Potential for Isolation of Immortalized Hepatocyte Cell Lines by Liver-Directed In Vivo Gene Delivery of Transposons in Mice by Masahiro Sato, Issei Saitoh, Emi Inada, Shingo Nakamura, Satoshi Watanabe

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Polyethylene Glycol Loxenatide (PEX-168) Reduces Body Weight and Blood Glucose in Simple Obese Mice by Yuting Wu, Zeyuan Guo, Junlu Wang, Yong Wang, Daorong Wang, Ying Li, Lihua Zhu, Xiaofang Sun

“…The aim of the present study was to investigate the effect of PEX-168 on blood glucose and body weight of mice with simple obesity. Methods. Thirty healthy and 6-week-old C57BL/6 male mice were randomly divided into a normal control group (NC, n = 6) and obesity model group (n = 24). …”
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Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice by Jie Li, Yuanjie Guo, Liyuan Ma, Yixiang Liu, Chao Zou, Huiying Kuang, Bing Han, Yingliang Xiao, Yanbo Wang

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Effects of Functional Red Pine Seed Direct-Drinking Oil on Constipation and Intestinal Barrier Function in Mice by Jie Li, Haonan Zheng, Jiahui Liu, Jie Ding, Qingqi Guo, Na Zhang

“…The study investigated the effects and mechanisms of this red pine seed direct-drinking oil in alleviating constipation in mice. Results showed that, compared to normal mice, constipated mice exhibited symptoms of dry stools, difficulty defecating, abnormal neurotransmitter levels, oxidative stress, and colonic tissue damage. …”
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Effects of the Glutamine Administration on T Helper Cell Regulation and Inflammatory Response in Obese Mice Complicated with Polymicrobial Sepsis by Chiu-Li Yeh, Li-Han Su, Jin-Ming Wu, Po-Jen Yang, Po-Chu Lee, Po-Da Chen, Chun-Chieh Huang, Der-Yirng Hsieh, Hsueh-Ju Wang, Sung-Ling Yeh, Ming-Tsan Lin

“…This study investigated the impacts of GLN on inflammation and T cell dysregulation in obese mice complicated with sepsis. Mice were divided into normal control (NC) and high-fat diet groups. …”
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Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice by Yangchen Dhondup, Ivar Sjaastad, Øystein Sandanger, Jan Magnus Aronsen, Muhammad Shakil Ahmed, Håvard Attramadal, Alexandra Vanessa Finsen, Lili Zhang, Trine Ranheim, Katrine Alfsnes, Pål Aukrust, Geir Christensen, Arne Yndestad, Leif Erik Vinge

“…We crossed SERCA2a KO and TLR9 KO mice to generate four mouse lines. Tamoxifen-induced cardiomyocyte SERCA2a gene excision was carried out in mice, causing diastolic HF. …”
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Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals by Tomoyuki Niimi, Nanae Miyazaki, Hironobu Oiki, Mami Uemura, Shihan Zeng, Watcharapon Promsut, Noriaki Ota, Shunji Nonaka, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Shohei Takami, Jun Fujishiro, Yoshiakira Kanai

“…Despite its efficacy in embryos, its suitability for adult mice and small to medium-sized mammals remained uncertain. …”
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Investigating the impact of Multiwalled Carbon Nanotubes exposure on enzymatic activities and histopathological variations in Swiss albino mice by Iqra Nasim, Nadia Ghani, Rab Nawaz, Emilio Mateev, Yousef A. Bin Jardan

“…Abstract Present study was conducted to evaluate the detrimental impacts of exposure of Multi-walled Carbon Nanotubes (MWCNT-NP) on enzymatic activities and tissue structures in Swiss albino mice. The experimental groups of mice received MWCNT-NP for specific time period (seven or fourteen days). …”
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Optimization of the cholesterol gallstone model in C57BL/6 mice and evaluation of Lactobacillus intervention effects by Cong Wang, Ting Jiang, Lvwang Ye, Mengyan Du, Fang Liu

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Peripheral Blood DNA Methylation Changes in Response to <i>Centella asiatica</i> Treatment in Aged Mice by Olivia Monestime, Brett A. Davis, Cora Layman, Kandace J. Wheeler, Wyatt Hack, Jonathan A. Zweig, Amala Soumyanath, Lucia Carbone, Nora E. Gray

