The Late Orchid Catches the Bee: Frost Damage and Pollination Success in the Face of Global Warming in a European Terrestrial Orchid by Florian P. Schiestl, Beat A. Wartmann, Ruth Bänziger, Brigitte Györög‐Kobi, Klaus Hess, Jürg Luder, Edith Merz, Beat Peter, Max Reutlinger, Tobias Richter, Heinz Senn, Thomas Ulrich, Beate Waldeck, Claudia Wartmann, Roland Wüest, Walter Wüest, Quint Rusman

“…We measured flowering time, frost damage, and fruiting success in 1250 individually marked plants during 3 years, and documented spring temperatures. Using regression models with historical climate data, we estimated past and future frost damage. …”
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Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders by David Mataix-Cols, Christian Rück, Lorena Fernández de la Cruz, Kayoko Isomura, Henrik Larsson, Paul Lichtenstein, Brian M D’Onofrio, Anna Sidorchuk, Zheng Chang, James J Crowley, Ralf Kuja-Halkola, Isabell Brikell, Josep Pol-Fuster, Anna Holmberg, Lina Martinsson

“…Cox proportional hazards regression models, incorporating time-varying exposures, estimated HRs.Results OCD was associated with an increased risk of CVD (HR 1.47; 95% CI 1.43 to 1.51), obesity (HR 1.69; 95% CI 1.63 to 1.74), type 2 diabetes (HR 2.01; 95% CI 1.90 to 2.12) and hyperlipidaemia (HR 1.42; 95% CI 1.33 to 1.52). …”
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Estimation and mapping of the contribution of nitric acid to atmospheric corrosion of zinc by J. Castillo-Miranda, F. Rodríguez-Gómez, J. Genescá-Llongueras, L. Ruiz-Suárez, J. García-Reynoso

“…FINDINGS: The results showed that spatial and temporal estimation of corrosion rates in grams per square meter of zinc was made for 2015-2019, using data modeling in a geographic information system. The maps of corrosion rates allowed us to visualize that, in general, the "southwest" zone has the most significant effects and that the lowest corrosion rates were presented in 2019 as an outcome of the implementation of air quality programs. …”
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Prognostication in emergency room patients: comparing ultrasensitive and contemporary quantification of cardiac troponin levels below the 99th percentile by Anna Carrasquer, Anna Carrasquer, Anna Carrasquer, Germán Cediel, Germán Cediel, Germán Cediel, Alma Gómez-Sanz, Alma Gómez-Sanz, Óscar M. Peiró, Óscar M. Peiró, Óscar M. Peiró, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Isabel Fort-Gallifa, Alfredo Bardaji, Alfredo Bardaji, Alfredo Bardaji, Jose Luis Ferreiro, Jose Luis Ferreiro, Jose Luis Ferreiro

“…However, there were no statistically significant difference between the two predictive models that included the aforementioned troponin assays.ConclusionsDetectable levels of cardiac troponin using a contemporary analytical method or those near the 99th percentile using an ultra-sensitive analytical method improve the predictive efficacy for cardiovascular events, with no differences between the two methods…”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…Porcine has spurred an increased interest in biomedical research models and xenotransplantation, owing to most of its organs share similarities in physiology, cellular composition and size to humans. …”
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Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases by Yiyuan Xiao, Sihua Xu, Wenyan Hu, Jiapeng Huang, Deke Jiang, Rong Na, Zhaoqing Yin, Jingjing Zhang, Haitao Chen

“…The odd ratio (OR) and the hazard ratio (HR) were calculated using the logistic regression modals and Cox regression models, respectively. Results: Among 39,230 eligible individuals, 6,865 MASLD subjects, 2,379 MetALD subjects and 884 ALD subjects were diagnosed. …”
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Impact of PM2.5, relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei by Nguyen Thanh Tung, Yueh-Lun Lee, Wen-Te Liu, Yuan-Chien Lin, Jer-Hwa Chang, Huynh Nguyen Xuan Thao, Hoang Ba Dung, Lam Viet Trung, Tran Phan Chung Thuy, Nguyen Thi Hien, Cheng-Yu Tsai, Chen-Chen Lo, Kang Lo, Kin Fai Ho, Kai-Jen Chuang, Hsiao-Chi Chuang

