BiomiX, a user-friendly bioinformatic tool for democratized analysis and integration of multiomics data by Cristian Iperi, Álvaro Fernández-Ochoa, Guillermo Barturen, Jacques-Olivier Pers, Nathan Foulquier, Eleonore Bettacchioli, Marta Alarcón-Riquelme, PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium, Divi Cornec, Anne Bordron, Christophe Jamin

“…BiomiX fine-tunes MOFA models, to optimize factors number selection, distinguishing between cohorts and providing tools to interpret discriminative MOFA factors. …”
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Age and sex differences in the relationship of body weight changes with colon cancer risks: A nationwide cohort study by Jae Hyun Kim, Young Ko, Hyun Jung Kim, Seun Ja Park

“…The Kaplan–Meier method estimated the cumulative incidence of colon cancer, and Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI), adjusting for confounding factors. …”
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Radiolabeled Anti-Adenosine Triphosphate Synthase Monoclonal Antibody as a Theragnostic Agent Targeting Angiogenesis by Bok-Nam Park PhD, Su Jin Lee MD, PhD, Jung Hyun Roh MS, Kyung-Han Lee MD, PhD, Young-Sil An MD, PhD, Joon-Kee Yoon MD, PhD

“…Conclusion: The specific binding and antitumor effects of radioiodinated ATPS mAb were confirmed in in vitro and in vivo models of stomach cancer.…”
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Maximizing the performance of heat stressed broilers by optimizing starch-to-lipid ratios, digestible amino acid, and metabolizable energy during the finisher phase by Dilshaan Duhra, Denise Beaulieu, Tory Shynkaruk, Juliano C. de Paula Dorigam, Rose Whelan, Karen Schwean-Lardner

“…A {3,3} simplex lattice design was used to assess relative effects and generate predictive models. Three basal finisher diets were formulated to have the highest S:L ratio (Basal A; 20:1), DigLys (Basal B; 1.30 %), or AME (Basal C; 3300 kcal/kg). …”
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A multidisciplinary pain management program for patients with chronic low back pain: a randomized, single-blind, controlled, feasibility study by Anna Dalmau-Roig, Christian Dürsteler, Mirari Ochandorena-Acha, Francisco Vilchez-Oya, Inés Martin-Villalba, Amadeu Obach, Marc Terradas-Monllor

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Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…The present study extends these findings using selective CRF receptor ligands, gene KO models, and miniature IPSC (mIPSC) analysis to assess further a presynaptic role for the CRF receptors in mediating ethanol effects in the CeA. …”
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First evidence of transovarial transmission of Kyasanur Forest disease virus in Haemaphysalis and Rhipicephalus ticks in the wild by Sarah J. Burthe, Bhimanagoud Kumbar, Stefanie M. Schäfer, Bethan V. Purse, Abi T. Vanak, Natrajan Balakrishnan, Richard Hassall, Subhash L. Hoti, Darshan Narayanaswamy, Santoshkumar Potadar, Mujeeb Rahman, Mohammed Mudassar Chanda

“…Empirical data on pathogen-vector-host interactions and incrimination have not been updated since the last century, despite significant local changes in land use and the expansion of KFD to new areas. Mathematical models predict that transovarial transmission, whereby adult female ticks pass KFDV infections to their offspring, plays an important role in the persistence of KFD, but this has not been shown in the wild. …”
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Interprofessional collaborative practice in health and social care for people living with multimorbidity: a scoping review protocol by Josephine-L. K. Murray, Virginia Hernandez-Santiago, Frank Sullivan, Joanna Hornal, Farhana Badshah, Ben Keatley, Jillian Galbraith, Pam Channer, Anne Fearfull, Anne Haddow, Eleanor Johnston, Maureen Ward, Veronica O’Carroll

“…This poses a significant challenge for current models of healthcare delivery, which are now ill-equipped to meet the future population health needs. …”
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Exploring the relationship between established HIV risk factors and depressive symptoms amongst young women without HIV in two sites in South Africa. by Zanenhlanhla Gumbi, Celia Mehou-Loko, Lindi Masson, Makhosazana Mdladla, Nokuthula Maphumulo, Jo-Ann Passmore, Sanele Mbeje, Linda Gail Bekker, Disebo Potloane, Heather Jaspan, Nina Radzey, Andrea Abrahams, Rushil Harryparsad, Pamela Mkhize, Hilton Humphries

“…The PHQ-9 scale was used to determine depressive symptomology, a socio-behavioural questionnaire was used to determine sexual behaviours, odds ratios and confidence intervals derived from logistic regression models were used to explore the associations between depressive symptomology and socio-behavioural factors associated with HIV acquisition.…”
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An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition by Cong Chen, Xin Luo, Xianchao Lin, Ronggui Lin, Yuanyuan Yang, Congfei Wang, Haizong Fang, Tianhong Teng, Heguang Huang, Fengchun Lu

“…Multivariate Cox proportional hazards models were used to determine prognostic factors. …”
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Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…The interaction between COL17A1 and ACTN4 was analyzed by Co-immunoprecipitation and immunofluorescence assays. Animal models were established for in vivo analysis. Results CAF incubation promoted GEM resistance and enhanced the proliferation, invasion and stemness in GEM-resistant PC cells. …”
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The association between dietary omega-3 intake and osteoporosis: a NHANES cross-sectional study by Zhiwen Liu, Shaoming Cai, Yuzhen Chen, Zijing Peng, Huanling Jian, Zhihai Zhang, Hongxing Huang

