Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…Allogenic bone-marrow transplantation (BMT) was performed from B10.D2. to BALB/c mice, leading to sclerodermatous GVHD. GVHD mice were treated with delgocitinib eye drops or ointment with samples analyzed at 4 weeks post-BMT. …”
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Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model by Ming-Jen Chen, Tsang-En Wang, Shu-Jung Tsai, Ching-Chung Lin, Chia-Yuan Liu, Horng-Yuan Wang, Shou-Chuan Shih, Yu-Jen Chen

“…Half of the mice were sacrificed at day 76 to measure the amount of ascitic fluid and pancreatic tumor volume. …”
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Lactoferrin alleviates the adverse effects of early-life inflammation on depression in adults by regulating the activation of microglia by Wenli Wang, Qin An, Yunxia Zou, Yunping Dai, Qingyong Meng, Yali Zhang

“…Lactation LF-deficient mice were established by nursing wild-type mice using LF systemic knockout mother mice. …”
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Ventral Prostate Fibrosis in the Akita Mouse Is Associated with Macrophage and Fibrocyte Infiltration by Sanghee Lee, Guang Yang, William Mulligan, Jerry Gipp, Wade Bushman

“…We observed significantly greater numbers of monocytes/macrophages and fibrocytes specifically in the ventral prostate of the Akita mice and found that this was associated with significant greater collagen content specifically in the ventral prostate of the Akita mice. …”
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Lack of adipocyte FAM20C improves whole body glucose homeostasis by Liping Deng, Yanshan Huang, Feifei Zhao, Puxin Chen, Xiaohong Huang

“…Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. …”
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Genotoxicity Assessment and Protective Effect of Anogeissus leiocarpus Roots against Cyclophosphamide-Induced DNA Damage In Vivo by Aku Enam Motto, Povi Lawson-Evi, Aboudoulatif Diallo, Kwashie Eklu-Gadegbeku

“…Hence, this study was designed to evaluate the potential genotoxic and protective effects of extract of Anogeissus leiocarpus roots using the micronucleus test on mice bone marrow cells in vivo. Methods. Three different concentrations (250, 500, and 1000 mg·kg−1) of hydroalcoholic extract of roots of A. leiocarpus were administered daily for 7 days per os to mice, and the genotoxicity was induced by the administration ip of cyclophosphamide. …”
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Antinociceptive and Anti-Inflammatory Activities of Leaf Methanol Extract of Cotyledon orbiculata L. (Crassulaceae) by George J. Amabeoku, Joseph Kabatende

“…Leaf methanol extract of C. orbiculata L. was investigated for antinociceptive and anti-inflammatory activities using acetic acid writhing and hot-plate tests and carrageenan-induced oedema test in mice and rats, respectively. C. orbiculata (100–400 mg/kg, i.p.) significantly inhibited acetic acid-induced writhing and significantly delayed the reaction time of mice to the hot-plate-induced thermal stimulation. …”
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Efficacy of melatonin treatment in a cystic fibrosis mouse model of airway infection by Kristen R. Schaefer, Sara Rogers, Zachary Faber, Thomas J. Kelley

“…Melatonin-treated mice exhibited improved bacterial clearance, reduced inflammatory markers. …”
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Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor by Ke Sun, Yong-Li Wang, Chen-Chen Hou, Da Shang, Lin-Juan Du, Lan Bai, Xing-Yu Zhang, Chuan-Ming Hao, Sheng-Zhong Duan

“…KO mice also showed significantly higher BP than littermate control (LC) mice in deoxycorticosterone acetate (DOCA)-salt model. …”
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Caffeic Acid Phenethyl Ester Protects Neurons Against Oxidative Stress and Neurodegeneration During Traumatic Brain Injury by Nurul Sulimai, Jason Brown, David Lominadze

“…A cortical contusion injury -induced model of TBI in C57BL/6 mice was used. Mice were treated with CAPE for two weeks. …”
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Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics by Xiuwei Shen, Xiangyi Dai, Yifan He, Congcong Wen, Qingwei Zhang

