Study on the Regulation Effect of Optogenetic Technology on LFP of the Basal Ganglia Nucleus in Rotenone-Treated Rats by Zongya Zhao, Yanxiang Niu, Peiqi Chen, Yu Zhu, Liangliang Shi, Xuewei Zhao, Chang Wang, Yehong Zhang, Zhixian Gao, Wenshuai Jiang, Wu Ren, Renjun Gu, Yi Yu

“…After observing the behavior and brain morphology, 16 models were finally determined to be successful. LFP results showed that approximate entropy and fractal dimension of rats in the control group were significantly greater than those in the experimental group after light treatment (p<0.05). …”
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A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability by Xiujuan Yang, Zhongzhi Gan, Xiaoling Guo, Xiang Huang, Juan Liu, Yingchun Zheng, Xiaoqiang Zhou, Jingli Lian, Yue Liu, Tingting Yang, Chao Li, Fenying Chen, Fei He, Xiangmin Xu, Yasi Zhou, Qian Liu, Xingkun Yang, Fu Xiong

“…Additionally, protein stability was evaluated using I-Mutant, and 3D protein structures were modeled with I-TASSER. Western blots and QPCR were employed to assess gene expression and protein stability. …”
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The interplay between sex, lifestyle factors and built environment on 20-year cardiovascular disease incidence; the ATTICA study (2002–2022) by Evangelia G. Sigala, Christina Chrysohoou, Fotios Barkas, Evangelos Liberopoulos, Petros P. Sfikakis, Antigoni Faka, Costas Tsioufis, Christos Pitsavos, Demosthenes Panagiotakos

“…Multivariate analyses, including generalized structural equation modeling (GSEM), revealed that the impact of the urban built environment on the long-term (20-year) CVD risk is mediated by lifestyle-related risk factors.ConclusionUrban inhabitants exhibit a higher long-term CVD incidence compared to their rural counterparts, which was partially explained by their lifestyle behaviors. …”
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Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction by Xinxin Ma, Xiaolu Hou, Peixin Dong, Jiayan Ye, Yangyang Gao, Ling Huang, Xiuping Bai

“…[Objective] To investigate the effect of partially oxidized sodium alginate gel combined with intramyocardial injection of myogenic stem cells on cardiac function in aged rats with myocardial infarction. [Methods] The models of myocardial infarction in aged rats were established by ligating the coronary arteries and divided randomly into the group of saline control group, sodium alginate group, myogenic stem cells group and sodium alginate combined with myogenic stem cells group(joint group), each had 30 rats.The same amount of corresponding material was injected into the myocardial infarction area of rats in each group respectively.The cardiac structure and function of the rats were evaluated by echocardiography 8 weeks after the operation, and then the rats were executed.The hearts were removed to observe the differences in ventricular remodeling by histological analysis and the angiogenesis and collagen secretion of the ventricular slices were further analyzed. …”
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A Simple Nomogram to Predict Contrast-Induced Acute Kidney Injury in Patients with Congestive Heart Failure Undergoing Coronary Angiography by Li Lei, Yibo He, Zhaodong Guo, Bowen Liu, Jin Liu, Zhiqiang Nie, Guanzhong Chen, Liwei Liu, Mengfei Lin, Wenhe Yan, Shiqun Chen, Chen Jiyan, Yong Liu

“…Patients with congestive heart failure (CHF) are vulnerable to contrast-induced kidney injury (CI-AKI), but few prediction models are currently available. Therefore, we aimed to establish a simple nomogram for CI-AKI risk assessment for patients with CHF undergoing coronary angiography. …”
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Adsorption properties and competitive adsorption mechanism exhibited by carbon-nanotube-modified biochar for removal of crude oil and Ni(II) pollutants from water by Di Cao, Ruiyan Niu, Guanglu Mo, Huiwen Deng, Rui Liu, Jie Liu, Jialin Fan

