The association between cognitive impairment and oral health or oral hygiene behaviors among multiethnic older adults in Western China: a cross-sectional multicenter study by Yuqing Xie, Xin Xia, Xin Tian, Yuexia Hu, Yun Li, Xiao Tan, Wenwen Wu, Birong Dong, Yanyan Wang

“…Three multiple regression models were used to examine the associations between cognitive impairment and oral health or oral hygiene behaviors, with adjustments for relevant variables. …”
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Association Between Surgeon Sex and Days Alive at Home Following Surgery: A Population-Based Cohort Study by Kiyan Heybati, BHSc, Raj Satkunasivam, MD, MS, Khatereh Aminoltejari, MD, MSc, FRCSC, Hannah S. Thomas, MBChB, MS, Arghavan Salles, MD, PhD, Natalie Coburn, MD, MPH, Frances C. Wright, MD, Med, FRCSC, Lesley Gotlib Conn, PhD, Amy N. Luckenbaugh, MD, Sanjana Ranganathan, MD, Carlos Riveros, MD, Colin McCartney, MBChB, PhD, FRCA, FFARCSI, FRCPC, Kathleen Armstrong, MD, MSc, FRCSC, Barbara Bass, MD, Allan S. Detsky, MD, PhD, CM, Angela Jerath, MD, MSc, Christopher J. D. Wallis, MD, PhD

“…Multivariable regression modeling revealed that patients of male surgeons had a significantly lower number of DAH versus female surgeons. …”
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Carthamin yellow-loaded glycyrrhetinic acid liposomes alleviate interstitial fibrosis in diabetic nephropathy by Yifei Wang, Wenfang He, Peiyao Ren, Li Zhao, Danna Zheng, Juan Jin

“…Objectives To investigate the therapeutic efficacy of Carthamin yellow (CY)-loaded glycyrrhetinic acid (GA) liposomes in treating diabetic nephropathy (DN), particularly in alleviating renal interstitial fibrosis and improving kidney function.Methods CY-loaded GA liposomes were prepared and characterized for structural stability and controlled release. DN rat models were treated with CY-loaded GA liposomes, and kidney pathology, function, collagen deposition, and TGF-β1 expression were evaluated. …”
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Comparative Analysis of <i>In Vivo</i> and <i>In Vitro</i> Virulence Among Foodborne and Clinical <i>Listeria monocytogenes</i> Strains by Hui Yan, Biyao Xu, Binru Gao, Yunyan Xu, Xuejuan Xia, Yue Ma, Xiaojie Qin, Qingli Dong, Takashi Hirata, Zhuosi Li

“…Through the integration of <i>in vivo</i> and <i>in vitro</i> infection models with information on the expression of virulence factor genes, the differences in virulence between strains or subtypes can be better understood.…”
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Genome‐Wide Diversity in Lowland and Highland Maize Landraces From Southern South America: Population Genetics Insights to Assist Conservation by Pia Guadalupe Dominguez, Angela Veronica Gutierrez, Monica Irina Fass, Carla Valeria Filippi, Pablo Vera, Andrea Puebla, Raquel Alicia Defacio, Norma Beatriz Paniego, Veronica Viviana Lia

“…Finally, species distribution models were obtained for two future climate scenarios, showing a notable reduction in the potential planting area of HNWA and a shift in the cultivation areas of FNEA. …”
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Derivation and Characterization of Isogenic <i>OPA1</i> Mutant and Control Human Pluripotent Stem Cell Lines by Katherine A. Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A. Sadun, Xian-Jie Yang

“…These isogenic PSC lines will be valuable tools for establishing <i>OPA1</i>-DOA disease models in vitro and developing treatments for mitochondrial deficiency associated neurodegeneration.…”
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IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M by Fernando Botelho, Anisha Dubey, Ehab A. Ayaub, Rex Park, Ashley Yip, Allison Humbles, Roland Kolbeck, Carl D. Richards

“…The interleukin-1 family member IL-33 participates in both innate and adaptive T helper-2 immune cell responses in models of lung disease. The IL-6-type cytokine Oncostatin M (OSM) elevates lung inflammation, Th2-skewed cytokines, alternatively activated (M2) macrophages, and eosinophils in C57Bl/6 mice in vivo. …”
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Bacterial pathogens dynamic during multi-species infections by Barny, Marie-Anne, Thieffry, Sylvia, Gomes de Faria, Christelle, Thebault, Elisa, Pédron, Jacques

