Health effects of mixed metal exposure on accelerating aging among the elderly population by Chuanli Yang, Jijun Zhang, Haohan Liu, Qin Hong, Yunhe Fan, Jie An, Haijia Zhang, Xiaobing Shen, Xiushan Dong

“…Weighted multivariable logistic regression models were applied to analyze the relationship between metal exposure with AgeAccelGrim. …”
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Genome-Wide Identification and In Silico Expression Analysis of <i>CCO</i> Gene Family in <i>Citrus clementina</i> (Citrus) in Response to Abiotic Stress by Sadaf Sarwar, Adnan Sami, Muhammad Zeshan Haider, Layba Tasawar, Jannat Akram, Arsalan Ahmad, Muhammad Shafiq, Haitham E. M. Zaki, Gabrijel Ondrasek, Muhammad Shafiq Shahid

“…Clementine</i> and <i>Arabidopsis thaliana</i> models was conducted to understand their functional characteristics. …”
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Responsiveness and clinical utility of PROMIS instruments in pediatric Crohn's disease: insights from a longitudinal study by Sara Azevedo, Sara Azevedo, Maria Miguel Oliveira, Maria Miguel Oliveira, Paulo Nogueira, Paulo Nogueira, Paulo Nogueira, Ana Isabel Lopes, Ana Isabel Lopes

“…Linear mixed-effects models (LMMs) and bivariate analyses were used to assess changes over time.ResultsPROMIS Global Health scores showed significant improvement over time, indicating enhanced overall health perceptions among patients. …”
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The Impact of Heating Methods on Respiratory and Allergic Diseases in Preschool Children: A Repeated Cross-Sectional Survey Across Northern and Southern China by Chenyang Wang, Shaohua Li, Yan Zhang, Haixia Zhou, Peiwen Zhang, Wei Yu

“…Using Pearson’s chi-squared tests, we analyzed the associations between four indoor heating methods—convective heating (CH), convective and radiant heating (CH&RH), radiant heating (RH), and polluting heating (PH)—and nine respiratory and allergic diseases. Logistic regression models were employed to explore the relationships between heating methods and disease prevalence. …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…This study investigates the role and potential mechanisms of metallothionein 1B (MT1B) in MASH through bioinformatics analysis and experimental validation. quantitative reverse transcription PCR and Western blot analyses confirm that MT1B expression is significantly downregulated in liver tissues of MASH patients, in high-fat diet–induced mouse models, and in hepatocytes induced by FFAs. Further functional experiments show that upregulation of MT1B reduces intracellular triglycerides and total cholesterol levels, lipid droplet formation, and proinflammatory factors. …”
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Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy by Qianqian Yan, Zihao Zhao, Dongwei Liu, Jia Li, Shaokang Pan, Jiayu Duan, Zhangsuo Liu

“…Next, multiple machine learning models were applied to confirm the optimal cross-talk genes. …”
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Associations of substance use and positive coping behaviors with sleep quality during the COVID-19 pandemic by Jessica Laudie, Bethany L. Stangl, Tommy Gunawan, Tommy Gunawan, Melanie L. Schwandt, Cecilia Cheng, Amanda K. Gilmore, Amanda K. Gilmore, David Goldman, David Goldman, Vijay A. Ramchandani, Nancy Diazgranados, Jeremy W. Luk

“…Participants (N = 373, 50.9% male, mean age = 43.7, 37.3% with AUD history) reported their sleep quality using the Pittsburgh Sleep Quality Index (PSQI) for the month prior to the pandemic and the past month before the time of assessment. Multilevel modeling and linear regression analyses were conducted.ResultsIndividuals with AUD history reported worse overall sleep quality than those without AUD history both before and during the pandemic. …”
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Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial by Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia, Edward F. Patz

