Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

“…In Cpk mice, total GLI3 and GLI3 repressor protein levels were also increased. …”
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Alpinetin Attenuates Persistent Inflammation, Immune Suppression, and Catabolism Syndrome in a Septic Mouse Model by Yukun Liu, Kang Wang, Qaunrui Feng, Yongsheng Zhang, Chuntao Wang, Qinxin Liu, Xinghua Liu, Xiang Wang, Wei Gao, Xiangjun Bai, Zhanfei Li, Yuchang Wang

“…Eight days after sham operation or CLP surgery, mice were euthanized for subsequent examination. …”
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The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland by Moran Melamed, Hila Asraf, Noa Livne, Milos Bogdanovic, Anil Shendge, Gilad Shamir, Maayan Mero, Omer Adir, Avi Schroeder, Israel Sekler, Michal Hershfinkel

“…By monitoring transport of NH4+, a surrogate for K+, we revealed that Zn2+ upregulates the Na+/K+ ATPase pump activity in parotid and submandibular salivary gland epithelium from wildtype (WT), but not from ZnR/GPR39 knockout (KO), mice. Since Na+/K+ ATPase activity is crucial for solute transport, we compared saliva composition in WT and ZnR/GPR39 KO mice and found impaired ionic concentration and reduced saliva secretion in ZnR/GPR39 KO mice. …”
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Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen by Dang Sheng, Sui Xin, Wu Dongxing, Wen Shubo, Song Yang, Chen Zeliang, Zhai Jingbo

“…The S2-Ag85A vaccine was effective in activating dsDNA and RNA transduction pathways in intestinal cells and improving intestinal antigen presentation in mice.…”
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Gaussia Luciferase for Bioluminescence Tumor Monitoring in Comparison with Firefly Luciferase by Yusuke Inoue, Fugeng Sheng, Shigeru Kiryu, Makoto Watanabe, Harnprasopwat Ratanakanit, Kiyoko Izawa, Arinobu Tojo, Kuni Ohtomo

“…Gluc allows tumor monitoring in mice and should be applicable to dual-reporter assessment in combination with Fluc. …”
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Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota: A Three-Way Crosstalk by C. V. Srikanth, Beth A. McCormick

“…Several experimental model systems, including germ-free mice and antibiotic-treated mice, have been used by various researchers to study this complex relationship. …”
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Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine by Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan

“…Since the protein binding of MDMA in mouse serum is considerably lower than in humans and rats, caution should be exercised when using mice for in vitro studies involving MDMA.…”
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Role of CEACAM1, ECM, and Mesenchymal Stem Cells in an Orthotopic Model of Human Breast Cancer by Sridhar Samineni, Carlotta Glackin, John E. Shively

“…The previously observed difference in gland development between the long and short cytoplasmic domain isoforms of CEACAM1 is no longer observed in pregnant NOD/SCID mice suggesting that stimulation of the mammary fat pad by pregnancy critically affects xenograft differentiation.…”
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Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…In DEREG mice, Foxp3+ Tregs selectively express enhanced green fluorescent protein (eGFP) and diphtheria toxin (DT) receptor, allowing for the specific depletion of Tregs through DT administration. …”
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The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. by M Elise Bullock, Thea Hogan, Cayman Williams, Sinead Morris, Maria Nowicka, Minahil Sharjeel, Christiaan van Dorp, Andrew J Yates, Benedict Seddon

“…The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age, but it is unclear whether these changes are driven by the aging host environment, by cell age effects, or both. …”
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The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model by Junyan Han, Katsuyuki Takeda, Erwin W. Gelfand

“…In this paper, we discuss experimental models of RSV infection in mice and highlight a new investigative approach in which mice are initially infected as neonates and then reinfected later in life. …”
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Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives by Pravin O. Patil, Sanjay B. Bari

“…The antidepressant activity of the synthesized compounds (3a–3n) was evaluated by forced swim test in mice and their locomotor activity was assessed using actophotometry. …”
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miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney Injury through Downregulation of NEK7 by Meng Zhang, Deyuan Zhi, Jin Lin, Pei Liu, Yajun Wang, Meili Duan

