PGC-1α activation to enhance macrophage immune function in mycobacterial infections. by Joel R Frandsen, Zhihong Yuan, Brahmchetna Bedi, Zohra Prasla, Seoung-Ryoung Choi, Prabagaran Narayanasamy, Ruxana T Sadikot

“…Mitochondrial transcription factor A (TFAM) is a protein essential for mitochondrial DNA (mtDNA) genome stability, integrity, and metabolism. …”
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Morphological and Molecular studies of Acanthobra marmid Heckel, 1843 (Piscies, Cypriniformes, Leuciscidae) from the Middle of Iraq by Hind Dyia Hadi, Abed Hassan Baraaj, Atheer Hussein Ali

“…Twenty specimens of Acanthobrama marmid were collected from two localities at Tigris River, in the middle of Iraq; 15 specimens from the Al-Zubaydia sub-district and five specimens from Al-Tharthar Lake. We used the mitochondrial DNA cytochrome b (cytb) gene to sequence the DNA of A. marmid. …”
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Mitochondrial Cytochrome c Oxidase Subunit 1 Sequence Variation in Prostate Cancer by Takara A. Scott, Rebecca S. Arnold, John A. Petros

“…Purpose. Mitochondrial DNA (mtDNA) mutations have been described in every adult neoplasm including prostate cancer. …”
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DNA analysis indicates that Asian elephants are native to Borneo and are therefore a high priority for conservation. by Prithiviraj Fernando, T N C Vidya, John Payne, Michael Stuewe, Geoffrey Davison, Raymond J Alfred, P Andau, Edwin Bosi, Annelisa Kilbourn, Don J Melnick

“…We compared DNA of Borneo elephants to that of elephants from across the range of the Asian elephant, using a fragment of mitochondrial DNA, including part of the hypervariable d-loop, and five autosomal microsatellite loci. …”
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Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq by Kaniaw Rafat Khafar, Dr. Esmail S Kakey

“…Blood sera was obtained for oxidative status including catalase (CAT), superoxide dismutase (SOD), Total antioxidant capacity (T-AOC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)) and molecular markers (including telomere length (T/S) and mitochondrial DNA copy number (mtDNA)). The findings highlighted that oxidative and molecular markers have significant changes with ageing and high changes significantly associated with diabetes mellitus of aged group. …”
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Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq by Kaniaw Rafat Khafar, Dr. Esmail S Kakey

“…Blood sera was obtained for oxidative status including catalase (CAT), superoxide dismutase (SOD), Total antioxidant capacity (T-AOC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)) and molecular markers (including telomere length (T/S) and mitochondrial DNA copy number (mtDNA)). The findings highlighted that oxidative and molecular markers have significant changes with ageing and high changes significantly associated with diabetes mellitus of aged group. …”
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Therapies for Mitochondrial Disorders by Kayli Sousa Smyth, Anne Mulvihill

“…Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. …”
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Phylogeographic analyses reveal recent dispersal and multiple Wolbachia infections of the bright-eyed ringlet Erebia oeme within the European mountain systems by Valentine Mewis, Martin Wendt, Thomas Schmitt

“…However, recent Wolbachia impact on the mitochondrial DNA and consequently influence on the intraspecific genetic structure was not detected.…”
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Indoxyl Sulfate-Induced Oxidative Stress, Mitochondrial Dysfunction, and Impaired Biogenesis Are Partly Protected by Vitamin C and N-Acetylcysteine by Wen-Chin Lee, Lung-Chih Li, Jin-Bor Chen, Hsueh-Wei Chang

“…High doses of IS also corresponded to increased mitochondrial depolarization and decreased mitochondrial DNA copy number and mitochondrial mass. However, these effects could be reversed by the addition of antioxidants, namely, vitamin C and N-acetylcysteine. …”
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Mitochondrial Dysfunction and Sirtuins: Important Targets in Hearing Loss by Lingjun Zhang, Zhengde Du, Shusheng Gong

“…Reactive oxygen species (ROS) are mainly derived from mitochondria, and oxidative stress induced by ROS contributes to cochlear damage as well as mitochondrial DNA mutations, which may enhance the sensitivity and severity of hearing loss and disrupt ion homeostasis (e.g., Ca2+ homeostasis). …”
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New records and unusual morphology of the cave hydrozoan Velkovrhia enigmatica Matjašič & Sket, 1971 (Cnidaria: Hydrozoa: Bougainvilliidae) by Maja Zagmajster, Teo Delić, Simona Prevorčnik, Valerija Zakšek

