Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia by Megumi Andoh, Natsuki Shinoda, Yusuke Taira, Tasuku Araki, Yuka Kasahara, Haruki Takeuchi, Masayuki Miura, Yuji Ikegaya, Ryuta Koyama

“…Furthermore, activity-dependent caspase-3 activation at inhibitory presynapses induces microglial phagocytosis in mice and increases seizure susceptibility. This increased susceptibility is reversed by genetic depletion of microglial complement receptors. …”
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Molecular Circuits of Resolution in the Eye by Elvira L. Liclican, Karsten Gronert

“…Protective endogenous roles of LXA4 and NPD1 have been established utilizing lipidomic analysis, knockout mice, and pharmacological, genetic, and dietary manipulation, providing compelling evidence that these intrinsic lipid autacoid circuits play essential roles in restraining inflammation, promoting wound healing, inhibiting pathological angiogenesis, and providing neuroprotection in the delicate visual axis.…”
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Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 by Aziz Alami Chentoufi, Simon Gaudreau, Alex Nguyen, Mahmoud Sabha, Abdelaziz Amrani, Geyhad ElGhazali

“…Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. …”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…At genetically sensitive animals inflammatory bowel diseases (IBD) develop at various effects on innate and adaptive systems of immune defense (knock-out and transgenic mice), causing changes of expression of significant immunologic factors with distortion of pro- and anti-inflammatory cells and molecules ratio at their contact to microbiota structures. …”
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Pleiotropic effects of a recessive Col1a2 mutation occurring in a mouse model of severe osteogenesis imperfecta. by Michelangelo Corcelli, Rachel Sagar, Ellen Petzendorfer, Mohammad Mehedi Hasan, Fleur S van Dijk, Anna L David, Pascale V Guillot

“…To investigate this, one of the OI murine models was used, i.e. the oim/oim (OIM) mice, which closest resembling severely deforming OI in humans. …”
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LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study by Lili Cui, Zhipeng Wang, Shi Qiu, Mengwei Zhang, Yanping Liu, Fengjing Xu, Xinhua Song, Shouhong Gao, Wansheng Chen

“…The results of the pharmacokinetic study presented an average half-life time 21.14 ± 10.31 h (mean ± SD) of HCQ, which is much shorter in human compared to that in mice. For the three metabolites, longer half-life times (approximately 100 h) were shown in rat.…”
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Closed-loop control of tumor growth by means of anti-angiogenic administration by Filippo Cacace, Valerio Cusimano, Alfredo Germani, Pasquale Palumbo, Federico Papa

“…Simulations are carried out in order to mimic a real experimental framework on mice. These results seem extremely promising: they provide very good performances according to the measurements sampling interval suggested by the experimental literature, and show a noticeable level of robustness against the observer initial estimate, as well as against the uncertainties affecting the model parameters.…”
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Early Therapy Evaluation of Combined Cetuximab and Irinotecan in Orthotopic Pancreatic Tumor Xenografts by Dynamic Contrast-Enhanced Magnetic Resonance Imaging by Hyunki Kim, Karri D. Folks, Lingling Guo, Jeffery C. Sellers, Naomi S. Fineberg, Cecil R. Stockard, William E. Grizzle, Donald J. Buchsbaum, Desiree E. Morgan, James F. George, Kurt R. Zinn

“…Groups 1 to 4 ( n = 6/group) of SCID mice bearing orthotopic pancreatic adenocarcinoma xenografts expressing luciferase were treated with phosphate-buffered saline, cetuximab, irinotecan, or cetuximab combined with irinotecan, respectively, twice weekly for 3 weeks. …”
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Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation by M. A. Tikhonova, T. G. Amstislavskaya

“…ASC (Antidepressant Sensitive Catalepsy) mice, proposed as a model of depression, had a decreased manifestation of sexual motivation, while male GC (Genetic Catalepsy) strain rats had enhanced sexual motivation. …”
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Synthesis and Anti-inflammatory Activity of Some Novel 2,4-Diaryl-3,5-bis(arylimino)-1,2,4-thiadiazolidine Derivatives by P. Venkatesh, S. N. Pandeya

