Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study by Xiang Si, Hao Yuan, Rui Shi, Wenliang Song, Jiayan Guo, Jinlong Jiang, Tao Yang, Xiaoxun Ma, Huiming Wang, Minying Chen, Jianfeng Wu, Xiangdong Guan, Xavier Monnet

“…., while the Landiolol group exhibited notably higher minimal ScvO2 levels (72% [63%, 78%] vs 68% [55%, 73%], respectively, p = 0.006) and a lower maximal PCO2 gap compared to the Esmolol group (7.0 [6.0, 9.0] vs. 8.0 [6.0, 10.0] mmHg, respectively, p = 0.040). …”
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Radiotherapy-induced Hypothalamic-Pituitary axis dysfunction in adult Brain, head and neck and skull base tumor patients – A systematic review and Meta-Analysis by J.M.J. Paulissen, C.M.L. Zegers, R.M. Houben, D. Hofstede, M. Kars, H.M. van Santen, F.J.P. Hoebers, D.K.M. De Ruysscher, D.B.P. Eekers

“…More research is needed to establish dose thresholds for the hypothalamus and the pituitary to minimize the risk for pituitary insufficiency. Based on this knowledge, radiotherapy and follow-up of these patient groups should be standardized to establish a normal tissue complication probability (NTCP) model for the HPA.…”
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Artificial intelligence contouring in radiotherapy for organs-at-risk and lymph node areas by Céline Meyer, Sandrine Huger, Marie Bruand, Thomas Leroy, Jérémy Palisson, Paul Rétif, Thomas Sarrade, Anais Barateau, Sophie Renard, Maria Jolnerovski, Nicolas Demogeot, Johann Marcel, Nicolas Martz, Anaïs Stefani, Selima Sellami, Juliette Jacques, Emma Agnoux, William Gehin, Ida Trampetti, Agathe Margulies, Constance Golfier, Yassir Khattabi, Olivier Cravéreau, Alizée Renan, Jean-François Py, Jean-Christophe Faivre

“…We have chosen to define the threshold of an average score equal to or greater than 2 to characterize a high-performing AI software, meaning an AI with minimal to moderate corrections but usable in clinical routine. …”
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Modeling Seed Longevity and Percentile Prediction: A Sigmoidal Function Approach in Soybean, Maize, and Tomato by Felipe Souza Carvalho, Brunna Rithielly Rezende, Amanda Rithieli Pereira dos Santos, Maria Márcia Pereira Sartori

“…These findings emphasize the importance of using viability percentiles to optimize storage practices, minimize economic losses, and prevent genetic erosion in conservation programs. …”
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Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms by Shivan Sivakumar, Ashwin Jainarayanan, Edward Arbe-Barnes, Piyush Kumar Sharma, Maire Ni Leathlobhair, Sakina Amin, David J. Reiss, Lara Heij, Samarth Hegde, Assaf Magen, Felicia Tucci, Bo Sun, Shihong Wu, Nithishwer Mouroug Anand, Hubert Slawinski, Santiago Revale, Isar Nassiri, Jonathon Webber, Gerard D. Hoeltzel, Adam E. Frampton, Georg Wiltberger, Ulf Neumann, Philip Charlton, Laura Spiers, Tim Elliott, Maria Wang, Suzana Couto, Thomas Lila, Pallavur V. Sivakumar, Alexander V. Ratushny, Mark R. Middleton, Dimitra Peppa, Benjamin Fairfax, Miriam Merad, Michael L. Dustin, Enas Abu-Shah, Rachael Bashford-Rogers

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Dynamics of Somatic and Comorbid Mental Disorders (Distress, Anxiety, Somatisation and Depression) in Patients with Irritable Bowel Syndrome during Therapy with Alimemazine: Result... by V. T. Ivashkin, O. Z. Okhlobystina, M. V. Mayevskaya, O. S. Shifrin, Z. A. Mamieva, Yu. E. Azimova

“…The proportion of patients with the minimal or mild severity of complaints increased by 36.7 % and 8.2 % (from 3.3 % to 40.0 % and from 11.8 % to 20.0 %), respectively. …”
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Research on formant estimation algorithm for high order optimal LPC root value screening by Hua LONG, Shumeng SU

