CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors by Chrystal Paulos, Mary Jo Turk, Megen C Wittling, Yina H Huang, Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm

“…Here, we describe the intrinsic ability of CAR T cells to differentiate into memory T cells, the effect of cytokine armoring, and neoadjuvant CD4 depletion therapy on CAR and tumor-specific endogenous memory T cells.Methods TRP1-specific or NKG2D CAR T cells alone or with Super2+IL-33 (S233) armoring and/or CD4 depletion were evaluated in immunocompetent B16F10 melanoma or MC38 colon cell carcinoma models without preconditioning. We characterized CAR and endogenous tumor-specific memory T cell precursors, establishment of circulating (TCIRC) and resident (TRM) memory T cell subsets, and ability to protect against secondary tumors.Results TRP1-specific or NKG2D CAR T cells had no effect on primary tumor growth in immunocompetent mice unless they were combined with S233 armoring or CD4 depletion. …”
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30 Years of Research in Brand Personality: Mapping Knowledge and Analyzing the Thematic Structure by a Scientometrics Approach by Mohammad Rahim Esfidani, Mohsen Nazari, Shahriar Gharibzadeh, Nakisa Rezaie

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Cigarette Smoking Patterns Among Racial and Ethnic Groups With Chronic Lung Diseases During the COVID-19 Pandemic by Vijaya L. Seegulam, MPH, Caretia J. Washington, BS, Parvathy P. Surendran, BPT, Alyssa M. Falise, PhD, MSPH, Diana Gomez-Manjarres, MD, Catalina Lopez-Quintero, MD, MPH, PhD

“…The authors estimated predicted probabilities derived from multiple logistic regression and negative binomial regression models to examine changes in (1) the prevalence of current cigarette smoking in the target population, (2) the mean number of days of cigarette smoking in the past 30 days, and (3) the mean number of cigarettes smoked in the past 30 days across racial/ethnic subgroups and prepandemic, pandemic, and postpandemic periods. …”
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De la police coloniale française à la police nationale marocaine : décolonisation et héritages policiers (1953-1960) by Benjamin Badier

“…Undergoing several reforms and modeling itself after the metropolitan police, the colonial police became increasingly centralized and specialized in intelligence. …”
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Global Navigation Satellite System (GNSS) radio occultation climatologies mapped by machine learning and Bayesian interpolation by E. Shehaj, E. Shehaj, S. Leroy, K. Cahoy, A. Geiger, L. Crocetti, G. Moeller, G. Moeller, B. Soja, M. Rothacher

“…Meteorologists routinely assimilate RO observations into numerical weather models. RO-based climatologies, however, are complicated to construct as their sampling densities are highly non-uniform and too sparse to resolve synoptic variability in the atmosphere.…”
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Guidance and Counselling and Learners’ Discipline in Kasese District: A Case of Selected Government-Aided Secondary Schools in Bukonzo County. by Kule, Samson

“…Social Behaviour Theory: Albert Bandura (1966) posited that people learn from one another through observation, imitation and modelling. The study adopted mixed-methods research that incorporated elements of both Qualitative and Quantitative approaches to provide deeper and wider insights in the data evaluation. …”
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Guidance and Counselling and Learners’ Discipline in Kasese District: A Case of Selected Government-Aided Secondary Schools in Bukonzo County. by Kule, Samson

“…Social Behaviour Theory: Albert Bandura (1966) posited that people learn from one another through observation, imitation and modelling. The study adopted mixed-methods research that incorporated elements of both Qualitative and Quantitative approaches to provide deeper and wider insights into the data evaluation. …”
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Patient-centred care and quality of life and hope among Japanese patients receiving home medical care: a multicentre, cross-sectional study by Nobuhiro Ikeda, Michiko Hinata, Noriaki Kurita, Tomoka Nakamura, Takashi Fujii, Chihiro Tsuchiya, Yukio Tsugihashi, Hidekazu Iida, Shinu Hayashi, Masakazu Yasunaka, Misaki Hirose, Yutaka Shirahige, Shinsuke Muto, Tatsunobu Natsubori, Wataru Nakagawa, Akihiko Yonenaga, Lina Inagaki, Shioto Itakura, Naoya Miyashita, Takuya Furugen, Takafumi Abo, Sadayuki Okudaira, Kazuhiko Takuma, Masahiro Deguchi, Yoshitaka Harada, Seiji Matsuo, Motomichi Nakagawa, Ken Tanigawa, Yoshio Ochi, Sadanobu Ogasawara, Kazuhiko Hoshino, Momoko Aruga, Yoshinori Nakamura, Nobuhiro Sawa, Yosuke Akashi, Nobuyuki Miyagi, Toyohiro Terasaki, Kunihiro Kinoshita, Masaji Kikukawa, Hisakazu Kato, Masayuki Amano, Kentaro Asakura, Naoto Fukui

