hyrina, Janine Kah, Zhijuan Song, Josolyn Chan, Katja Giersch, Tassilo Volz, Marc Lütgehetmann, Jeffrey J. Wallin, Dmitry Manuilov, Meghan M. Holdorf, Simon P. Fletcher, Ansgar W. Lohse, Antonio Bertoletti, Julian Schulze zur Wiesch, Maura Dandri

“…In this study, we demonstrated that HDV infection triggers CXCL9–11 expression in hepatocytes and liver infiltration of CXCR3-expressing CD4 T cells in preclinical models as well as patient biopsies. Because recruitment of Th1-polarised CD4 T cells to the liver has been also described for other severe liver diseases, such as autoimmune hepatitis, it may represent an important mechanism of aggravating liver diseases. …”
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<i>Cichorium intybus</i> L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress by Yanqin Luo, Xueyi Bei, Yiwen Zhang, Xinran Sun, Yongzhi Zhao, Fang Chen, Ruile Pan, Qi Chang, Qinghu He, Xinmin Liu, Ning Jiang

“…This study explores the antianxiety and antidepressant effects and mechanisms of CIOs by using acute behavioral despair and chronic unpredictable mild stress mice models and measuring the levels of 5-HT and the expression of proteins related to the BDNF/ERK and PI3K/Akt/mTOR pathways. …”
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Comparative end-of-life communication and support in hospitalised decedents before and during the COVID-19 pandemic: a retrospective regional cohort study in Ottawa, Canada by Shirley H Bush, Monisha Kabir, Peter Lawlor, James Downar, Brandi Vanderspank-Wright, Sarina Isenberg, Peter Tanuseputro, Akshai Iyengar, Claire Dyason, Julie Lapenskie, Colleen Webber, Henrique Parsons, Samantha Rose Adeli, Ella Besserer, Leila Cohen, Valérie Gratton, Rebekah Murphy, Grace Warmels, Adrianna Bruni, Chelsea Noel, Brandon Heidinger, Koby Anderson, Kyle Arsenault-Mehta, Krista Wooller, Daniel Bedard, Paula Enright, Isabelle Desjardins, Khadija Bhimji

“…End-of-life (last 5 days) rates of in-person and telephone team–family communication encounters were examined using mixed-effects negative binomial models with incidence rate ratios (IRRs) and 95% CIs.Results End-of-life in-person family presence decreased progressively across pre-COVID (90.6%), COVID-ve (79.4%) and COVID+ve (47.1%) groups: adjusted ORs=0.38 (0.2–0.73) and 0.09 (0.04–0.17) for COVID-ve and COVID+ve groups, respectively. …”
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Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…We estimated familial aggregation/coaggregation using generalised estimating equations, heritability and genetic correlations using structural equation modelling. We also analysed ∼30,000 genotyped MDD cases from the UK Biobank and a Swedish cohort to explore which polygenic risk score (PRS) may predispose individuals to psychotic MDD. …”
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Prevalence and determinants of faecal carriage of carbapenem- and third-generation cephalosporin-resistant Enterobacterales: a cross-sectional household survey in northern VietnamR... by Max van Wijk, Hoang Huy Tran, Bich Ngoc Thi Vu, Costanza Tacoli, Tu Cam Thi Nguyen, Quynh Dieu Pham, Thương Hong Thi Nguyen, Trang Thu Nguyen, Hien Anh Thi Nguyen, Tung Son Trinh, Thai Duy Pham, Huong Kieu Thi Tran, Dung Tien Viet Vu, Duc Anh Dang, Tien Dac Tran, Duong Thanh Nguyen, H. Rogier van Doorn, Thomas Kesteman, Sonia Lewycka

“…Faecal samples were cultured on meropenem and ceftazidime supplemented media to identify CRE and C3GRE, respectively. Logistic regression models were used to explore risk factors for CRE and C3GRE carriage compared to susceptible strains. …”
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Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized... by Anthony C Keech, Vijaya Sundararajan, Bruce R King, Sara Vogrin, Richard J MacIsaac, Leon A Bach, Jane Speight, Alicia J Jenkins, Christel Hendrieckx, David O’Neal, Sybil A McAuley, Geoff R Ambler, Fergus J Cameron, Jan M Fairchild, Elizabeth A Davis, Timothy W Jones, Morton G Burt, Philip M Clarke, Neale D Cohen, Peter G Colman, Joey Kaye, Kavita Kumareswaran, Melissa H Lee, Roland W Mccallum, Barbora Paldus, Stephen N Stranks, Steven Trawley, Glenn M Ward, David N O’Neal, Sienna Russell-Green, Deborah Jane Holmes-Walker, Benjamin Lam, Jennifer A Halliday, Glenn Ward, Catriona M Sims, D Jane Holmes-Walker, Andrzej Januszewski, Hanafi Mohammed Husin, Martin I de Bock, Mary B Abraham

“…Psychological outcomes (awareness and fear of hypoglycemia; and diabetes-specific positive well-being, diabetes distress, diabetes treatment satisfaction, and diabetes-specific quality of life (QoL)) were measured at enrollment, mid-trial and end-trial. Linear mixed models were conducted, using restricted maximum likelihood estimation, unadjusted and adjusted (for covariates: age, sex, diabetes duration, glycated hemoglobin, recent severe hypoglycemia, pre-trial insulin delivery modality, enrollment and mid-study scores).Results 120 participants (mean age 44±12 years) were randomized to intervention (n=61) or standard therapy (n=59). …”
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Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study by Yijing Li, Juan Li, Tianning Sun, Zhigang He, Cheng Liu, Zhixiao Li, Yanqiong Wu, Hongbing Xiang

“…After accounting for confounding variables, the associations between fat mass index (FMI), appendicular skeletal muscle mass index (ASMI), body fat percentage (BFP), body composition phenotypes, and depression risk were assessed using restricted cubic spline (RCS) curves and multivariable logistic regression models. We further conducted interaction analyses for ASMI and FMI in females. …”
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Prevalence of anxiety symptoms and associated factors at 2 months postpartum, results from a 2021 French national prospective cohort study by Alexandra Doncarli, Virginie Demiguel, Camille Le Ray, Catherine Deneux-Tharaux, Elodie Lebreton, Gisèle Apter, Julie Boudet-Berquier, Catherine Crenn-Hebert, Marie-Noëlle Vacheron, Nolwenn Regnault, Sarah Tebeka, Members of the ENP2021 Study Group

“…We estimated the adjusted prevalence ratios (aPR) of PPA symptoms using Poisson regression models with robust variance. Results PPA symptom prevalence at 2 months was 27.6% (95% CI [26.5–28.8]). …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Following a prespecified analysis plan, rwOS by TMB level was assessed using Cox PH models adjusted for Eastern Cooperative Oncology Group performance status, prior treatment, microsatellite instability, sex, age, opioid rx pretherapy, and socioeconomic assessment.Results 8440 patients met inclusion criteria. …”
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