The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma by Shahid Banday, Alok K. Mishra, Romana Rashid, Tianyi Ye, Amjad Ali, Junhui Li, Jason T. Yustein, Michelle A. Kelliher, Lihua Julie Zhu, Sara K. Deibler, Sunil K. Malonia, Michael R. Green

“…Itraconazole, an FDA-approved anti-fungal agent that is known to inhibit C1GALT1, reduces EWSR1::FLI1 levels in ES cell lines and suppresses growth of ES xenografts in mice. Our study reveals a therapeutically targetable mechanism that promotes EWSR1::FLI1 expression and ES tumor growth.…”
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The effect of differences in the third domain of the glycoprotein E of tick-borne encephalitis virus of the Far Eastern, Siberian and European subtypes on the binding of recombinan... by I. K. Baykov, A. L. Matveev, L. A. Emelianova, G. B. Kaverina, S. E. Tkachev, N. V. Tikunova

“…It was previously shown that this antibody is able to protect mice from the European subtype of TBEV, strain “Absettarov”, and the presence of virus-neutralizing activity against the Far Eastern subtype of TBEV, strain 205 was also shown for this antibody. …”
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Phytochemical screening and neuro-pharmacological activity of Mimosa pudica flowers: Integrating in vitro, in silico and in vivo approaches by Fahmida Alam, Rashedul Alam, A.T.M. Yusuf, Joya Datta Ripa, Raktim Das Nithin, Sourav Barua, Mohammed Fazlul Kabir, Seong-Tshool Hong, Hea-Jong Chung

“…In order to evaluate the neuro-pharmacological effects of the extract, we conducted a comprehensive set of neurobehavioral tests on Swiss Albino mice. These tests included the open field test, light-dark box test, elevated plus maze test, tail suspension test, forced swim test, Y-maze test, hole cross test, and social interaction test. …”
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Elevation of High-Mobility Group Protein Box-1 in Serum Correlates with Severity of Acute Intracerebral Hemorrhage by Yu Zhou, Kun-Lin Xiong, Sen Lin, Qi Zhong, Feng-Lin Lu, Hong Liang, Jing-Cheng Li, Jing-Zhou Wang, Qing-Wu Yang

“…In comparison with the control group, the levels of HMGB1 in the perihematomal tissue in mice with ICH increased dramatically, peaked at 72 hours, and decreased at 5 days. …”
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Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents by Ryuji Ohashi, Ryuji Fukazawa, Makoto Watanabe, Hanako Tajima, Noriko Nagi-Miura, Naohito Ohno, Shinichi Tsuchiya, Yuh Fukuda, Shunichi Ogawa, Yasuhiko Itoh

“…At 2 and 4 weeks, the mice were sacrificed, and plasma cytokines and chemokines were measured. …”
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Anti-Idiotypic Antibody as a Booster Vaccine Against Respiratory Syncytial Virus by Shreya Mukhopadhyay, Ioannis Manolaridis, Christopher Warren, Aimin Tang, Gregory O’Donnell, Bin Luo, Ryan P. Staupe, Kalpit A. Vora, Zhifeng Chen

“…In an immunogenicity study, mice primed with RSV F and boosted with 1A6 Fab showed a site IV-specific antibody response with a concurrent increase in RSV virus neutralization. …”
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Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia by Zeng Zhang, Quan Guo, Zhihan Yang, Yukai Sun, Shuaiming Jiang, Yangli He, Jiahe Li, Jiachao Zhang

“…This finding was validated in aged mice. Metabolomics analysis identified nicotinic acid as a key metabolite produced by B. adolescentis, linked to improvements in muscle mass and functionality in individuals with sarcopenia. …”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Results: GIP108 treatment led to weight loss and improved glucose homeostasis in mice. Prolonged exposure to GIPR agonists produced homologous functional GIPR desensitisation in isolated islets. …”
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Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model by Atsushi Mima, Azuma Kimura, Ryo Ito, Yu Hatano, Hiraku Tsujimoto, Shin-Ichi Mae, Junko Yamane, Wataru Fujibuchi, Norimitsu Uza, Taro Toyoda, Hiroshi Seno, Kenji Osafune

“…In this study, we aimed to elucidate the developmental mechanisms of pancreatic exocrine acinar lineages to establish a directed differentiation method for pancreatic acinar cells from hiPSCs. hiPSC-derived pancreatic endoderm cells were spontaneously differentiated into both pancreatic exocrine and endocrine tissues by implantation into the renal subcapsular space of NOD/SCID mice. Single-cell RNA-seq analysis of the retrieved grafts confirmed the differentiation of pancreatic acinar lineage cells and identified REG4 as a candidate marker for pancreatic acinar progenitor cells. …”
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α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation by Haowei Wang, Huijie Zhang, Lin Miao, Chan Wang, Hanxin Teng, Xiaodong Li, Xiaoxing Zhang, Genmeng Yang, Shangwen Wang, Xiaofeng Zeng

