Showing 3,641 - 3,660 results of 3,719 for search '"mice"', query time: 0.06s Refine Results
  1. 3641

    Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury by Christian J. Entenmann, Emily J. von Bronewski, Lilly Waldmann, Lea Meyer, Katharina Kersting, Laurens T. Roolfs, Lasse M. Schleker, Melina Nieminen-Kelhä, Irina Kremenetskaia, Frank L. Heppner, Michael G. Fehlings, Peter Vajkoczy, Vanessa Hubertus

    Published 2025-01-01
    “…Materials and methods: Adult C57BL/6J mice were subjected to clip-compression SCI (Th 6/7, 5g, 60s, n = 20) or sham injury (laminectomy, n = 4), and sacrificed at 1, 3, 7, 14, and 28 days (d) post-injury following intracardial fluorescein isothiocyanate (FITC)-Lectin perfusion. …”
    Get full text
    Article
  2. 3642

    Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes by Weiyun Wang, Yaru Chu, Yunkun Lu, Jie Xu, Weixuan Zhao, Zhuo Liang, Xueqiang Guo, Lingling Xi, Tao Han, Yaping Shen, Wenjuan Song, Yanhua Tang, Mengnan Wen, Zhuang Qian, Lei Wang, Zhenlin Fan, Guangdong Zhou, Wenjie Ren

    Published 2025-01-01
    “…In vivo experiments demonstrated that skatole administration markedly reduced synovitis and cartilage damage in both destabilization of medial meniscus (DMM)-induced OA mice and monosodium iodoacetate (MIA)-induced OA rats. …”
    Get full text
    Article
  3. 3643

    Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model by Yuri Kadota, Takeshi Kato, Kana Kasai, Takako Kawakita, Misaki Murayama, Akari Shinya, Hikari Sasada, Sachiko Katayama, Mari Nii, Shota Yamamoto, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Miyu Taniguchi, Tomotaka Nakagawa, Takashi Kaji, Masato Nishimura, Riyo Kinouchi, Kanako Yoshida, Takeshi Iwasa

    Published 2024-04-01
    “…We established an endometriosis murine model via the intraperitoneal administration of endometrial tissue and blood from donor mice. Activin A was intraperitoneally administered to the activin group. …”
    Get full text
    Article
  4. 3644

    Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

    Published 2025-03-01
    “…TI-076 exhibits long-term stability and its major constituents are well absorbed orally in mice and rats. The five in vivo proofs of concept studies revealed that TI-076 reduced obesity, hyperglycaemia, blood pressure, liver fat accumulation, levels of serum insulin, leptin and cholesterol, food intake, inflammation and increased GLP-1 levels. …”
    Get full text
    Article
  5. 3645

    Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function by Bo Li, Bo Li, Haoyu Wang, Haoyu Wang, Haoyu Wang, Mengmeng Wang, Mengmeng Wang, Hewei Liang, Hewei Liang, Hewei Liang, Tongyuan Hu, Tongyuan Hu, Tongyuan Hu, Jinlong Yang, Jinlong Yang, Jinlong Yang, Shangyong Li, Xinbi You, Xinbi You, Xinbi You, Binbin Xia, Binbin Xia, Binbin Xia, Yue Yuan, Yue Yuan, Yuanqiang Zou, Yuanqiang Zou, Yinglei Miao, Yinglei Miao, Yang Sun, Yang Sun, Yang Sun

    Published 2025-01-01
    “…Genomic analysis highlighted the probiotic attributes of B. adolescentis AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. …”
    Get full text
    Article
  6. 3646

    A single residue switch mediates the broad neutralization of Rotaviruses by Yang Huang, Feibo Song, Yuanjun Zeng, Hui Sun, Roufang Sheng, Xuechun Wang, Liqin Liu, Guoxing Luo, Yanan Jiang, Yaling Chen, Mengxuan Zhang, Shiyin Zhang, Ying Gu, Hai Yu, Shaowei Li, Tingdong Li, Qingbing Zheng, Shengxiang Ge, Jun Zhang, Ningshao Xia

