CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex by Annabella Pignataro, Antonella Borreca, Martine Ammassari-Teule, Silvia Middei

“…Here we studied the effects of vibrissae trimming, a widely used model of sensory deprivation-induced cortical plasticity, on processes associated with dendritic spine rearrangements in the barrel cortex of a transgenic mouse model of CREB downregulation (mCREB mice). We found that sensory deprivation through prolonged whisker trimming leads to an increased number of thin spines in the layer V of related barrel cortex (Contra) in wild type but not mCREB mice. …”
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Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root by Mikhail Olugbemiro Nafiu, Taoheed Adedeji Abdulsalam, Musbau Adewumi Akanji

“…Twenty-four (24) albino mice were infected by intraperitoneal injection of standard inoculum of chloroquine sensitive Plasmodium berghei (NK 65). …”
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Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway by Jiahui An, Chao Zhang, Jinshuang Cai, Yufeng Li

“…In this study, BALB/c mice and RAW264.7 cells were used to study the inflammation and related mechanism caused by the coinfection of PCV2 and G. parasuis. …”
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Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis by Eun Ju Shin, Mi Jeong Sung, Hye Jeong Yang, Myung Sunny Kim, Jin-Taek Hwang

“…EBN administered at 100, 200, or 500 mg/(kg·d) reduced COX-2 levels in the DSS-treated mice. In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). …”
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High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L. by Pierre Watcho, Roman Stavniichuk, David M. Ribnicky, Ilya Raskin, Irina G. Obrosova

“…., on neuropathy in high-sfat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. …”
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Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis by Aijaz Ahmad, Ravineel B. Singh, Kara L. Nickolich, Matthew J. Pilewski, Caden Ngeow, Kwame Frempong-Manso, Keven M. Robinson

“…In this study, we investigate the role of IL-17 and Type 17 immune signaling components during IAPA.MethodsWild-type mice were challenged with influenza A H1N1 (flu) and then exposed to Aspergillus fumigatus ATCC42202 resting conidia on day 6 post-influenza infection, followed by the quantification of cytokines and chemokines at 48 h post-fungal infection.Results and discussionThe gene and protein expression levels revealed that IL-17 and Type 17 immune cytokines and antimicrobial peptides are downregulated during IAPA compared to mice singularly infected solely with A. fumigatus. …”
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Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy by Luwei Zhang, Jinhang Zhang, Xinnong Liu, Shengli Liu, Jun Tian

“…The expression of TRB3, TGF-β1, and collagen type IV was increased in kidneys of db/db diabetic mice. TGF-β1 and collagen type IV regulated by high glucose through ERK1/2 MAPK were downregulated by silencing TRB3 in renal mesangial cells. …”
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Potential Antinociceptive Effects of Chinese Propolis and Identification on Its Active Compounds by Liping Sun, Lei Liao, Bei Wang

“…Antinociceptive effects by these propolis fractions were evaluated in mice using acetic acid-induced writhing test, hot plate test, and tail immersion test, respectively. …”
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Minimal state models for ionic channels involved in glucagon secretion by Virginia González-Vélez, Amparo Gil, Iván Quesada

“…During low glucose levels, alpha cells exhibit electrical activity related to glucagon secretion.In this paper, we introduce minimal state models for those ionic channels involved in this electrical activity in mice alpha cells. For estimation of model parameters, we use Monte Carlo algorithms to fit steady-state channel currents. …”
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Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model by Zhichao Hu, Zhichao Hu, Ting Chen, Ting Chen, Ting Chen, Daoming Chen

“…Herein, we employed 6-hydroxydopamine (6-OHDA) to induce sympathetic nerve depletion in mice before vitiligo induction. Sympathetic nerve ablation was confirmed through immunofluorescent staining of tyrosine hydroxylase. …”
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Distribution and functional significance of KLF15 in mouse cerebellum by Dan Li, Shuijing Cao, Yanrong Chen, Yueyan Liu, Kugeng Huo, Zhuangqi Shi, Shuxin Han, Liecheng Wang