“…We estimated individual-level exposure to RH, temperature, and PM2.5 over 1-day, 7-day, and 30-day periods. Linear regression models assessed the relationship between these environmental factors and sleep parameters across different seasons. …”
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RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease by Manuel Lentzen, Srinivasan Vairavan, Marijn Muurling, Vasilis Alepopoulos, Alankar Atreya, Merce Boada, Casper de Boer, Pauline Conde, Jelena Curcic, Giovanni Frisoni, Samantha Galluzzi, Martha Therese Gjestsen, Mara Gkioka, Margarita Grammatikopoulou, Lucrezia Hausner, Chris Hinds, Ioulietta Lazarou, Alexandre de Mendonça, Spiros Nikolopoulos, Dorota Religa, Gaetano Scebba, Pieter Jelle Visser, Gayle Wittenberg, Vaibhav A. Narayan, Neva Coello, Anna-Katharine Brem, Dag Aarsland, Holger Fröhlich, on behalf of RADAR-AD

“…The machine-learning-based analysis demonstrated that RMT-based models could identify subjects in the prodromal stage with an Area Under the ROC Curve of 73.0 %. …”
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Residency training programs to support residents working in First Nations, Inuit, and Métis communities by Marghalara Rashid, Julie Nguyen, Wayne Clark, Jessica L. Foulds, Ida John, Ming-Ka Chan, Molly Whalen-Browne, Pamela Roach, Melanie Morris, Sarah Forgie

“…Results Our data analysis revealed five themes: Five themes were generated: Complexity of voluntourism as a concept; Diversity of knowledge representation required for developing curriculum; Effective models of care for First Nations, Inuit and/or Métis health; Essential traits that residents should have for working in First Nations, Inuit and/or Métis communities; and Building relationships and trust by engaging the community. …”
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Response of plant life forms and soil physical properties to near-natural restoration measures in alpine grassland, Tibetan plateau by Guoxing He, Guoxing He, Xiaoni Liu, Xiaoni Liu, Yali Li, Yali Li, Tong Ji, Tong Ji

“…We utilized redundancy analysis (RDA), variation partitioning(VP), hierarchical partitioning (HP), and partial least squares pathway modeling (PLS-PM) to dissect the quantitative relationships between the distribution of plant life forms and soil physical properties under these restoration measures.Results and discussionThe results indicated the following: 1) Under each restoration measure, the distribution of life form plants were predominantly characterized by the highest number of hemicryptophytes, followed by geophytes, with the least number of therophytes. …”
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Artificial Intelligence in Cardiac Surgery: Transforming Outcomes and Shaping the Future by Vasileios Leivaditis, Eleftherios Beltsios, Athanasios Papatriantafyllou, Konstantinos Grapatsas, Francesk Mulita, Nikolaos Kontodimopoulos, Nikolaos G. Baikoussis, Levan Tchabashvili, Konstantinos Tasios, Ioannis Maroulis, Manfred Dahm, Efstratios Koletsis

“…AI demonstrated superior predictive capabilities in risk stratification, with machine learning models outperforming traditional scoring systems in mortality and complication prediction. …”
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Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation by Hermine Counil, Rummenigge Oliveira Silva, Jean‐Michel Rabanel, Charlotte Zaouter, Mohamed Haddad, Mohamed Raâfet Ben Khedher, Davide Brambilla, Tamas Fülöp, Shunmoogum A. Patten, Charles Ramassamy

“…The objective of our study was to compare the passage of pEVs from adults, cognitively healthy elderly, and AD patients through the blood‐brain barrier (BBB), to evaluate their uptake in the brain and to assess their impact on the microglia activity using in vitro and in vivo models. To this end, pEVs were enriched, characterized, and fluorescently labelled. …”
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A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity by Victoria Shevchenko, R. Austin Benn, Robert Scholz, Wei Wei, Carla Pallavicini, Ulysse Klatzmann, Francesco Alberti, Theodore D. Satterthwaite, Demian Wassermann, Pierre-Louis Bazin, Daniel S. Margulies

