Pharmacokinetic Evaluation of Neutral Sphinghomyelinase2 (nSMase2) Inhibitor Prodrugs in Mice and Dogs by Arina Ranjit, Chae Bin Lee, Lukáš Tenora, Vijaya Saradhi Mettu, Arindom Pal, Jesse Alt, Barbara S. Slusher, Rana Rais

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Condensed tannin from Caragana korshinskii extraction and protection effects on intestinal barrier function in mice by Xiaoyu Niu, Wei Qu, Zhiyu Chen, Hui Li, Peinan Liu, Mei Sun, Jing Yang, Yuanyuan Xing, Dabiao Li

“…Caragana korshinskii tannins (CKT) were extracted by response surface methodology and the protection effect of CKT on the jejunal mucosal barrier function of mice was investigated. Firstly, this work presents the extraction, purification and characterization of CKT. …”
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Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice by Yingqun Zhou, Weiqi Dai, Chunlei Lin, Fan Wang, Lei He, Miao Shen, Ping Chen, Chenfen Wang, Jie Lu, Ling Xu, Xuanfu Xu, Chuanyong Guo

“…This study was designed to examine the protective effects and mechanisms of Nec-1 in concanavalin A- (ConA-) induced hepatitis in mice. Methods. C57BL/6 mice were exposed to ConA via tail vein injection and injected intraperitoneally with Nec-1 or vehicle. …”
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Effect of neonatal dexamethasone treatment on cognitive abilities of adult male mice and gene expression in the hypothalamus by N. P. Bondar, V. V. Reshetnikov, K. V. Burdeeva, T. I. Merkulova

“…Dexamethasone treatment in early life had a negative impact on the learning and spatial memory of adult mice in the Morris water maze. We analyzed the effect of elevated glucocorticoid levels in early life on the expression of the Crh, Avp, Gr, and Mr genes involved in the regulation of the HPA axis in the hypothalami of adult mice. …”
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Effect of Maternal Administration of Edible Bird’s Nest on the Learning and Memory Abilities of Suckling Offspring in Mice by Yong Xie, Hongliang Zeng, Zhiji Huang, Hui Xu, Qunyan Fan, Yi Zhang, Baodong Zheng

“…In this study, by oral administration of EBN to female mice during the pregnancy or lactation period, the effects of EBN on the levels of sialic acid in mouse milk were determined using high-performance liquid chromatography (HPLC). …”
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Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose by Rong Liu, Zukang Fu, Fengjie Zhang, Qingzhong Mao, Chunguang Luan, Xinglin Han, Jie Xue, Deliang Wang, Si Qin, Feike Hao

“…The present study is focused on investigation of the health protective effect of yellow rice wine (YRW) in mice and the potential underlying mechanism. Symptoms of aging were induced in mice by using D-galactose (D-gal), and different doses of YRW (4, 8, and 12 mL/kg BW) were orally administrated to D-gal-treated mice for a period of six weeks. …”
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Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice by Qianqian Zhang, Xiaofeng Yu, Linghan Tian, Yanjun Cong, Linfeng Li

“…To investigate the anti-αs1-casein allergy mechanism of two tea-derived polyphenols, epigallocatechin (EGC) and epigallocatechin gallate (EGCG), BALB/c mice were sensitized and challenged with αs1-casein and nutritional intervention was given by EGC and EGCG during the sensitization provocation phase. …”
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Morphophysiological alterations caused by insertional mutagenesis of contactin 5 (Cntn5) gene in transgenic mice by A. V. Smirnov, N. A. Feofanova, G. V. Kontsevaya, M. V. Anisimova, I. I. Kovrigin, I. A. Serova, M. P. Moshkin, L. A. Gerlinskaya, N. R. Battulin

“…Our results uncovered that homozygous mutant mice have lower body weight than controls and that it is caused by slower accumulation of fat tissue. …”
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Co-expression of glutamatergic and autism-related genes in the hippocampus of male mice with disturbances of social behavior by I. L. Kovalenko, A. G. Galyamina, D. A. Smagin, N. N. Kudryavtseva

“…Transcriptomic analysis revealed a down-regulation of autism-related (Shank3, Auts2, Ctnnd2, Nrxn2) and glutamatergic (Grm4) genes in aggressive mice. At the same time, the expression of GA-related genes (Shank2, Nlgn2, Ptcdh10, Reln, Arx) and GG genes (Grik3, Grm2, Grm4, Slc17a7, Slc1a4, Slc25a22) excluding Grin2a was increased in defeated mice. …”
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DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice by Jun-Eui Park, Jinah Jang, Ji-Hye Choi, Mi-sun Kang, Yun-Ju Woo, Young-Rim Seong, Chan-Bum Choi, Hye-Soon Lee, Sang-Cheol Bae, Yong-Soo Bae

