The externalization of internal experiences in psychotherapy through generative artificial intelligence: a theoretical, clinical, and ethical analysis by Yuval Haber, Dorit Hadar Shoval, Inbar Levkovich, Dror Yinon, Karny Gigi, Oori Pen, Tal Angert, Zohar Elyoseph, Zohar Elyoseph

“…Recent advances in generative artificial intelligence (GenAI), specifically large language models (LLMs), present new possibilities for therapeutic interventions; however, their integration into core psychotherapy practices remains largely unexplored. …”
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The effects of psychosocial aftercare following pediatric chronic pain treatment withstand the coronavirus disease 2019 pandemic: long-term outcomes of a randomized controlled tria... by Lisa-Marie Rau, Meltem Dogan, Gerrit Hirschfeld, Markus Blankenburg, Michael C. Frühwald, Rosemarie Ahnert, Sarah Braun, Ursula Marschall, Boris Zernikow, Julia Wager

“…A multicenter randomized controlled trial investigated the impact of PAC with follow-up assessments in 2021 during the COVID-19 pandemic (N = 209). Multilevel models and regression analyses explored long-term treatment effects on pain characteristics and psychological outcomes, associations of pandemic-related burden with these outcomes, and whether pandemic-related burden moderates those effects. …”
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Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis by Georgios K. Vasileiadis, Yuan Zhang, Tahzeeb Fatima, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Grondal, Kim Hørslev‐Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Till Uhlig, Tuulikki Sokka‐Isler, Anna Rudin, Cristina Maglio

“…Adjusted Cox proportional hazards models did not show any effect of baseline adiponectin, leptin, and resistin levels on the likelihood of achieving CDAI remission (adiponectin: hazard ratio [HR] 1.08, 95% confidence interval [CI] 0.80–1.45, P = 0.62; leptin: HR 0.89, 95% CI 0.64–1.26, P = 0.52; resistin: HR 0.86, 95% CI 0.65–1.13, P = 0.26). …”
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Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population by Qing Chen, Yanan Hou, Yifan Zhou, Jianfeng Luo, KaiweiSa Abuduxukuer, Chuchu Wang, Jialong Dong, Yiting Wang, Wenming Shi, Fei Shi, Qing Peng

“…For longitudinal analysis, generalised linear models with generalised estimating equations were used to determine the association between time-varying adiposity and visual status.Results Higher levels of WHtR/WWI/ABSI/BRI/ConI were significantly associated with an increased prevalence of VI, whereas a higher BMI was associated with a decreased prevalence of VI. …”
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Cross-sectional association among dietary habits, periodontitis, and uncontrolled diabetes in Hispanics: the LLIPDS study by Hunter Smith, David Travis Thomas, Gabriela Nicole Vázquez-Morales, Lakin Puckett, María Del Mar Rodriguez, Arnold Stromberg, Luciana Macchion Shaddox, Mauro Pedrine Santamaria, Kevin Pearce, Oelisoa Mireille Andriankaja

“…Glucose control was measured by glycated hemoglobin (HbA1c) levels, with uncontrolled glucose defined as HbA1c ≥ 7%. Linear regression models adjusted for demographic and clinical variables estimated associations with PD. …”
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Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1 by Suli Wang, Fujiao Nie, Qiuyue Yin, Haoyang Tian, Pizhang Gong, Jinhong Ju, Jiayi Liu, Pishan Yang, Chengzhe Yang

“…Methods Mouse oral or prostate cancer xenograft models were divided into control, periodontitis and periodontitis + anti-PD-1 groups. …”
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On the fence: Factors associated with COVID-19 vaccine hesitancy among sexually Minoritized men who use substances in the United States by Renessa S. Williams, Acklynn M. Byamugisha, Leah Davis-Ewart, Omar R. Valentin, Samantha E. Dilworth, Christian Grov, Adam W. Carrico

