Fosab, but not fosaa, plays important role in learning and memory in fish—insights from zebrafish gene knockout study by Qiuling Wang, Qiuling Wang, Qiuling Wang, Lixin Zhang, Lixin Zhang, Lixin Zhang, Chenyuan Zhu, Chenyuan Zhu, Chenyuan Zhu, Ke Lu, Ke Lu, Ke Lu, Jiaqi Wu, Jiaqi Wu, Jiaqi Wu, Xu-Fang Liang, Xu-Fang Liang, Xu-Fang Liang

“…We used CRISPR/Cas9 technology to generate fosaa and fosab knockout zebrafish models.Results: In this study, we discovered the brain weight marked reduction in fosaa−/− and fosab−/− zebrafish compared with the wild-type (WT) (AB strain) zebrafish. …”
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Land subsidence and rebound response to groundwater recovery in the Beijing Plain: A new hydrological perspective by Dexin Meng, Beibei Chen, Huili Gong, Shubo Zhang, Rui Ma, Chaofan Zhou, Kunchao Lei, Lewei Xu, Xincheng Wang

“…The aquifer schematic models suggest that the differential deformation response is related to lithology and residual deformation. …”
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Neutrophil to Lymphocyte Ratio as a Predictor of Adverse Outcome in Patients with Decompensated Liver Cirrhosis by Valeriy D. Lunkov, Marina V. Maevskaya, Ekaterina K. Tsvetaeva, Ana G. Mendez, Maria S. Zharkova, Petr E. Tkachenko, Vladimir T. Ivashkin

“…Current clinical and laboratory prognostic models, such as Child-Pugh and MELD scales, do not take into account immune dysregulation, as well as it potential impact on the LC decompensation and the survival. …”
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Combined spatial Keratin expression profiles at the invasive front represent a prognostic classifier for head and neck cancer by Peter D. Haughton, Wisse E. Haakma, Sven van Kempen, Emma J. de Ruiter, Stefan M. Willems, Patrick W.B. Derksen

“…Here, we have assessed a panel of Keratin markers in four HPV negative HNSCC patient-derived organoid (PDO) models and their corresponding primary patient tissue to define spatial expression profiles of basal and supra-basal Keratins during invasion in Collagen-I matrices. …”
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Organizational factors impacting the implementation of a digital mental health tool in Alberta's mental health care of youth and young adults by Marianne Barker, Julia Hews-Girard, Karina Pinston, Sarah Daniel, Lauren Volcko, Lia Norman, Emilie Bassi, Katherine Bright, Ian Hickie, Frank Iorfino, Haley LaMonica, Karen Moskovic, Melanie Fersovitch, Jessica Bradley, Leanne Stamp, Jason Gondziola, David Johnson, Gina Dimitropoulos

“…These tools may function as alternatives or adjuncts to face-to-face models of care. Innovative solutions in the form of digital mental health (dMH) services not only provide support, resources and care, but also decrease wait times and waitlists, increase access, and empower youth. …”
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In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [18F]FAHA and [18F]FDG PET/CT Imaging by Skye Hsin-Hsien Yeh, Ming Hsien Lin, I. I. Leo Garcia Flores, Uday Mukhopadhyay, Danial Young, Kazuma Ogawa, Jeong-Hwan Jeong, William Tong, Juri G. Gelovani, Nobuyoshi Fukumitsu

“…We evaluated the synergistic anticancer effects of cisplatin and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in xenograft models of nonsmall cell lung cancer (NSCLC) using [18F] FAHA and [18F] FDG PET/CT imaging. …”
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Resistance to P. brasiliensis Experimental Infection of Inbred Mice Is Associated with an Efficient Neutrophil Mobilization and Activation by Mediators of Inflammation by Felipe Fornias Sperandio, Gisele Pesquero Fernandes, Ana Carolina Silvério Cerqueira Mendes, Giulia Maria de Alencar Castro Bani, Vera Lucia Garcia Calich, Eva Burger

