NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice by Shi‐Qing Li, Ya‐Ru Wang, Zhong‐Liang Xie, Yan Wang, Zi‐Han Feng, Jian‐Hao Xu, Bing Yuan, Yi‐Tong Zhang, Guan Yang, Jing‐Lin Wang, Yuan Yuan

“…Methods We established ALD mice models of WT, Nlrp3−/− and Gsdmd−/− through chronic alcohol consumption feeding and acute alcohol induction. …”
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Learning health system research as a catalyst for promoting physician wellness: EHR InBasket Spring cleaning and team‐based compassion practice by Ming Tai‐Seale, Amanda Walker, Yuwei Cheng, Nathan Yung, Sophie Webb, Ottar Lunde, David Bazzo, Ammar Mandvi, Neal Doran, Gene Kallenberg, Christopher A. Longhurst, Sidney Zisook, Thomas J. Savides, Marlene Millen, Lin Liu

“…Linear and generalized mixed‐effects models assessed intervention effects, accounting for covariates. …”
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Colon Epithelial MicroRNA Network in Fatty Liver by Paule V. Joseph, Sarah K. Abey, Dan Wang, Nicolaas H. Fourie, Natnael D. Kenea, Tatyana G. Vishnyakova, Jeffrey M. Robinson, Kristen R. Weaver, Christina M. Boulineaux, Hannah R. Davidson, LeeAnne B. Sherwin, Onyinyechi Ozoji, Ana F. Diallo, Paul A. Smyser, Amy P. Patterson, Wendy A. Henderson

“…This study investigates an epithelial-focused miR network in colorectal cell models based on the previously reported MetS-FL miR trio of hsa-miR-142-3p, hsa-miR-18b, and hsa-miR-890. …”
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Prevalence and determinants of intimate partner violence in pregnancy: a multicentre, binational study by Akaninyene E. Ubom, Chidinma P. Ohachenu, Suraiya S. Auwal, Safiyya F. Usman, Akwasi B. Opoku, Caesar A. Ansing, Jamiu S. Shehu, Peter C. Oriji, Komommo O. Okpebri, Ademola S. Olutoye, Rasheedat O. Balogun, Joshua E. Ifebude, Oluwole D. Obadina, Solomon Nyeche, Abdurrahman A. Bunawa, Ukeje J. Ifeanyi, Fatima A. Mahmud, Hauwa S. Gumbi, Akeem O. Ojugbele, Olubusayo O. Areo, Olakunle E. Ogunjide, Mariam M. Shiru, Ada C. Okpighe, Chia Iornengen, David M. Aqua, Suleiman Z. Abubakar, Fadekemi O. Gabriel-Raji, Oyiana I. Gregory, Lukman O. Lawal, Mathias Abude, David Walawah, Aderopo I. Adelola, Akpofure H. Ese, Jane C. Orijani, Ephraim A. Suobite, Olire C. Afon, Obinna P. Ekwebalam, Baderinwa O. Akanji, Emmanuel E. John, Ibraheem O. Awowole, Omotade A. Ijarotimi, Ngozi Thompson, John I. Ikimalo, Olusola B. Fasubaa

“…Factors found to be statistically significant were subjected to binary logistic regression modelling to determine the predictors of IPV. The level of statistical significance was set at a p-value of < 0.05. …”
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Response of South Asia PM2.5 pollution to ammonia emission changes and associated impacts on human health by Yuanlin Wang, Eiko Nemitz, Samuel J. Tomlinson, Edward J. Carnell, Liquan Yao, Janice Scheffler, Tomas Liska, Clare Pearson, Ulrike Dragosits, Chandra Venkataraman, Srinidhi Balasubramanian, Rachel Beck, Mark A. Sutton, Massimo Vieno

“…Using an advanced regional atmospheric chemistry and transport modelling system (WRF-EMEP) with a new estimate of anthropogenic NH3 emissions inputs, we estimate the influence of agricultural NH3 emissions on surface PM2.5 in South Asia and evaluate the health impacts and the economic losses attributable to PM2.5 in 2018. …”
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Combination of clinical factors predicts successful glucocorticoid withdrawal in systemic lupus erythematosus (SLE): results from a multicentre, retrospective cohort study by Alessandra Bortoluzzi, Marcello Govoni, Dimitrios T Boumpas, Antonis Fanouriakis, Prodromos Sidiropoulos, George Bertsias, Konstantinos Parperis, Argyro Repa, Ettore Silvagni, Myrto Nikoloudaki, Nestor Avgoustidis, Sofia Pitsigavdaki, Antonio Marangoni, Irini Flouri, Spyridon Katechis