“…In vivo, α-amanitin induced dose-dependent liver injury in mice, evident by elevated serum ALT and AST, and histological liver damage. …”
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Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in <i>Leptin</i>-Deficient Rats by Xiaoming Xin, Yaohua Ni, Jing Wang, Fenglin Wu, Meichen Liu, Lingjuan Wu, Jiaxing Dai, Chenglin Wu, Xiaolei Song, Wang Zhang, Guangrui Yang, Ruling Shen, Xianmin Zhu

“…Macrophages play important roles in metabolic dysfunction-associated steatohepatitis (MASH), an advanced and inflammatory stage of metabolic dysfunction-associated steatotic liver disease (MASLD). In humans and mice, the cellular heterogeneity and diverse function of hepatic macrophages in MASH have been investigated by single cell RNA sequencing (scRNA-seq). …”
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Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p by Lei Xu, Gang Zhao, Hong Zhu, Shijun Wang, Aijun Sun, Yunzeng Zou, Junbo Ge

“…Here we showed that Rosiglitazone treatment significantly attenuated the expressions of LOX-1, ICAM-1, VCAM-1, p47phox, and the atherosclerotic lesions in ApoE-/- mice with high-fat diet. In vitro, we revealed that Rosiglitazone inhibited LOX-1 by regulating miR-590-5p. …”
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Mouse Umbilical Cord Mesenchymal Stem Cell Paracrine Alleviates Renal Fibrosis in Diabetic Nephropathy by Reducing Myofibroblast Transdifferentiation and Cell Proliferation and Upr... by Hongde Li, Pengfei Rong, Xiaoqian Ma, Wei Nie, Yan Chen, Juan Zhang, Qiong Dong, Min Yang, Wei Wang

“…Herein, we firstly investigated the therapeutic effects of mouse UC-MSC infusion on kidney structural and functional impairment in streptozotocin- (STZ-) induced diabetic mice. We found that the repeated injection with mUC-MSCs alleviates albuminuria, glomerulus injury, and fibrosis in DN mouse models. …”
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Hantavirus Cardiopulmonary Syndrome and Diffuse Alveolar Hemorrhage in the Era of COVID-19 by Khizar Hamid, Swaminathan Perinkulam Sathyanarayanan, Touba Naim, Muhammad Hamza, Mirza Omer Mahmood Baig, Emad Abu Sitta

“…We report a patient with a history of alcohol abuse and recent exposure to mice and sick kittens who presented with cough with sputum production, shortness of breath, orthopnea, and new-onset lower extremity edema. …”
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Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity by Wassim Daher, Vincent Le Moigne, Yara Tasrini, Shweta Parmar, Danielle L. Sexton, John Jairo Aguilera-Correa, Valentin Berdal, Elitza I. Tocheva, Jean-Louis Herrmann, Laurent Kremer

“…Macrophage infections showed that ESX-3 and ESX-4 contribute to bacterial internalization, phagosomal escape, and intracellular survival. In mice, infections with eccC3- and/or eccC4-deletion mutants resulted in complete survival and reduced bacterial loads in the lungs. …”
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G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication by Ryoya Sekine, Kouki Takeda, Tsukasa Suenaga, Satsuki Tsuno, Takumi Kaiya, Maki Kiso, Seiya Yamayoshi, Yoshihide Takaku, Shiho Ohno, Yoshiki Yamaguchi, Seiichi Nishizawa, Kazuhiro Sumitomo, Kazufumi Ikuta, Teru Kanda, Yoshihiro Kawaoka, Hidekazu Nishimura, Shusuke Kuge

“…Moreover, G12(S) alleviated the weight loss caused by coronavirus infection in mice. G12(S) might exhibit a stable G-tetrad with left-handed parallel-stranded G-quadruplex, and inhibit the replication process by impeding interaction between viral nucleoproteins and viral RNA in the cytoplasm. …”
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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…At 2 mg/kg, Ir-6 markedly prolonged the bleeding time in experimental mice. In conclusion, Ir-6 plays a crucial role by inhibiting platelet activation through the inhibition of signaling pathways, such as the PLCγ2–PKC cascade and the subsequent suppression of Akt and MAPK activation, thereby ultimately inhibiting platelet aggregation. …”
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Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection by Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan

“…Our results demonstrated that the DMT-adjuvanted CMFO could confer more significant protection against M. tuberculosis infection than the CMFO/MTO did in mice. In particular, the adjuvant DMT showed a stronger ability than the O/W emulsion to adjuvant CMFO subunit vaccine and enhanced protection, attributed to elicit Th1-biased responses, strong Th1/Th17 cytokine responses, and IFN-γ+ or IL-2+ T cell responses. …”
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DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway by Hui Wang, Shen Luo, Yue Yin, Yang Liu, Xiaomei Sun, Ling Qiu, Xin Wu

“…A subcutaneous tumor model was established in BALB/c mice to confirm the role of the DLAT/SREBP1 axis in OC growth and metastasis in vivo. …”
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Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary by Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika

“…Surgical model of esophageal reflux injury and L2-IL1β transgenic mice were used to investigate the mechanisms of protein misfolding and aggregation. …”
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