Activation of PPARγ Protects Obese Mice from Acute Lung Injury by Inhibiting Endoplasmic Reticulum Stress and Promoting Mitochondrial Biogenesis by Yin Tang, Ke Wei, Ling Liu, Jingyue Ma, Siqi Wu, Wenjing Tang

“…We determined PPARγ expression in the lung tissues of normal and obese mice. ALI models of alveolar epithelial cells and of obese mice were used and treated with either PPARγ activator rosiglitazone (RSG) or PPARγ inhibitor GW9662. …”
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Continuous Consumption of Reused Palm Oil Induced Hepatic Injury, Depletion of Glutathione Stores, and Modulation of Cytochrome P450 Profiles in Mice by Waranya Chatuphonprasert, Yollada Sriset, Kanokwan Jarukamjorn

“…This study evaluated the effects of palm ( Elaeis guineensis Jacq.) oil on hepatic histology, redox status, and cytochrome P450 (CYP) profiles. Adult female mice were orally given purified water (control), fresh, or reused palm oil (4.5 g/kg/day) daily for 16, 24, and 36 weeks. …”
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Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses by Subhadip Das, Nabanita Chatterjee, Dipayan Bose, Somenath Banerjee, Prajnamoy Pal, Tarun Jha, Krishna Das Saha

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Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice by Weifeng Gu, Tingting Zheng, Wen Li, Xinkai Luo, Xiaowei Xu, Ying Wang, Chaoming Mao, Yongbin Ma, Liyang Dong

“…More importantly, we found that adoptive transfer of hUCMSC-migrasomes-treated BMDCs was sufficient to protect mice from allergic airway inflammation. In addition, we found that hUCMSC-migrasomes inhibited the receptor for advanced glycation end-products (RAGE) signal in OVA-treated BMDCs in vitro and in asthma mice lung in vivo. …”
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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Therefore, in the present study, the effects of high-dose thiamine supplementation on HFFD-induced obesity and gut microbiota dysbiosis were investigated.MethodsHFFD-fed mice were supplemented with high-dose thiamine for eight weeks. …”
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Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice by Safhi Mohammed M., Alam Mohammad Firoz, Khuwaja Gulrana, Hussain Sohail, Siddiqui Mohammed Hakeem, Islam Farah, Khardali Ibrahim, Al-Sanosi Rashad Mohammed, Alhazmi Hassan A., Khan Andleeb, Islam Fakhrul

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Experimental opisthorchiasis: a study of blood cells, hematopoiesis and startle reflex in laboratory animals by D. F. Avgustinovich, I. A. Orlovskaya, L. B. Toporkova, G. B. Vishnivetskaya, A. V. Katokhin, M. N. Lvova, E. V. Kashina, N. P. Bondar, N. A. Feofanova, V. A. Mordvinov

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Mutation yellow in agouti loci prevents age-related increase of skeletal muscle genes regulating free fatty acids oxidation by Y. V. Piskunova, A. Y. Kazantceva, A. V. Baklanov, N. M. Bazhan

Subjects: “…c57bl/6j mice…”
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Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear by Peipei Li, Zongzhuang Wen, Guangkai Zhang, Aizhen Zhang, Xiaolong Fu, Jiangang Gao

“…No difference in hearing between 2-month-old Myo3a mutant mice and wild-type mice was observed. The hearing threshold of the ≥6-month-old mutant mice was significantly elevated compared with that of the wild-type mice. …”
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Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes by Yunus E. Dogan, Yunus E. Dogan, Yunus E. Dogan, Niharika Bala, Niharika Bala, Erika S. Galban, Erika S. Galban, Russell L. Lewis, Nancy D. Denslow, Sihong Song, Abdel A. Alli, Abdel A. Alli

“…Here, we hypothesized that administration of pharmaceutical-grade human AAT (hAAT) is effective in mitigating hypertension induced by salt-loading in juvenile mice by reducing the concentration of diacylglycerols (DAGs) and activity of protein kinase C (PKC) in the kidney.MethodsFour-week old 129Sv mice were salt-loaded to induce hypertension and then administered hAAT or vehicle.ResultsAdministration of hAAT was found to significantly reduce high blood pressure in both the active and inactive cycles of the 129Sv hypertensive mice. …”
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Electroacupuncture and Tongbian decoction ameliorate CUMS-induced depression and constipation in mice via TPH2/5-HT pathway of the gut-brain axis by Yi Chen, Peihua Shen, Qi Li, Shun Seng Ong, Yunzhi Qian, Hai Lu, Ming Li, Tianshu Xu