“…Participants in the highest quartile of omega-3 intake had a significantly lower risk (OR = 0.71, 95% CI: 0.53–0.93) compared to those in the lowest quartile, with a consistent trend across all adjusted models (p for trend <0.05). Subgroup analyses indicated stronger associations in individuals under 60 years of age, female and non-smokers. …”
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Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants by Shujing Ma, Xue Liu, Ruilang Lin, Ye Yao, Min Zhao, Yongfu Yu, Costan G. Magnussen, Bo Xi

“…Associations of childhood body size or adulthood adiposity status as well as child–adult weight status change with incident adulthood hypertension were estimated by multivariate Cox proportional regression models. Results Participants with childhood thinner body size and adulthood obesity had the highest risk of incident hypertension (hazard ratio, HR = 3.09, 95% CI = 2.88–3.32) compared with those with “average → normal” pattern, followed by those with “average → obese” pattern (HR = 2.45, 95% CI = 2.31–2.61) and “plumper → obese” pattern (HR = 2.82, 95% CI = 2.62–3.02). …”
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Plasma circulating cell–free DNA integrity and relative telomere length as diagnostic biomarkers for Parkinson’s disease and multiple system atrophy: a cross-sectional study by Chao Ying, Chao Han, Yuan Li, Mingkai Zhang, Shuying Xiao, Lifang Zhao, Hui Zhang, Qian Yu, Jing An, Wei Mao, Yanning Cai

“…The diagnostic potential of the cell-free DNA parameters was evaluated using receiver operating characteristic (ROC) analysis, and their association with disease prevalence was examined through logistic regression models, adjusting for confounders such as age, sex, body mass index, and education level. …”
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Determinants of poor access to health care among women of reproductive age in Sierra Leone: a cross-sectional study by Augustus Osborne, Peter Bai James, Camilla Bangura

“…A mixed-effect multilevel binary logistic regression analysis was conducted, determining the factors associated with poor access to healthcare using a four-modeled approach. The results were presented as adjusted odds ratios (aOR) with a 95% confidence interval (CI). …”
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Comparative clinical impact of low-curvature and normal-curvature titanium mesh in cranioplasty: a retrospective analysis of patient outcomes by Shengkai Yang, Weihua Chen, Hongwei Teng, Lei Zhang, Kangkang Ji, Hai Zhou

“…Moreover, satisfaction with molding (Before: 4.23 ± 0.75 vs. 3.18 ± 0.81, P = 0.001; After: 4.13 ± 0.72 vs. 3.25 ± 0.78, P < 0.001), Karnofsky's Performance Status score (Before: 93.32 ± 1.67 vs. 90.38 ± 3.50, P = 0.001; After: 93.56 ± 1.75 vs. 91.00 ± 3.78, P < 0.001), and Quality of Life score (Before: 52.95 ± 2.13 vs. 50.18 ± 3.54, P = 0.001; After: 53.31 ± 2.12 vs. 50.38 ± 4.23, P = 0.001) were significantly higher in the low-curvature titanium mesh group than the normal-curvature titanium mesh group.ConclusionsApplying low-curvature titanium mesh for skull repair effectively shortens the hospital stay, reduces overall hospitalization costs,enhances patient satisfaction with surgical modeling, and improves the postoperative functional status and quality of life of patients undergoing neurosurgery. …”
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Nonlinear association between glycated hemoglobin levels and mortality in elderly patients with non-diabetic chronic kidney disease: a national health and nutrition examination sur... by Lihua Huang, Liuliu He, Qingfeng Zeng, Jinjing Huang, Xiaoyan Luo, Qiuming Zhong

“…Hazard ratios (HR) and 95% confidence intervals (CIs) for all-cause and CVD mortality were calculated using weighted Cox proportional hazards and restricted cubic spline models.ResultsAmong the 1,931 participants (mean [SE] age, 73.2 [0.2] years; 61.9% female), over a median follow-up period of 7.6 years, a total of 1,003 deaths were observed, including 412 from CVD. …”
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Assessing the Applicability of Photocatalytic-Concrete Blocks in Reducing the Concentration of Ambient NO2 of Chandigarh, India, Using Box–Behnken Response Surface Design Technique... by Neeru Singla, Sandeep Singla, Parteek Singh Thind, Sandeep Singh, Jasgurpreet Singh Chohan, Raman Kumar, Shubham Sharma, Somnath Chattopadhyaya, Shashi Prakash Dwivedi, Ambuj Saxena, Alibek Issakhov, Nima Khalilpoor

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Psychometric characteristics and feasibility of microinteraction-based Ecological Momentary Assessment in audiology research by Yu-Hsiang Wu, Elizabeth Stangl, Samuel Smith, Jacob Oleson, Christi Miller, Octav Chipara

“…Participants provided feedback on their experience with micro-EMA.ResultsIn the dual-task experiment, participants reported improved hearing performance in micro-EMA as SNRs and speech recognition scores increased across all three response formats, supporting the tool's construct validity. Statistical models indicated that the 5-point and 10-point scales yielded larger relative changes between SNRs, suggesting higher responsiveness, compared to the 2-point scale. …”
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Health recommender systems to facilitate collaborative decision-making in chronic disease management: A scoping review by Antonia Barbaric, Kenneth Christofferson, Susanne M Benseler, Chitra Lalloo, Alex Mariakakis, Quynh Pham, Joost F Swart, Rae S M Yeung, Joseph A Cafazzo

“…From the thematic analysis, we conclude: (a) the main goal of HRSs is to induce behavior change, but limited research investigates their effectiveness in achieving this aim; (b) studies acknowledge that theories, models, frameworks, and/or guidelines help design HRSs to elicit specific behavior change, but they do not implement them; (c) connections between CDM and HRS purpose should be more explicit; and (d) HRSs can often offer other self-management services, such as progress tracking and chatbots. …”
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