“…A species that was unable to induce disease in potato was efficiently maintained and eventually became dominant in some of the communities tested, indicating that cheating can shape dominant species. Modeling indicates that the cost of PCWDEs production and secretion, the rate of potato degradation and the diffusion rate of degraded substrate could favor the cheater species. …”
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Protocol for project recovery after cardiac surgery: a single-center cohort study leveraging digital platform to characterise longitudinal patient-reported postoperative recovery p... by Harlan M Krumholz, Erica Spatz, Sanket S Dhruva, Yawei Zhang, Makoto Mori, Cornell Brooks, Bobak J Mortazavi, George C Linderman, Lawrence A Grab, Arnar Geirsson, Sarwat I Chaudhry

“…We will apply group-based trajectory modelling to the time-series PROM and device data to classify patients into distinct categories of recovery trajectories. …”
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Fractures in sub-Saharan Africa: epidemiology, economic impact and ethnography (Fractures-E3): study protocol [version 1; peer review: 2 approved] by Christopher Grundy, Simon Matthew Graham, Hannah Wilson, Samuel Hawley, Kebba Marenah, Tadios Manyanga, James Masters, Bintou Trawally, Munyardardzi Ndekwere, Prudance Mushayavanhu, Mkhululi Lukhele, Rachael Gooberman-Hill, Farhanah Paruk, Kate A. Ward, Matthew Costa, Celia L. Gregson, Rashida A. Ferrand, Sarah Drew, Anya Burton, Landing M. Jarjou, Bilkish Cassim, Nyashadzaishe Mafirakureva, Sian Noble

“…Age- and sex-stratified household sampling will recruit 5030 adults aged 40 years and older; (ii) prospective cohort studies in adults aged 40 years and older will determine hip fracture incidence, associated risk factors, and outcomes over one year (e.g. mortality, disability, health-related quality of life); (iii) economic studies of direct health costs of hip fracture with projection modelling of future national health costs and cost-effectiveness analyses of different hip fracture care pathways; (iv) national surveys of hip fracture services (including traditional bonesetters in The Gambia); and (v) ethnographic studies of hip fracture care provision and experiences will understand fracture service pathways. …”
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Returning to the emergency department: a retrospective analysis of mental health re-presentations among young people in New South Wales, Australia by Rebecca Ivers, Michael Dinh, Patricia Cullen, Bette Liu, Katharine Steinbeck, Natasha Walker, Robert Neil Leong

“…Objectives This study aimed to describe mental health emergency department (ED) presentations among young people aged 8–26 years in New South Wales, Australia, and to identify key characteristics associated with higher risk of ED mental health re-presentation.Design, setting and participants Retrospective analysis of linked ED data records for mental health presentations between 1 January 2015 and 30 June 2018.Main outcome measures The main outcome was the total number of mental health ED re-presentations within 1 year, following initial presentation. Count regression models were fitted to estimate factors associated with higher likelihood of re-presentations.Results Forty thousand two hundred and ninety patients were included in the analyses, and 9713 (~25%) re-presented during the following year; 1831 (20%) presented at least three times. …”
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Unveiling inequalities: Racial, ethnic, and socioeconomic disparities in diabetes: Findings from the 2007-2020 NHANES data among U.S. adults by Yangyang Deng, Mohammad Moniruzzaman, Breanna Rogers, Lu Hu, Ram Jagannathan, Kosuke Tamura

“…Sociodemographic factors included racial and ethnic groups and SES. Weighted Poisson models were used to examine the association of racial and ethnic groups and SES with diabetes, stratified by age groups (20–44, 45–64, 65–79), sex, and racial and ethnic groups for SES, separately. …”
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Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…Accordingly, the main objective is to implement a novel integrated care preventive service for enhanced management of these patients, as well as to evaluate its potential for value generation.Methods and analysis At the end of 2024, the specifics of the novel service will be defined through the articulation of its four main components: (1) enhanced lung function testing through oscillometry, (2) continuous monitoring of indoor air quality as a potential triggering factor, (3) digital support with an adaptive case management (ACM) approach and (4) predictive modelling for early identification and management of exacerbations. …”
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Global Insights from Patients, Providers, and Staff on Challenges and Solutions in Managing Neovascular Age-Related Macular Degeneration by Anat Loewenstein, Michelle Sylvanowicz, Winfried M. Amoaku, Tariq Aslam, Chui Ming Gemmy Cheung, Bora Eldem, Robert P. Finger, Richard P. Gale, Laurent Kodjikian, Adrian Koh, Jean-François Korobelnik, Xiaofeng Lin, Paul Mitchell, Moira Murphy, Mali Okada, Ian Pearce, Francisco J. Rodriguez, Jude Stern, S. James Talks, David T. Wong, Tien Yin Wong, Focke Ziemssen, Jane Barratt

