Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection by Chandran Ramakrishna, Mari S. Golub, Abby Chiang, Teresa Hong, Markus Kalkum, Edouard M. Cantin

“…Anxiety levels were high in HSV-infected PBS and ACV-treated mice compared to mice treated with ACV + IVIG, consistent with reports implicating inflammation in anxiety induced by lipopolysaccharide (LPS) or stress. …”
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Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin by Esben Axelgaard, Jakob Appel Østergaard, Steffen Thiel, Troels Krarup Hansen

“…MBL was found to accumulate in the kidneys of diabetic mice as compared to healthy control mice (p<0.0001). …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Methods We performed single-cell RNA sequencing (scRNA-seq) analyses to elucidate immune and structural milieu in the intestinal epithelium of MRL/Lpr lupus mice (Lpr mice) and MRL/Mpj control mice (Mpj mice). …”
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The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis by Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

“…There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/−) mice are a translatable disease model for glucose control in type 2 diabetes. …”
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Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X Receptor Alpha by Yu-Jui Yvonne Wan, Mostafa Z. Badr

“…These effects were also significantly diminished or absent in hepatocyte-specific RXRα-deficient mice. In contrast, aspirin reduced carrageenan-induced paw edema equally in WT and hepatocyte-specific RXRα-deficient mice. …”
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miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury by Liufang He, Tingyan Wei, Yong Huang, Xueli Zhang, Dongbo Zhu, Huazhen Liu, Zhangxing Wang

“…Pharmacology inhibition of caspase-1 cleavage alleviated the pathogenesis of WMI mice. The expression of microRNA miR-214-3p was largely reduced in the microglia of WMI mice compared to controls. …”
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Cytokine Profile of Mouse Vaginal and Uterus Lymphocytes at Estrus and Diestrus by Maria C. Lopez, Margaret A. Stanley

“…Two different mice strains, BALB/c and C57BL/6 mice, were used. …”
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The Role of Dendritic Cell Subsets in Recurrent Spontaneous Abortion and the Regulatory Effect of Baicalin on It by Nannan Lai, Xiaoxiao Fu, Guozhen Hei, Weiwei Song, Ran Wei, Xiaoxiao Zhu, Qiang Guo, Zhen Zhang, Chu Chu, Ke Xu, Xia Li

“…Here, we analyzed the changes of peripheral and maternal-fetal interface DC subsets and function in patients and mice with RSA, respectively. Then, we further treated RSA mice with baicalin and analyzed the therapeutic effect and underlying mechanism. …”
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Chitosan as an Immunomodulating Adjuvant on T-Cells and Antigen-Presenting Cells in Herpes Simplex Virus Type 1 Infection by Bunsoon Choi, Do-Hyun Jo, A. K. M. Mostafa Anower, S. M. Shamsul Islam, Seonghyang Sohn

“…The frequencies of DC and NK cells were also significantly different between chitosan treated mice and control mice. In addition, anti-HSV IgG antibody was downregulated in chitosan treated mice. …”
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High-fat diet triggers transcriptomic changes in the olfactory bulb by Young-Kook Kim, Danbi Jo, Seoyoon Choi, Juhyun Song

“…This study investigated transcriptomic changes in the olfactory bulb in high-fat diet (HFD)-fed mice compared to that in normal-diet–fed mice. We sampled olfactory bulbs from HFD-fed mice, performed RNA sequencing, and measured mRNA levels in olfactory bulb tissue. …”
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Synergistic Effect of Hyperglycemia and Suppression on Adult Mouse Islet Beta Cell Replication by Szu-Tah Chen, Shin-Huei Fu, Samuel Hsu, Yu-Yao Huang, Brend Ray-Sea Hsu

“…The mice in the targeting-islet group had a significantly shorter duration of temporary hyperglycaemia than mice in the non-targeting-islet group. …”
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Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy by Chin-Wei Chiang, Hsueh-Te Lee, Der-Cherng Tarng, Ko-Lin Kuo, Li-Ching Cheng, Tzong-Shyuan Lee

“…The protein level of sEH in kidney was increased in UUO-treated mice group compared to nonobstructed group. Additionally, UUO-induced hydronephrosis, renal tubular injury, inflammation, and fibrosis were ameliorated in sEH−/− mice with the exception of glomerulosclerosis. …”
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Second-Hand Smoke Increases Bronchial Hyperreactivity and Eosinophilia in a Murine Model of Allergic Aspergillosis by Brian W. P. Seymour, Edward S. Schelegle, Kent E. Pinkerton, Kathleen E. Friebertshauser, Janice L. Peake, Viswanath P. Kurup, Robert L. Coffman, Laurel J. Gershwin

“…Mice that were sensitized to Af antigen and exposed to ETS developed significantly greater airway hyperreactivity than did mice similarly sensitized to Af but housed in ambient air. …”
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Regular Voluntary Exercise Potentiates Interleukin-1β and Interleukin-18 Secretion by Increasing Caspase-1 Expression in Murine Macrophages by Ken Shirato, Kazuhiko Imaizumi, Takuya Sakurai, Junetsu Ogasawara, Hideki Ohno, Takako Kizaki

“…These results indicate that the increased IL-1β and IL-18 secretion in VE mice are regulated posttranscriptionally. On the other hand, macrophages from VE mice showed higher amounts of caspase-1 protein than did cells from SC mice. …”
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Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Mi-Rae Shin, Sung Ho Shin, Seong-Soo Roh

“…Serum AST, ALT, and TG levels in the HFD control mice were significantly higher than those of normal mice. …”
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Morphometric parameters of pelvic lymph nodes in experimental metastatic prostate cancer by V. V. Astashov, N. G. Kulchenko

“…The study included 30 male mice aged 3 months. All animals (n = 30) were divided into 2 groups. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…We found that the Tregs in TLR2−/− mice were significantly reduced and the nonlethal dose of A. fumigatus conidia did not cause severe lung damage in TLR2−/− mice. …”
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Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model by Tereza Hornikova, Anna Jelinkova, Zuzana Jiraskova Zakostelska, Tomas Thon, Stepan Coufal, Andrea Polouckova, Eliska Kopelentova, Miloslav Kverka, Peter Makovicky, Helena Tlaskalova-Hogenova, Anna Sediva, Martin Schwarzer, Dagmar Srutkova

“…Changes in the β-diversity of the gut microbiome reflect both the genetic background as well as the OVA treatment of experimental mice. Compared to SPF mice, GF mice developed more severe anaphylactic hypothermia but no diarrhea, although they had a higher mast cell count, increased MCPT-1 production in the jejunum and serum, and increased arachidonate 5-lipoxygenase mRNA expression.ConclusionsWe show that the BALB/c mice are a mouse strain of choice for model of adjuvant-free epicutaneous sensitization through the disrupted skin barrier and following food allergy development. …”
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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

“…We have reported that pre-mature vascular aging in MFS mice could extend to cerebrovasculature, where peak blood flow velocity in the posterior cerebral artery (PCA) of 6-month-old (6M) MFS mice was reduced, similarly to 12-month-old (12M) control mice. …”
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Hamster and Murine Models of Severe Destructive Lyme Arthritis by Erik Munson, Dean T. Nardelli, Brian K. Du Chateau, Steven M. Callister, Ronald F. Schell

“…Infection of immunocompetent LSH hamsters or C3H mice results in a transient synovitis. However, severe destructive Lyme arthritis can be induced by infecting irradiated hamsters or mice and immunocompetent Borrelia-vaccinated hamsters, mice, and interferon-gamma- (IFN-γ-) deficient mice with viable B. burgdorferi. …”
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