HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer by Xin Li, Peng Yang, Jin Gu, Nan Chen, Dengbo Ji, Jinhong Xia, Jinying Jia, Zhuang Sun, Mengyuan Shi, Hanyang Wang, Zhaoya Gao

“…Background B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies. Recent clinical attempts, such as BRAF inhibitors (BRAFi) monotherapy and combining BRAFi with other inhibitors, have yielded unsatisfactory efficacy. …”
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Effects of Temperature and Light Intensity on the Growth and Physiological and Biochemical Characteristics of Young Sporophyte of a Novel Saccharina japonica "Huangguan No.2" by Guiyang SONG, Zhourui LIANG, Xiaoping LU, Yanmin YUAN, Wenjun WANG

“…The activities of key antioxidant enzymes and the antioxidant contents in the high light and high temperature groups were significantly higher, indicating that the antioxidant systems of young sporophytes responded positively to high light and high temperature stresses to minimize the damage caused by reactive oxygen species. …”
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Modeling feed efficiency over productive lifetime and integrating a submodel for body reserve management in Nordic dairy cattle by R.B. Stephansen, J. Lassen, V.M. Thorup, B.G. Poulsen, J. Jensen, G. Sahana, O.F. Christensen

“…Our analysis indicated that improving gRFI with one genetic SD unit corresponded to a 2% to 3% gain in net return profit per cow-year, with no or minimal impact on production and body reserve management. …”
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Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid by Juanjuan Zhou, Minghui Zhen, Kaijie Gao, Lu Xu, Dongyu Zhang, Junmei Yang

“…Antimicrobial susceptibility testing indicated that all strains were resistant to meropenem [minimal inhibitory concentration (MICs) ≥ 8 µg/mL] and imipenem (MICs > 8 µg/mL). …”
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Human health risk assessment of drinking water using heavy metal pollution index: a GIS-based investigation in mega city by Maria Latif, Iqra Nasim, Mubeen Ahmad, Rab Nawaz, Arifa Tahir, Muhammad Atif Irshad, Aamal A. Al-Mutairi, Ali Irfan, Sami A. Al-Hussain, Magdi E. A. Zaki

“…It is suggested that for drinking water supplies, there is need of installation of treatment plants in the industrial areas to minimize the risk of metal contamination and health issues.…”
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Latarjet procedure versus iliac crest autograft transfer for anterior shoulder instability: a systematic review and meta-analysis of comparative studies by Lang Li, Bofang Zeng, Meng Ding, Sha Wan, Kefu Lin, Zhen Tian

“…However, these differences did not surpass the minimal clinically important difference (MCID). Radiological evaluations showed that the ICBGT procedure had statistically better outcomes in immediate glenoid augmentation, preservation and reduced fatty degeneration of the subscapularis (SSC) tendon, and graft remodeling at short-term follow-up. …”
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Enhanced Safety and Efficacy of O‐Arm Navigation Over C‐Arm Guidance in Percutaneous Kyphoplasty for Patients With Osteoporotic Vertebral Compression Fractures and Spinal Deformity... by Zhong‐Wei Ji, Min‐Jie Shen, Jia‐Jia Sun, Jia‐Le Wang, Yong‐Kang Deng, Yao Zhang, Xie‐Xing Wu, Kang‐Wu Chen, Hai‐Qing Mao

“…Conclusion O‐arm navigation‐assisted PKP demonstrates better clinical safety and efficacy than C‐arm‐guided PKP, marking it as a minimally invasive, safe, and effective procedure for treating patients with OVCF with spinal deformity.…”
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Research status and future prospect of carbon capture technology using steel slag in the context of carbon neutrality by Lei AN, Xiaoyuan ZHANG, Yu LIU

“…The increasing production of steel slag has prompted government and public efforts to develop suitable treatment and disposal methods that minimize environmental impact. As an alkaline solid waste, steel slag not only offers favorable accessibility but also serves as a promising resource for high-value recycling. …”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…For sotorasib versus docetaxel, our estimation showed no difference in QALYs (1.28 QALYs for both treatments), as the reduced adverse events reported in CodeBreak 200 for sotorasib had a minimal impact on the QALYs in our calculation. This made an incremental cost-effectiveness ratio (ICER) calculation irrelevant. …”
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Targeted intra-tumoral hyperthermia using uniquely biocompatible gold nanorods induces strong immunogenic cell death in two immunogenically ‘cold’ tumor models by Barry E. Kennedy, Erin B. Noftall, Cheryl Dean, Alexander Roth, Kate N. Clark, Darren Rowles, Kulbir Singh, Len Pagliaro, Carman A. Giacomantonio, Carman A. Giacomantonio, Carman A. Giacomantonio

“…Gold nanorods (GNRs) offer a precise, minimally invasive alternative by leveraging near-infrared (NIR) light to deliver targeted hyperthermia therapy (THT). …”
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Assessment of out-of-pocket (OOP) expenditures on essential medicines for acute and chronic illness: a comparative study across regional and socioeconomic groups in India by Ranjit Kumar Dehury, Imteyaz Ahmad, Manas Ranjan Behera, Janmejaya Samal, Varalakshmi Manchana, Jalal Mohammed, Parthsarathi Dehury, Deepanjali Behera, Nafisa Vaz e Desouza, Abhishek Dondapati

“…That association must be minimized or nullified for equitable economic and social development.…”
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Cocktail of Ropivacaine, Morphine, and Diprospan Reduces Pain and Prolongs Analgesic Effects after Total Knee Arthroplasty: A Prospective Randomized Controlled Trial by Zhenyu Luo, Weinan Zeng, Xi Chen, Qiang Xiao, Anjing Chen, Jiali Chen, Haoyang Wang, Zongke Zhou

