Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…Whereas previous research demonstrated improved sepsis survival in Ticam2 -/- mice, the contribution of TICAM2 to long-term exhaustion memory remained unknown. …”
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Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins by Donna Brennan, Ying Hu, Walid Medhat, Alicia Dowling, Mỹ G. Mahoney

“…In response to PF Ig, we observed either a dramatic loss or a reorganization of Dsg1-α, Dsg1-β, and, to a lesser extent, Dsg1-γ, in WT mice. The Inv-Dsg2 Tg mice showed enhanced retention of Dsg1 at the cell-cell border. …”
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Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis by Weishuai Zheng, Menglin Zou, Xingxing Hu, Han Gao, Weiwei Song, Qinhui Hou, Yuan Liu, Zhenshun Cheng

“…HE4 knockdown primarily in epithelial cells attenuates BLM-induced PF in mice, whereas the administration of recombinant mouse HE4 exacerbates fibrosis after BLM stimulation. …”
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Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier by Shinobu Watarai, Tana Iwase, Tomoko Tajima, Eiji Yuba, Kenji Kono

“…The usefulness of pH-sensitive fusogenic polymer-(succinylated poly(glycidol)-(SucPG-) modified liposomes as a vaccine carrier in the induction of immune responses was evaluated. Mice were intraperitoneally immunized with ovalbumin- (OVA-) containing SucPG-modified liposomes. …”
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Local Gene Transfer of OPG Prevents Joint Damage and Disease Progression in Collagen-Induced Arthritis by Qingguo Zhang, Weiming Gong, Bin Ning, Lin Nie, Paul H. Wooley, Shang-You Yang

“…Clinical disease scores were significantly improved in OPG treated mice starting at 28-day post-treatment (P<0.05). …”
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A Study of the Granulomatous Responses Induced by Different Strains of Schistosoma mansoni by Nádia Regina Borim Zuim, Silmara Marques Allegretti, Arício Xavier Linhares, Luiz Augusto Magalhães, Eliana Maria Zanotti-Magalhães

“…Four experimental groups were analyzed. Two groups contained mice inoculated in the caudal vein with eggs from the S. mansoni BH or SJ strains and the other two contained mice that were infected with cercariae of the BH strain prior to being inoculated with eggs. …”
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NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease by Honglei Guo, Xiao Bi, Ping Zhou, Shijian Zhu, Wei Ding

“…The severe glomerular injury and tubulointerstitial fibrosis induced in WT mice by UUO was markedly attenuated in NLRP3−/− mice as evidenced by blockade of extracellular matrix deposition, decreased cell apoptosis, and phenotypic alterations. …”
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Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3 by Rodrigo F. Torres, Bredford Kerr

“…Increased DNA methylation was observed in hippocampal samples from spatially trained mice, and increased DNA hydroxymethylation was found in samples from mice trained using a visible platform. …”
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Neuronal BDNF Signaling Is Necessary for the Effects of Treadmill Exercise on Synaptic Stripping of Axotomized Motoneurons by Joey Krakowiak, Caiyue Liu, Chandana Papudesu, P. Jillian Ward, Jennifer C. Wilhelm, Arthur W. English

“…No further reduction in coverage was found if nerves were cut in knockout mice. Two weeks of moderate daily treadmill exercise following nerve injury in these BDNF knockout mice did not affect synaptic inputs onto motoneurons. …”
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In Vivo and In Vitro Studies Assessing the Antiviral Efficacy of Double Combinations Against Coxsackievirus B Infection by Adelina Stoyanova, Simeon Galabov, Vadim Makarov, Angel S. Galabov

“…The CAA combinations of pleconaril achieved a survival rate, in infected mice, of up to 59%, while the combinations of MDL-860 showed no significant effects. …”
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Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells by Zeenath Unnisa, Kameshwar P. Singh, Ellen C. Henry, Catherine L. Donegan, John A. Bennett, Thomas A. Gasiewicz

“…We examined BM and niche cells harvested from 8-week-old AHR null-allele (KO) mice in which exon 3 was deleted in the Ahr gene and compared these data to cells from B6 control mice; young and old (10 months) animals were also compared. …”
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Corynebacteria from the respiratory microbiota modulate inflammatory responses and associate with a reduced pneumococcal burden in the lungs by Caroline Bergenfelz, Phuong Do, Liv Larsson, Hanna Ivarsson, Kasper Malmborn, Anders P. Håkansson

