Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…Importantly, the multitarget compounds 6d, 8c, and 8d exhibited remarkable efficacy in simultaneously mitigating Aβ-induced toxicity in SH−SY5Y cells while demonstrating minimal cytotoxicity. Furthermore, predicted ADMET results suggested that 6d, 8c, and 8d possessed favorable pharmacokinetic properties and demonstrated low toxicity levels. …”
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Chemical Fingerprints of M Dwarfs: High-resolution Spectroscopy on 31 M Dwarfs with SPIRou by Farbod Jahandar, René Doyon, Étienne Artigau, Neil J. Cook, Charles Cadieux, Jean-François Donati, Nicolas B. Cowan, Ryan Cloutier, Stefan Pelletier, Alan Alves-Brito, Jorge H. C. Martins, Hsien Shang, Andrés Carmona

“…Our high-resolution chemical analysis examines hundreds of absorption lines using χ ^2 minimization using PHOENIX-ACES stellar atmosphere models. …”
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Concentrations and exposure risks of per- and polyfluoroalkyl substances in human milk from Southern China during the first 400 days of lactation by Meng-Tao Yang, Fei Yang, Qiu-Ye Lan, Si-Yu Huang, Xiao-Yan Chen, Ying-Zhen Qiu, Hui-Lian Zhu

“…It is crucial to reduce human milk PFASs concentrations by minimizing dietary and environmental exposures among lactating women.…”
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Assessment of improvement in functional outcomes between a novel knee replacement design and conventional designs in 240 patients: a randomized controlled trial by Tero Irmola, Aleksi Reito, Jarmo Kangas, Antti Eskelinen, Mika Niemeläinen, Ville M Mattila, Teemu Moilanen

“…Results: Of 240 randomized patients, 225 were included in the intention-to-treat analysis (mean age 61.8 years; 67.5% females). The OKS exceeded minimal clinical important difference (MCID) from baseline to 2 years in all 3 treatment groups (Persona CR: 18.9 points, PFC CR: 20.3 points, NexGen CR: 19.4 points). …”
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Ultrasonic and Microwave-assisted Solid-Liquid Extraction of Ginkgo biloba Phenolics: Study about Mass Transfer and PID Control by Chi XU, Hebin XU, Rui ZHU, Jing LI, Dandan LI, Yongbin HAN, Yi ZHENG, Yang TAO

“…Furthermore, fuzzy-PID controllers optimized by genetic algorithms or particle swarm optimization (PSO) algorithms outperformed traditional PID controller and individual fuzzy-PID controller to control the extraction process, achieving faster convergence with minimal overshoot. Specifically, under microwave power of 4800 W/L and a solvent-to-liquid ratio of 1:20 g/mL, the fuzzy-PID controller optimized by PSO algorithm proved optimal, with PSO factors set at 4.1350, 0.1100, and 0.0001. …”
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Mechanisms of N2O production in salinity-adapted partial nitritation systems for high-ammonia wastewater treatment by Xiang Li, Yingxin Jin, Yanying He, Yufen Wang, Tingting Zhu, Yingxin Zhao, Bing-Jie Ni, Yiwen Liu

“…The results showed that the specific ammonia oxidation rates of the control and two salinity-acclimated PN reactors were 78.84, 75.03, and 42.60 mg N/(g VSS·h), indicating that low salinity (2.5 g NaCl/L) had minimal effect, while high salinity (10 g NaCl/L) significantly inhibited ammonia-oxidating bacteria and associated nitritation processes. …”
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A fuzzy logic approach within the DPSIR framework to address the inherent uncertainty and complexity of water security assessments by Liang Yuan, Zhijie Zhou, Weijun He, Xia Wu, Dagmawi Mulugeta Degefu, Juan Cheng, Lin Chai, Thomas Stephen Ramsey

“…Responses (R) and water security are positively correlated. (3) The driving force has the strongest positive impact on water security in Laos, while it has a negative impact on Vietnam. Pressures has a minimal impact on China’s water security, while Cambodia faces a larger impact from Pressures. …”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Consequently, there is significant in discovering new drugs that have minimal side effects and a pronounced hypoglycemic effect. …”
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Quantification of Myocardial Biomarkers in Sudden Cardiac Deaths Using a Rapid Immunofluorescence Method for Simultaneous Biomarker Analysis by Matteo Antonio Sacco, Valerio Riccardo Aquila, Saverio Gualtieri, Roberto Raffaele, Maria Cristina Verrina, Lucia Tarda, Santo Gratteri, Isabella Aquila

“…Conclusions: This study supports the potential use of cardiac markers, particularly TnI, in peripheral blood for postmortem SCD diagnosis, emphasizing the importance of rapid and systematic analysis to minimize hemolysis-related variability. While further validation is needed to confirm these findings, this approach offers a less invasive, economical, and practical method for forensic investigations.…”
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Metal Powder Production by Atomization of Free-Falling Melt Streams Using Pulsed Gaseous Shock and Detonation Waves by Sergey M. Frolov, Vladislav S. Ivanov, Viktor S. Aksenov, Igor O. Shamshin, Fedor S. Frolov, Alan E. Zangiev, Tatiana I. Eyvazova, Vera Ya. Popkova, Maksim V. Grishin, Andrey K. Gatin, Tatiana V. Dudareva

