A Subanesthetic Dose of Isoflurane during Postconditioning Ameliorates Zymosan-Induced Neutrophil Inflammation Lung Injury and Mortality in Mice by Hui Wang, Jing Fan, Nan-lin Li, Jun-tang Li, Shi-fang Yuan, Jun Yi, Ling Wang, Jiang-hao Chen, Yong-gang Lv, Qing Yao, Ting Wang, Yu-cai Wang, Rui Ling

“…We found that ISO improved the survival rate of mice and mitigated lung injury as characterized by the histopathology, wet-to-dry weight ratio, protein leakage, and lung function index. …”
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Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease by Shruti Singh Kakan, Sara Abdelhamid, Sara Abdelhamid, Yaping Ju, Yaping Ju, J. Andrew MacKay, J. Andrew MacKay, J. Andrew MacKay, Maria C. Edman, Indu Raman, Chengsong Zhu, Prithvi Raj, Sarah F. Hamm-Alvarez, Sarah F. Hamm-Alvarez

“…Igha and Ighg2b expressing cells were identified in the plasma cell cluster of NOD.H2b LG.ConclusionNOD and NOR mice with SjD-associated AD have distinct autoantibody profiles in tears and serum. …”
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γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation by Weixi Zhang, Xueya Zhang, Anqun Sheng, Cuiye Weng, Tingting Zhu, Wei Zhao, Changchong Li

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GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with MAGE-AX in Mice with Melanoma by Gabriela Piñón-Zárate, Miguel Ángel Herrera-Enríquez, Beatriz Hernández-Téllez, Katia Jarquín-Yáñez, Andrés Eliú Castell-Rodríguez

“…In addition, the use of BMDCs TNFα/GK-1/MAGE-AX induced the highest survival and the smallest tumors in mice. Besides, the treatment helped to increase CD8 lymphocytes levels and to produce IFNγ in lymph nodes. …”
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PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice by Ying Sun, Zhanjun Jia, Gang Liu, Li Zhou, Mi Liu, Baoxue Yang, Tianxin Yang

“…The present study was undertaken to investigate the regulation of PGE2 synthetic pathway and the interaction between peroxisome proliferator-activated receptor (PPAR)γ and PGE2 synthesis in the kidneys of db/db mice. Strikingly, urinary PGE2 was remarkably elevated in db/db mice paralleled with the increased protein expressions of COX-2 and mPGES-1. …”
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Anxious and Nonanxious Mice Show Similar Hippocampal Sensory Evoked Oscillations under Urethane Anesthesia: Difference in the Effect of Buspirone by János Horváth, Balázs Barkóczi, Géza Müller, Viktor Szegedi

“…Interestingly, Bus treatment increased hippocampal oscillatory frequency in the AX but left it unaltered in nAX mice. Saline injection did not have any effect on the oscillation. …”
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Icaritin alleviates motor impairment and osteoporosis in Parkinson’s disease mice via the ER-PI3K/Akt pathway by Xianmei Lin, Xinyu Zhou, Xingman Liu, Lingqiong Xia, Jing Cai, Nanqu Huang, Yong Luo, Weidong Wu

“…Seventy-five 8-week-old C57BL/6J female mice underwent ovariectomy, followed by MPTP (20 mg/kg) injection for 7 days. …”
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Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice by Olívia Gonçalves de Matos, Sylvia Stella Amaral, Pedro Elias Marques Pereira da Silva, Denise Alves Perez, Débora Moreira Alvarenga, Adaliene Versiani Matos Ferreira, Jacqueline Alvarez-Leite, Gustavo Batista Menezes, Denise Carmona Cara

“…Mice were fed with regular diet in which 7% of lipid content was provided by soybean (5% of n-3 PUFA) or fish (25% of n-3 PUFA) oil. …”
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A Joint Technology Combining the Advantages of Capillary Microsampling with Mass Spectrometry Applied to the Trans-Resveratrol Pharmacokinetic Study in Mice by Ying Xu, Song-xia Zhang, Jing Guo, Li-jie Chen, Yu-ligh Liou, Tai Rao, Jing-bo Peng, Ying Guo, Wei-hua Huang, Zhi-rong Tan, Dong-sheng Ou-yang, Hong-hao Zhou, Wei Zhang, Yao Chen

