Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 by Qi Zhang, Lan Luo, Lai-lai Yan, Lai-lai Yan, Jing Guo, Hui-jun Wu, Zi-wei Zhang, Yu-hua Zhu, Rui Qiao, Rui Qiao

“…Some low-SDI countries have achieved minimal theoretical disease burdens, whereas certain high-SDI countries lag in reducing their neonatal disease burdens.ConclusionOver the past 32 years, the global burden of neonatal diseases attributable to LBW has significantly decreased, but inequality in disease burden has intensified. …”
Get full text

Assessment of Some Physicochemical Parameters and Heavy Metals in Hand-Dug Well Water Samples of Kafta Humera Woreda, Tigray, Ethiopia by Kiros Gebremichail Gebresilasie, Goitom Gebreyohannes Berhe, Amanual Hadera Tesfay, Samuel Estifanos Gebre

“…Therefore, the government should adopt some treatment technologies such as sedimentation and aeration to minimize the concentration of iron for safe drinking the water to the community of Kafta Humera Woreda.…”
Get full text

Assessing One Health integration in Somalia’s school curriculum for future pandemic preparedness by Ahmed Abdulkadir Hassan-Kadle, Aamir Muse Osman, Abas Mohamed Sharif

“…While some materials address environmental health and infectious diseases, crucial areas such as zoonosis, antimicrobial resistance, and climate change are minimally covered. Additionally, the study underscores the challenges faced by teachers, including inadequate OH training and resources, and the importance of interdisciplinary collaboration for successful One Health implementation. …”
Get full text

A rapid and simple clonality assay for bovine leukemia virus-infected cells by amplified fragment length polymorphism (AFLP) analysis by Tomoko Kobayashi, Sakurako Makimoto, Nagaki Ohnuki, Md Belal Hossain, M. Ishrat Jahan, Misaki Matsuo, Kazuhiko Imakawa, Yorifumi Satou

“…Overall, BLV-AFLP is suitable for practical use in the field, improving BLV management strategies and minimizing economic losses.IMPORTANCEEnzootic bovine leukosis (EBL) is routinely diagnosed based on external manifestations at the farm, such as the presence of tumors and/or general lymph node enlargement. …”
Get full text

Combined characterization of pore structurein deep medium-rank coal using mercury intrusion and liquid nitrogen adsorption methods and its pore fractal characteristics by Qi LI, Yong WU, Lei QIAO

“…Micropores accounted for more than 70% of the total specific surface area, while the proportions of mesopores and macropores were minimal, indicating that micropores had the strongest adsorption capacity, which was negatively affected gas management in deep coal seams. …”
Get full text

Particulate matter emission in agricultural biomass residue combustion by M.G. Nugraha, A. Sharfan, V.S.Y. Prakoso, M. Hidayat, H. Saptoadi

“…These findings not only propose better practices for disposing of agricultural waste and minimizing air pollution but also emphasize the potential of utilizing biomass waste for energy conversion.…”
Get full text

Evaluasi Maturitas Teknologi Informasi Pada Proses Problem Management PT. XYZ Menggunakan Kerangka Kerja COBIT 5 by Muhammad Naufal Pratama, Andi Reza Perdanakusuma, Aditya Rachmadi

“…XYZ as one of the State-Owned Enterprises (SOE) subsidiary which is engaged in the field of port services and the utilization of information technology, service desk quite often receives reports of problems with services and IT infrastructure so that efficient and effective management of information technology problems is needed so that the impact of the issues arising from the use of information technology can be minimized. Based on the issues, it is necessary to conduct research that aims to determine the capability level of the problem management process implemented by the company using the COBIT 5 framework as a measuring tool for the Capability level in the Manage Problem sub-process (DSS03). …”
Get full text

Application of Rapid Impacts Assessment Matrix (RIAM) in Detecting Environmental Impacts of Chabahar Desalination Plant by Hasan Sayyad, Mohsen Shahriari Moghaddam, Malihe Erfani, Saeed Mohammadi

“…Given the project's proximity to the Sea of Oman and coral islands that host unique species and valuable ecosystem services, it is necessary to evaluate strategies to eliminate the negative effects resulting from changes in water quality and to minimize them. In the biological-ecological section, the most significant negative effects are on the fauna. …”
Get full text

Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collab... by Giulia Turri, MD, Luigi Martinelli, MD, Daniela Rega, MD, Nicolò Tamini, MD, Lucia Paiano, MD, Simona Deidda, MD, QuocRiccardo Bao, MD, Laura Lorenzon, MD, PhD, Raffaele De Luca, MD, Caterina Foppa, MD, PhD, Valentina Mari, MD, Giovanni Taffurelli, MD, Arcangelo Picciariello, MD, PhD, Patrizia Marsanic, MD, Leandro Siragusa, MD, Francesco Bagolini, MD, Riccardo Nascimbeni, MD, Gianluca Rizzo, MD, PhD, Sara Vertaldi, MD, Michele Zuolo, MD, Giorgio Bianchi, MD, Lisa Marie Rorato, MD, Rossella Reddavid, MD, PhD, Gaetano Gallo, MD, PhD, Lorenzo Crepaz, MD, Alberto Di Leo, MD, Mario Trompetto, MD, Enrico Potenza, MD, Mauro Santarelli, MD, Nicola de’Angelis, MD, PhD, Francesco Ciarleglio, MD, Marco Milone, MD, PhD, Claudio Coco, MD, Guido Alberto Tiberio, MD, Gabriele Anania, MD, Giuseppe S. Sica, MD, PhD, Andrea Muratore, MD, Donato Francesco Altomare, MD, Isacco Montroni, MD, PhD, Maurizio De Luca, MD, Antonino Spinelli, MD, PhD, Michele Simone, MD, Roberto Persiani, MD, Gaya Spolverato, MD, Angelo Restivo, MD, Nicolò de Manzini, MD, Marco Braga, MD, Paolo Delrio, MD, Giuseppe Verlato, MD, PhD, Corrado Pedrazzani, MD, Adriana Gioia, Cristina Vacca, Dario Parini, Giovanni Tomasicchio, Marcello Calabrò, Bruno Sensi, Filomena Misuriello, Carlo Alberto Schena, Silvia Picotto

Get full text

Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation by Oana Hangiu, Oana Hangiu, Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Laura Rubio-Pérez, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Laura Díez-Alonso, Laura Díez-Alonso, Laura Díez-Alonso, Marina Gómez-Rosel, Marina Gómez-Rosel, Marina Gómez-Rosel, Noelia Silva-Pilipich, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Cristian Smerdou, Kenneth A. Howard, Laura Sanz, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Marta Compte

“…Bispecific T cell-engaging (TCE) antibodies are an effective way to provide tumor-specific T cell receptor-mediated signaling to tumor-infiltrating lymphocytes. mRNA-based delivery of bispecific antibodies, offer a novel approach to enhance tumor-specific immune responses while minimizing adverse effects.MethodsTwo bispecific antibodies were generated: the EGFR x CD3 TCE antibody (LiTE) and the PD-L1 x 4-1BB costimulatory antibody (LiTCo), which was further fused to a high FcRn albumin variant (Albu-LiTCo). …”
Get full text

Amoeba plate test with Acanthamoeba castellanii as an innovative tool for Nocardia recovery from sputum samples: a proof-of-concept study by Coralie Espinasse, Ghislaine Descours, Marine Ibranosyan, Laetitia Beraud, Christophe Ginevra, Joelle Chastang, Oana Dumitrescu, Frédéric Laurent, Verónica Rodriguez Nava, Sophie Jarraud, Camille Allam

“…Culture positivity rates, minimal growth concentrations, growth times, and abundance of flora overgrowth were compared for each condition. …”
Get full text

A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical tria... by Floriane Jochum, Madeleine Doll, Anne-Sophie Hamy, Lou Donval, Paul Gougis, Élise Dumas, Lise Lecointre, Thomas Gaillard, Fabien Reyal, Fabrice Lecuru, Cherif Akladios, Enora Laas

“…Bayesian structural time series analysis assessed the causal effects of the LACC and LION trials on the discontinuation of minimally invasive surgery (MIS) and lymphadenectomy, respectively. …”
Get full text

The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro by Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy

“…Therefore, the incidence of hard-to-treat candidiasis has increased dramatically in the past decade, and the demand to identify antifungal compounds with minimal potential to trigger resistance is substantial. …”
Get full text