“…In that way, this study aimed to present and compare different experimental models of PCM (intraperitoneal and subcutaneous) regarding PMN production and maturation inside femoral bone marrow and also PMN infiltration in peritoneal and subcutaneous exudates of resistant and susceptible mice. …”
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Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study by Raquel Behar-Lagares, Ana Virseda-Berdices, Ana Virseda-Berdices, Óscar Martínez-González, Óscar Martínez-González, Óscar Martínez-González, Rafael Blancas, Rafael Blancas, Rafael Blancas, Marcela Homez-Guzmán, Eva Manteiga, Juan Churruca-Sarasqueta, Madian Manso-Álvarez, Madian Manso-Álvarez, Madian Manso-Álvarez, Ángela Algaba, Ángela Algaba, Ángela Algaba, Salvador Resino, Salvador Resino, Amanda Fernández-Rodríguez, Amanda Fernández-Rodríguez, María A. Jiménez-Sousa, María A. Jiménez-Sousa

“…The association between coagulation protein levels and hospitalization variables was carried out by generalized linear models adjusted by the most relevant covariates.ResultsAt ICU admission, lower factor XII, antithrombin, and protein C levels were linked to the need for invasive mechanical ventilation (IMV) or its duration (p=0.028; p=0.047 and p=0.015, respectively). …”
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Air pollution, temperature and mumps: A time-series study of independent and interaction effects by Haoyue Cao, Rongrong Xu, Xiqian Lu, Wenguo Jiang, Lihua Wang, Miao Yu, Wenjun Wang, Juxiang Yuan

“…This time-series study was conducted in Jining city using data on daily mumps cases, meteorological factors and air pollutants obtained from 2015 to 2021. Distributed lag models combined with quasi-Poisson regressions were applied to examine these associations. …”
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Estimating population attributable risk fraction of determinants of pediatric obesity by Maryam Yazdi, Ibrahim Abdollahpour, Mostafa Qorbani, Saba Karimi, Mohammad Esmail Motlagh, Majid Khademian, Roya Kelishadi

“…In addition to physical examination, a self-administered questionnaire was completed to obtain the study variables including dietary behavior, physical activity, screen time, sleep duration, socioe-conomic status (SES), and passive smoking. Logistic regression models were applied to assess the relationship between modifiable risk factors and obesity. …”
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Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function by Isabel Fonseca, José Carlos Oliveira, Manuela Almeida, Madalena Cruz, Anabela Malho, La Salete Martins, Leonídio Dias, Sofia Pedroso, Josefina Santos, Luísa Lobato, António Castro Henriques, Denisa Mendonça

“…Linear mixed and multivariable regression models, receiver-operating characteristic (ROC), and areas under ROC curves were used. …”
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ALMA FACTS. II. Large Scale Variations in the 12CO(J = 2 – 1) to 12CO(J = 1 – 0) Line Ratio in Nearby Galaxies by Shinya Komugi, Tsuyoshi Sawada, Jin Koda, Fumi Egusa, Fumiya Maeda, Akihiko Hirota, Amanda M. Lee

“…We use position–velocity diagrams along the major axis and tilted ring models to separate the normal rotating galactic disk from kinematic outliers that deviate from pure circular rotation. …”
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Insulator–metal transition in VO2 film on sapphire studied by broadband dielectric spectroscopy by Arsenii A. Gavdush, Vladislav A. Zhelnov, Kirill B. Dolganov, Alexander A. Bogutskii, Sergey V. Garnov, Maria G. Burdanova, Dmitry S. Ponomarev, Qiwu Shi, Kirill I. Zaytsev, Gennadii A. Komandin

“…The dielectric response is modeled using Lorentz and Drude kernels, which make possible splitting contributions from vibrational modes and free charge carriers to the total dynamic conductivity. …”
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Cardiovascular mortality risk among small bowel adenocarcinoma patients: a population-based study by Yao Zhang, Shicong Zeng, Zongwen Wang, Qiankun Zhu, Jingtao Li, Xiaohang Ren, Shuoheng Ma, Gang Tan, Bo Zhai

