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3641
Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury
Published 2025-01-01“…Materials and methods: Adult C57BL/6J mice were subjected to clip-compression SCI (Th 6/7, 5g, 60s, n = 20) or sham injury (laminectomy, n = 4), and sacrificed at 1, 3, 7, 14, and 28 days (d) post-injury following intracardial fluorescein isothiocyanate (FITC)-Lectin perfusion. …”
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3642
Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes
Published 2025-01-01“…In vivo experiments demonstrated that skatole administration markedly reduced synovitis and cartilage damage in both destabilization of medial meniscus (DMM)-induced OA mice and monosodium iodoacetate (MIA)-induced OA rats. …”
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3643
Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model
Published 2024-04-01“…We established an endometriosis murine model via the intraperitoneal administration of endometrial tissue and blood from donor mice. Activin A was intraperitoneally administered to the activin group. …”
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3644
Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome
Published 2025-03-01“…TI-076 exhibits long-term stability and its major constituents are well absorbed orally in mice and rats. The five in vivo proofs of concept studies revealed that TI-076 reduced obesity, hyperglycaemia, blood pressure, liver fat accumulation, levels of serum insulin, leptin and cholesterol, food intake, inflammation and increased GLP-1 levels. …”
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3645
Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function
Published 2025-01-01“…Genomic analysis highlighted the probiotic attributes of B. adolescentis AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. …”
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3646
A single residue switch mediates the broad neutralization of Rotaviruses
Published 2025-01-01“…Here, focusing on the pivotal viral protein VP4 of rotavirus (RV), we identify a potent bNAb, 7H13, exhibiting broad-spectrum neutralization across diverse RV genotypes and demonstrating strong prevention of virus infection in female mice. A combination of time-resolved cryo-electron microscopy (cryo-EM) and in situ cryo-electron tomography (cryo-ET) analysis reveals a counterintuitive dynamic process of virus inactivation, in which 7H13 asymmetrically binds to a conserved epitope in the capsid-proximal aspect of VP4, triggers a conformational switch in a critical residue—F418—thereby disrupts the meta-stable conformation of VP4 essential for normal viral infection. …”
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3647
Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides
Published 2025-01-01“…We found that S. salivarius may prevent host obesity caused by excess sucrose intake via the exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived S. salivarius produced high EPS levels from sucrose but not from other sugars. …”
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3648
Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regul...
Published 2025-01-01“…Experimental results showed that Lithospermum erythrorhizon oil significantly improved AD symptoms in mice, reduced IL-4 and IL-13 levels, and decreased p-PI3K, p-PI3K/PI3K, p-Akt, and p-Akt/Akt expression, inhibiting PI3K-Akt pathway activation. …”
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3649
Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model
Published 2025-03-01“…A novel hydroxyapatite/aragonite (HAA) biomaterial was implanted into C57BL/6 mice juxtaskeletally between the tibia and tibialis anterior muscle. …”
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3650
Dynamic Profile of CD4+ T-Cell-Associated Cytokines/Chemokines following Murine Myocardial Infarction/Reperfusion
Published 2019-01-01“…The protein levels of 26 CD4+ T-cell-associated cytokines/chemokines were detected in the heart tissues and serum of mice at day 7 and day 14 post-MI/R or sham surgery. …”
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3651
Genetic and Molecular Characterization of Avian Influenza A(H9N2) Viruses from Live Bird Markets (LBM) in Senegal
Published 2025-01-01“…The A/H9N2 strains carried the low pathogenicity RSSR/GLF motif at the HA cleavage site and possessed several key amino acid mutations, including HA-I155T and HA-Q226L, which are associated with human host adaptation, PB2-T105V, PB2-A661T, and PB2-A588V, which are linked to the human-to-human transmission and increased polymerase activity, NS2-T14M, NS2-M100I, NS1-I106M, NS1-V222M, NS1-E223A, NS1-I226V, NS1-E227G, and NS1-P228S, which are known to alter virulence (increased or reduced) in humans or mice, and M2-S31N, which promotes drug resistance. …”
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3652
European distribution and intramuscular pathogenicity of divergent lyssaviruses West Caucasian bat virus and Lleida bat lyssavirus
Published 2025-02-01“…We confirmed LLEBV’s intramuscular a-pathogenicity using mice. Infected hamsters developed antibodies by day seven, regardless the virus and the clinical outcome. …”
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3653
Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel
Published 2025-01-01“…More importantly, in vivo stimulation of TRPML1 ameliorates multiple clinical signs of Dextran sulfate sodium-induced colitis in mice, suggesting TRPML1 has potential in treating inflammatory bowel disease.…”
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3654
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
Published 2025-01-01“…Importantly, it also prevented tumor development in xenografted NOD/SCID mice. The synergistic effect of inhibiting DNA replication and CHK2 signaling identifies a vulnerability of cancer cells that might be exploited by using clinically approved inhibitors in novel combination therapies.…”
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3655
VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1
Published 2025-02-01“…Moreover, the combination of VSIG4 blockade with a BRAF inhibitor synergistically enhanced anti-tumor activity in ATC-tumor bearing mice. VSIG4 deficiency recovered the antigen presentation (B2m, H2-k1, H2-d1) of TAMs and activated antigen-specific CD8+ T cells by promoting their in vivo proliferation and intratumoral infiltration. …”
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3656
Exposure of wild mammals to glyphosate, AMPA, and glufosinate: a case for “emerging organic contaminants”?
Published 2025-01-01“…The detection and levels of GLY, AMPA and GLUF were greater in herbivorous and omnivorous voles than in insectivorous shrews and omnivorous wild mice. The three compounds showed comparable ranges of concentrations: 0.018-7.74 pg/mg with an outlier of 522 pg/mg for GLY (median = 2.65 pg/mg), 0.240-33.6 pg/mg for AMPA (median = 1.39 pg/mg), and 1.16-25.5 pg/mg for GLUF (median = 3.51 pg/mg). …”
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3657
Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer
Published 2025-01-01“…<b>Objective</b>: We evaluate the immunotherapeutic potential of the yellow fever virus vaccine strain 17D (YFV 17D) for intratumoral therapy of pancreatic cancer in mice. <b>Methods</b>: The cytopathic effect of YFV 17D on mouse syngeneic pancreatic cancers cells were studied both in vitro and in vivo and on human pancreatic cancers cells in vitro. …”
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3658
Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration
Published 2025-02-01“…Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. …”
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3659
IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization...
Published 2025-01-01“…The results verified that IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> significantly improved this mechanism and maintained normal pregnancy status in mice, but miR-30b-5p significantly reduced the M2 polarization by inhibiting SOCS1, which activated the NF-κB signaling pathway, and then leading to the failure of embryo implantation. …”
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3660
Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function
Published 2025-01-01“…Our aims were multifaceted: to pinpoint the specific cognitive domains affected during the infection in adult mice, to unravel the complex interplay between glial and immune cells within the central nervous system (CNS), and crucially, to explore the potential therapeutic role of regular physical exercise in counteracting the deleterious effects of schistosomiasis on the CNS. …”
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