“…The operation process is visualized by a video camera. The minimal size of the powders obtained by the method is shown to be as low as 0.1 to 1 μm, while the maximum size of particles exceeds 400–800 μm. …”
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Response surface methodology for the design of malachite green dye removal by γ-Fe2O3 dispersed on reduced graphene oxide sheets by Liu Zhu, Anam Sana, Muhammad Tariq Qamar, Ali Bahadur, Guocong Liu, Mohammad Aslam, Ammar Zidan, İsmail Seçkin Çardaklı, Shahid Iqbal, Sajid Mahmood, Muhammad Saad, Khalid M. Alotaibi

“…The adsorbent’s surface charge (pHPZC = ~ 7.1) was also estimated using the salt addition technique. To minimize experiments and optimize adsorption parameters for the removal of MG by the nanocomposite at 25 °C, central composite design (CCD) using response surface methodology (RSM) was used. …”
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NORDIC denoising on VASO data by Lasse Knudsen, Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K. Faes, Daniel A. Handwerker, Steen Moeller, Peter A. Bandettini, Peter A. Bandettini, Laurentius Huber

“…For the data presented here, with a proper set of parameters, NORDIC reduced thermal noise with minimal bias on the underlying signal and preserved spatial resolution. …”
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GANCE: Generative Adversarial Network Assisted Channel Estimation for Unmanned Aerial Vehicles Empowered 5G and Beyond Wireless Networks by Chirag Gupta, Ramani Kumar Das, Rabindra K. Barik, Shahazad Niwazi Qurashi, Diptendu Sinha Roy, Satyendra Singh Yadav

“…The proposed model has also demonstrated robustness against the Doppler effect caused by the high mobility of UAVs, with only a minimal decrease in NMSE performance of 2-3 dB for every 50 km/h increase in speed. …”
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Optimal multiobjective design of an autonomous hybrid renewable energy system in the Adrar Region, Algeria by Abderrahmane Mehallou, Benalia M’hamdi, Abderrahmane Amari, Madjid Teguar, Abdelaziz Rabehi, Mawloud Guermoui, Amal H. Alharbi, El-Sayed M. El-kenawy, Doaa Sami Khafaga

“…The proposed methods are carried out to select the optimal system size, which is a multi-objective problem involving the minimization of the annual cost of electricity (COE), and the loss of power supply probability (LPSP) simultaneously. …”
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Particle emission and thermal efficiency analysis of a diesel vehicle using biodiesel and a platinum metallic partial-flow particulate filter by Huy Quang Dang, Mi Zwe Mon Phyo, Poonnut Thaeviriyakul, Plan Teekatasn Cosh, Mek Srilomsak, Therdsak Petblengsri, Ittipol Pawarmart, Sompong Srimanosaowapak, Hidenori Kosaka, Preechar Karin

“…Installation of a P-CDPF had a minimal impact, resulting in less than a 3.4% increase in the BSFC and a 1% decrease in brake thermal efficiency across all tested fuels, owing to its relatively low pressure drop. …”
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Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…The gained knowledge provided essential baseline information that may be utilized for regular tracking of MDR Salmonella transmission in the food chain to minimize potential future outbreaks.…”
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Integrated assessment of carbon dioxide removal portfolios: land, energy, and economic trade-offs for climate policy by Solene Chiquier, Angelo Gurgel, Jennifer Morris, Yen-Heng Henry Chen, Sergey Paltsev

“…Finally, this study reveals that incentivizing timely and large-scale CDR deployment by policy and financial incentives could reduce the risk of deterring climate change mitigation, notably by minimizing carbon prices.…”
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Long-term volume stability of steel slag sand mortar and concrete by Zhenhao Zhou, Qiang Jin, Di Hu, Lin Zhu, Zihua Li, Wanzhong Su

“…The results from the long-term alkali-aggregate reaction tests conducted over 0−156 weeks indicated that the replacement ratio of steel slag sand has a minimal impact on the volume of mortar and concrete. …”
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Comparative Evaluation of Functional Outcomes in High Condylar Fractures Treated with Closed Methods with and without Temporomandibular Joint Arthrocentesis: A Research Protocol fo... by Sachindra Dubey, Nitin Bhola, Anchal Agarwal

“…It has emerged as a valuable tool in the multidisciplinary approach to managing TMDs, offering patients a minimally invasive option to relieve their symptoms and restore jaw function. …”
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The Long-Term Immunity of a Microneedle Array Patch of a SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice by Eun Kim, Muhammad S. Khan, Juyeop Shin, Shaohua Huang, Alessandro Ferrari, Donghoon Han, Eunjin An, Thomas W. Kenniston, Irene Cassaniti, Fausto Baldanti, Dohyeon Jeong, Andrea Gambotto

“…The rS1RS09 in MAP has remained stable with minimal protein degradation for 19 months at room temperature or under refrigeration, regardless of gamma-irradiation. …”
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