    Published 2025-01-01
    “…Here, focusing on the pivotal viral protein VP4 of rotavirus (RV), we identify a potent bNAb, 7H13, exhibiting broad-spectrum neutralization across diverse RV genotypes and demonstrating strong prevention of virus infection in female mice. A combination of time-resolved cryo-electron microscopy (cryo-EM) and in situ cryo-electron tomography (cryo-ET) analysis reveals a counterintuitive dynamic process of virus inactivation, in which 7H13 asymmetrically binds to a conserved epitope in the capsid-proximal aspect of VP4, triggers a conformational switch in a critical residue—F418—thereby disrupts the meta-stable conformation of VP4 essential for normal viral infection. …”
    Get full text
    Article
  7. 3647

    Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides by Hidenori Shimizu, Junki Miyamoto, Keiko Hisa, Ryuji Ohue-Kitano, Hiromi Takada, Mayu Yamano, Akari Nishida, Daiki Sasahara, Yuki Masujima, Keita Watanabe, Shota Nishikawa, Sakura Takahashi, Takako Ikeda, Yuya Nakajima, Naofumi Yoshida, Chiaki Matsuzaki, Takuya Kageyama, Ibuki Hayashi, Akari Matsuki, Ryo Akashi, Seiichi Kitahama, Masako Ueyama, Takumi Murakami, Shinsuke Inuki, Junichiro Irie, Noriko Satoh-Asahara, Hirokazu Toju, Hiroshi Mori, Shinji Nakaoka, Tomoya Yamashita, Atsushi Toyoda, Kenji Yamamoto, Hiroaki Ohno, Takane Katayama, Hiroshi Itoh, Ikuo Kimura

    Published 2025-01-01
    “…We found that S. salivarius may prevent host obesity caused by excess sucrose intake via the exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived S. salivarius produced high EPS levels from sucrose but not from other sugars. …”
    Get full text
    Article
  8. 3648

    Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regul... by Weisheng Hu, Yinlan Wang, Yingjie Zhou, Junbao Shi, Zengyan Li, Xiaoling Jiang, Qinyuan Wu, Changming Zhong, Huilan Weng, Sijie Ouyang, Yuan Jing, Xianxiang Cai, Mingda Ye, Ning Huang

    Published 2025-01-01
    “…Experimental results showed that Lithospermum erythrorhizon oil significantly improved AD symptoms in mice, reduced IL-4 and IL-13 levels, and decreased p-PI3K, p-PI3K/PI3K, p-Akt, and p-Akt/Akt expression, inhibiting PI3K-Akt pathway activation. …”
    Get full text
    Article
  9. 3649
  10. 3650

    Dynamic Profile of CD4+ T-Cell-Associated Cytokines/Chemokines following Murine Myocardial Infarction/Reperfusion by Dongsheng Yuan, Jinjun Tie, Zhican Xu, Guanya Liu, Xinyu Ge, Zhulin Wang, Xumin Zhang, Shiyu Gong, Gang Liu, Qingshu Meng, Fang Lin, Zhongmin Liu, Huimin Fan, Xiaohui Zhou

    Published 2019-01-01
    “…The protein levels of 26 CD4+ T-cell-associated cytokines/chemokines were detected in the heart tissues and serum of mice at day 7 and day 14 post-MI/R or sham surgery. …”
    Get full text
    Article
  11. 3651

    Genetic and Molecular Characterization of Avian Influenza A(H9N2) Viruses from Live Bird Markets (LBM) in Senegal by Mamadou Malado Jallow, Moussa Moise Diagne, Marie Henriette Dior Ndione, Mamadou Aliou Barry, Ndiendé Koba Ndiaye, Davy Evrard Kiori, Marie Pedapa Mendy, Déborah Goudiaby, Gamou Fall, Malick Fall, Ndongo Dia

    Published 2025-01-01
    “…The A/H9N2 strains carried the low pathogenicity RSSR/GLF motif at the HA cleavage site and possessed several key amino acid mutations, including HA-I155T and HA-Q226L, which are associated with human host adaptation, PB2-T105V, PB2-A661T, and PB2-A588V, which are linked to the human-to-human transmission and increased polymerase activity, NS2-T14M, NS2-M100I, NS1-I106M, NS1-V222M, NS1-E223A, NS1-I226V, NS1-E227G, and NS1-P228S, which are known to alter virulence (increased or reduced) in humans or mice, and M2-S31N, which promotes drug resistance. …”
    Get full text
    Article
  12. 3652
  13. 3653

    Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel by Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang

    Published 2025-01-01
    “…More importantly, in vivo stimulation of TRPML1 ameliorates multiple clinical signs of Dextran sulfate sodium-induced colitis in mice, suggesting TRPML1 has potential in treating inflammatory bowel disease.…”
    Get full text
    Article
  14. 3654

    Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

    Published 2025-01-01
    “…Importantly, it also prevented tumor development in xenografted NOD/SCID mice. The synergistic effect of inhibiting DNA replication and CHK2 signaling identifies a vulnerability of cancer cells that might be exploited by using clinically approved inhibitors in novel combination therapies.…”
    Get full text
    Article
  15. 3655

    VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

    Published 2025-02-01
    “…Moreover, the combination of VSIG4 blockade with a BRAF inhibitor synergistically enhanced anti-tumor activity in ATC-tumor bearing mice. VSIG4 deficiency recovered the antigen presentation (B2m, H2-k1, H2-d1) of TAMs and activated antigen-specific CD8+ T cells by promoting their in vivo proliferation and intratumoral infiltration. …”
    Get full text
    Article
  16. 3656

    Exposure of wild mammals to glyphosate, AMPA, and glufosinate: a case for “emerging organic contaminants”? by Fritsch, Clémentine, Appenzeller, Brice M. R., Bertrand, Colette, Coeurdassier, Michael, Driget, Vincent, Hardy, Emilie M, Palazzi, Paul, Schaeffer, Charline, Goydadin, Anne-Claude, Gaba, Sabrina, Bretagnolle, Vincent, Pelosi, Céline

    Published 2025-01-01
    “…The detection and levels of GLY, AMPA and GLUF were greater in herbivorous and omnivorous voles than in insectivorous shrews and omnivorous wild mice. The three compounds showed comparable ranges of concentrations: 0.018-7.74 pg/mg with an outlier of 522 pg/mg for GLY (median = 2.65 pg/mg), 0.240-33.6 pg/mg for AMPA (median = 1.39 pg/mg), and 1.16-25.5 pg/mg for GLUF (median = 3.51 pg/mg). …”
    Get full text
    Article
  17. 3657

    Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer by Alina S. Nazarenko, Yulia K. Biryukova, Kirill N. Trachuk, Ekaterina A. Orlova, Mikhail F. Vorovitch, Nikolay B. Pestov, Nick A. Barlev, Anna I. Levaniuk, Ilya V. Gordeychuk, Alexander S. Lunin, Grigory A. Demyashkin, Petr V. Shegai, Andrei D. Kaprin, Aydar A. Ishmukhametov, Nadezhda M. Kolyasnikova

    Published 2025-01-01
    “…<b>Objective</b>: We evaluate the immunotherapeutic potential of the yellow fever virus vaccine strain 17D (YFV 17D) for intratumoral therapy of pancreatic cancer in mice. <b>Methods</b>: The cytopathic effect of YFV 17D on mouse syngeneic pancreatic cancers cells were studied both in vitro and in vivo and on human pancreatic cancers cells in vitro. …”
    Get full text
    Article
  18. 3658

    Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration by Peisheng Liu, Hao Guo, Xiaoyao Huang, Anqi Liu, Ting Zhu, Chenxi Zheng, Fei Fu, Kaichao Zhang, Shijie Li, Xinyan Luo, Jiongyi Tian, Yan Jin, Kun Xuan, Bingdong Sui

    Published 2025-02-01
    “…Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. …”
    Get full text
    Article
  19. 3659

    IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

    Published 2025-01-01
    “…The results verified that IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> significantly improved this mechanism and maintained normal pregnancy status in mice, but miR-30b-5p significantly reduced the M2 polarization by inhibiting SOCS1, which activated the NF-κB signaling pathway, and then leading to the failure of embryo implantation. …”
    Get full text
    Article
  20. 3660

    Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

    Published 2025-01-01
    “…Our aims were multifaceted: to pinpoint the specific cognitive domains affected during the infection in adult mice, to unravel the complex interplay between glial and immune cells within the central nervous system (CNS), and crucially, to explore the potential therapeutic role of regular physical exercise in counteracting the deleterious effects of schistosomiasis on the CNS. …”
    Get full text
    Article