Sex differences in the associations of water, coffee and tea consumption with cardiovascular diseases: a prospective cohort study by Dandan Ke, Dandan Ke, Yueqing Wang, Yabing Hou, Weihao Shao, Jiawen Ke, Xiaoxuan Zhang, Hongxi Yang, Zhong He, Zuolin Lu

“…CVDs, including coronary heart disease (CHD), stroke and heart failure (HF) were followed till March 1st, 2023. Sex-specific Cox models were utilized to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations.ResultsDuring a median follow-up of 8.7 years, 11,098 (2.40%) participants developed new-onset HF, 33,426 (7.24%) participants developed new-onset CHD, and 9,706 (2.10%) participants developed new-onset stroke. …”
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Low-grade systemic inflammation, but not neuroinflammation, is associated with 12-month postoperative outcome after total hip arthroplasty in patients with painful osteoarthritis:... by Morten R. Blichfeldt-Eckhardt, Claus Varnum, Jørgen T. Lauridsen, Lasse E. Rasmussen, Winnie C. P. Mortensen, Hanne I. Jensen, Henrik B. Vaegter, Kate L. Lambertsen

“…Postoperative outcome was assessed as change in Oxford Hip Score (OHS) from baseline to 12 months after THA, pain was assessed on a numerical rating scale, and disability using the Pain Disability Index. Multiple regression models for each clinical outcome were included for biomarkers in blood and CSF, respectively, including age, sex, BMI, and Kellgren-Lawrence score. …”
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Prognostic value of inflammatory markers for all-cause mortality in patients with acute myocardial infarction in the coronary care unit: a retrospective study based on MIMIC-IV dat... by Fen Cao, Jun-jun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhong-Wu Bao, Kun Wu, Yong-zhi Zhu

“…Various clinical and laboratory data were extracted. Logistic regression models were employed to determine the correlation between NLR and in-hospital mortality, 30-day mortality, and 90-day mortality. …”
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Antitumor effect of a new human epidermal growth factor receptor inhibitor by O. I. Kit, I. P. Kodonidi, E. M. Frantsiyants, I. V. Kaplieva, A. A. Glushko, L. K. Trepitaki, E. I. Surikova, V. A. Bandovkina, Yu. A. Pogorelova, I. V. Neskubina, O. V. Bykadorova, E. V. Serdyukova

“…This indicates the promising potential of this compound and the need to continue its preclinical study in other tumor models.…”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…Differential gene expression analysis, transcription factor activity profiling, and cell‐cell communication modeling were performed to elucidate the immune mechanisms underlying the disease. …”
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Prenatal vitamin utilization and its determinants among pregnant women in south Gondar zone: multicenter cross-sectional study by Begizew Yimenu Mekuriaw, Dagne Addisu, Wassie Yazie Ferede, Fillorenes Ayalew Sisay, Assefa kebie Mitiku, Tegegne Wale Belachew, Tigist Seid Yimer, Habtie Bantider Wubet, Selamawit Girma Tadesse, Negesse Zurbachew Gobezie, Alemie Fentie Mebratie, Moges Kefale Alachew, Temesgen Dessie Mengistu, Yonas Zenebe Yiregu, Rahel Birhanu Arage, Anteneh Mengist Dessie, Fikadu Geremew Gebeyehu, Geremew Bishaw Mekonen, Habtam Desse Alemayehu, Abeba Belay Ayalew, Yitayal Ayalew Goshu, Besfat Berihun Erega

“…Factors associated with utilization of prenatal vitamins were identified using bi-variable and multi variable logistic regression models. Statistical significance was declared at 95%CI and p-value < 0.05.ResultIn this study, we found that 87.5% (95% CI: 84.31, 90.34) of pregnant women did not use prenatal vitamins. …”
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Short-term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort by Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Anja Hviid Simonsen, Nicholas J. Ashton, Hanna Huber, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

“…Inter-individual variability ranged from ~ 7% (Aβ40) to ~ 39% (NfL). Adjusting the models for time, eGFR, Hba1c, and BMI did not affect the variation. …”
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Prevalence and determinants of nasal carriage of penicillin non-susceptible Streptococcus pneumoniae: a cross-sectional household survey in northern VietnamResearch in context by Costanza Tacoli, Hien Anh Thi Nguyen, Tu Cam Thi Nguyen, Bich Ngoc Thi Vu, Max van Wijk, Quynh Dieu Pham, Huong Kieu Thi Tran, Thuong Hong Thi Nguyen, Trang Thu Nguyen, Tung Son Trinh, Dung Tien Viet Vu, Hoang Huy Tran, Thai Duy Pham, Duc Anh Dang, Tien Dac Tran, Duong Thanh Nguyen, H. Rogier van Doorn, Thomas Kesteman, Sonia Lewycka

“…Penicillin susceptibility was tested by E-test. Logistic regression models were used to explore risk factors for PNSP carriage compared to susceptible strains. …”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…The individual-level models were adjusted for confounders, such as age, sex, noradrenaline dosage and patient (random effect). …”
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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