“…The anti-inflammatory activity of new compounds was determined by λ-Carrageenan induced mice paw edema method using diclofenac sodium as a standard. …”
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Infiltration of the liver by cells of innate and adaptive immunity and their destruction in development of experimental immune concanavalin-A-induced hepatitis by S. I. Pavlovich, T. M. Bryzgina, N. V. Makogon, L. I. Aleksyuk, T. V. Martynova, R. I. Yanchy, I. N. Alekseyeva

“…To study damage of liver tissue, its infiltration by cells of innate and adaptive immunity and cell deathin the development of concanavalin (ConA)-induced hepatitis in mice.Material and methods. Histological, cytologic and biochemical methods were applied. …”
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A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats by Pratama Nurmalik Adhuri, Neni Susilaningsih, Sigit Adi Prasetyo, Nani Maharani, Trilaksana Nugroho

“…The combination of UDCA and A. sativum extract significantly reduced the degree of liver fibrosis and increased albumin levels in mice with cholestasis (p [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 192-199]…”
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Evaluation of cold atmospheric pressure plasma effects on Pseudomonas aeruginosa wound infection in a mouse model by Reyhaneh Shekari, Gholamreza Zarrini, Vahid Siahpoush, Farzam Sheikhzadeh Hesari

“…In the in vivo study, plasma reduced the wound's microbial load in mice by 1.9 log. The antibiotic treatment group had a 1.2 log reduction. …”
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Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal by Diego E. Hernandez, Andrei Ciuparu, Pedro Garcia da Silva, Cristina M. Velasquez, Benjamin Rebouillat, Michael D. Gross, Martin B. Davis, Honggoo Chae, Raul C. Muresan, Dinu F. Albeanu

“…To this end, we engage head-fixed male mice in a multimodal rule-reversal task guided by olfactory and auditory cues. …”
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Evaluation of Wound-Healing Activity of Hydrogel Extract of Sansevieria trifasciata Leaves (Asparagaceae) by Nia Yuniarsih, Himyatul Hidayah, Neni Sri Gunarti, Anggun Hari Kusumawati, Farhamzah Farhamzah, Asman Sadino, Maulana Yusuf Alkandahri

“…In the incision wound model, the experiment was divided into 5 groups, each consisting of 4 mice. Groups 1 and 2 served as a negative and positive control (octenidine gel), while 3, 4, and 5 were given HESt formulations of 15%, 20%, and 25% (w/w), respectively, for 15 days. …”
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IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease by Xinyao Wang, Zhenling Deng, Yue Wang

“…IgG expression was also enhanced in the renal tubulointerstitium of DKD mice, which was positively correlated with TIF. High glucose induced an over expression of IgG in human renal tubular epithelial cells, and knockdown of IgG with siRNA relieved the expression of α-smooth muscle actin (SMA), collagen IV, fibronectin, and transforming growth factor (TGF)-β1 under high glucose conditions. …”
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Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy by Peace Mayen Edwin Ubulom, Chinweizu Ejikeme Udobi, Mark Iheukwumere Madu

“…The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated using Swiss albino mice. Results. Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to have antimalarial effect) showed an insignificant antiplasmodial effect reducing the parasites for every 100 RBC from 65 to 64 (1.53%) at the tolerable dosage level of 10.7 mg/kg body weight. …”
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The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity by Hui Li, Fang Wang, Mu Yang, Jiao Sun, Yi Zhao, Dongqi Tang

“…Irisin, a newly identified exercise-responsive myokine, which is produced by the proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has emerged as a promising therapeutic strategy to combat obesity and obesity-related complications. Various studies in mice have shown that irisin could respond to systematic exercise training and promote white-to-brown fat transdifferentiation, but the role and function of irisin in humans are controversial. …”
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SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity by Ke Wang, Zuojian Hu, Cuiping Zhang, Lujie Yang, Li Feng, Pengyuan Yang, Hongxiu Yu

“…In this work, we found that Sirt5 knockout mice were resistant to AOM and DSS-induced colitis-associated colorectal tumorigenesis and the level of IFN-γ in their tumor microenvironment was higher. …”
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Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut by Mehari Endale, H. Ibrahim Aksoylar, Kasper Hoebe

“…In this review, we summarize recent findings derived from studies involving a novel early-onset model of colitis as it develops in GTPase of immunity-associated protein 5- (Gimap5-) deficient mice. In humans, GIMAP5 has been associated with autoimmune diseases although its function is poorly defined. …”
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