“…Conclusions:The method of formant detection based on LPC is improved.The effect of improving the order of linear prediction on formant extraction was studied.Aiming at the problem of multiple pseudo-roots and multi-pole interaction caused by increasing the order of linear prediction, the error of formant extraction constrained by the speech-digital resonance model is minimized. The relationship between the order of linear prediction and the screening threshold of root amplitude was analyzed. …”
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Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

“…When comparing older versus newer equations of eGFR in African American and non-African American participants in association with incident stroke and dementia, differences were minimal. Limitations: Incident dementia was ascertained through International Classification of Diseases (Ninth and Tenth Revisions) codes. …”
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Zolpidem: Efficacy and Side Effects for Insomnia by Amber N. Edinoff, Natalie Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye

“…The most effective therapies utilize cognitive behavioral therapy in conjunction with pharmacotherapy to minimize the needed dose and any resulting side effects. …”
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Precision Target Spraying System Integrated with Remote Deep Learning Recognition Model for Cabbage Plant Centers by ZHANG Hui, HU Jun, SHI Hang, LIU Changxi, WU Miao

“…Specifically, when tested at a speed of 7.2 km/h, the difference between the actual spray volume delivered and the required spray volume, after accounting for compensation, was found to be a mere 0.01 L/min. This minimal difference indicates that the system met the standard operational requirements for effective pesticide application, thereby demonstrating its precision and reliability in practical settings.…”
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Fatty Acids of Erythrocyte Membranes and Blood Serum as Possible Predictors of Exacerbation in Patients with Inflammatory Bowel Diseases by M. V. Kruchinina, M. F. Osipenko, A. I. Valuyskikh, E. Yu. Valuiskikh, I. O. Svetlova

“…In the acute stage, patients with IBD have a higher total content of saturated fatty acids (SFAs) in erythrocyte membranes compared to the control group (p = 0.006), and, on the contrary, lower levels of unsaturated fatty acids (UFAs) (p = 0.005), mainly due to polyunsaturated FAs (PUFAs) (p = 0.026), namely omega-6 PUFAs (p = 0.011).Remission of IBD is associated with an increase in the level of a number of SFAs in the blood serum — margaric C17:0 (p = 0.024), arachidic acid (C20:0) — in erythrocyte membranes and serum (p = 0.0001 and p = 0.019, respectively), with a decrease in the total content of monounsaturated FAs in erythrocyte membranes (p = 0.022), an increase in the total concentration of PUFAs due to both omega-3 PUFAs (p = 0.0008) and omega-6 PUFAs (p = 0.033) in erythrocyte membranes compared with a group of healthy individuals.The exacerbation stage in patients with IBD examined over time is associated with higher levels of stearic FA C18:0 (p = 0.005), SFA/UFA (p = 0.034) and SFA/PUFA (p = 0.039) ratios in erythrocyte membranes, serum level of arachidic FA C20:0 (p = 0.008), and, on the contrary, lower content of UFAs in erythrocyte membranes — eicosapentaenoic C20:5n-3 (p = 0.0023), eicosadienoic C20:2n-6 (p = 0.0027), hexadecadienoic C16:2n-6 (p = 0.006), docosatetraenoic C22:4n-6 (p = 0.008) and alpha-linolenic C18:3n-3 (p = 0.039).A combined “panel” of fatty acids, including the levels of C20:2n-6, C18:0 in erythrocyte membranes and the content of C20:0 in blood serum, provided an AUC of 0.683 (95 % CI: 0.500–0.844), sensitivity 91.4 %, specificity 68.3 %.Levels of C20:5n-3, C20:2n-6, C18:0, C16:2n-6, C22:4n-6, C18:3n-3 fatty acids, SFA/UFA and SFA/PUFA ratios in erythrocyte membranes and content C20:0 in blood serum, used as biomarkers — predictors of the development of exacerbation in patients with IBD who were in remission, predicted the development of exacerbation of IBD after 2–4 months in the case of maximally changed levels of FAs, after 6–8 months — with moderately changed levels FAs, maintaining remission for 12 months — with minimally changed FAs levels.Conclusion. Fatty acids of erythrocyte membranes and blood serum should be considered as promising markers for further studies related to the diagnosis and prediction of exacerbation in IBD.…”
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Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

