Biological Response Modifiers in Combination with Antivirals against Experimentally-Induced Virus Infections by Robert W Sidwell, John H Huffman, Donald F Smee, John Gilbert, Roland K Robins, Meir Kende, John Huggins

“…Reported here are a series of studies which have used two BRMs in combination with the antiviral drug, ribavirin (l-β-o-ribofuranosyl-1,2,4-triazole-3-carboxamide) in treatment of experimentally-induced phlebovirus (Punta Toro virus) infections in mice. The positive BRMs studied include bropirimine (2-amino-5-bromo-6-phenyl-4[3H]pyrimidinone) given orally at dosages of 25, 50 and 100 mg/kg/day beginning 24 h after virus inoculation. and 7-thia-8-oxoguanosine administered intrapcritoneally at dosages of 6.3, 12.5 and 25 mg/kg/day given 24 and 31 h after virus inoculation. …”
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Chemical catalyst manipulating cancer epigenome and transcription by Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo R. Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, Atsushi Kaneda, Shigehiro A. Kawashima, Motomu Kanai

“…This H2BK120 acetylation-mediated removal of NELFE from chromatin reshapes transcription, slows leukemia cell viability, and reduces their tumorigenic potential in mice. Therefore, this histone acetylation catalyst provides a unique tool for elucidating the time-resolved consequences of histone PTMs and may offer a modality for cancer chemotherapy.…”
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Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations by Peter Rotheneichner, Simona Lange, Anna O’Sullivan, Julia Marschallinger, Pia Zaunmair, Christian Geretsegger, Ludwig Aigner, Sebastien Couillard-Despres

“…Furthermore, considering the fact that neurogenesis strongly diminishes along aging, we investigated the response to electroconvulsive shocks in young as well as in aged cohorts of mice.…”
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Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. by Athos Silva De Oliveira, Leroy Versteeg, Neima Briggs, Rakesh Adhikari, Maria Jose Villar, JeAnna R Redd, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

“…After one immunization in mice, mRNA vaccines induced an earlier onset of antigen-specific antibodies compared to rNa-GST-1. …”
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Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies by Yong-Hua Wu, Feng Xiong, Zheng-Wen Ou, Jing-An Wang, Jing Cui, Lin Jiang, Wen-Jian Lan

“…Animal studies examined the tumor-suppressive effects, safety (hepatotoxicity and nephrotoxicity), and immune impact of these treatments in tumor-bearing mice. VBV monotherapy significantly inhibited the growth of HepG2 cells by suppressing their proliferation and invasion and induced apoptosis in vitro. …”
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TIM-3 and TIM-1 Could Regulate Decidual γδTCR Bright T Cells during Murine Pregnancy by Jasper Nörenberg, Matyas Meggyes, Pal Jakso, Eva Miko, Aliz Barakonyi

“…Gamma/delta T cells from the uterus and spleen of pregnant and nonpregnant mice were analyzed by flow cytometry. We confirmed that the rate of γδT cells in the decidua increases during murine pregnancy and half of decidual γδT cells are CD4+. …”
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Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cell... by Dong-Seol Lee, Yeo Joon Song, Hye Ri Gug, Ji-Hyun Lee, Hyun Sook Bae, Joo-Cheol Park

“…Among its members, nuclear factor I-C (NFI-C) has been reported to play an essential role in odontogenesis. Nfic knockout mice show malformation in all mineralized tissues, but it remains unclear which stage of development Nfic is involved in. …”
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The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes by Manasi Suchit Halurkar, Oto Inoue, Archana Singh, Rajib Mukherjee, Meghana Ginugu, Christopher Ahn, Christian Louis Bonatto Paese, Molly Duszynski, Samantha A. Brugmann, Hee-Woong Lim, Joan Sanchez-Gurmaches

“…Overall, comprehensive validation of transgenic mice is imperative to maximize discovery while mitigating unexpected, off-target effects.…”
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Osteopontin Expression in the Brain Triggers Localized Inflammation and Cell Death When Immune Cells Are Activated by Pertussis Toxin by Maria Cecilia Garibaldi Marcondes, Ryan Ojakian, Nikki Bortell, Claudia Flynn, Bruno Conti, Howard S. Fox

“…To understand the role of OPN in inflammation and cell survival, we expressed OPN, utilizing an adenoviral vector, in the caudoputamen of mice deficient in OPN, using beta-galactosidase- (β-gal-) expressing vector as control. …”
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Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation by L. Caccialupi Da Prato, A. Rezzag Lebza, A. Consumi, M. Tessier, A. Srinivasan, C. Rivera, C. Rivera, J. Laurin, C. Pellegrino