“…Group B had lower resting VAS pain scores (1.54 ± 0.60, 95% CI = 1.37 to 1.70 vs. 2.00 ± 0.63, 95% CI = 2.05 to 2.34) and active VAS pain scores (2.64 ± 0.62, 95% CI = 2.46 to 2.81 vs. 3.16 ± 0.75, 95% CI = 2.95 to 3.36) within 48 h postoperatively than Group A (P<0.001), while none of the pain differences exceeded the minimal clinically important difference (MCID). Group B had significantly lower CRP levels (59.49 ± 13.01, 95% CI = 55.88 to 63.09 vs. 65.95 ± 14.41, 95% CI = 61.95 to 69.94) and IL-6 levels (44.11 ± 13.67, 95% CI = 40.32 to 47.89 vs. 60.72 ± 15.49, 95% CI = 56.42 to 65.01), lower opioid consumption (7.60 ± 11.10, 95% CI = 4.52 to 10.67 vs. 13.80 ± 14.68, 95% CI = 9.73 to 17.86), better ROM (110.20 ± 10.46, 95% CI = 107.30 to 113.09 vs. 105.30 ± 10.02, 95% CI = 102.52 to 108.07), better sleep quality (3.40 ± 1.03, 95% CI = 3.11 to 3.68 vs. 4.20 ± 1.06, 95% CI = 3.90 to 4.49), and higher satisfaction rates than Group A within 48 h postoperatively (P < 0.05). …”
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Comparing cup placement, leg length, and offset discrepancy after total hip arthroplasty between CT-based robotic arm-assisted and navigation systems by Akira Shimizu, Satoshi Murakami, Takayuki Tamai, Yuuki Haga, Tatsuhiko Kutsuna, Tomofumi Kinoshita, Masaki Takao

“…This study aimed to determine whether a CT-based robotic arm-assisted system helps surgeons perform accurate cup placement, minimizes leg length, and offsets discrepancies more than a CT-based navigation system. …”
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Farm-to-fork changes in poultry microbiomes and resistomes in Maputo City, Mozambique by Natalie Olson, Frederica Lamar, Hermógenes Mucache, José Fafetine, Joaquim Saíde, Amélia Milisse, Denise R. A. Brito, Kelsey J. Jesser, Karen Levy, Matthew C. Freeman, Maya L. Nadimpalli

“…Evaluating how poultry gut bacterial communities, including potential human pathogens and high-risk antimicrobial resistance genes, differ from farm to market could help identify where to target interventions to minimize transmission risks to human populations. In this study in Maputo City, Mozambique, we found compositional differences between commercial and local chicken breeds at production and market sites. …”
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Is Intra-articular Platelet-rich Plasma Injection Safe and Effective in Osteoarthritis Knee? A Prospective Study: A Case Series by R Sahaya Jose, N Kattu Bava, M Syed Moosa

“…Conclusion: Based on our results, this minimally invasive PRP injection to the knee joint is a safe and effective treatment in mild to moderate OA. …”
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Refraction in adolescents with various severity of Internet addiction and intensity of device use by T.R. Mukhamadeev, R.R. Akhmadeev, E.F. Shaykhutdinova, A.R. Khusniyarova

“…Mean SE was shifted toward myopia (OD -1.5±0.2 D and OS -1.7±0.2). Minimal SE (OD -0.5±0.3 D and OS -0.8±0.3 D) was reported in adolescents with developed IA. …”
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Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial by Ruihao Huang, Xiaoqi Wang, Hongju Yan, Xu Tan, Yingying Ma, Maihong Wang, Xiao Han, Jia Liu, Li Gao, Lei Gao, Guangjun Jing, Cheng Zhang, Qin Wen, Xi Zhang

“…By day 28, six of ten patients had achieved minimal residual disease (MRD)-negative complete remission. …”
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TiMON: a real-time integrated monitor for improving the placement and wear of emergency tourniquets by John Quan Nguyen, Avery Goss, Helen Keshishian, Francis Berchard, Jonathan Parks, Conor Evans

“…Conclusion Trained soldiers and lay volunteers using the TiMON were able to consistently apply tourniquets at clinically recommended occlusion pressures between 180 and 300 mmHg with significantly less under and over tightening while minimizing any negative effects to their application speeds. …”
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Fitness Profiling in Women Soccer: Performance Characteristics of Elite Turkish Women Soccer Players by Aras Beka Yaşar, Serdar Bayrakdaroğlu, Beyza Yıldız, İbrahim Can

“…Relative and absolute anaerobic power values for elite women football players were obtained as 439,7 (± 61,18 W) and 8,04 (± 1,09 W/kg) for maximal anaerobic power, 316,1 (± 34,46 W) and 5,78 (± 0,56 W/kg) for maximal anaerobic capacity, 193,6 (±22,30 W) and 3,55 (± 0,61 W/kg) for minimal anaerobic power, respectively. In addition, fatigue index values measured as 55,7 (± 3,75 %). …”
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Intricating connections: the role of ferroptosis in systemic lupus erythematosus by Guowang Zhao, Xinghai Li, Ying Zhang, Ying Zhang, Xingzi Wang, Li Deng, Juan Xu, Shumei Jin, Zan Zuo, Zan Zuo, Linting Xun, Linting Xun, Mei Luo, Mei Luo, Fan Yang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Ping Fu

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