“…The oral bioavailability of senegenin and tenuifolin in mice was 8.7% and 4.0%, respectively. The established UPLC-MS/MS method is suitable for pharmacokinetic studies of senegenin and tenuifolin in mice.…”
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Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies by Kazunari Sekiyama, Shuei Sugama, Masayo Fujita, Akio Sekigawa, Yoshiki Takamatsu, Masaaki Waragai, Takato Takenouchi, Makoto Hashimoto

“…To better understand neuroinflammation in PD, we focused on glial activation in α-synuclein (αS) transgenic and related model mice. In the majority of αS transgenic mice, astrogliosis was observed concomitantly with accumulation of αS during the early stage of neurodegeneration. …”
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Moxibustion Regulates the BRG1/Nrf2/HO-1 Pathway by Inhibiting MicroRNA-222-3p to Prevent Oxidative Stress in Intestinal Epithelial Cells in Ulcerative Colitis and Colitis-Associat... by Xuejun Wang, Haiyang Ji, Yanting Yang, Dan Zhang, Xiehe Kong, Xiaoying Li, Hongna Li, Yunqiong Lu, Guang Yang, Jie Liu, Huangan Wu, Jue Hong, Xiaopeng Ma

“…The effect of HPM was inhibited in miR-222-3p overexpression mice, further demonstrating that the protective effect of HPM on UC and CAC mice was through inhibiting miR-222-3p. …”
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Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic... by Anna Lethicia L. Oliveira, Gisele G. L. Santos, Renan F. Espirito-Santo, Gessica Sabrina A. Silva, Afrânio F. Evangelista, Daniela N. Silva, Milena B. P. Soares, Cristiane Flora Villarreal

“…Importantly, this mitochondrial atypia was strongly reduced in MSC-treated neuropathic mice. Moreover, MSC-treated neuropathic mice showed upregulation of Sod and Nrf2 mRNA in the sciatic nerve and DRG. …”
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Per1/Per2 double knockout transcriptome analysis reveals circadian regulation of hepatic lipid metabolism by Yiran Bu, Si Chen, Mengcheng Ruan, Libang Wu, Hualin Wang, Na Li, Xiuju Zhao, Xiaoli Yu, Zhiguo Liu

“…At the end of the experiment, mice were sacrificed at zeitgeber time (ZT) 0 (7:00 am) or ZT12 (7:00 pm). …”
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ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism by Erin McLean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu

“…Administration of STZ and U0126 in mice was performed via intraperitoneal injection. …”
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Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver by Yuki Ito, Toshiki Nakamura, Yukie Yanagiba, Doni Hikmat Ramdhan, Nozomi Yamagishi, Hisao Naito, Michihiro Kamijima, Frank J. Gonzalez, Tamie Nakajima

“…The activation of PPARα was stronger in mPPARα mice than in hPPARα mice, while the opposite was true of CAR.…”
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Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency by Yunting Zhou, Junming Zhou, Yumin Zhang, Jun Tang, Bo Sun, Wei Xu, Xiaohang Wang, Yang Chen, Zilin Sun

“…Here, we explored whether and how intestinal microbiota affects glucose homeostasis in VA-deficient diet-fed mice. Methods. Six-week-old male C57BL/6 mice were randomly placed on either a VA-sufficient (VAS) or VA-deficient (VAD) diet for 10 weeks. …”
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TOXICOLOGIC CHARACTERISTICS OF THE PREVENTIVE IODINE-CONTAINING PREPARATION “VANGTSEYOD” by T. V. Kruchinkina, Yu. A. Gavrilov, G. A. Gavrilova

“…It’s inclusion into mice diet at 1.0 and 2.0 g/kg dose during two months did not induce any signs of chronic intoxication as 100% mice of experimental group survived in comparison with the control group (57%). …”
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Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease by Yan Wu, Narayan R. Bhat, Meng Liu

“…We performed a sleep study on Tg-SwDI mice, a cerebral amyloid angiopathy (CAA) model, and age-matched wild-type (WT) control mice. …”
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