“…We performed a mediation analysis using the Karlson-Holm-Breen method, and factors associated with the likelihood of vaccine uptake were modeled using logistic regression, adjusting for time and age. …”
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Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children by Steven M. Brunwasser, Tebeb Gebretsadik, Anisha Satish, Jennifer C. Cole, William D. Dupont, Christine Joseph, Casper G. Bendixsen, Agustin Calatroni, Samuel J. Arbes, Jr, Patricia C. Fulkerson, Joshua Sanders, Leonard B. Bacharier, Carlos A. Camargo, Jr, Christine Cole Johnson, Glenn T. Furuta, Rebecca S. Gruchalla, Ruchi S. Gupta, Gurjit K. Khurana Hershey, Daniel J. Jackson, Meyer Kattan, Andrew Liu, George T. O'Connor, Katherine Rivera-Spoljaric, Wanda Phipatanakul, Marc E. Rothenberg, Max A. Seibold, Christine M. Seroogy, Stephen J. Teach, Edward M. Zoratti, Alkis Togias, Tina V. Hartert

“…Primary analyses used generalized linear and generalized mixed-effects modelling. Results: Caregivers with high enrollment levels of worry about COVID-19 illness were more likely to reduce direct social contact outside the household, particularly during the U.S.'…”
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The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study by Pedro Javier Tárraga Marcos, Ángel Arturo López-González, Emilio Martínez-Almoyna Rifá, Hernán Paublini Oliveira, Cristina Martorell Sánchez, Pedro Juan Tárraga López, José Ignacio Ramírez-Manent

“…Descriptive analysis included categorical and quantitative variables, which were assessed through frequencies, Student’s <i>t</i>-test, chi-square, and binary logistic regression models. Logistic regression and Cohen’s kappa were used to evaluate associations and concordances. …”
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Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study by Shihan Zhen, Na Li, Yan Li, Qian Li, Lu Zheng, Zhouxin Yin, Yan Dou, Shuqi Wu, Yilin Liu, Xiaoyan Zhang, Xinyue Yang, Ye Wang, Wenxiu Ge, Xiaoyu Gao, Jing Yang, Fengchao Liang, Jiajin Hu, Ying Zhao

“…The association between maternal exposure to PM2.5, and the risk of birth defects, was estimated using logistic regression models. For each 10 μg/m³ increase in PM2.5, the odds ratios of birth defects were 1.68 (95% CI: 1.65, 1.70) and 2.41 (95% CI: 2.36, 2.45) during the preconception period and pregnancy, respectively. …”
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Learning from wildfires: A scalable framework to evaluate treatment effects on burn severity by Caden P. Chamberlain, Garrett W. Meigs, Derek J. Churchill, Jonathan T. Kane, Astrid Sanna, James S. Begley, Susan J. Prichard, Maureen C. Kennedy, Craig Bienz, Ryan D. Haugo, Annie C. Smith, Van R. Kane, C. Alina Cansler

“…Our framework used (1) machine learning to identify key bioclimatic, topographic, and fire weather drivers of burn severity in each fire, (2) standardized workflows to statistically sample untreated control units, and (3) spatial regression modeling to evaluate the effects of treatment type and time since treatment on burn severity. …”
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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer by Peter Jung, Stefan P. Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian Martin, Christoph Albrecht, Barbara Drobits-Handl, Sathanandam S. Anand, Srinath Kasturirangan, Francesca Trapani, Norbert Schweifer, Joseph R. Marszalek, Ulrike Tontsch-Grunt, Mark Pearson, Timothy P. Heffernan, Norbert Kraut, Christopher P. Vellano, Juan Manuel García-Martínez

“…TR2/CDH3 BAB demonstrated anti-tumor activity in a panel of PDAC patient-derived xenograft models, including tumor regressions. By combining TR2/CDH3 BAB with chemotherapeutic agents, deeper and more sustained anti-tumor responses were observed when compared to monotherapy. …”
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Nomograms Predicting Survival, Recurrence and Beneficiary Identification of Adjuvant Chemotherapy in Treatment-naïve Patients with Rectal Cancer who Underwent Upfront Curative Rese... by Yukihide Kanemitsu, MD, Tomofumi Uotani, MD, Shunsuke Tsukamoto, PhD, Hideki Ueno, PhD, Megumi Ishiguro, PhD, Soichiro Ishihara, PhD, Koji Komori, PhD, Kenichi Sugihara, PhD, Study Group for Nomogram of the Japanese Society for Cancer of the Colon and Rectum