“…Hierarchical logistic regression models will test the study hypotheses, and qualitative methods, such as interviews and focus groups, will provide contextual understanding. …”
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Phylogeographic breaks and how to find them: An empirical attempt at separating vicariance from isolation by distance in a lizard with restricted dispersal by Rancilhac, Loïs, Miralles, Aurélien, Geniez, Philippe, Mendez-Aranda, Daniel, Beddek, Menad, Brito, José Carlos, Leblois, Raphaël, Crochet, Pierre-André

“…Using the nuclear markers, we then applied linear regression models to investigate whether genetic divergence could be explained by geographical distances alone, or barriers to gene flow (real phylogeographic breaks). …”
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Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections by Ryosuke Yamamura, Yu Nagayoshi, Kayo Nishiguchi, Hitomi Kaneko, Keiichi Yamamoto, Koki Matsushita, Miho Shimamura, Akihiro Kunisawa, Korin Sakakida, Takeshi Chujo, Masataka Adachi, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Kazuhito Tomizawa

“…Furthermore, we found that m2A was elevated in the urine from animal models of bacterial infection and the urine of patients with bacterial infections. …”
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Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma by Wei Gao, Tong Ding, Beicheng Sun, Nan Li, Fang Gao, Meng Jia, Mitchell Ho, Na Li, Luan Sun, Zhanhui Gao, Lei Ao, Sujuan Ma, Peihua Lu, Shaochang Jia

“…The existence of sGPC3 significantly inhibited the release of cytokines and the cytotoxicity of anti-GPC3 CAR-T cells in vitro. In animal models, mice carrying Hep3B xenograft tumors expressing sGPC3 exhibited a worse response to the treatment with CAR-T cells under both a low and high tumor burden. sGPC3 bound to CAR-T cells but failed to induce the effective activation of CAR-T cells. …”
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PET/CT-derived coronary calcium score may predict cardiac complications in anthracycline-treated patients with lymphoma by Genevieve Douglas, Zoe Loh, Evonne S.Y. Shum, Sze-Ting Lee, Niamh Waters, Garry Hamilton, Geoffrey Chong, Alexandra C. Murphy, Eliza A. Hawkes

“…Logistic and Cox regression models were used to assess associations between CVR, CACS categories (CACS = 0, CACS 1-400, CACS >400), and new cardiac events. …”
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Antimicrobial Profiling of Bacteria Isolated from Fish Sold at Informal Market in Mufakose, Zimbabwe by Claudious Gufe, Tinashe Canaan Hodobo, Bernard Mbonjani, Otlia Majonga, Jerikias Marumure, Shuvai Musari, Gilbert Jongi, Pious Vengesayi Makaya, Jairus Machakwa

“…These significant findings call for effective risk assessment models and management plans that protect human, animal, and environmental health.…”
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Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“…Newly approaches, like machine learning models and AMH-based screening programs in countries like Portugal emerge. …”
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Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula by Nao Fujimori, Takashi Osoegawa, Akira Aso, Soichi Itaba, Yosuke Minoda, Masatoshi Murakami, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Takehiro Takaoka, Takamasa Oono, Eikichi Ihara, Tomoharu Yoshizumi, Takao Ohtsuka, Masafumi Nakamura, Yoshihiro Ogawa

“…Factors prolonging hospital stay were also analyzed using Cox proportional hazard models. Results. Thirty patients (median age, 64.5 years) were enrolled. …”
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Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors by Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, Marta Salido, Nuria Juanpere‐Rodero, Federico Rojo, Aura Muntasell, Joan Albanell, Ana Rovira, Joaquim Bellmunt

“…In our study, we investigated how phosphoinositide 3‐kinase (PI3K)/AKT/mTOR pathway inhibitors (TAK‐228, everolimus and TAK‐117) affect PD‐L1 expression and function in preclinical bladder cancer cell models. TAK‐228 increased cell surface levels of glycosylated PD‐L1 in all but one of the seven cell lines, regardless of baseline levels. …”
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Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context by Anne M. Gehrels, Pauline A.J. Vissers, Mirjam A.G. Sprangers, Nienke M. Fijnheer, Esther N. Pijnappel, Lydia G. van der Geest, Geert A. Cirkel, Judith de Vos-Geelen, Marjolein Y.V. Homs, Geert- Jan Creemers, Martijn W.J. Stommel, Lois A. Daamen, Marc G. Besselink, Johanna W. Wilmink, Hanneke W.M. van Laarhoven

“…HRQoL was assessed using the EORTC QLQ-C30 and -PAN26 questionnaires at baseline, during treatment, and at 0–3 months and 3–6 months after treatment. Linear mixed models were used to analyze changes in HRQoL over time, with clinically relevant changes defined as a minimal mean difference of 10 points in absolute scores and reported with 95% confidence intervals. …”
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Associations of maternal PM2.5 exposure with preterm birth and miscarriage in women undergoing in vitro fertilization: a retrospective cohort study by Miaoxin Chen, Qiaoyu Chen, Gengze Liao, Chunyan Sun, Cong Liu, Xia Meng, Wentao Li, Andong Qiu, Orhan Bukulmez, Haidong Kan, Feng Wang, Lap Ah Tse, Xiaoming Teng

“…Our study used multinomial logistic regression models to explore the potential associations between PM2.5 exposure and adverse pregnancy outcomes. …”
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