Genomic selection strategies to overcome genotype by environment interactions in biosecurity-based aquaculture breeding programs by Ziyi Kang, Jie Kong, Qi Li, Juan Sui, Ping Dai, Kun Luo, Xianhong Meng, Baolong Chen, Jiawang Cao, Jian Tan, Qiang Fu, Qun Xing, Sheng Luan

“…A family-based BS selective breeding program should monitor the level of G × E and genotyping 50 SG individuals per candidate family to minimize the loss of genetic gain due to G × E, unless the level of G × E is confirmed to be low.…”
Get full text

Associations of dose to the urethra and long-term patient-reported outcomes after radiotherapy with EBRT and HDR brachytherapy boost for prostate cancer by Lars Haack, David Krug, Justus Domschikowski, Olaf Wittenstein, Severin Rodler, Philipp Nuhn, Christof van der Horst, Claudia Schmalz, Christian Schulz, Oliver Blanck, Frank-André Siebert, Alexander Fabian

“…Urethral dose should be considered in practice and future trials to potentially minimize long-term urinary morbidity. Trial registration: The study protocol was pre-registered prior to patient accrual on the Open Science Framework (https://doi.org/10.17605/OSF.IO/A6DC3).…”
Get full text

Four-dimensional flow magnetic resonance imaging for noninvasive diagnosis of clinically significant portal hypertension and high-risk gastroesophageal varices in patients with cir... by Jiachen Ji, Yi Xiang, Jinghui Dong, Hanyu Jiang, Tianyi Xia, Yunduo Li, Mengmeng Zhang, Changchun Liu, Xijun Gong, Bo Jin, Wen Shen, Gangfeng Zhu, Jianming Cai, Rui Li, Xiaolong Qi

“…Conclusion: As a noninvasive imaging modality, 4D flow MRI exhibits considerable potential for the diagnosis of CSPH and high-risk gastroesophageal varices; thus, it may minimize the reliance on invasive procedures in patients with cirrhosis.…”
Get full text

Factors influencing in-hospital mortality for salvage percutaneous transjugular intrahepatic portosystemic shunting in cirrhotic patients with recalcitrant variceal bleeding after... by J E J Krige, E G Jonas, M Setshedi, S J Beningfield, U K Lotze, M M Bernon, S Burmeister, J C Kloppers

“…In high-risk patients with persistent AVB despite pharmacological treatment and endoscopic intervention, percutaneous transjugular intrahepatic portosystemic shunting (TIPS) provides a minimally invasive salvage method to reduce portal pressure and control bleeding. …”
Get full text

Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Bland-Altman analysis confirmed strong agreement, with minimal mean differences and narrower limits of agreement for the New OCT. …”
Get full text

Diagnostics of lung cancer by fragmentated blood circulating cell-free DNA based on machine learning methods by Ivan O. Meshkov, Alexander P. Koturgin, Pavel V. Ershov, Liubov A. Safonova, Julia A. Remizova, Valentina V. Maksyutina, Ekaterina D. Maralova, Vasilisa A. Astafieva, Alexey A. Ivashechkin, Boris D. Ignatiev, Antonida V. Makhotenko, Ekaterina A. Snigir, Valentin V. Makarov, Vladimir S. Yudin, Anton A. Keskinov, Sergey M. Yudin, Anna S. Makarova, Veronika I. Skvortsova

“…IntroductionMinimally invasive diagnostics based on liquid biopsy makes it possible early detection of lung cancer (LC). …”
Get full text

Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia by Mary Kay Koenig, Vincenzo Leuzzi, Riadh Gouider, Riadh Gouider, Eppie M. Yiu, Eppie M. Yiu, Barbara Pietrucha, Asbjørg Stray-Pedersen, Susan L. Perlman, Steve Wu, Trudy Burgers, Rupam Borgohain, Rukmini Mridula Kandadai, Isabelle Meyts, Giorgia Bucciol, Anaita Udwadia-Hegde, Ravi Yadav, Donna Roberts, Aaron Dane, Maureen Roden, Dirk Thye, Biljana Horn, Howard M. Lederman, William P. Whitehouse

“…Longitudinal height and weight mean z-scores showed minimal change from baseline to month 24 for height (−0.06 ± 0.49), weight (−0.02 ± 0.71), and body mass index (0.03 ± 0.87). …”
Get full text