“…Yet, the high dimensionality of predictive models trained on functional connectomes, combined with small sample sizes in clinical research, increases the risk of overfitting. …”
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Lipoxin A4 levels correlate with severity in a Spanish COVID-19 cohort: potential use of endogenous pro-resolving mediators as biomarkers by Sergio Sánchez-García, Rafael I. Jaén, Roberto Lozano-Rodríguez, José Avendaño-Ortiz, Alejandro Pascual‐Iglesias, Laura Hurtado-Navarro, Eduardo López-Collazo, Eduardo López-Collazo, Lisardo Boscá, Lisardo Boscá, Patricia Prieto, Patricia Prieto, Patricia Prieto

“…These lipids have pro-resolving actions in several pathological models, including reducing NF-κB-mediated inflammation, and inducing the antioxidant response through the Nrf-2 pathway. …”
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Threshold responses of freshwater fish community size spectra to invasive species by Bradley Novak, Brent A. Murry, Jeff S. Wesner, Vojsava Gjoni, Caroline C. Arantes, Erin Shepta, Justin P. F. Pomeranz, James R. Junker, Kathrine Zipfel, Andrew Stump, Levi E. Solomon, Kristopher A. Maxson, Jason A. DeBoer

“…Subsequent changepoint models indicated that a Silver Carp relative biomass of ~24% represents a threshold below which negative food web impacts should be minimized. …”
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Four decades of phenology in an alpine amphibian: trends, stasis, and climatic drivers by Lenzi, Omar, Grossenbacher, Kurt, Zumbach, Silvia, Lüscher, Beatrice, Althaus, Sarah, Schmocker, Daniela, Recher, Helmut, Thoma, Marco, Ozgul, Arpat, Schmidt, Benedikt R.

“…The goal of this study is to assess the main factors determining the timing of breeding in an alpine population of the common toad (Bufo bufo) and to describe the observed shifts in its breeding phenology. We modelled the effect of environmental variables on the start and peak dates of the breeding season using 39 years of individual-based data. …”
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TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner by Arun Chhetri, Channy Park, Hyunsoo Kim, Laxman Manandhar, Chagtsalmaa Chuluunbaatar, Jaetaek Hwang, Xiaofan Wei, Gyuho Jang, Batching Chinbold, Hyug Moo Kwon, Sang-wook Lee, Raekil Park

“…Methods: We used in vivo, ex vivo, and in vitro models of steatosis. TMEM135 knockout (TMEM135KO) and wild type (WT) mice were fed a high-fat diet (HFD) to induce hepatic steatosis. …”
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In-silico study of E169G and F242K double mutations in leucine-rich repeats (LRR) polygalacturonase inhibiting protein (PGIP) of Gossypium barbadense and associated defense mechani... by Sneha Murmu, Mayank Rashmi, Dipak T. Nagrale, Tejasman Kour, Mahender Kumar Singh, Anurag Chaurasia, Santosh Kumar Behera, Raja Shankar, Rajiv Ranjan, Girish Kumar Jha, Shailesh P. Gawande, Neelakanth S. Hiremani, Y. G. Prasad, Sunil Kumar

“…Results To unravel the molecular mechanisms underlying these PR proteins, we conducted a comprehensive study involving molecular modeling, protein-protein docking, site-specific double mutation (E169G and F242K), and molecular dynamics simulations. …”
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Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning by Sajid Naveed, Mujtaba Husnain, Ali Samad, Amna Ikram, Hina Afreen, Ghulam Gilanie, Najah Alsubaie

“…A panel of 47 genes associated with GBM was processed using two deep learning models: Artificial Neural Network (ANN) and Convolutional Neural Network (CNN). …”
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Outbreak of carbapenem resistant Klebsiella pneumoniae in a neurorehabilitation unit: Genomic epidemiology reveals complex transmission pattern in a tertiary care hospital by Maria Grazia Silvotti, Erika Scaltriti, Luca Bolzoni, Beatrice Zerbi, Gabriella Tocci, Andrea Zappavigna, Gianfranco Lamberti, Federico Donati, Franco Federici, Stefano Pongolini, Giuliana Lo Cascio

“…The most likely transmission networks of KPC-Kp were reconstructed with Bayesian discrete-time stochastic models. Results: Nineteen patients were colonized by KPC-Kp. …”
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