Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein by Oscar Herrera-Calderon, Abdulrahman M. Saleh, Andres F. Yepes-Perez, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Renan Dilton Hañari-Quispe, Haydee Chavez, Josefa Bertha Pari-Olarte, Eddie Loyola-Gonzales, José Santiago Almeida-Galindo, José Francisco Kong-Chirinos, Taoufiq Benali

“…The aim in this computational study was to determine the main phytochemical constituents from U. tomentosa stem bark against the SARS-CoV-2 Omicron spike protein based on molecular modeling. A molecular docking was carried out on the isolated phytochemicals in a previous work against the SARS-CoV-2 Omicron spike protein-binding domain (PDB ID: 7T9K). …”
Get full text

Addressing the rising colorectal cancer burden in the older adult: examining modifiable risk and protective factors for comprehensive prevention strategies by Ke‐Jie He, Zhejun Liu, Guoyu Gong

“…Epidemiological techniques, including age-period-cohort modeling and joinpoint regression analysis, were employed to provide insights into the potential drivers of the evolving disease burden while controlling for relevant confounding factors.ResultsThe analysis revealed significant geographical disparities in the burden of colorectal cancer among the older adult population. …”
Get full text

Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer by Alan Zambeli-Ljepović, MD, MHS, Daniel Hoffman, MD, Katherine E. Barnes, BS, Fernanda Romero-Hernandez, MD, Amir Ashraf Ganjouei, MD, MPH, Mohamed A. Adam, MD, Ankit Sarin, MD, MHA

“…We used Cox proportional hazards models to assess overall survival and restricted cubic splines to estimate the optimal LNY threshold to dichotomize patients based on overall survival. …”
Get full text

Effectiveness of Single-Tablet Combination Therapy in Improving Adherence and Persistence and the Relation to Clinical and Economic Outcomes by Carly J. Paoli, Jörg Linder, Khushboo Gurjar, Deepika Thakur, Julie Wyckmans, Stacy Grieve

“…All 6 cost-effectiveness or cost-utility analyses found FDCs were less expensive and more efficacious than LDCs. Four budget impact models found that STCTs were associated with cost savings. …”
Get full text

Presenting two new methods for solving linear interval optimal control problems using the resilience approach of control signal by Elnaz Hosseini, Mehdi Allahdadi, Samaneh Soradi-Zeid

“…By considering the variation limits for the control signal, the optimal solution of the main problem is obtained.Methodology: In this research, two methods are presented to solve the deterministic sub-models of linear interval optimal control problems and find a good approximation for the optimal solution of them. …”
Get full text

Supply chain performance in the age of Industry 4.0 by Tahsina Khan, Md Mehedi Hasan Emon

“…Structural equation modeling (SEM) using SmartPLS was applied to analyze the data and test the hypothesized relationships. …”
Get full text

The Tasmanian Estuary Perch Population—A Threatened Species? by Jonah L. Yick, Bryan Van Wyk, James Haddy

“…This study also confirms this population has a delayed spawning season in comparison to mainland populations, with growth models and tag recaptures (32 fish) demonstrating a very slow but sexually dimorphic growth rate. …”
Get full text

Parenting after a history of childhood maltreatment: A scoping review and map of evidence in the perinatal period. by Catherine Chamberlain, Graham Gee, Stephen Harfield, Sandra Campbell, Sue Brennan, Yvonne Clark, Fiona Mensah, Kerry Arabena, Helen Herrman, Stephanie Brown, ‘Healing the Past by Nurturing the Future’ group

“…Theoretical constructs include: attachment, social learning, relational-developmental systems, family-systems and anger theories; 'hidden trauma', resilience, post-traumatic growth; and 'Child Sexual Assault Healing' and socioecological models. Observational studies illustrate sociodemographic and mental health protective and risk factors that mediate/moderate intergenerational pathways to parental and child wellbeing. …”
Get full text

Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study by Tilal Elsaman, Magdi Awadalla Mohamed, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla

“…Following this, computational filters, including ADME-T profiling and pharmacophore modeling, were applied to further refine the selection. …”
Get full text

Metabarcoding the night sky: Monitoring landscape-scale insect diversity through bat diet by Cynthia Tobisch, Svenja Dege, Bernd Panassiti, Julian Treffler, Christoph Moning