“…Mice are the most frequently used animals in pharmacokinetic studies; however, collecting series of blood samples from mice is difficult because of their small sizes and tiny vessels. …”
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Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing by Chen Wenyi, Wu Xuelin, Yaqoob Muhammad Danish, Liu Kangxing, Hu Yanqing, Ke Xiuling, Hu Yongxuan

“…Chromoblastomycosis (CBM) is a chronic neglected fungal disease that causes serious damage to the physical and mental health of patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has garnered significant attention in the recent era for the treatment of CBM and has exhibited promising effects in several clinical case reports. We established a mice footpad infection model with Fonsecaea monophora and analyzed the impact of PDT treatment on the immune response of macrophages using single-cell sequencing. …”
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CHARACTERISTIC CHANGES IN THE COPY NUMBER OF INTERSPERSED REPEATS IN BONE MARROW CELLS OF MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS HUMAN DNA by E. V. Dolgova, A. V. Prokopenko, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. V. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…Mice were observed to get sick and die upon administration of exogenous DNA in a specific period of time following their pretreatment with the cytostatic cyclophosphamide (CP) (Dolgova et al., 2011). …”
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Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model by Sean P. Kessler, Dana R. Obery, Carol de la Motte

“…Our data demonstrate that both the HAS1/HAS3 double and the HAS3 null mice are protected from colitis, compared to wild-type and HAS1 null mice, as determined by measurement of weight loss, disease activity, serum IL-6 levels, histologic scoring, and immunohistochemistry. …”
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High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice by Eya Sellami, Paulo Henrique Evangelista-Silva, Caio Jordão Teixeira, Khoudia Diop, Patricia Mitchell, Fernando Forato Anhê

“…While glucose is the primary dietary energy source absorbed in the gut, it is unknown whether excess fructose alters gut glucose sensing to impair blood glucose regulation and liver homeostasis. Methods: Mice were fed diets where carbohydrates were either entirely glucose (70 %Kcal) or glucose partially replaced with fructose (8.5 %Kcal). …”
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Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice by Dwi Winarni, Fitria Nikmatul Husna, Muhammad Farraz Syadzha, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, Arif Nur Muhammad Ansori, Mochammad Amin Alamsjah, Muhamad Nur Ghoyatul Amin, Pugar Arga Christina Wulandari, Pratiwi Pudjiastuti, Khalijah Awang

“…This study concluded that the topical administration of the combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice.…”
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Estimation for Akshaya Failure Model with Competing Risks under Progressive Censoring Scheme with Analyzing of Thymic Lymphoma of Mice Application by Tahani A. Abushal, Jitendra Kumar, Abdisalam Hassan Muse, Ahlam H. Tolba

“…In group 1, we considered thymic lymphoma to be the first cause and other causes to be the second. On the base of mice data, the survival mean time (cumulative incidence function) of mice of the second cause is higher than the first cause.…”
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Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice by Wei Song, Zi-ming Zhou, Le-le Zhang, Hai-feng Shu, Jin-ru Xia, Xia Qin, Rong Hua, Yong-mei Zhang

“…Furthermore, adoptive transfer of TREM-1-expressing monocytes from PD model mice to naive mice induced neuronal damage and motor deficits. …”
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Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…Consistent with a role for IL-6 in this observation, early LTP was suppressed in dystrophin-expressing wildtype slices exposed to IL-6. In dystrophic mdx mice, exposure to IL-6 suppressed mitochondrial-mediated basal metabolism in CA1, CA3 and DG hippocampal regions. …”
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Transient sex-related changes in the mice hypothalamo–pituitary–adrenal (HPA) axis during the acute phase of the inflammatory process by T. Daneva, E. Spinedi, R. Hadid, M.-C. Jacquier, M. Giacomini, R. C. Gaillard

“…Whereas adrenal B returned to basal content 72 h after treatment in male mice, it remained significantly enhanced up to 120 h post-LPS in female animals. …”
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Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

“…A model of colitis-associated cancer (CAC) was established in C57BL/6j mice following induction with AOM/DSS. The levels of autophagy and apoptosis proteins, tight junction proteins, and inflammatory factors were detected by western blotting, immunofluorescence assay, and enzyme-linked immunosorbent assay. …”
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Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins by Malihe Soltani, Majid Rahmati, Mohammad Reza Nikravesh, Shahin Saeedi Nejat, Mahdi Jalali

“…The study sample includes two groups of adult mice: sham and HS groups. In the HS group, the right testis was transferred to the abdominal cavity for 120 hours and then returned to the scrotum where it remained for 7 days. …”
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