“…Survival and generalised linear models estimated SELENA-SLEDAI flare risks and their predictors.Results GCs were discontinued in 220 (67.9%) patients with 1-year risks for overall and severe flares of 50% and 25%, respectively (HR: 1.48; 95% CI: 1.12 to 1.96 for overall flares; HR: 1.52; 95% CI: 1.03 to 2.25 for severe flares, compared with non-withdrawers). …”
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Cardiomyopathy and kidney function in agalsidase beta‐treated female Fabry patients: a pre‐treatment vs. post‐treatment analysis by Christoph Wanner, Ulla Feldt‐Rasmussen, Ana Jovanovic, Aleš Linhart, Meng Yang, Elvira Ponce, Eva Brand, Dominique P. Germain, Derralynn A. Hughes, John L. Jefferies, Ana Maria Martins, Albina Nowak, Bojan Vujkovac, Frank Weidemann, Michael L. West, Alberto Ortiz

“…Methods and results Self‐controlled pretreatment and post‐treatment comparison (piecewise mixed linear modelling) included Fabry female patients ≥18 years at treatment initiation who received agalsidase beta (0.9–1.1 mg/kg every other week) for ≥2 years, with ≥2 pretreatment and ≥2 post‐treatment outcome measurements during 10‐year follow‐up. …”
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Serum advanced glycation end products as a putative biomarker in Type2 DKD patients’ prognosis by Ze-Hou Wang, Ze-Hou Wang, Zong-Jin Zhang, Yue-Fen Wang, Jin Xie, Jin Xie, Yi-Min Li, Cun Shen, Yuan Meng, Wen-Jing Zhao, Lu-Ying Sun, Wei Jing Liu

“…The association between corrected lgAGEs and renal outcomes was assessed using Cox proportional hazards models. Receiver operating characteristic (ROC) curve was utilized to evaluate the predictive performance of corrected lgAGEs alone and in combination with the urinary albumin-to-creatinine ratio (UACR).ResultsHigh level of corrected lgAGEs was independently associated with adverse renal outcomes [hazard ratio (HR), 3.252; 95% confidence interval (CI), 1.461–7.243; p = 0.003]. …”
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Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibiti... by Hui Luo, Jianhua Chen, Cao Li, Tian Wu, Siyue Yin, Guangping Yang, Yipin Wang, Zhihan Guo, Saifei Hu, Yanni He, Yingnan Wang, Yao Chen, Youqiang Su, Congxiu Miao, Yun Qian, Ruizhi Feng

“…Methods Using microinjection mRNA and genome engineering to reintroduce the conserved pathogenic missense variants into oocytes or in generating TUBB8 variant knock‐in mouse models, we investigated that the human deleterious variants alter microtubule nucleation and spindle assembly during meiosis. …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

“…One-way analysis of variance, univariate analysis, and multiple linear regression models (with age, sex, height, weight, parental myopia, continuous near-work time, electronic products use, and outdoor activity time as variables) were used to compare the effects of different variables on the AL, CR, and AL/CR ratio.ResultsOverall, 1,353 participants (708 boys; mean age, 4.37 ± 0.82 years) were included in this study. …”
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Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition by Dongsheng Di, Haolong Zhou, Zhangbo Cui, Jianli Zhang, Qian Liu, Tingting Yuan, Tingting Zhou, Xiao Luo, Danyang Ling, Qi Wang

“…Linear, Cox, and Laplace regression models were mainly used for data analysis. Results: Individuals with IUTSE showed a higher OP risk [hazard ratio (HR): 1.06, 95 % confidence interval (CI): 1.01, 1.11] and experienced earlier OP onset by 0.30 years [50th percentile difference = -0.30, 95 % CI: −0.51, −0.09] compared to those without. …”
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Potential impact and mechanism of aged polyethylene microplastics on nitrogen assimilation of Lactuca sativa L. by Xiaoli Mou, Hedong Zhu, Renrui Dai, Li Lu, Shengqi Qi, Min Zhu, Yuyang Long, Nan Ma, Chao Chen, Jiali Shentu