“…Abstract GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes anti-cancer immunity in preclinical models. We conducted a first-in-human phase 1b study dose escalation trial of GT103 in refractory non-small cell lung cancer to assess the safety of GT103 (NCT04314089). …”
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Racial disparities in acute care utilization among individuals with myasthenia gravis by Cynthia Qi, Pushpa Narayanaswami, Ashley E. L. Anderson, Deborah Gelinas, Yuebing Li, Jeffrey T. Guptill, Dakshinamoorthy Amirthaganesan, Charlotte Ward, Rupesh Panchal, Amit Goyal, Glenn Phillips

“…Multivariable regression models were used to assess the association between acute care utilization and race/ethnicity, insurance, exacerbation at index, and other covariates.ResultsA total of 7,058 patients met the study inclusion criteria, of whom 57% (n = 4,052) identified as Caucasian, 6% (n = 445) African American, 3% (n = 235) Hispanic, 1% (n = 94) Asian, and 32% (n = 2,232) with missing race/ethnicity information. …”
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Results from the PROmoting Early Childhood Outside cluster randomized trial evaluating an outdoor play intervention in early childhood education centres by Rachel Ramsden, Dawn Mount, Yingyi Lin, Emily Fox, Susan Herrington, Janet Loebach, Adina Cox, Anita Bundy, Amber Fyfe-Johnson, Ellen Beate Hansen Sandseter, Michelle Stone, Mark S. Tremblay, Mariana Brussoni

“…The intervention effect on children’s outdoor play participation was examined using logistic regression mixed effect models. Controlling for gender, weather and temperature, there were no changes in children’s outdoor play participation following implementation of the PRO-ECO intervention in the between-group analysis. …”
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Methodological advances in seismic noise imaging of the Alpine area by Paul, Anne, Pedersen, Helle A., Bodin, Thomas, Kästle, Emanuel, Soergel, Dorian, Alder, Chloé, Lu, Yang, Nouibat, Ahmed

“…The three-dimensional S-wave velocity models have been further improved by wave-equation based inversions accounting for the physics of seismic wave propagation, including elastic–acoustic coupling at the sea bottom. …”
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Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol by Amali Mallawaarachchi, Hugh McCarthy, Thomas A. Forbes, Kushani Jayasinghe, Chirag Patel, Stephen I. Alexander, Tiffany Boughtwood, Jeffrey Braithwaite, Aron Chakera, Sam Crafter, Ira W. Deveson, Randall Faull, Trudie Harris, Lilian Johnstone, Matthew Jose, Anna Leaver, Melissa H. Little, Daniel MacArthur, Tessa Mattiske, Christine Mincham, Kathy Nicholls, Catherine Quinlan, Michael C. J. Quinn, Gopala Rangan, Jessica Ryan, Cas Simons, Ian Smyth, Madhivanan Sundaram, Peter Trnka, Laura Wedd, Erik Biros, Zornitza Stark, Andrew Mallett

“…These include re-analysing existing data and/or undergoing advanced genomic testing methods, including short and long-read whole-genome sequencing, RNA sequencing, and functional genomics strategies using mouse modelling or kidney organoids. Discussion The KidGen National Kidney Genomics Study is a coordinated, multidisciplinary extension of previous research projects that aims to assess the diagnostic yield of advanced genomic approaches. …”
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Quality of life among healthcare workers in the hospitals and primary healthcare centers in Gaza Strip: a cross-sectional study by Joma Younis, Lina Wang, Amal Abed, Hong Jiang, Yahui Fan, Zhaofang Li, Mei Ma, Le Ma, Zhaozhao Hui, Linlin Hua, Wei Zhang

“…Factors associated with QoL were examined using an independent t-test, Chi-square test, and multivariate logistic regression models. Results The study included HCWs with a mean age of 38.62 years old, of whom 61.9% were male. …”
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Suppression of MCP-1, IFN-γ and IL-6 production of HNSCC ex vivo by pembrolizumab added to docetaxel and cisplatin (TP) exceeding those of TP alone is linked to improved survival by Jana Wellhausen, Louisa Röhl, Michael Berszin, Irene Krücken, Irene Krücken, Veit Zebralla, Veit Zebralla, Markus Pirlich, Markus Pirlich, Matthaeus Stoehr, Matthaeus Stoehr, Susanne Wiegand, Susanne Wiegand, Susanne Wiegand, Andreas Dietz, Andreas Dietz, Theresa Wald, Theresa Wald, Gunnar Wichmann, Gunnar Wichmann