“…To streamline the learning process, we used cloud-based applications that minimize the need for software installations while maximizing student engagement. …”
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Ultrafast dynamic contrast-enhanced breast MRI with quantitative perfusion parameters in differentiating breast cancer: a study focusing on triple-negative and HER2 positive breast... by Guo Haodong, Zhu Jianguo, Dmytro Pylypenko, Dou Weiqiang, Su Sheng, Xu Jie, Li Haige

“…DISCO is a more recent DCE MRI technique that has achieved high spatial and temporal resolution and minimized image artifacts in cases like malignant focal liver lesions, enhanced focal breast lesions, and intracranial aneurysms.ObjectiveTo employ the method mentioned above to differentiate between triple-negative and non-triple-negative as well as HER2 positive and HER2 negative cancer lesions, and to assess the value of quantitative and semi-quantitative parameters in molecularly typing breast cancer.MethodsAll participants were scanned with a 3.0-T MR scanner (GE SIGNA™ Premier) using a 16-channel phased-array body coil. …”
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Recurrent adenoid cystic carcinoma of the left upper palate accompanied by massive maxillary hemorrhage: a case report and literature review by ZHANG Wangru, CHEN Yuanyuan, LI Zhiping, MENG Jian

“…In complex cases involving positive margins, recurrence, and metastasis, the MDT model employed interdisciplinary collaboration to devise a comprehensive treatment plan that may have included re-operation, radiotherapy, and chemotherapy, with the aim of minimizing the risk of ACC recurrence and controlling distant metastasis. …”
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Human hair biochar to remove malachite green dye and bisphenol-A contamination by M. Kamaraj, P. Kamali, R. Kaviya, K. Abishek, B. Navinkumar, T.G. Nithya, L.S. Wong, J. Aravind

“…This work explores the feasibility of human hair biochar as a potential adsorbent for possible solid waste management processes to minimize environmental pollution. Malachite green and bisphenol-A were selected as model pollutants, and the response surface methodology was used to identify the maximal removal of these hazardous substances.METHODS: Samples of human hair waste are collected and processed. …”
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Tax Exemptions and R;D Expenditures in Iran Saeed Dorokhshi Moghaddam by Saeed Dorokhshi Moghaddam, Bahram Sahabi, Hassan Heydari, Sajad Barkhordari

“…Financial incentives should be utilized in a manner that minimizes costs and maximizes economic growth and productivity. …”
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Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD by Mengya Zhang, Kun Li, Xiaoxing Huang, Dongqin Xu, Ruobin Zong, Qintong Hu, Xiaoyu Dong, Qinyong Zhang, Chaochen Jiang, Yue Ge, Changyong Li, Jie Ping

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Forest fire hazard assessment based on forest typology by Volodymyr P. Voron, Andriy D. Kuzyk, Sergiy V. Ivashyniuta, Yilia R. Tsipan

“…When assessing the potential fire hazards, a contradiction arises because the fire risk is minimal in wet hygrotopes, but on the other hand, the total supply of terrestrial combustible materials is greater in forest types with excessive soil moisture, where organic matter decomposes. …”
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Research on expansion joint for high-speed railway long-span bridges in China by Hui Guo, Jinzhou Jiang, Suoting Hu, Chun Yang, Qiqi Xiang, Kou Luo, Xinxin Zhao, Bing Li, Ziquan Yan, Liubin Niu, Jianye Zhao

“…Detailed BEJ structural design must stress minimization of the frictional resistance of its sliding surface. …”
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Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i> by Anna N. Tsapieva, Alexander N. Chernov, Nadezhda V. Duplik, Anastasiya O. Morozova, Tatiana A. Filatenkova, Mariia A. Suvorova, Elena Egidarova, Elvira S. Galimova, Kseniya Bogatireva, Alexander N. Suvorov

“…This study aimed to investigate the oncolytic efficacy of <i>S. pyogenes</i> GUR and its M protein knockout mutant, <i>S. pyogenes</i> strain GURSA1, which was genetically constructed to minimize overall toxicity, against mouse hepatoma 22A, pancreatic cancer PANC02, and human glioma U251 cells, both <i>in vitro</i> and <i>in vivo</i>, using the C57BL/6 mouse model. …”
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