Modulatory Effect of Probiotic Lactobacillus rhamnosus PB01 on Mechanical Sensitivity in a Female Diet-Induced Obesity Model by Hiva Alipour, Parisa Gazerani, Mahmoud Heidari, Fereshteh Dardmeh

“…Hence, this study aimed at investigating the potential effects of oral probiotic supplementation on mechanical pain thresholds in female diet-induced obese mice compared with controls. Thirty-two adult female mice (N=32) were randomly divided into two groups receiving standard (normal-weight group; NW) or high-fat diet (diet-induced obesity; DIO). …”
Get full text

Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide Synthase-Knockout Mouse by Takashi Kitano, Hiroshi Yamada, Maki Kida, Yuka Okada, Shizuya Saika, Munehito Yoshida

“…KO and wild type (WT) mice of C57BL/6 background were used. Under general anesthesia two round full-thickness excision wounds of 5.0 mm in diameter were produced in dorsal skin. …”
Get full text

Gene therapy by hepatocyte growth factor results in regression of experimental liver fibrosis by N. A. Dzhoyashvili, N. I. Kalinina, I. B. Beloglazova, Z. I. Tsokolayeva, P. I. Makarevich, Yu. L. Perov, Ye. V. Parfenova, V. A. Tkachuk

“…Studying of efficacy of genetic therapy of liver fibrosis at mice by human hepatocyte growth factor (HGF) and evaluation of potentials of hydroporation method for delivery of genetic complexes to the liver.Material and methods. …”
Get full text

High-Yield Generation of Glucose-Responsive Pseudoislets From Murine Insulinoma Cells for Studies and Longitudinal Monitoring of Graft Survival by Grisell C. Gonzalez, Chris M. Li, Ilaria Pasolini, Sophia I. Pete, Connor Verheyen, Sofia M. Vignolo, Teresa De Toni, Aaron A. Stock, Alice A. Tomei

“…After subcutaneous implantation, we show capability to monitor graft survival in immunodeficient mice, recurrence of autoimmunity in non-obese diabetic mice, and allorejection in C57BL/6 mice. …”
Get full text

Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer by Nabila Priscilla Putri, Hirowati Ali, Tofrizal Tofrizal, Eryati Darwin, Restu Susanti, Hasmiwati Hasmiwati

“…Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. …”
Get full text

Combined delivery of IL12 and an IL18 mutant without IL18BP-binding activity by an adenoviral vector enhances tumor specific immunity by Yan Cheng, Renjie Luo, Erguang Li

“…Moreover, mice received oAd.DR18/IL12 had more robust tumor-specific cytotoxicity. …”
Get full text

The Mast Cell Is an Early Activator of Lipopolysaccharide-Induced Neuroinflammation and Blood-Brain Barrier Dysfunction in the Hippocampus by Yiwei Wang, Huanhuan Sha, Leting Zhou, Yinan Chen, Qin Zhou, Hongquan Dong, Yanning Qian

“…Notably, LPS-induced proinflammatory cytokine secretion, microglial activation, and BBB damage were inhibited in KitW-sh/W-sh mice. However, no detectable astrocytic changes were found in WT and KitW-sh/W-sh mice at 4 h after LPS stimulation. …”
Get full text

Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity by Areej I. Alhazmi, Mohamed F. El-Refaei, Eman A. A. Abdallah

“…This study investigated the mechanism by which gallic acid (GA) protects mice kidneys against renal damage induced by Nickel oxide nanoparticles (NiO-NPs). …”
Get full text

Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea by Katsuo Tomoyose, Yuka Okada, Takayoshi Sumioka, Masayasu Miyajima, Kathleen C. Flanders, Kumi Shirai, Tomoya Morii, Peter S. Reinach, Osamu Yamanaka, Shizuya Saika

“…To investigate the effects of loss of transient receptor potential vanilloid receptor 1 (TRPV1) on the development of neovascularization in corneal stroma in mice. Blocking TRPV1 receptor did not affect VEGF-dependent neovascularization in cell culture. …”
Get full text

Low-Dose Oxygen Enhances Macrophage-Derived Bacterial Clearance following Cigarette Smoke Exposure by William G. Bain, Ashutosh Tripathi, Pooja Mandke, Jonathan H. Gans, Franco R. D’Alessio, Venkataramana K. Sidhaye, Neil R. Aggarwal