“…The experimental data conformed closely to the Elovich, Langmuir, and Freundlich adsorption models, underscoring the significant contributions of both physical and chemical adsorption mechanisms. …”
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H-AMR FORGE’d in FIRE. I. Magnetic State Transitions, Jet Launching, and Radiative Emission in Super-Eddington, Highly Magnetized Quasar Disks Formed from Cosmological Initial Cond... by Nicholas Kaaz, Matthew Liska, Alexander Tchekhovskoy, Philip F. Hopkins, Jonatan Jacquemin-Ide

“…Quasars are powered by supermassive black hole (SMBH) accretion disks, yet standard thin disk models are inconsistent with many observations. Recently, P. …”
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Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

“…The novel LAMP (lysosomal-associated membrane protein)-based DNA vaccine ASP2390 targets major HDM allergens, potentially shifting immune responses toward nonallergic pathways and minimizing the risk of atopy, with positive safety and efficacy signals in preclinical models. Objective: We evaluated the safety, tolerability, and efficacy of first-in-human intradermal ASP2390 in adults with HDM allergy. …”
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Demographic and motivational factors affecting the whole-body donation programme in Nanjing, China: a cross-sectional survey by Li Yuan, Jiayi Jiang, Mingyi Zhang, Haojie Meng, Xiang Cui, Yuxin Yang, Chuan Su, Jinfan Wang, Luqing Zhang

“…Interviews of the 68 living donors revealed the following major motivations for the decision to donate: to support medical education; to reduce their children’s funeral burden; no longer holding traditional Chinese views on life and death; influence by role models and annoyance at complex funeral ceremonies.Conclusions Older people, people with an education level of college or above, labourers, teachers, government officials and farmers are the major groups that donate their bodies. …”
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Influence of hypertension diagnosis and subjective life expectancy on health behaviors among middle-aged and older Chinese adults by Xiaoxiao Liu, Xiaoyi Ji, Honghong Xia, Yuxin Tian, Weihong Zheng, Linyun Fu, Peiyuan Qiu, Yang Wan

“…Linear mixed-effects models were employed to investigate the influence of receiving a hypertension diagnosis, as well as SLE, on hypertension related behaviors.ResultsAmong the respondents, 27.65% reported doctor-diagnosed hypertension, while 19.91% of those who were undiagnosed with hypertension had measured hypertension at baseline. …”
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Inheritance of resistance to maize lethal necrosis in tropical maize inbred lines by Hilda M. Kavai, Hilda M. Kavai, Dan Makumbi, Felister M. Nzuve, Vincent W. Woyengo, L. M. Suresh, William M. Muiru, Manje Gowda, Boddupalli M. Prasanna

“…Disease ratings at four time points, grain yield (GY), and other agronomic traits were analyzed using Griffing’s Method 3 and Hayman’s diallel models. Significant (P &lt; 0.001) GCA and SCA mean squares were observed for all traits under disease conditions and most traits under rainfed conditions, highlighting the importance of both additive and non-additive genetic effects. …”
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A lesson for post-COVID healthcare: assessment of physical and psychosocial risk factors on perceived pain intensity among urban individuals by Hung Chak Ho, Hung Chak Ho, Wentao Bai, Stanley Sau-Ching Wong, Chi Wai Cheung, Chi Wai Cheung

“…Based on the variables associated with a severe increase in pain score (NRS), multivariate regression models were applied to identify risk factors on perceived pain intensity.ResultsAmong 3,237 urban individuals in Hong Kong, 20.95 and 30.58% were with severe pain (NRS &gt; = 4) before and after pandemic. …”
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Intestinal tissue levels of anti-TNF alpha, antibodies, and cytokines in paediatric Crohn disease by Vojtech Dotlacil, Stepan Coufal, Tereza Lerchova, Kristyna Zarubova, Barbora Kucerova, Helena Tlaskalova-Hogenova, Miloslav Kverka, Richard Skaba, Jiri Bronsky, Ondrej Hradsky, Michal Rygl