“…Individuals from the two caves were morphologically different: polyps from the type locality had 4–9 tentacles, while the ones from Logarček had 14–36 tentacles. The mitochondrial DNA sequences in populations from both caves did not differ. …”
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Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq by Kaniaw Rafat Khafar, Dr. Esmail S Kakey

“…Blood sera was obtained for oxidative status including catalase (CAT), superoxide dismutase (SOD), Total antioxidant capacity (T-AOC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)) and molecular markers (including telomere length (T/S) and mitochondrial DNA copy number (mtDNA)). The findings highlighted that oxidative and molecular markers have significant changes with ageing and high changes significantly associated with diabetes mellitus of aged group. …”
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Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq by Kaniaw Rafat Khafar, Dr. Esmail S Kakey

“…Blood sera was obtained for oxidative status including catalase (CAT), superoxide dismutase (SOD), Total antioxidant capacity (T-AOC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)) and molecular markers (including telomere length (T/S) and mitochondrial DNA copy number (mtDNA)). The findings highlighted that oxidative and molecular markers have significant changes with ageing and high changes significantly associated with diabetes mellitus of aged group. …”
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Effects of subclinical hypothyroidism during pregnancy on mtDNA methylation in the brain of rat offspring by Liangzhuo Xie, Yangling Huang, Xiande Ma, Xiaoqiu Ma, Jian Wang, Tianshu Gao, Wei Chen

“…Abstract Objective This study aims to investigate the impact of subclinical hypothyroidism (SCH) during pregnancy on mitochondrial DNA (mtDNA) methylation in the brain tissues of rat offspring. …”
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Navigating the complex role of senescence in liver disease by Qiuting Li, Lin Wang, Yuanyuan Ji

“…The objective of this review is to offer a contemporary overview of the pathophysiological events involving hepatic senescent cells and to elucidate their role in the onset and progression of liver diseases, particularly through mechanisms like telomere shortening, genomic and mitochondrial DNA damage, and inflammation. Additionally, this review discusses the emerging senolytic therapies aimed at targeting senescent cells to delay or mitigate liver disease progression. …”
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Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson’s Disease Penetrance by Alessandra Zanon, Peter P. Pramstaller, Andrew A. Hicks, Irene Pichler

“…We discuss genetic and environmental factors as well as mitochondrial DNA alterations and protein-protein interactions, all involved in mitochondrial function, as potential causes to modify penetrance of mutations in dominant PD genes and to determine manifestation of heterozygous mutations in recessive PD genes.…”
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Skeletal Muscle Mitochondria and Aging: A Review by Courtney M. Peterson, Darcy L. Johannsen, Eric Ravussin

“…Animal and human studies typically show that skeletal muscle mitochondria are altered with aging, including increased mutations in mitochondrial DNA, decreased activity of some mitochondrial enzymes, altered respiration with reduced maximal capacity at least in sedentary individuals, and reduced total mitochondrial content with increased morphological changes. …”
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Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene by Ke Li, Lijun Wu, Jianjiang Liu, Wei Lin, Qiang Qi, Tianlan Zhao

“…By molecular analysis of the complete mitochondrial genome in this family, we identified the homoplasmic m.15897G>A mutation underwent sequence analysis of whole mitochondrial DNA genome, which localized at conventional position ten of tRNAThr, and distinct sets of mtDNA polymorphisms belonging to haplogroup D4b1. …”
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Mitochondrial disease and epilepsy in children by Xuan Zhang, Xuan Zhang, Xuan Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Zhiming Tao, Zhiming Tao, Zhiming Tao, Jianmin Liang, Jianmin Liang, Jianmin Liang

“…Mitochondrial disease refers to a group of clinically heterogeneous disorders caused by dysfunction in the mitochondrial respiratory chain, often due to mutations in mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) that encodes mitochondrial proteins. …”
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Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols by Tingting DENG, Jinchan PI, Xiaoping PENG, Yufei YAO, Yiquan LI, Wenjuan LI

“…From the perspective of ROS-mitochondrial pathway, the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins, reducing the opening of mitochondrial membrane permeability transition pore, maintaining cellular calcium homeostasis, mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways. …”
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