“…Macrophages from these mice expressed less TNF-α and more scavenger receptors. …”
Get full text

Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen-Specific T Lymphocyte Responses against Melanoma by Zheng Gong, Ming Chen, Jie Miao, Chao-Jie Han, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…Furthermore, OVAp-CRT protected immunized mice against OVA-expressing B16 melanoma cells in vivo. …”
Get full text

Properties of Actinobacillus pleuropneumoniae isolates by V. А. Evgrafova, О. V. Pruntova, N. B. Shadrova, А. М. Timina

“…Actinobacillus рleuropneumoniae isolates were tested for their pathogenic properties by experimental infection of white mice and 2.5–3 month-old piglets. All tested isolates were pathogenic for both white mice and piglets. …”
Get full text

Metformin delays the decline in thermogenic function of brown adipose tissue in a mouse model of Hutchinson-Gilford progeria syndrome by Xin Xiang, Yuyue Feng, Hongcheng Li, Wenbo Li, Jia Li, Zhu Xia, Hua Pang, Zhengjie Wang

“…To mitigate the age-related decline in BAT thermogenic capacity, we treated progeroid mice with metformin to investigate the potential mechanisms by which metformin can slow the reduction in BAT thermogenic function. …”
Get full text

Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines by Elizabeth Curtiss, Youde Jiang, Li Liu, Claire Hawthorne, Jessica Zhang, Jena J. Steinle

“…Confocal microscopy was performed to localize the insulin receptor in the retina of Epac1 floxed and endothelial cell-specific Epac1 knockout mice. Whole retinal lysates from Epac1 floxed and endothelial cell-specific Epac1 knockout mice were used to investigate proteins involved in the insulin signaling cascade. …”
Get full text

Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia by Ke Zhang, Zhenfeng Dai, Runzhe Liu, Fang Tian, Xi Liu, Yi Sun, Xin Zhao, Xiaoping Pu

“…The antiplatelet sera were derived from guinea pigs immunized with the platelets of BALB/c mice. Mice with ITP were treated with icaritin at low, moderate, or high doses of 4.73, 9.45, and 18.90 mg/kg, respectively, for fourteen consecutive days. …”
Get full text

Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue by Ye Seul Park, Md Jamal Uddin, Lingjuan Piao, Inah Hwang, Jung Hwa Lee, Hunjoo Ha

“…Thus, we examined the role of endogenous catalase, a key regulator of oxidative stress, in the activity of adipose tissue macrophages in obese mice. Catalase knockout (CKO) exacerbated insulin resistance, amplified oxidative stress, and accelerated macrophage infiltration into epididymal white adipose tissue in mice on normal or high-fat diet. …”
Get full text

Extracts of Coreopsis tinctoria Nutt. Flower Exhibit Antidiabetic Effects via the Inhibition of α-Glucosidase Activity by Wujie Cai, Lijing Yu, Yu Zhang, Li Feng, Siyuan Kong, Hongsheng Tan, Hongxi Xu, Cheng Huang

“…The aim of this study was to assay the effects of Coreopsis tinctoria Nutt. flower extracts on hyperglycemia of diet-induced obese mice and the underlying mechanisms. Coreopsis tinctoria flower was extracted with ethanol and water, respectively. …”
Get full text

Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes by Hirofumi Nagao, Hitoshi Nishizawa, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Norikazu Maeda, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura

“…The plasma glutamate level was most significantly increased in obese mice compared to control mice, and it was negatively correlated with APN. …”
Get full text

Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy by Heng Zhou, Guomin Xie, Yudi Mao, Ke Zhou, Ruixue Ren, Qihong Zhao, Hua Wang, Shi Yin

“…Predamaged livers in mice were induced by concanavalin A (ConA)/carbon tetrachloride (CCl4) following PHx with or without IL-22-FP treatment. …”
Get full text

Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism by Michael L. Cunningham, Bradley J. Collins, Milton R. Hejtmancik, Ronald A. Herbert, Gregory S. Travlos, Molly K. Vallant, Matthew D. Stout

“…There was morphologic evidence of peroxisome proliferation in rats and mice. Increased hepatocyte proliferation was observed in rats, primarily at the earliest time point. …”
Get full text