Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice by Zhe-Zhe Zhang, Li-Ping Zeng, Jing Chen, Yong-Fang Wu, Ya-Tao Wang, Lan Xia, Qi-Gang Yang, Fang Wang, Gui-Hai Chen

“…Analysis revealed that at 15 months of age, the control mice experienced a reduction in cognitive ability and elevated expression levels of Arc and Syt1 genes when compared to control mice at 3 months of age. …”
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Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair by Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo

“…More importantly, our in vivo functional experiment showed that combinational utilization of miR-124 overexpression and TMZ presents a synergetic therapeutic benefit in the orthotopic GBM mice model. Taken together, we rationally explained a novel and important mechanism of the miR-124-mediated high sensitivity to TMZ-induced cell death in GBM and provided evidence to support that miR-124-RAD51 regulatory axis could be a promising candidate in the comprehensive treatment with TMZ in GBM.…”
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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice by Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Maha Bikheet, Rokayya Sami, Hassan Mohamed, Xiangchen Meng

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Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage–myofibroblast transition by Yueyuan Zhou, Zhilan Li, Shenyi Yu, Xuan Wang, Tingting Xie, Weiru Zhang

“…Three different concentrations of iguratimod (30 mg/kg/day, 10 mg/kg/day, and 3 mg/kg/day) were used to intervene in unilateral ureteral obstruction (UUO) model mice. Iguratimod at 10 mg/kg/day was observed to be effective in slowing UUO-mediated renal fibrosis. …”
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Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice by Chao Tang, Weiwei Zhou, Mengyuan Shan, Zhaoxin Lu, Yingjian Lu

“…This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism, and suppressed microbial dysbiosis in high-fat diet (HFD)-fed mice. Results showed that oral administration of L. plantarum Q16 improved serum and hepatic lipid profile. …”
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B Cell Precursors in Senescent Mice Exhibit Decreased Mitotic Recruitment, Increased Apoptosis, and Altered Expression of Bcl-2 Family Members by Richard L. Riley, Erin M. Sherwood

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Paeoniflorin alleviates sepsis-associated acute kidney injury in mice by inhibiting aerobic glycolysis through the β-catenin/c-Myc pathway by GONG Yu, LEI Jiao, ZHANG Ming

“…Objective‍‍　‍To investigate the role and mechanism of paeoniflorin （PF） in sepsis-associated acute kidney injury （SA-AKI） in mice. Methods‍　‍Mouse SA-AKI model was constructed by intraperitoneal injection of 15 mg/kg LPS. …”
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Retracted: Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β-Cell Mass in Middle-Aged Obese Diabetic Mice by Journal of Diabetes Research

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Blockade of IL-17A/IL-17R Pathway Protected Mice from Sepsis-Associated Encephalopathy by Inhibition of Microglia Activation by Bo Ye, Tianzhu Tao, Andong Zhao, Liyuan Wen, Xiaofei He, Yi Liu, Qiang Fu, Weidong Mi, Jingsheng Lou

“…Furthermore, as compared to the sham control, microglia cultured from CLP mice produced significantly higher levels of cytokines and expressed with higher fluorescence intensity of Iba-1 in response to IL-17A or LPS. …”
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GV1001, hTERT Peptide Fragment, Prevents Doxorubicin-Induced Endothelial-to-Mesenchymal Transition in Human Endothelial Cells and Atherosclerosis in Mice by Wei Chen, Seojin Kim, Sharon Y. Kim, Cheyenne Beheshtian, Naryung Kim, Ki-Hyuk Shin, Reuben H. Kim, Sangjae Kim, No-Hee Park

“…Additionally, GV1001 reduced systemic and vascular inflammation, lipid accumulation, and monocyte/macrophage infiltration within arterial walls in mice. In conclusion, GV1001 appears to prevent doxorubicin-induced atherosclerosis by safeguarding vascular endothelial cells from mitochondrial dysfunction, inflammation, and phenotypic changes. …”
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The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice by Song M, Han M, Zhang H, Yang Y, Tian Y, Li J, Zhao J

“…The current study aimed to investigate the effect of ECC-BYF III on mitochondrial dysfunction in COPD mice and elucidate its potential mechanisms.Methods: Twenty-eight BALB/c mice were randomized into four groups: control, model, ECC-BYF III, and NAC (N-acetylcysteine) groups. …”
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The comparison of biodistribution of glutathione PEGylated nanoliposomal doxorubicin formulations prepared by pre‐insertion and post‐insertion methods for brain delivery in normal mice by Amin Mehrabian, Saba Dadpour, Mohammad Mashreghi, Javad Zarqi, Anis Askarizadeh, Ali Badiee, Leila Arabi, Seyedeh Alia Moosavian, Mahmoud Reza Jaafari