“…Mixed-effects linear models were applied.Results A higher JPCAT-SF total score was associated with a higher QOL-HC score (adjusted mean difference per 10-point increase: 0.28, 95% CI 0.16 to 0.40). …”
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Cognitive decline in relation to later-life high temperature exposure in a Chinese nationwide cohort by Yu-Qian Huang, Lian-Sheng Zhang, Ji-Xing Yang, Fang Wang, Ya-Qi Wang, Li-Feng Zhu, Yuan-Yuan Zhang, Bo-Ning Deng, Qian-Qian Xiang, Yun-Quan Zhang

“…Linear mixed-effects models were utilized to examine the relationship between high temperature exposure and cognitive function. …”
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Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation by Oana Hangiu, Oana Hangiu, Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Laura Rubio-Pérez, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Laura Díez-Alonso, Laura Díez-Alonso, Laura Díez-Alonso, Marina Gómez-Rosel, Marina Gómez-Rosel, Marina Gómez-Rosel, Noelia Silva-Pilipich, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Cristian Smerdou, Kenneth A. Howard, Laura Sanz, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Marta Compte

“…The in vivo efficacy of the mRNA-encoded bispecific antibodies was evaluated in xenograft tumor models expressing EGFR.ResultsWe investigated the combined effect of two mRNA-encoded Fc-free bispecific antibodies with complementary mechanisms of action: an EGFR-targeting TCE and a half-life extended PD-L1 x 4-1BB costimulatory antibody. …”
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Norepinephrine use in cardiogenic shock patients is associated with increased 30 day mortality by Xin Lu, Xue Wang, Yanxia Gao, Joseph Harold Walline, Shiyuan Yu, Zengzheng Ge, Mubing Qin, Huadong Zhu, Yi Li

“…Cox proportional‐hazards models and multivariable logistic regression were used to investigate the relationship between norepinephrine treatment and mortality. …”
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Oral health care in older people in long-term care facilities: An updated systematic review and meta-analyses of implementation strategies by Lina F. Weening-Verbree, Anouk Douma, Cees P. van der Schans, Getty J. Huisman-de Waal, Annemarie A. Schuller, Sytse U. Zuidema, Wim P. Krijnen, Johannes S.M. Hobbelen

“…Meta-analyses of oral health outcomes (“plaque” and “denture plaque”) were performed with random-effects models using R language for statistical computing. …”
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Multimorbidity latent classes in relation to 11-year mortality, risk factors and health-related quality of life in Malaysia: a prospective health and demographic surveillance syste... by Michelle M. C. Tan, Charlotte Hanlon, Graciela Muniz-Terrera, Tatiana Benaglia, Roshidi Ismail, Devi Mohan, Ann Breeze Joseph Konkoth, Daniel Reidpath, Pedro José M. Rebello Pinho, Pascale Allotey, Zaid Kassim, Matthew Prina, Tin Tin Su

“…Multinomial logistic regression and Cox proportional hazards regression models were conducted to investigate the adjusted association of multimorbidity patterns with the risk factors and mortality, respectively. …”
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Abortion-related complications in Brazil: results from the World Health Organization Multi-country Survey on Abortion (MCS-A) by Nelio Neves Veiga Junior, Luiz Francisco Cintra Baccaro, Adriana Mendonça da Silva Alexandrino, Alexandre Volta Andrade do Nascimento, Camila Tereza Camilo Clerot, Cintya Andreia do Nascimento Santos, Claudia Lucrécia de Matos Silva, Claudio Lucio de Medeiros Albuquerque, Débora Paulo Santos, Demétrio Antonio Gonçalves da S. Gomes, Édson Cunha de Araújo Junior, Elizabete das Chagas Vilanova, Georgina Costa Teixeira, Graciete Helena Nascimento dos Santos, Guilherme Augusto Guerra Avelar, Iara Elce Lopes Barros, Jaqueline Polon Abboud, Jeane Cristina Antas Lins, Joanne Thalita Pereira Silva, Kelma H. Aguiar de Lucena, Lara Wanderley Paes Barbosa, Lia Ferreira Caixeta Barreto de Siqueira, Luciana de Melo Freitas Carneiro, Lucila Nagata, Márcia de Oliveira Pereira Lúcio, Maria Cleane Rodrigues da Silva, Maria da Conceição Ribeiro Simões, Maria Fernanda da Mota Magalhães, Mariana Viana Almeida, Michelle Regina Faria Lira, Nádia Martins de Paula Souza, Rafael Martins Papa, Rafael Ribeiro Matos, Renata Porto Pinheiro, Roberta Souza dos Anjos, Suelen Miranda de Jesus, Tedy Roger Flores Ynturias, Valéria Cristina Gonçalves, Viviane Resende de Abreu Caetano