“…Multivariate Cox proportional hazard regression modeling revealed MCP-1, IFN-γ and IL-6 as independent outcome predictors.ConclusionsComparing response to TP vs. pembrolizumab vs. …”
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Major adverse cardiovascular events among Black and White Veterans receiving androgen deprivation therapy for prostate cancer: a retrospective cohort study by Alexander R. Lucas, Dustin Bastiach, Bassam Dahman, Asit K. Paul, Samina Hirani, Vanessa B. Sheppard, W. Gregory Hundley, Bhaumik B. Patel, Rhonda L. Bitting, Michael G. Chang

“…The majority had stage 2 disease (83.0%) classified as intermediate risk (43.1%). Treatment-matched models showed men receiving ADT + RT were less likely to develop MACE when they no pre-existing CMD. …”
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Epidemiological Study of Uveal Melanoma from US Surveillance, Epidemiology, and End Results Program (2010–2015) by Yufeng Xu, Lixia Lou, Yijie Wang, Qi Miao, Kai Jin, Menglu Chen, Juan Ye

“…Age, AJCC stage, and radiation therapy were found to be consistent predictors in both univariate and multivariate analysis models. Conclusion. Incidence of uveal melanoma increased by significant APC and varied between genders. …”
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Neonatal BCG vaccination and child survival in TB-exposed and TB-unexposed children: a prospective cohort study by Peter Aaby, Per Kallestrup, Christine Stabell Benn, Sanne M Thysen, Ane Fisker, Victor Francisco Gomes, Frauke Rudolf, Christian Wejse, Adam Roth

“…Children residing in the same house as a TB case were classified as TB-exposed from 3 months prior to case registration to the end of follow-up.Methods Using Cox-proportional hazards models with age as underlying time scale, we compared mortality of children with and without neonatal BCG between October 2003 and September 2017.Main outcome measure HR for neonatal BCG compared with no neonatal BCG by TB-exposure status.Results Among the 39 421 children who entered the analyses, 3022 (8%) had observation time as TB-exposed. …”
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Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study by Jing Qian, Jiahao Zhu, Yifan Wang, Ruoqi Dai, Jingyou Miao, Ye Yang, Wenxia Zhao, Jing Wang, Lilu Ding, Dan Zhou, Min Yu, Yingjun Li

“…Methods: We conducted a prospective cohort study in the UK Biobank, estimating exposure levels of particulate matter (PM2.5, PM10, PM2.5–10), nitrogen oxides (NO2, NOx), and air pollutants exposure score (APES). Cox models assessed associations between air pollution exposure and OA incidence, joint replacement, and survival. …”
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Thermal ablation included in multimodality treatment predicts enhanced survival in advanced non-small cell lung cancer: a propensity score-matched outcome study by Stella Chin-Shaw Tsai, Yi-Min Chen, Yueh-Han Ku, Chia-Hsuan Hsu, Tzu-Hsuan Hsiao, Pin-Hsu Liao, Tzu-Chin Wu, Frank Cheau-Feng Lin

“…Statistical analyses, including propensity score matching and Cox regression models, were used to account for potential confounders.Results The TA group demonstrated a significantly longer median overall survival (OS) of 37 months compared to 15 months in the non-TA group (p < 0.001), with five-year OS rates of 32.4% and 9.8%, respectively. …”
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Increased indexed proximal aortic diameter is a predictor of poor prognosis in maintenance hemodialysis patients by Junwei Xu, Wenyi Tang, Lizheng Song, Yuxi Huang, Li Xiao, Fangyuan Cheng, Qianglin Guan, Mei Xu, Chuoxin Ma, Jian Chen, Jianting Ke

“…Cox proportional hazards models were conducted to evaluate the association between baseline ARD/BSA and clinical outcomes.Results A total of 391 patients were included in this study. …”
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