“…Structural equation modeling showed that soil nitrogen positively affected total nitrogen (TN) (0.359), chlorophyll (0.665), Rubisco (0.441), soluble protein (0.383), and biomass (0.460), and negatively affected phosphoenolpyruvate carboxylase (PEPC) (-0.325), soluble sugar (-0.134). …”
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Relevance of the synergy of surveillance and populational networks in understanding the Usutu virus outbreak within common blackbirds (Turdus merula) in Metropolitan France, 2018 by Bouchez-Zacria, Malika, Calenge, Clément, Villers, Alexandre, Lecollinet, Sylvie, Gonzalez, Gaelle, Quintard, Benoit, Leclerc, Antoine, Baurier, Florence, Paty, Marie-Claire, Faure, Éva, Eraud, Cyril, Decors, Anouk

“…Using generalised additive mixed models on REZOP data, we also highlighted the decline in common blackbird population trends in areas with medium and even more with high USUV pressure (areas defined based on SAGIR-AFVPZ data) following the 2018 outbreak (respectively −7.4% [−11.4; −3.9]95% and −15.7% [−16.2; −9.1]95%). …”
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Cancer-related health behaviors during the COVID 19 pandemic in geographically diverse samples across the US by Breanna B. Greteman, Allison Cole, Mary E. Charlton, Jackilen Shannon, Deanna Kepka, Electra D. Paskett, Evelinn A. Borrayo, Jamie L. Studts, Hayley S. Thompson, Isabel Scarinci, Lynn Chollet Hinton, Elizabeth A. Chrischilles, Crystal J. Garcia-Auguste, Kaila Christini, Heather Aker, Jesse J. Plascak, Felicity W. K. Harper, Monica L. Baskin, Sejong Bae, Vishruti Pandya, Young-il Kim, Babalola Faseru, Christie Befort, Hanluen Kuo, Mark Dignan, Juan Canedo, Victoria Champion, Bettina F. Drake, Kia L. Davis, Debra L. Friedman, Mohamed I. Elsaid, Scherezade K. Mama, Wendy F. Cohn

“…Descriptive analyses and logistic regression models assessed association of variables with behavior change. …”
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A digital intervention to reduce home-office workers’ sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial by Judit Bort-Roig, Iris Parés-Salomón, Bette Loef, Cristina Vaqué-Crusellas, Alan Coffey, Arnau Gustems-Morral, Anna M. Señé-Mir, Izabela Luznik, Maja Pajek, Kieran P. Dowd, Anna Puig-Ribera, Karin I. Proper

“…Focus groups will be conducted with employees post-intervention. Linear mixed models, accounting for covariates, will be employed to determine the effects of the intervention. …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…The in vivo antitumoral efficacy of CM272 was evaluated in PDAC xenograft and syngeneic mouse models, both alone and in combination with anti-PD1 immunotherapy. …”
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Evaluation of eco-driving performance of electric vehicles using driving behavior-enabled graph spectrums: A naturalistic driving study in China by Hui Zhang, Yiyue Luo, Naikan Ding, Toshiyuki Yamamoto, Chenming Fan, Chunhui Yang, Wei Xu, Chaozhong Wu

“…This study proposes a method for visualizing ecology driving behavior that not only help understand the individual characteristics of ecological driving behaviors, but also offers substantial application value for the subsequent construction of Ecological driving behavior regulation models.…”
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Effect of Information Genotype on Investors' Inertia by Fatemeh Jahandari, Amirhossein Taebi Noghondari, Hadis Zeinali

“…Understanding the effect of information presentation models is important for investors facing a wide range of information to make optimal decisions. …”
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Source-specific acute cardio-respiratory effects of ambient coarse particulate matter exposure in California’s Salton Sea region by Yaning Miao, William C Porter, Tarik Benmarhnia, Catherine Lowe, Timothy W Lyons, Caroline Hung, Charles Diamond

“…Here we use observed coarse particulate matter (PM _c ) concentrations and modeled atmospheric back trajectories along with land surface data to estimate individual source region contributions to particulates observed at long term surface air quality monitoring sites in the Salton Sea region. …”
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Preliminary effectiveness of social prescription and virtual patient information in increasing tertiary prevention among cancer patients (ESPRIT): protocol for a single-centre, ran... by Karen Steindorf, Michael Koller, Michael Leitzmann, Wolfgang Herr, Daniel Heudobler, Lisa Boyer, Anne Herrmann, Tobias Pukrop, Christine Bernardi, Sabine Einhell

“…The analysis of secondary endpoints will include appropriate statistical methods such as the χ2 test of independence or linear regression models, which will be used to analyse secondary endpoints and to investigate factors influencing preliminary effectiveness.Ethics and dissemination This trial has been approved by the ethics committee of the University of Regensburg (reference: 23-3317-101). …”
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