“…The expression of NLRP3, NEK7, ASC, active caspase-1, and N-GSDMD was significantly enhanced (P<0.05) and the inflammatory factors including IL-18, IL-1β, and THF-α were all increased in LPS-induced HK-2 cells and CLP-induced mice. Renal edema, serum Cr and BUN, and expression of KIM-1 and NGAL were significantly higher (P<0.05) in CLP-induced S-AKI mice than the sham group. miR-101-3p, miR-144-3p, miR-181a-5p, miR-4262, and miR-513b-5p could inhibit NEK7. …”
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FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia by Anne Morice, Amélie de La Seiglière, Alexia Kany, Roman H. Khonsari, Morad Bensidhoum, Maria-Emilia Puig-Lombardi, Laurence Legeai Mallet

“…Bone mineralization of the calluses was abnormally high in Crz mice and abnormally low in Hch mice. The latter model presented pseudarthrosis and impaired chondrocyte differentiation. …”
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Atractylenolide I prevents acute liver failure in mouse by regulating M1 macrophage polarization by Hui Zhang, Min Gao, Haiyan Wang, Junfeng Zhang, Lin Wang, Guanjun Dong, Qun Ma, Chunxia Li, Jun Dai, Zhihua Li, Fenglian Yan, Huabao Xiong

“…Given the key role of oxidative stress and inflammation in ALF pathogenesis, this study investigates the protective effects of ATR-I on LPS/D-GalN-induced ALF in mice. The results suggest that ATR-I pretreatment significantly ameliorates ALF, as evidenced by decreased serum aminotransferase levels and prolonged mice survival. …”
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Interleukin-22 Plays a Protective Role by Regulating the JAK2-STAT3 Pathway to Improve Inflammation, Oxidative Stress, and Neuronal Apoptosis following Cerebral Ischemia-Reperfusio... by Yongfei Dong, Chengyun Hu, Chunxia Huang, Jie Gao, Wanxiang Niu, Di Wang, Yang Wang, Chaoshi Niu

“…In addition, IL-22 treatment also decreased oxidative stress and neuronal apoptosis in mice after cerebral I/R injury. Moreover, IL-22 treatment significantly increased Janus tyrosine kinase (JAK) 2 and signal transducer and activator of transcription (STAT) 3 phosphorylation levels in mice and PC12 cells, and STAT3 knockdown abolished the IL-22-mediated neuroprotective function. …”
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RETRACTED ARTICLE: Combined treatment of glibenclamide and CoCl2 decreases MMP9 expression and inhibits growth in highly metastatic breast cancer by Zhe Rong, Li Li, Fei Fei, Lailong Luo, Yang Qu

“…All of these mice were inoculated with TA2 spontaneous breast cancer cells in the left groin. …”
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Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis by Wenchang Yang, Yaxin Wang, Peng Zhang, Tao Wang, Chengguo Li, Xin Tong, Xiangyu Zeng, Yuping Yin, Kaixiong Tao, Ruidong Li

“…Therefore, OI protected mice from Con A-induced liver damage and may be associated with Nrf2 activation and NF-𝜅B inhibition. …”
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Honokiol Provides Cardioprotection from Myocardial Ischemia/Reperfusion Injury (MI/RI) by Inhibiting Mitochondrial Apoptosis via the PI3K/AKT Signaling Pathway by Linhua Lv, Qiuhuan Kong, Zhiying Li, Ying Zhang, Bijiao Chen, Lihua Lv, Yubi Zhang

“…The mice in the Honokiol cohort were treated with Honokiol before MI/RI surgery (0.2 mg/kg/day for 14 days, intraperitoneal), while the mice in the Con cohort were given an intraperitoneal injection with an equivalent volume of vehicle (DMSO) daily in 14 days prior to exposure to MI/RI. …”
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The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns by Minting Chen, Abdirahman Abdinasir Gureeye, Yacouba Cissé, Lang Bai

“…After the model was performed, C57BL/6J mice received topical treatment with saline eye drops or pranoprofen eye drops and were, respectively, categorized as saline group and pranoprofen group, whereas the remaining normal mice that were not subjected to alkali burns served as control, each group containing 15 mice (n = 45). …”
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