“…This study explores this potential with a water extract of the botanical <i>Centella asiatica</i> (CAW). Eighteen-month-old mice were treated with CAW in their drinking water for 5 weeks alongside vehicle-treated eighteen-month-old C57BL6 mice. …”
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The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…Additionally, ΔmcpC demonstrated significantly decreased colonization in the liver, spleen, and cecum of mice, indicating attenuated virulence. Immunization with ΔmcpC induced the production of specific IgG and SIgA antibodies, enhanced lymphocyte proliferation, upregulated cytokine expression, and achieved a 100% survival rate in immunized mice. …”
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Changes in Metabolic Regulation and the Microbiota Composition after Supplementation with Different Fatty Acids in db/db Mice by Beatriz Elina Martínez-Carrillo, Talia Mondragón-Velásquez, Ninfa Ramírez-Durán, José Félix Aguirre-Garrido, Roxana Valdés-Ramos, Ana Laura Guadarrama-López, Arturo Castillo-Cardiel

“…The aim was to investigate the changes in metabolic regulation and the composition of the culture-dependent microbiota after supplementation with different fatty acids in db/db mice. Material and Methods. We were using 32 8-week-old db/db mice, supplemented for eight weeks with EPA/DHA derived from microalgae as well as coconut oil. …”
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Electron Microscopic Radioautographic Study on Mitochondrial DNA Synthesis in Adrenal Cortical Cells of Developing and Aging Mice by Tetsuji Nagata

“…It was shown that the activity of intramitochondrial DNA synthesis in the adrenal cortical cells in developing and aging mice changed due to aging.…”
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Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via GSDMD-mediated pyroptosis by JianFeng Liu, Chenyang Han, Jian Shen, Yingcong Lin, Heping Shen, Genghuan Wang

“…Conclusion: AM can promote the progression of depression in CUMS-like mice via GSDMD-mediated pyroptosis, while also increasing tissue inflammatory levels. …”
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Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins by Hu Wei, Jiang Wen-Bing

“…C57BL/6 mice with dilated cardiomyopathy (DCM) were randomly divided to receive placebo or pitavastatin at a dose of 1 or 3 mg kg-1d-1. …”
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Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice by Yiyun Zhang, Jinxing Wang, Qi Zhang, Liling Deng, Siyao Miao, Geng Zhong

“…Overall findings suggest that KMCP could suppress the inflammatory response in AR mice, and serve as a novel curative therapeutic for AR without side effects.…”
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Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice by Li Sun, Li Bao, Dorji Phurbu, Shanshan Qiao, Shanshan Sun, Yangzom Perma, Hongwei Liu

“…Oral administration of PAE reduced hyperglycemia, hyperlipidemia, hepatic steatosis, and LPS-related inflammation in high fat diet-induced obese (DIO) mice. Furthermore, we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice. …”
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Alleviating effects and mechanisms of action of large-leaf yellow tea drinking on diabetes and diabetic nephropathy in mice by Guangshan Zhao, Jianyuan Teng, Ruixia Dong, Qiuyan Ban, Lian Yang, Kang Du, Yifei Wang, Hanlin Pu, Chung S. Yang, Zhe Ren

“…Our previous study found that large-leaf yellow tea (LYT) had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the present study further investigated the preventive effects and mechanisms of action of LYT administration on diabetes and diabetic nephropathy in high-fat diet plus streptozotocin-induced diabetic mice. …”
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Cyclic di AMP phosphodiesterase nanovaccine elicits protective immunity against Burkholderia cenocepacia infection in mice by Wesam E. Gawad, Yosra I. Nagy, Tamer M. Samir, Ahmed Mohamed Ibrahim Mansour, Omneya M. Helmy

“…In conclusion, cyclic-di-AMP phosphodiesterase (WP_012493605.1) is a promising vaccine candidate that elicited IgG and IgA antibodies, Th1, Th2, and Th17 cellular immunity in BALB/c mice and protected against B. cenocepacia infection. …”
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Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice by Yuki Nakamura, Kayoko Ishimaru, Yu Tahara, Shigenobu Shibata, Atsuhito Nakao

“…We found that mechanical disruption of the SCN resulted in the absence of a time of day-dependent variation in passive systemic anaphylactic (PSA) reaction in mice, associated with loss of daily variations in serum histamine, MCP-1 (CCL2), and IL-6 levels. …”
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