“…Statistical analysis was performed using chi-square test and Poisson regression models. Among 1,683 women included, 82.5% had mild complications, 13.6% had moderate complications, 3.2% had potentially life-threatening conditions (PLTC) and 0.7% had severe maternal outcomes (SMO). …”
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Perceived healthiness of sugary drinks and related social norms among adults in five countries: evidence from the International Food Policy Study by Virginie Drolet-Labelle, Christine M. White, Jean Adams, Sharon I. Kirkpatrick, Alejandra Jáuregui, Lilia S. Pedraza, Véronique Provencher, Gary Sacks, James F. Thrasher, Gabriela C. Armendariz, Simón Barquera, David Hammond, Lana Vanderlee

“…The 24-item Beverage Frequency Questionnaire was used to estimate beverage intake in the past 7 days. Logistic regression models examined trends over time in odds of perceiving each beverage type as unhealthy and agreeing with social norms discouraging sugary drink consumption, across countries and sociodemographic characteristics. …”
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Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF by Karen Pieper, Xian-hong Fang, Kai Sun, Ajay K Kakkar, Saverio Virdone, Shinya Goto, Gloria Kayani, Zhi-Cheng Jing, John Camm, Chun-Yan Cheng, Tian-Yu Lian, Xi-Jie Zhu, Xian-Mei Li

“…The association of geographical region with clinical outcomes (event rates per 100 person-years) were estimated using multivariable Cox models.Results 13 841/52 057 (26.6%) GARFIELD-AF participants were enrolled in Asia. …”
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Relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut micro... by Feng Yong, Bo Liu, Huijuan Li, Houxu Hao, Yueli Fan, Osmond Datsomor, Rui Han, Hailong Jiang, Dongsheng Che

“…In vitro digestion and fermentation models were used to compare the fermentation characteristics of feedstuffs and ileal digesta in the pig’s hindgut. …”
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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…Linear mixed-effects models determined significant improvements in PHQ-9 and GAD-7 scores for participants across both conditions (ps < 0.001). …”
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Cross-sectional and longitudinal associations between serum vitamin D and continuous metabolic syndrome score among children and adolescents: roles of levels of inflammation in per... by Yanyan Li, Zhuang Ma, Yan Li, Ting Xiong, Ziyang Zhang, Bingxuan Kong, Wenlong Lu, Xiu Zhao, Rongfei Zheng, Yuhan Tang, Ping Yao, Zhe Su, Yuanjue Wu, Jingfan Xiong

“…Restricted cubic splines (RCS) were used to visualize dose–response relationships and generalized linear models (GLM) were used to estimate potential associations. …”
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Cost-effectiveness analysis of proactive home visits compared with site-based community health worker care on antenatal care outcomes in Mali: a cluster-randomised trial by Osondu Ogbuoji, Caroline Whidden, Emily Treleaven, Youssouf Keita, Kassoum Kayentao, Ari Johnson, Jenny X Liu, Minahil Shahid, Mohamed Berthé, Armand Zimmerman, David Charles Boettiger, Coumba Traoré, Mahamadou Sogoba, Saibou Doumbia, Amadou Beydi Cissé

“…However, despite the success of CHW programmes in various countries, WHO has called for additional research to develop evidence-based models that optimise CHW service delivery and that can be replicated across geographies.Methods The ProCCM Trial was a cluster-randomised controlled trial to compare proactive home visits by CHWs (intervention, 69 village clusters) to the provision of CHW care at community fixed sites only (control, 68 village clusters) in the Bankass health district in Central Mali. …”
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