Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice by Wei Wei, Zhicheng Lin, PeiTao Xu, Xinru Lv, Libin Lin, Yongxu Li, Yangjie Zhou, Taotao Lu, Xiehua Xue

“…Twenty-week-old ApoE-/- mice were fed a HFD for 8 weeks and then were treated with diet control and/or swimming for 8 weeks. …”
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Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression by Naxin Sun, Guiwen Yang, Heng Zhao, Huub F. J. Savelkoul, Liguo An

“…On the other hand, the levels of IFN-γ or IL-4 of splenocytes in diabetic mice were significantly higher compared to the control mice. …”
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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

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Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice by Jing Xue, Yu Cheng, Haojie Hao, Jieqing Gao, Yaqi Yin, Songyan Yu, Junyan Zou, Jiejie Liu, Qi Zhang, Yiming Mu

“…Methods. We induced a T2D mice model by high-fat diets and streptozotocin (STZ) injection. …”
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Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice by Hailyn V. Nielsen, Letitia Yang, James L. Mueller, Alexander J. Ritter, Ryosuke Hiwa, Irina Proekt, Elze Rackaityte, Dominik Aylard, Mansi Gupta, Christopher D. Scharer, Mark S. Anderson, Byron B. Au-Yeung, Julie Zikherman

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Therapeutic Efficacy of Intranasal <i>N</i>-Acetyl-L-Cysteine with Cell-Penetrating Peptide-Modified Polymer Micelles on Neuropathic Pain in Partial Sciatic Nerve Ligation Mice by Hiroshi Nango, Ai Takahashi, Naoto Suzuki, Takumi Kurano, Saia Sakamoto, Taiki Nagatomo, Toyofumi Suzuki, Takanori Kanazawa, Yasuhiro Kosuge, Hiroko Miyagishi

“…<b>Results</b>: Mechanical allodynia was exacerbated 11 days after the ligation in PSNL mice. The intranasal administration of NAC alone prevented allodynia exacerbation but failed to provide a therapeutic effect against allodynia in PSNL mice. …”
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Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil by Eliana Lucchinetti, Phing-How Lou, Alessandro Quaranta, Craig E. Wheelock, Akash Chakravarty, Martin Hersberger, Stefanie D. Krämer, Michael Zaugg

“…Mice infused with 0.9% saline and free access to water and rodent diet served as controls. …”
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<i>Sambucus nigra</i>-Lyophilized Fruit Extract Attenuated Acute Redox–Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephrotoxicity by Kamelia Petkova-Parlapanska, Ivaylo Stefanov, Julian Ananiev, Tsvetelin Georgiev, Petya Hadzhibozheva, Veselina Petrova-Tacheva, Nikolay Kaloyanov, Ekaterina Georgieva, Galina Nikolova, Yanka Karamalakova

“…<b>Methods:</b> The <i>S. nigra</i> extract was lyophilized (300 rpm; 10 min; −45 °C) to improve pharmacological properties. Balb/c mice were divided into four (n = 6) groups: controls; <i>S. nigra</i> extract per os (120 mg kg⁻¹ day⁻¹ bw); GM (200 mg kg⁻¹ day⁻¹ bw) (4); and GM + <i>S. nigra</i> therapy. …”
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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Diabetic Mice by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Immunopathological analysis showed that Foxp3+ Tregs accumulated in the islets in RGI-3100-iB-treated mice. Cotransfer of diabetogenic T cells and splenocytes of NOD mice treated with RGI-3100-iB, but not liposomal α-GalCer encapsulating an unrelated peptide, to NOD-SCID mice resulted in the prevention of diabetes and elevation of Foxp3 mRNA expression in the islets. …”
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Retinal Levels of Amyloid Beta Correlate with Cerebral Levels of Amyloid Beta in Young APPswe/PS1dE9 Transgenic Mice before Onset of Alzheimer’s Disease by Xi Mei, Mengxiang Yang, Lina Zhu, Qi Zhou, Xingxing Li, Zhongming Chen, Chenjun Zou

“…Methods. APP mice and age-matched wild-type mice were investigated every month from age 2 months to 6 months to assess changes in Aβ content in the retina and cerebrum. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-&kappa;B/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…The effect of IRAK3 on ICH mice was assessed by Western blotting and short-term and long-term neurological function evaluation. …”
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Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune Responses in Mice by Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic

“…Due to the fact that IM delivery of NoV VLPs does not generate mucosal immunity, we investigated whether NoV genotype GII.4 VLPs coadministered with aluminum hydroxide (Al(OH)3) or monophosphoryl lipid A (MPLA) would induce mucosal antibodies in mice. Systemic as well as mucosal IgG and IgA antibodies in serum and intestinal and nasal secretions were measured. …”
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The expression of apoptosis-regulating proteins Bcl-2 and Bad in liver cells of C57Bl/6 mice under light-induced functional pinealectomy and after correction with melatonin by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, A. Yu. Letyagin, M. A. Korolev, E. L. Zavjalov

“…To create LIFP, C57Bl/6 mice were kept under 24-hour lighting (24hL) for 14 days. …”
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Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice by Denis N. Kisakov, Larisa I. Karpenko, Lyubov A. Kisakova, Sergey V. Sharabrin, Mariya B. Borgoyakova, Ekaterina V. Starostina, Oleg S. Taranov, Elena K. Ivleva, Oleg V. Pyankov, Anna V. Zaykovskaya, Elena V. Dmitrienko, Vladimir A. Yakovlev, Elena V. Tigeeva, Irina Alekseevna Bauer, Svetlana I. Krasnikova, Nadezhda B. Rudometova, Andrey P. Rudometov, Artemiy A. Sergeev, Alexander A. Ilyichev

“…Then, we used the selected protocol to immunize BALB/c mice with mRNA-RBD encoding the SARS-CoV-2 receptor-binding domain (RBD). …”
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Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model by Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza, Anderson Miyoshi

“…Therefore, the aim of this study was to investigate the effect of orally administered Lactococcus lactis MG1363 FnBPA+ strains carrying plasmids encoding IL-4 and IL-10 in the streptozotocin- (STZ-) induced diabetes model and in nonobese diabetic (NOD) mice. The STZ-induced mice that were treated with combined bacterial strains carrying plasmids encoding IL-4 and IL-10 showed lower incidence of diabetes and more preserved pancreatic islets than the mice that received the individual bacterial strains. …”
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Effect of Exogenous of Transforming Growth Factor-β1 on Pregnancy Outcome in Mice with Recurrent Pregnancy Loss by Persistent Enhancement of Placental Tissue Indoleamine 2,3-Dioxygenase Expression by Xinghui Wen, Xiaojuan Chen, Mei Li, Jinnian Zhou, Shouli Dao, Shixiang Li, Hui Cheng, Shuyun Zhao, Guanyou Huang

“…The mice were sacrificed at 13.5 days of pregnancy and the embryo resorptionrate was determined. …”
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The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice by Yange Liu, Ronglong Chen, Lanzhou Li, Ruitao Dong, Hui Yin, Yawen Wang, Anhui Yang, Jianbin Wang, Changtian Li, Di Wang

“…This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia (ACT) in chronic alcohol-induced liver injury mice, establishing in C57BL/6 mice through gradient alcohol feeding for 24 weeks. …”
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Momordica Charantia Polysaccharides Attenuates MPP+-Induced Injury in Parkinson’s Disease Mice and Cell Models by Regulating TLR4/MyD88/NF-κB Pathway by Dengjun Guo, Jie Zhou, Meng Zhang, Reyisha Taximaimaiti, Xiaoping Wang, Hai Wang

“…Method. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (1-methyl-4-phenylpyridinium, MPP+) were used to establish PD mice and cell models. The mice and cells were divided into 4 groups: Control group, Control+MCPs group, PD group, and PD+MCPs group. …”
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Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic pathways and BDNF expression by Hart Mann Alain Youbi Mambou, Simon Pale, Orelien Sylvain Mtopi Bopda, Vanessa Tita Jugha, Nji Seraphin Ombel Musa, Tambong Ako Ojongnkpot, Bertrand Yuwong Wanyu, Raymond Bess Bila, Rashed N. Herqash, Abdelaaty A. Shahat, Germain Sotoing Taiwe

“…Then, 23 hours after the injection of pilocarpine to the mice, once again, they received their different treatments. …”
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IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells by Li Cheng, Yang Jiao, Wei Jiang, Xin Zhang, Liping Zhang, Gongwei Jia

“…Methods. IL-33 gene knockout mice and the administration of recombinant mouse IL-33 (rmIL-33) were used to investigate the role of IL-33 and the underlying mechanisms in an LPS-induced ARDS model. …”
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