“…Mixed-effects regression models, adjusted for potential confounders, were used. …”
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Multiomics profiling reveals the benefits of gamma-delta (γδ) T lymphocytes for improving the tumor microenvironment, immunotherapy efficacy and prognosis in cervical cancer by Xiaofeng Wang, Chen Li, Jie Chen, Zhiqiang Wu, Zhen Zhang, Junyi Li, Lu Yu, Yong Guan, Yuhan Zhang, Yuanjie Cao, Yancheng Liu, Hui Bai, Shaochuan Liu, Miaomiao Gao, Chenglu Lu, Zhen Tao, Zhiyong Yuan

“…We found that these intricate features can be observed by MRI-based radiomics models to non-invasively assess γδ T-cell proportions in tumor tissues in patients. …”
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Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients by Chong Zhang, Wenjin Peng, Meng Ning, Weiru Liang, Bin Su, Tingting Guo, Kun Hu, Wei Su, Yi Chen, Yingwu Liu

“…In Cox proportional hazards models, a low HALP score (HALP score < 3.2) was also associated with a higher risk of 28-day mortality (adjusted hazard ratio: 1.52, 95% CI: 1.33 to 1.74). …”
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Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes by Baohong Wen, Keke Fang, Qiuying Tao, Ya Tian, Lianjie Niu, Wenqing Shi, Zijun Liu, Jin Sun, Liang Liu, Xiaopan Zhang, Ruiping Zheng, Hui-Rong Guo, Yarui Wei, Yong Zhang, Jingliang Cheng, Shaoqiang Han

“…We recruited 100 untreated, first-episode OCD patients and 106 healthy controls for structural imaging scans. Utilizing normative models of gray matter volume, we identified subtypes based on individual morphological abnormalities. …”
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Combination of ataxia telangiectasia and Rad3-related inhibition with ablative radiotherapy remodels the tumor microenvironment and enhances immunotherapy response in lung cancer by Jenny Ling-Yu Chen, Chun-Kai Pan, Li-Cheng Lin, Yu-Sen Huang, Tsung-Hsuan Huang, Shu-Jyuan Yang, Sung-Hsin Kuo, Yu-Li Lin

“…Treatment response and survival were evaluated in vivo using A549 xenograft flank tumor and synchronous LLC lung and flank tumor mouse models. Mice received ablative radiotherapy (12 Gy/d for 2 d), ATR inhibitor, and ICI. …”
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Childhood socioeconomic background and elevated mortality among the young adult second generation in Sweden: a population-based cohort study by Lisa Harber-Aschan, Matthew Wallace, Ben Wilson, Eleonora Mussino, Siddartha Aradhya

“…Here, we instead analyse the association of second-generation status with childhood SEB.Methods We use administrative register data from Sweden to fit multistate, competing-risk, flexible parametric survival models on a data set of 13 404 deaths in 2.35 million young adults. …”
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Metabolic profile of blood serum in experimental arterial hypertension by A. A. Seryapina, A. A. Malyavko, Yu. K. Polityko, L. V. Yanshole, Yu. P. Tsentalovich, A. L. Markel

“…Hence, there is a need to perform research on experimental models – inbred animal strains, one of them being ISIAH rat strain, which is designed to simulate inherited stress-induced arterial hypertension as close as possible to primary (or essential) hypertension in humans. …”
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HET-CAM test in evaluation of irritating action of adhesives used in shoe making industry by U.B. Lototska-Dudyk, B.P. Kuzminov, N.Ye. Chemodurova, V.A. Turkina

“…The global tendency of the contemporary scientific studies is using alternative biologic models as substitutes of experimental animals. HET-CAM (The Hen's Egg Test on the Chorioallantoie Membrane Assay) is an alternative to in vivo tests involving experimental animals. …”
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