“…Chronic unpredictable mild stress (CUMS) was employed to induce a comorbidity model of depression and constipation in mice, followed by the administration of EA, EA + TB, and fluoxetine (FLX). …”
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Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice by Shailendra P. Singh, Lars Bellner, Luca Vanella, Jian Cao, John R. Falck, Attallah Kappas, Nader G. Abraham

“…Cultured murine adipocytes and mice fed a high fat (HF) diet were used to assess the functional relationship among EETs, PGC-1α, HO-1, and mitochondrial signaling using an EET-agonist (EET-A) and PGC-1α-deficient cells and mice using lentiviral PGC-1α(sh). …”
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Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice by Jin Zhang, Jin Zheng, Haitao Chen, Xinrong Li, Chenxiao Ye, Fan Zhang, Zewei Zhang, Qinghua Yao, Yong Guo

“…The 4T1 cells were subcutaneously injected into BALB/c mice to induce breast cancer cachexia. After tumor formation, the animals were divided into groups and given curcumin or saline interventions. …”
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The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

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Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model by Hossein Rahavi, Seyed Mahmoud Hashemi, Masoud Soleimani, Jamal Mohammadi, Nader Tajik

“…Pancreatic islets were isolated from normal mice and splenocytes prepared from normal and diabetic mice. …”
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Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease by Zhongquan Xin, Zhenya Zhai, Hongrong Long, Fan Zhang, Xiaojun Ni, Jinping Deng, Lunzhao Yi, Baichuan Deng

“…First, a refined and translationally relevant model of DSS chronic colitis in C57BL/6 mice was established, and cecropin A and antibiotics were used as interventions. …”
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Mixed vitamin C and zinc diet supplements co-administered with artemether drug improved haematological profile and survival of mice infected with Plasmodium berghei by Felicia N. Ekeh, Nkiru E. Ekechukwu, Chimdinma F. Chukwuma, Ifeanyi Oscar N. Aguzie, Chinenye M. Ohanu, Chike Ebido, Stanley N. Oluah

“…This study evaluated the effect of different combinations of vitamin C and zinc on haematological parameters and mortality of Plasmodium berghei-infected mice (Mus musculus). A three-week trial was carried out to assess haematological changes and mortality of mice after 3-day artemether treatment co-administered with vitamin C - zinc supplements. …”
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Wound-healing activity of solvent fractions and antiinflammatory activity of crude extract and solvent fractions of Acokanthera schimperi Schweinf (Apocynaceae) leaves in mice model by Workineh Woldeselassie Hammeso, Tesfaye Yimer, Getnet Tadege, Wakuma Wakene Jifar, Dejen Nureye

“…Purpose: Therefore, this experiment has been initiated to look into the solvent fractions' ability to heal wounds and the anti-inflammatory properties of the A. schimperi leaf 80 % methanol extract and its fractions in mice. Study design: The experimental study design was conducted to evaluate wound healing and the anti-inflammatory properties of the A. schimperi leaf 80 % methanol extract and its fractions in mice. …”
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Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway by Haijuan Liu, Guohua Wang, Conglu Sui, Yanan Guo, Xiangyu He

“…Some mice is induced by dehydroepiandrosterone sulfate (DHEA) and high-fat diet (HFD) for 3 weeks. …”
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BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice by Hong-Mei Li, Yan-Rong Gao, Qing Chang, Xiu-Ying Pei, Jia-He Sun, Yu-Jia Lin, Ya-Nan Tian, Qiang-Wang, Bin Zhao, Heidi Qunhui Xie, Hui-Ming Ma, Hai-Ming Xu

“…Similar disrupted effects were detected in testes of mice on PND14, which could be antagonized by ICI 182780 (estrogen receptor antagonist). …”
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