“…Knockdown of KLF15 led to loss of Purkinje cells and impaired motility in mice. Therefore, our study aims to elucidate the relationship between KLF15 and Purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum.…”
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Antibodies directed to antigens secreted by murine epithelioid macrophages modulate BCG-induced granulomata by Mario Mariano, Tania Aguiar, Celia R. W. Carneiro, Edilberto Postol, Venânclo A. F. Alves, Ricardo Ribeiro-dos-Santos

“…The authors have previously shown that epithelioid cells isolated from mice secrete a factor, called macrophage deactivating factor (MDF), that promptly deactivates superoxide release by activated macrophages and neutrophils. …”
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Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model. by Yoon Seok Nam, Eun-Ji Gi, Yoo-Seung Ko, Sungsu Lee, Hyong-Ho Cho

“…We investigated the effect of Trichostatin A (TSA), an HDACi, to assess its potential to inhibit hearing deterioration in AS. Col4a3 knockout (KO) mice were treated with TSA at 3 weeks of age, and hearing levels were measured using auditory brainstem response (ABR). …”
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Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway by Quan Wang, Shuai Ni, Li Ling, Siqi Wang, Hanbin Xie, Zhanhong Ren

“…Here, we show that Ginkgolide B (GB), a naturally occurring terpene lactone, effectively suppresses vascular remodeling and subsequent restenosis in wild-type mice following left carotid artery (LCA) injury. …”
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Translating time: Challenges, progress, and future directions by Christine J. Charvet, Alexandra A. de Sousa, Tatianna Vassilopoulos

“…Mice are the dominant model system to study human health and disease. …”
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Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines by Chi-Won Choi, Edmond Changkyun Park, Sung Ho Yun, Sang-Yeop Lee, Seung Il Kim, Gun-Hwa Kim

“…Although the S. pneumoniae bacteria were highly pathogenic in a mouse model, the EMVs purified from these bacteria showed low pathological activity both in cell culture and in mice. When mice were injected intraperitoneally with S. pneumoniae EMVs and then challenged, they were protected from both the homologous strain and another pathogenic serotype of S. pneumoniae. …”
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Scaffolded Antigens in Yeast Cell Particle Vaccines Provide Protection against Systemic Polyoma Virus Infection by Donald J. Tipper, Eva Szomolanyi-Tsuda

“…For U65-green fluorescent protein (GFP) or U65-Apolipoprotein A1 (ApoA1) subcutaneous vaccines, maximal IgG responses in mice required 10% glucan exposure. IgG responses to yeast proteins were 5-fold lower. …”
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Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration by Ahmed Z. Ibrahim, Kareem Abdou, Masanori Nomoto, Kaori Yamada-Nomoto, Reiko Okubo-Suzuki, Kaoru Inokuchi

“…We have designed “Auditory-Gated Patience-to-Action” Task in which mice should process different auditory signals before action execution as well as analyzing the visual inputs for feedback of their action. …”
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5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation by Jinque Luo, Jinque Luo, Xin Li, Xin Li, Li Zhang, Li Zhang, Meijing Deng, Jieyang Zhao, Jinghuan Zhang, Wenyu Tang, Qinghua Guo, Ling Wang

“…Various techniques including histopathology, Western blotting, and luciferase reporter assay were employed.Results5-DR treatment significantly reduced lung edema, inflammatory cell infiltration in mice with LPS burden, and reduced the levels of inflammatory mediators like interleukin-1β in the mice and in LPS-stimulated J774A.1 mouse macrophages. …”
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ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation by Li-Quan Huang, Ting-Xuan Yan, Bao-Sheng Wang, Hao Li, Nai-Bao Zhou

“…Initially, we observed a significant increase in the expression of ZC3H15 in dorsal horn spinal cord tissues of BCP mice, along with severe oxidative stress and inflammation. …”
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