“…The specific role of Corynebacteria during respiratory health and disease is, however, largely uncharacterized.MethodRespiratory tract epithelial cells NCI-H292 and BALB/cByJ mice were inoculated with Corynebacteria (C. propinquum 2018M3 and 2019M4, and C. pseudodiphtheriticum 2019M8 and 2020M12) alone or with subsequent challenge with Streptococcus pneumoniae (pneumococci). …”
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iNOS Promotes the Development of Osteosarcoma via Wnt/β-Catenin Pathway by Wei Chu, Lirong Cao, Gui Daokun, Jiali Zhao

“…Western blotting determined the expressions of iNOS, MMP2, MMP9, C-MYC, Ki67, PCNA, and β-catenin. Mice transfected with OS cells were to evaluate tumor formation. …”
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Hypermethylation of Hif3a and Ifltd1 is associated with atrial remodeling in pressure-overload murine model by Keiko Abe, Tetsuo Sasano, Yurie Soejima, Haruhisa Fukayama, Shigeru Maeda, Tetsushi Furukawa

“…After 14 days, the TAC-operated mice showed a significant increase in the atrium/body weight ratio and deposition of collagen fibers in the atria. …”
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Salivary stimulatory and anti-inflammatory effects of aqueous Lilium brownii var. viridulum Baker extract for Sjögren’s syndrome: in vitro and in vivo studies by Na-Yeon Ha, Haein Jeong, Mun Seog Chang, Jinsung Kim

“…This study evaluated LB’s efficacy in alleviating xerostomia using non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice and human salivary gland acinar (NS-SV-AC) cells. …”
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The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease by Xudong Sha, Jiayuan Lin, Kexin Wu, Jia Lu, Zhihua Yu

“…Capsaicin also rescued neuronal loss, tau pathology, and memory impairment in 3xTg mice. Our study suggests that TRPV1-PKM2-SREBP1 axis regulation of microglia lipid metabolism could be a therapeutic approach to alleviate the consequences of AD.…”
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Interleukin-4 (IL-4) enhances and soluble interleukin-4 receptor (sIL-4R) inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo by B. Niggemann, T. Zuberbier, U. Herz, K. Enssle, U. Wahn, H. Renz

“…The effects of IL-4 and sIL4R were dose- and time-dependent. Mice sensitized to ovalbumin and treated with soluble recombinant murine sIL-4R showed significantly reduced immediate-type cutaneous hypersensitivity responses compared with untreated mice. …”
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Skeletal Muscle-Specific CPT1 Deficiency Elevates Lipotoxic Intermediates but Preserves Insulin Sensitivity by Wanchun Shi, Siping Hu, Wenhua Wang, Xiaohui Zhou, Wei Qiu

“…CPT1b M−/− model was successfully established, with impaired muscle CPT1 activity. Compared with CPT1b mice, CPT1b M−/− mice had similar food intake but lower body weight or fat mass and higher lipids but similar glucose or insulin levels. …”
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Neuropharmacological profile of new thiazepinone and thiazolidinone compounds designed by virtual screening by Juan Sebastian Carrero-Sandoval, Paola Andrea Cuervo-Prado, Fabian Orozco-Lopez, Christian Alonso Becerra-Rivas, Estefany Arias-Quiroz, Mario Francisco Guerrero-Pabón

“…Abstract To evaluate the neuropharmacological profile of new spiro thiazepinone and thiazolidinone compounds in CD1 mice after a computer-aided virtual screening based on a GABA-A/BZD site. …”
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Toll-Like Receptor-4 Mediated Inflammation Is Involved in the Cardiometabolic Alterations Induced by Intermittent Hypoxia by Laureline Poulain, Vincent Richard, Patrick Lévy, Maurice Dematteis, Claire Arnaud

“…Lean adult male TLR4-deficient (TLR4−/−) mice and their controls (C57BL/6 mice) were exposed to either IH (FiO2 21-5%, 1 min cycle, 8 h/day) or air (normoxic mice) for 4 weeks. …”
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