“…Methods A survey was carried out of patients with neovascular age-related macular degeneration, their providers, and clinic staff in 77 clinics across 24 countries on six continents, from a diverse range of healthcare systems, settings, and reimbursement models. Surveys comprised a series of single/multiple-response questions completed anonymously. …”
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Can muscle synergies shed light on the mechanisms underlying motor gains in response to robot-assisted gait training in children with cerebral palsy? by Gloria P. Vergara-Diaz, Stefano Sapienza, Jean-François Daneault, Eric Fabara, Catherine Adans-Dester, Giacomo Severini, Vincent C. K. Cheung, Carmen Echevarría Ruiz de Vargas, Donna Nimec, Paolo Bonato

“…Results Three and, less often, two muscle synergies were detected in study participants pre-RGT. Linear mixed effect models showed that composition of the muscle synergies and their temporal activation coefficients present deviations from normative data proportional to the severity of functional limitations (i.e., GMFCS levels, p < 0.01). …”
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Structured lactation support for mothers of very low birthweight preterm infants and establishment of human donor milk banks in German NICUs (Neo-MILK): protocol for a hybrid type... by Angela Kribs, Nicole Ernstmann, Nadine Scholten, Martin Hellmich, Antje Hammer, Eva Mildenberger, Andreas Müller, Dirk Horenkamp-Sonntag, Juliane Köberlein-Neu, Tim Ohnhäuser, Katja Matthias, Jens Ulrich Rüffer, Nicola Gabriela Dymek, Julia Jaschke, Anna Katharina Stirner, Isabella Schwab, Daniel Wiesen, Till Dresbach, Friederike Eyssel, Katharina Lugani, Anne Sunder-Plaßmann, Melanie Klein, Christoph Rupprecht

“…Statistical analysis will be performed using generalised linear mixed models.Ethics and dissemination Data collection, storage and analysis comply with current data protection regulations. …”
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Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Linear mixed-effects models examined the interaction of group and time. …”
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Multiple eco-regions contribute to the seasonal cycle of Antarctic aerosol size distributions by J. Brean, D. C. S. Beddows, E. Asmi, A. Virkkula, A. Virkkula, L. L. J. Quéléver, M. Sipilä, F. Van Den Heuvel, T. Lachlan-Cope, A. Jones, M. Frey, A. Lupi, J. Park, Y. J. Yoon, R. Weller, G. L. Marincovich, G. L. Marincovich, G. C. Mulena, G. C. Mulena, R. M. Harrison, R. M. Harrison, M. Dall'Osto

“…<p>In order to reduce the uncertainty of aerosol radiative forcing in global climate models, we need to better understand natural aerosol sources which are important to constrain the current and pre-industrial climate. …”
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Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties by Sarah Sarwar, Nadia Sarwar, Haleema Ali, Rafiullah, Rasool Khan, Ajaz Ahmad, Amin Ullah, Ho Soonmin, Nazif Ullah

“…Additionally, the derivatives were evaluated for their anti-inflammatory, antinociceptive, antipyretic, and antisedative properties using standardized models, including carrageenan-induced paw edema, acetic acid-induced abdominal writhes, yeast-induced fever, and white wood apparatus, respectively. …”
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Retrospective evaluation of risk factors for worsening renal function after angiotensin‐converting enzyme inhibitor treatment in dogs by Yelim Lee, Minju Baek, Dongseop Lee, Jinyeong Park, Yeon Chae, Byeong‐Teck Kang, Taesik Yun, Hakhyun Kim

“…Demographic and serum chemistry data, such as total protein, albumin, blood urea nitrogen, creatinine, symmetric dimethylarginine, glucose, triglyceride, total cholesterol concentrations, and serum electrolyte concentrations at first presentation, were evaluated. Multivariable modeling was performed to identify risk factors for WRF after treatment with ACEi. …”
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