“…CD4+Foxp3+ Treg populations and IL-10 secretion markedly increased, and CII-specific autoreactive T cells decreased in mice treated with CII-smDCs alone or in combination with MTX. …”
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Effect and Mechanism of Soluble Dietary Fiber from Corn Bran on Loperamide-induced Constipation in Mice by Xiangrui ZENG, Caixia JIANG, Xiaolan LIU, Xiqun ZHENG, Xuyao WEI

“…This study was performed to elucidate effects of corn bran soluble dietary fibers (CSDF) on loperamide-induced constipation and changes in intestinal flora in mice. Sixty male BALB/c mice were randomly divided into a normal group, a model group, CSDF low, medium, and high dose groups (3, 6, and 12 g·kg−1·d), and a combination group (CSDF: Lactobacillus paracasei=30:1(v:v)), with 10 mice in each group. …”
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A comparison of different cryoprotectant solutions and thawing methods for cryo­preservation of embryos of mice and rats by T. N. Igonina, E. Yu. Brusentsev, I. N. Rozhkova, V. A. Naprimerov, S. Ya. Amstislavsky

Subjects: “…icr mice…”
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Proximal tubular RAGE mediated the renal fibrosis in UUO model mice via upregulation of autophagy by Bohao Liu, Tianshi Sun, Huiling Li, Shuangfa Qiu, Yijian Li, Dongshan Zhang

“…Furthermore, PT-RAGE-KO mice reduced kidney fibrosis in UUO model via inhibiting Stat3/Atg7 axis by knocking down RAGE. …”
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Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice by Gilles Willemin, Catherine Roger, Armelle Bauduret, Kaori Minehira

“…After the high-fat diet, both groups developed obesity and hepatic steatosis with a similar degree of hepatic inflammation, suggesting no impact of the knockdown of MHC II on high-fat diet-induced inflammation in mice. In the second study, we confirmed that the CCl4 injection significantly upregulated the MHC II genes in wild-type mice. …”
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Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes by Anna Weiser, Pieter Giesbertz, Hannelore Daniel, Britta Spanier

“…We observed high concentrations of fatty acid-derived ACs in 11 female mice, high abundance of branched-chain amino acid- (BCAA-) derived ACs in 6 male mice, and slight increases in BCAA-derived ACs in the remaining 6 males. …”
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Blocking Interleukin-33 Alleviates the Joint Inflammation and Inhibits the Development of Collagen-Induced Arthritis in Mice by Yan Li, Yeqin Fu, Huan Chen, Xiaojin Liu, Mingcai Li

“…Interleukin-33 (IL-33) is a proinflammatory cytokine which is highly expressed in the synovium of RA patients and the joints of mice with collagen-induced arthritis (CIA) and exacerbates CIA in mice. …”
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Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice by Yaoxiang Li, Shivani Bansal, Baldev Singh, Meth M. Jayatilake, William Klotzbier, Marjan Boerma, Mi-Heon Lee, Jacob Hack, Keisuke S. Iwamoto, Dörthe Schaue, Amrita K. Cheema

“…In this study, urinary metabolites from mice exposed to high-dose and low-dose whole-body irradiation (WBI HDR, WBI LDR) or partial-body irradiation (PBI BM2.5) were analyzed using targeted and untargeted metabolomics approaches. …”
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Effect of Sipjeondaebo-Tang on Cancer-Induced Anorexia and Cachexia in CT-26 Tumor-Bearing Mice by Youn Kyung Choi, Ki Yong Jung, Sang-Mi Woo, Yee Jin Yun, Chan-Yong Jun, Jong Hyeong Park, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko

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Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice by Haiping Wang, Jing Sun, Zhanjun Jia, Tianxin Yang, Liang Xu, Bing Zhao, Kezhou Yu, Rong Wang

“…The present study was aimed at investigating the beneficial effects of OA-NO2 on the lipid metabolism and liver steatosis in deoxycorticosterone acetate- (DOCA-) salt induced hypertensive mice model. Male C57BL/6 mice were divided to receive DOCA-salt plus OA-NO2 or DOCA-salt plus vehicle and another group received neither DOCA-salt nor OA-NO2 (control group). …”
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Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in MiceSummary by Kensuke Hamada, Yuki Nakanishi, Yu Muta, Mayuki Omatsu, Kosuke Iwane, Munehiro Ikeda, Jiayu Chen, Yoko Masui, Naoki Aoyama, Nobukazu Agatsuma, Go Yamakawa, Takahiro Utsumi, Hiroki Kitamoto, Makoto Okabe, Yoshiro Itatani, Takumi Adachi, Koubun Yasuda, Shuji Yamamoto, Akihisa Fukuda, Etsushi Kuroda, Masaki Ohmuraya, Kazutaka Obama, Seiichi Hirota, Hiroki Ikeuchi, Kenji Nakanishi, Hiroshi Seno

“…We established dextran sodium sulfate (DSS)-induced colitis, azoxymethane (AOM)/DSS-induced CAC model, and ApcMin/+ sporadic tumor model using wild-type and Rbbp9-/- mice. RNA sequencing was analyzed to identify the phenotype alternation upon Rbbp9 deletion. …”
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