“…A training cohort (n = 1925) of treatment-naïve patients who underwent surgery between 2007 and 2008 was analyzed to construct prognostic models predicting postoperative survival and recurrence. …”
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Short-term Outcomes of Pancreatoduodenectomy in Patients with Liver Cirrhosis: A Systematic Review and Meta-analysis by Shahab Hajibandeh, MRCS, Shahin Hajibandeh, FRCS, Alwin Puthiyakunnel Saji, Ayman Ashabi, MRCS, Christopher Brown, FRCS, Nicholas G Mowbray, FRCS, Matthew Mortimer, FRCS, Guy Shingler, FRCS, Amir Kambal, FRCS, Bilal Al-Sarireh, FRCS, PhD

“…Short-term outcomes of pancreatoduodenectomy between patients with and without LC were compared using random effects modeling and the certainty of the evidence was assessed using the GRADE system. …”
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Effects of Trichinella spiralis and its serine protease inhibitors on intestinal mucosal barrier function by Ruibiao Wang, Yuheng Zhang, Zhixin Li, Jingbo Zhen, Qiankun Li, Qi Zhang, Yuqi Yang, Xueting Liu, Yixin Lu

“…Recombinant SPIs (rKaSPI, rAdSPI) were purified, co-cultured with intestinal epithelial cells (IPECs), and used in mouse models. The protein expression changes in IPECs and mice were consistent with those in T. spiralis-infected tissues. …”
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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice by Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Maha Bikheet, Rokayya Sami, Hassan Mohamed, Xiangchen Meng

“…The study aims to investigate the function of Lactobacillus brevis KLDS1.0727 and KLDS1.0373 strains as glutamic acid decarboxylase 65 (GAD65) carriers capable of generating GABA by comparing in vitro free and freeze-dried models and GABA intervention in vivo. PCR amplification of gad and in vitro i.e., (growth rate, viability at different pH, bile tolerance, and survivability in simulated gastric juice) were performed. …”
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Temporal Trends of Stillbirth in Brazil Disaggregated by Maternal and Gestational Age by Maria Isabel do Nascimento, Lara Miranda Marchesi, Wender Emiliano Soares, Jenaine Rosa Godinho Emiliano, Maria Auxiliadora Nogueira Saad, Glaucimara Gonzaga Nunes Hacar, Gabriel Eijiro Chiracava

“…Stillbirth rates were presented per 1,000 births, and trends were assessed via autoregressive models. Results: There were 228,386 stillbirths in Brazil, corresponding to 1 event per 133 live births at ≥ 22 gestational weeks in singleton pregnancies. …”
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Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet by Lingyue An, Shujue Li, Zhenglin Chang, Min Lei, Zhican He, Peng Xu, Shike Zhang, Zheng Jiang, Muhammad Sarfaraz Iqbal, Xinyuan Sun, Hongxing Liu, Xiaolu Duan, Wenqi Wu

“…Here, we investigated the therapeutic efficacy of fecal microbiota transplantation (FMT) sourced from healthy rats fed with standard pellet diet against urinary oxalate excretion, renal damage and calcium oxalate (CaOx) crystal depositions via using hyperoxaluria rat models. We observed dose-dependent increases in urinary oxalate excretion and CaOx crystal depositions due to hyperoxaluria, accompanied by significant reductions in gut microbiota diversity characterized by shifts in Ruminococcaceae_UCG-014 and Parasutterella composition. …”
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Modern perspective of the Rice Diet for hypertension and other metabolic diseases by Anthony Kuo, Pao-Hwa Lin, Yi-Ju Li, Friedrich C Luft, David López, Romeo Sommerfeld, Paul Ermler, Jana Fehr, Benjamin Bergner, Scott Sanoff, Francis Neelon, William McDowell, Smilla Fox, Abdullatif Ghajar, Elena Gensch, Cedric Lorenz, Martin Preiss, Tom Richter, Philip Klemmer, Anastacia Bohannon, Christoph Lippert

“…Manual transcription accuracy exceeded 97%. We used regression models to investigate the impact of dietary adherence on systolic BP (SBP) and body weight. …”
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Have crops already reached peak suitability: assessing global climatic suitability decreases for crop cultivation by Vhiny-Guilley Mombo, Mathilde Duvallet, Michiel Schaeffer, Florent Baarsch

“…We applied the method to evaluate the effects of climate change under two climatic scenarios (SSP2-4.5 and SSP5-8.5), using an ensemble of five general circulation models, for nine crops (Arabica coffee, cassava, common beans, common wheat, maize, plantain, rice, sorghum and sugarcane) for four periods of time: past (1995–2014), present day (2015–2034), medium term (2040–2059), long term (2080–2099). …”
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