“…Two multivariate competing risk models were established to determine the independent predictors for CVM. …”
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Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard by Roma Fraser, Keira Campbell, Pawel Pokorski, Eve MacKinnon, Katie McAllister, Karla B. Neves, Fiona Murphy

“…However, concerns regarding human and environmental exposure remain significant. Traditional in vivo models for safety assessments are increasingly viewed as unfeasible and unethical due to the diverse forms and biological effects of NMs. …”
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RailPC: A large‐scale railway point cloud semantic segmentation dataset by Tengping Jiang, Shiwei Li, Qinyu Zhang, Guangshuai Wang, Zequn Zhang, Fankun Zeng, Peng An, Xin Jin, Shan Liu, Yongjun Wang

“…Abstract Semantic segmentation in the context of 3D point clouds for the railway environment holds a significant economic value, but its development is severely hindered by the lack of suitable and specific datasets. Additionally, the models trained on existing urban road point cloud datasets demonstrate poor generalisation on railway data due to a large domain gap caused by non‐overlapping special/rare categories, for example, rail track, track bed etc. …”
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Optimization of bioactive compounds and sensory quality in thermosonicated black carrot juice: A study using response surface methodology, gradient boosting, and fuzzy logic by Seydi Yıkmış, Melikenur Türkol, Ishak Pacal, Aylin Duman Altan, Nazlı Tokatlı, Gholamreza Abdi, Nazan Tokatlı Demirok, Rana Muhammad Aadil

“…This study investigates the optimization of bioactive components in thermosonicated black carrot juice using response surface methodology (RSM) and gradient boosting (GB) modeling techniques. Thermosonication, a combination of ultrasound and heat, was applied to enhance the nutritional quality of black carrot juice, which is rich in anthocyanins, phenolic compounds, and antioxidants. …”
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Association of active commuting with incidence of depression and anxiety: prospective cohort study by Jingwen Fan, Xuesong Zhang, Xiaocan Jia, Zhixing Fan, Chaojun Yang, Yuping Wang, Chenyu Zhao, Nana Wang, Xuezhong Shi, Yongli Yang

“…Cox proportional hazard regression models were used to explore the hazard ratios (HRs) of active commuting with depression and anxiety, and mediation analyses were used to test the mediating role of inflammatory in this association. …”
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Assisted Parkinsonism Diagnosis Using Multimodal MRI—The Role of Clinical Insights by Tobias Meindl, Alexander Hapfelmeier, Tobias Mantel, Angela Jochim, Jonas Deppe, Silke Zwirner, Jan S. Kirschke, Yong Li, Bernhard Haslinger

“…Results Clinical diagnosis was accurately confirmed using machine learning models with only small differences when using imaging and clinical signs versus imaging variables only (expected multiclass AUC of 0.95 vs. 0.92). …”
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Development of Modified-Release Diclofenac Sodium Capsules Using Blends of Pectin-Clay Multiparticulate Hybrid Systems as Release Retardants by Ofosua Adi-Dako, Frederick William Akuffo Owusu, Isaac Yaw Attah, Doris Kumadoh, Prince George Acquah Jnr, Issaka Nelson, Nii Odartey Hutton-Mills, Karen Yaa Yeboaa Obese, Joseph Adusei Sarkodie, Benoit Banga N’guessan, Awo Afi Kwapong, Christina Osei-Asare, Emmanuel Adase, Mary-Ann Archer

“…The diclofenac content, uniformity of the weight of capsules, in vitro drug release, and the kinetics and mechanism of release of diclofenac from the hybrid systems were also investigated using mathematical models. The pectin yield was 23.3%, with the water-holding capacities of pectin-talc (PT) and pectin-bentonite (PB) hybrid systems being 6.4% and 5.0%, respectively. …”
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