“…Next, in vivo biodistribution of the produced formulations was tested on healthy mice to see if GSGGCE, as the targeted ligand, could cross the BBB compared to 5% pre‐inserted PEG2000‐GSH and Caelyx®. …”
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High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis by Peng Zou, Tianjing Li, Zixuan Cao, Erwan Yang, Mingdong Bao, Haofuzi Zhang, Zhuoyuan Zhang, Dan Liu, Min Zhang, Xiangyu Gao, Junmiao Ge, Xiaofan Jiang, Zhicheng Tian, Peng Luo

“…Down-regulation of Bach1 can effectively alleviate high-altitude TBI-induced neurological deficits and histopathological changes in mice. In conclusion, high-altitude hypoxia may significantly enhance the ferroptosis of astrocytes and aggravate TBI by up-regulating Bach1 expression. …”
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Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Env–gag virus-like particles (VLPs) were generated through co-transfection with env and gag mRNA vaccines. BALB/c mice were immunized with env mRNA, env–gag VLP mRNA, env plasmid DNA vaccine, or lipid nanoparticle (LNP) controls. …”
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Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway by Zhitao Hou, Ruijin Qiu, Qingshuang Wei, Yitian Liu, Meng Wang, Tingting Mei, Yue Zhang, Liying Song, Xianming Shao, Hongcai Shang, Jing Chen, Zhongren Sun

“…Main Methods. Thirty male SAMP8 mice were randomly divided into the model, the 2 Hz EA and 10 Hz EA groups. …”
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Dietary Cocoa Powder Improves Hyperlipidemia and Reduces Atherosclerosis in apoE Deficient Mice through the Inhibition of Hepatic Endoplasmic Reticulum Stress by Hua Guan, Yan Lin, Liang Bai, Yingfeng An, Jianan Shang, Zhao Wang, Sihai Zhao, Jianglin Fan, Enqi Liu

“…The aim of our study was to investigate whether the intake of cocoa powder has any influence on hyperlipidemia and atherosclerosis and examine the underlying molecular mechanisms. We fed apoE knockout mice a Western diet supplemented with either 0.2% (low group) or 2% (high group) cocoa powder for 12 weeks. …”
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Retraction Note: Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression by Kun Zhao, Zhe Wang, Thilo Hackert, Claudia Pitzer, Margot Zöller

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Luteolin Pretreatment Attenuates Hepatic Ischemia-Reperfusion Injury in Mice by Inhibiting Inflammation, Autophagy, and Apoptosis via the ERK/PPARα Pathway by Yuhui Jiang, Wenjuan Yang, Jiameng Ding, Jie Ji, Liwei Wu, Yuanyuan Zheng, Yan Li, Ziqi Cheng, Jie Zhang, Qiang Yu, Jiao Feng, Jingjing Li, Jianye Wu, Yingqun Zhou, Chuanyong Guo

“…The aim of this study was to explore the effectiveness of luteolin in hepatic IR injury and the underlying mechanism. BALB/c mice were randomly divided into six groups, including normal controls (NC), luteolin (50 mg/kg), sham procedure, IR+25 mg/kg luteolin, and IR+50 mg/kg luteolin group. …”
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Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury by Reena Kumari, Gabrielle V. Hammers, Robert H. Hammons, Andrew N. Stewart, Steven M. MacLean, Tracy Niedzielko, Lonnie E. Schneider, Candace L. Floyd, John C. Gensel

“…Interestingly, we observed a similar significant increase in intraspinal CD3 + T-cell accumulation in female vs. male mice at 6 weeks post-thoracic contusion SCI. Interpretation Our observations indicate that sex is a potential biological variable for T-cell infiltration and may contribute to sex-based differences in SCI pathophysiology and recovery outcomes.…”
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Hippocampal CA1 Pyramidal Neurons of Mecp2 Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage by Christopher A. Chapleau, Elena Maria Boggio, Gaston Calfa, Alan K. Percy, Maurizio Giustetto, Lucas Pozzo-Miller

“…Neurons in Mecp2-deficient mice show lower dendritic spine density in several brain regions. …”
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