“…Furthermore, we established a correlation between this decrease in KCC2 expression and the long-term consequences of brain trauma and identified a link between the loss of KCC2 expression and the emergence of depressive-like behavior observed in the mice.ConclusionWe successfully validated our previous findings, supporting the potential therapeutic benefits of bumetanide in mitigating post-traumatic depression (PTD) following TBI. …”
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TIM‐4 increases the proportion of CD4+CD25+FOXP3+ regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL‐6 secretion by Ziyao Wang, Zerong Xie, Yu Mou, Ruiman Geng, Chen Chen, Nengwen Ke

“…TIM‐4 influences the differentiation of Treg by inhibiting IL‐6 secretion in pancreatic cancer cells and facilitates the proliferation of pancreatic cancer in mice. Additionally, the mechanism may be through the CD8+ effector T cells (CD8+Tc). …”
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Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade by Victoria E. Stefan, Daniela D. Weber, Roland Lang, Barbara Kofler

“…In contrast, immune-suppressive cells such as regulatory CD4+ T lymphocytes, M2 macrophages, and myeloid-derived suppressor cells were reported to be decreased or largely unaffected in tumors of KD-fed mice. KDs also showed synergism with ICB therapy in several preclinical tumor studies. …”
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Identification and Functional Analysis of EPOR+ Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis by Yanxing Li, Ming Li, Rong Wei, Junlong Wu

“…Methods. EPOR-eGFPcre mice were used to determine the expression of EPOR on lung tissue-resident macrophages. …”
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Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae) by Jackson Roberto Guedes da Silva Almeida, Edigênia Cavalcante da Cruz Araújo, Luciano Augusto de Araújo Ribeiro, Julianeli Tolentino de Lima, Xirley Pereira Nunes, Ana Sílvia Suassuna Carneiro Lúcio, Maria de Fátima Agra, José Maria Barbosa Filho

“…The ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice. The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acetic-acid-induced abdominal writhes. …”
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Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD by Ye Xu, Yuan Zhang, Wen Sun, Qiang Tang, Wanyu Feng, Hongjian Xiao, Jingjie Wang, Xinmeng Yuan, Mengqi Xiang, Yaran Gao, Hanyu Zhang, Jiao Lu

“…This work aimed to investigate the alterations of CM and PDM in metabolic dysfunction-associated steatotic liver disease (MASLD) induced by spontaneous type-2 diabetes mellitus (T2DM) in db/db mice. It was found that insulin resistance increased both the number and size of lipid droplets in the liver by enhancing the accumulation of free fatty acids, which is accompanied by an increase in contacts with mitochondria. …”
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Antinociceptive and Antioxidant Activity of Zanthoxylum budrunga Wall (Rutaceae) Seeds by Md. Khirul Islam, Nripendra Nath Biswas, Sanjib Saha, Hemayet Hossain, Ismet Ara Jahan, Tanzir Ahmed Khan, Khalijah Awang, Jamil A. Shilpi

“…In acetic acid induced writhing test in mice, ZBSE showed 65.28 and 74.30% inhibition of writhing at the doses of 250 and 500 mg/kg and the results were statistically significant (P<0.001). …”
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Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage by Difei Li, Xing Shi, Yuqiong Yang, Yao Deng, Dandan Chen, Shuyu Chen, Jinyong Wang, Guanxi Wen, Zhenyu Liang, Fengyan Wang, Jiaqi Gao, Yuanyuan Liu, Danna Wang, Ruifang Liang, Haizhao Xu, Rongchang Chen, Shanze Chen, Lingwei Wang

“…In vivo, BRD4 inhibitor JQ1 and degrader ARV-825 were intraperitoneally administrated into emphysema mice to assess their effects on lung emphysema and inflammation. …”
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Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro by Fenghua Zhou, Yan Shi, Sujun Tan, Xiaoli Wang, Weicheng Yuan, Shuqi Tao, Ping Xiang, Bin Cong, Chunling Ma, Di Wen

“…JWH-018 induced time- and dose-dependent cannabinoid-like effects in mice (administration dosages: 0.02, 0.1, and 0.5 mg/kg, i.p.), and yielded dose-dependent anxiogenic effects and lower aggression behavior in zebrafish (administration dosages: 0.01, 0.05, and 0.25 µg/g, i.p.), unlike JWH-019. …”
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Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache by Gurueswar Nagarajan, Yumin Zhang

“…Methods A non-invasive repetitive mTBI (4 times with a 24-h interval) was induced in male mice and effect of mTBI was tested on either bregma or pre-bregma position on the head. …”
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Glycyrrhizin attenuates renal inflammation in a mouse Con A-hepatitis model via the IL-25/M2 axis by Lingyun Li, Yuanyue Zhang, Zhongyan Wang, Xiangyu Chen, Min Fang

“…Hepatorenal syndrome (HRS) is a functional acute renal impairment that occurs in severe liver disease, and we found that kidney injury also occurs in Con A-induced experimental hepatitis in mice. We previously found that GL can alleviate Con A-induced hepatitis by regulating the expression of IL-25 in the liver. …”
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