Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? by Stefania Gonfloni, Emiliano Maiani, Claudia Di Bartolomeo, Marc Diederich, Gianni Cesareni

“…Recent reports show that aberrant c-Abl activation causes neuroinflammation and neuronal loss in the forebrain of transgenic adult mice. In line with these observations, an increased c-Abl activation is reported in human neurodegenerative pathologies, such as Parkinson’s, and Alzheimer’s diseases. …”
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Novel Ethyl 1,5-Disubstituted-1H-Pyrazole-3-Carboxylates as a New Class of Antimicrobial Agents by Radwan Awwad A., Ghorab Mostafa M., Alsaid Mansour S., Alanazi Fares K.

“…Ethyl 5-(2,5-dimethylthiophen- 3-yl)-1-phenyl-1H-pyrazole-3-carboxylate (21) (MICE.coli = 0.038 μmol mL-1, MICP. aerug. = 0.067 μmol mL-1) is nearly as active as ampicillin (MIC = 0.033 and 0.067 μmol mL-1), respectively. …”
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GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway by Chenhua Luo, ZhiMing Xiao, WenLong Yang

“…In vivo studies using an orthotopic xenograft model demonstrated that GNG2 overexpression reduced brain metastasis and extended overall survival in mice. Immunohistochemistry and multiplex immunofluorescence confirmed the association between GNG2 overexpression, the PI3K/AKT/mTOR signaling pathway, and G0/G1 arrest. …”
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Roquefort Cheese Proteins Inhibit Chlamydia pneumoniae Propagation and LPS-Induced Leukocyte Migration by Ivan M. Petyaev, Naylia A. Zigangirova, Natalie V. Kobets, Valery Tsibezov, Lydia N. Kapotina, Elena D. Fedina, Yuriy K. Bashmakov

“…Moreover, short term feeding of mice with Roquefort cheese (twice, 10 mg per mouse with an interval of 24 hours) led to the inhibition of the migration of peritoneal leukocytes caused by intraperitoneal injection of E. coli lipopolysaccharide. …”
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MitoQ Modulates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction via Regulating Nrf2 Signaling by Shengfeng Zhang, Qingniao Zhou, Youcheng Li, Yunli Zhang, Yinmei Wu

“…Methods. 30 minutes before sepsis induction by lipopolysaccharide (LPS) treatment, mice were treated with MitoQ. Intestinal histopathology, mucosal permeability, inflammatory cytokines, and mucosal barrier proteins were evaluated in the present study. …”
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CTLA-4 Engagement Inhibits Th2 but not Th1 Cell Polarisation by Vanessa Ubaldi, Lucia Gatta, Luigia Pace, Gino Doria, Claudio Pioli

“…CTLA-4 deficient mice show severe lymphoproliferative disorders with T helper sub-population skewed toward the Th2 phenotype. …”
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Cow milk αs1-casein induces allergic responses in a mouse model of atopy by Guangyu Wang, Xiaofeng Yu, Yanjun Cong, Linfeng Li

“…The levels of specific IgE, mast cell proteinase, histamine and cytokines in sensitized mice were determined, and the clinical and pathological observation were evaluated. …”
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β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia by Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Nils Wierup, Frank Sundler, Birgitte Holst, Thue W. Schwartz

“…Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. …”
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Molecular basis and genetics of hypohidrotic ectodermal dysplasias by V. A. Kovalskaia, T. Cherevatova, A. V. Polyakov, O. P. Ryzhkova

“…Due to the cross-species genes conservation, their mutations cause the disruption of the development of ectoderm derivatives not only in humans, but also in mice, cows, dogs, and even fish. It can be exploited for a better understanding of the etiopathogenesis of ectodermal dysplasias. …”
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Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo by Song He, Ying-ze Wei, Gui-lan Wang, Yu-yin Xu, Jia-ming Zhou, Yi-xin Zhang, Li Chen