“…We explored spatial and temporal variation in the diet of P. pipistrellus and quantified effects of landscape composition and configuration on insect species richness and composition using generalized linear models and non-metric multidimensional scaling. A total of 405 different insect and other arthropod species were identified in the fecal samples, with high proportions of Diptera (45 %), Lepidoptera (18 %), Coleoptera (13 %) and Hymenoptera (11 %), but also many other taxonomic groups. …”
Get full text

Unhealthy alcohol use and risk of coronary heart disease among young and middle-aged adults by Jamal S. Rana, Felicia W. Chi, Isaac Acquah, Stacy A. Sterling

“…Cox proportional hazards models adjusted for age, sex, race/ethnicity, body mass index, physical activity, smoking, hypertension, diabetes, and hyperlipidemia. …”
Get full text

PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population by Gerard Criner, Fernando Martinez, Hitesh Gandhi, Norbert Feigler, Bruce Pyenson, Matthew Emery, Umang Gupta, Muthiah Vaduganathan

“…The US COPD population was modeled with 1000 simulations of patient progression over 10 years. …”
Get full text

Burden and Determinants of Anemia in a Rural Population in South India: A Cross-Sectional Study by Matthew Little, Chloe Zivot, Sally Humphries, Warren Dodd, Kirit Patel, Cate Dewey

“…We assessed associations between anemia outcomes and sociodemographic and dietary factors using linear and logistic regression modeling. Results. A total of 753 individuals (412 women and 341 men) participated in this study. …”
Get full text

Impacts of Biochar Application on Inorganic Phosphorus Fractions in Agricultural Soils by Liwen Lin, Yutao Peng, Lin Zhou, Baige Zhang, Qing Chen, Hao Chen

“…Due to the complex processes by which biochar affects soils, more systematic evaluations and predictive methods (e.g., modeling, machine learning) are needed to support sustainable agriculture and environmental practices.…”
Get full text

Multimorbidity in Atherosclerotic Cardiovascular Disease and Its Associations With Adverse Cardiovascular Events and Healthcare Costs: A Real-World Evidence Study by Dingwei Dai, Joaquim Fernandes, Xiaowu Sun, Laura Lupton, Vaughn W. Payne, Alexandra Berk

“…Multivariable generalized linear models were performed to examine the associations between multimorbidity and ACEs and healthcare costs. …”
Get full text

Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats by Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan

“…Male Sprague–Dawley rats were used in the experiment, and the hypertensive models were created by administering deoxycorticosterone acetate (DOCA) in conjunction with a high salt intake in uninephrectomized rats. …”
Get full text

Graft survival and mortality outcomes after kidney transplant in patients with lupus nephritis: a systematic review and meta-analysis by Weizhong Jiang, Yunfen Xu, Qichun Yin

“…Pooled effect estimates were calculated using random-effects models and reported as hazard ratio (HR) with 95% confidence intervals (CI). …”
Get full text

Effect of homemade peanut oil consumption during pregnancy on low birth weight and preterm birth outcomes: a cohort study in Southwestern China by Yanxu Zhong, Huan Lu, Yuyan Jiang, Minyan Rong, Xiangming Zhang, Tippawan Liabsuetrakul

“…The effect of homemade peanut oil exposure was analyzed using multiple logistic regression models using the directed acyclic graph (DAG) approach. …”
Get full text

Evaluation of Total Phenolic Content, HPLC Analysis, and Antioxidant Potential of Three Local Varieties of Mushroom: A Comparative Study by Anika Tabassum Bristy, Tairin Islam, Rezwana Ahmed, Jumana Hossain, Hasan Mahmud Reza, Preeti Jain

“…G. lucidum extract exhibited the highest antioxidant potential as evidenced by its lowest IC50 value in all the tested assay models (40.44±2.09 μg/mL, 151.32±0.35 μg/mL, 137.89±1.85 μg/mL in DPPH, H2O2, and NO scavenging assay, respectively) along with the highest phenolic content (81.34±0.68 GAE g-1 extract). …”
Get full text

Bankers' job stress, job performance, and job commitment trajectories during the COVID-19 pandemic by Sanjoy Kumar Roy, Md. Rahat Khan, Nazrul Islam Shanto

“…The exploratory factor analysis, confirmatory factor analysis, and structural equation modeling were run to test the proposed research framework with the help of MS Excel 2007, SPSS 22.0, and AMOS 23.0. …”
Get full text