“…MHCC97H cells with stable transfection of NET-1shRNA were injected subcutaneously to prepare nude mice model of HCC and Caspase-3, Caspase-8, and Caspase-9 mRNAs of tumor tissues in different groups were examined. …”
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Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis by Qi He, Xingyue Wu, Quan Shi

“…Furthermore, triptolide repressed the expression of proinflammatory cytokines in IMQ-evoked psoriasis-like mice. Conclusion. Triptolide inhibits STAT3 phosphorylation via upregulating miR-204-5p and thus suppressing Th17 response in psoriasis.…”
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Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca by Stella R. Zamuner, Catarina F. P. Teixeira

“…Anti-mouse LECAM-1, LFA-1, ICAM-1 and PECAM-1 monoclonal antibody injection resulted in a reduction of 42%, 80%, 66% and 67%, respectively, of neutrophil accumulation induced by BjV (250 μg/kg, intraperitoneal) injection in male mice compared with isotype-matched control injected animals. …”
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Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of Lyn/Syk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cell... by Hyun Ju Do, Tae Woo Oh, Kwang-Il Park

“…Lastly, 250–500 mg/kg SIE significantly attenuated the Ag/IgE-induced passive cutaneous anaphylaxis (PCA) reaction in mice. The potent effect of SIE on RBL-2H3 mast cell activation indicates that the extract could potentially be used as a novel inhibitor against allergic reactions.…”
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Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model by Yaoyi Zhang, Shuai Lv, Pinyuan Huang, Lingmin Xiao, Nan Lin, En Huang

“…Through a network pharmacology study, this study supported that BBR played a protective role in the AD mice model via blocking APP processing and amyloid plaque formation. …”
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Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosis by Wenqiang Yu, Jinfang Song, Shuangquan Chen, Jiayi Nie, Chujun Zhou, Jiamin Huang, Hua Liang

“…By contrast, inhibition of exosome production with GW4869 or exosome depletion from the conditioned media abolished the ability of myofibroblasts to induce MMT. Mice treatment with myofibroblast-derived exosomes (Myo-Exo) exhibited severe fibrotic lesion and more abundant MMT cells in kidneys with folic acid (FA) injury, which was negated by TANK-banding kinase-1 inhibitor. …”
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Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway by Weidong Cao, Qiang Zhou, Hongwei Wang, Wei Rao, Gang Cheng, Peng Wang, Shengli Guo, Bin Ren, Jianning Zhang

“…In addition, tumor growth in mice was enhanced by CoCl2 application but reversed following 14-3-3β knockdown, which also enhanced GSC cell apoptosis. …”
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Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…In vivo studies showed that colchicine significantly reduced elevated CXCL12 and CXCR4 levels in ALI mice. Conclusion. Our findings suggest that colchicine’s therapeutic effect on ALI might derive from its anti-inflammatory properties. …”
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Comparing imputation approaches to handle systematically missing inputs in risk calculators. by Anja Mühlemann, Philip Stange, Antoine Faul, Serena Lozza-Fiacco, Rowan Iskandar, Manuela Moraru, Susanne Theis, Petra Stute, Ben D Spycher, David Ginsbourger

“…We compare this approach to established imputation techniques like MICE by means of scoring rules and visualize in turn how probabilistic imputation can be used in sample size considerations.…”
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SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency by Brendan Connolly, Cleo Isaacs, Lei Cheng, Kirtika H. Asrani, Romesh R. Subramanian

“…In vivo studies in wild type mice demonstrate SERPINA1 mRNA biodistribution in liver and lungs, as well as SerpinA1 protein expression in these two target organs which are critically affected in AAT deficiency. …”
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Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression by Jie Qi, Jianguo Cui, Baobin Mi, Xiaohong Yan, Wenwen Xu, Hui Ma, Qingtan Zhang, Fang Xu

“…We found that in ApoE−/− mice ISL could attenuate atherosclerotic lesion, reduce serum lipid levels, and inhibit TRPC5 expression. …”
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