STEM CELL THERAPY ON ANIMAL MODEL (Rattus norvegicus) END GESTATIONAL TIME EXPOSED TO CARBON BLACK AS OBSERVED FROM CASPASE-3 EXPRESSION by Agung Budianto Achmad, Sri Pantja Madyawati, Widjiati Widjiati

“…The use of stem cells in treating white mice (Rattus norvegicus) exposed to carbon black can reveal the potential for treatment of placental impairment during pregnancy. …”
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Anti-Onchocercal Properties of Extracts of Scoparia dulcis and Cylicodiscus gabunensis by Tiku Edward Tiku, Moses Samje, Napoleon Mfonku, Fidelis Cho-Ngwa

“…Cytotoxicity and acute toxicity of active extracts were tested on monkey kidney epithelial cells (LLC-MK2) and Balb/C mice, respectively. Results. The hexane extract of Scoparia dulcis recorded the highest activity, with IC50s of 50.78 μg/ml on both adult male and female worms and 3.91 μg/ml on microfilariae. …”
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Depletion of Regulatory T Cells in a Mouse Experimental Glioma Model through Anti-CD25 Treatment Results in the Infiltration of Non-Immunosuppressive Myeloid Cells in the Brain by Wim Maes, Tina Verschuere, Anaïs Van Hoylandt, Louis Boon, Stefaan Van Gool

“…Interestingly, PC61-treated mice also showed a pronounced infiltration of CD11b+ myeloid cells in the brain. …”
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Study on the Effect of Deep Eutectic Solvent Liquid Phase Microextraction on Quality Standard, Antitussive, and Expectorant of Sangbaipi Decoction by Lijing Li, Yuejie Wang, Fangxin Liu, Yang Xu, Huiwei Bao

“…At the same time, in the mouse ammonia water inducing cough and phenol red excretion and expectorant experiments, SD high- and medium-dose groups have a significant inhibitory effect on the frequency of antitussive in mice and both can increase the excretion of phenol red to varying degrees, indicating that SD has good cough-relieving and expectorant effect. …”
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A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity by Sandra J. Hasstedt, Yuanpei Xin, Rong Mao, Tracey Lewis, Ted D. Adams, Steven C. Hunt

“…The strongest candidate is ARFRP1, which affects glucose metabolism in mice.…”
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Visfatin/Nampt: An Adipokine with Cardiovascular Impact by Tania Romacho, Carlos F. Sánchez-Ferrer, Concepción Peiró

“…Visfatin was initially identified as a novel adipokine with insulin-mimetic properties in mice. This adipokine was identical to two previously described molecules, namely, pre-B cell colony-enhancing factor (PBEF) and the enzyme nicotinamide phosphoribosyltransferase (Nampt). …”
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Syntalos: a software for precise synchronization of simultaneous multi-modal data acquisition and closed-loop interventions by Matthias Klumpp, Lee Embray, Filippo Heimburg, Ana Luiza Alves Dias, Justus Simon, Alexander Groh, Andreas Draguhn, Martin Both

“…Preliminary neuroscientific experiments on mice with different research questions show the successful performance and easy-to-learn structure of the software suite.…”
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Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation by Katja C. Weisel, Frank Bautz, Gabriele Seitz, Sedat Yildirim, Lothar Kanz, Robert Möhle

“…In mice, differential regulation of CXC chemokine receptor expression in circulating polymorphonuclear neutrophils (PMNs) undergoing senescence results in homing to the bone marrow. …”
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CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-κB p65 Signaling Pathway by Jinchuan Yan, Yunjie Yin, Wei Zhong, Cuiping Wang, Zhongqun Wang

“…Here, we investigated whether CD137 signaling regulates the expression of NFATc1 in mice VSMCs through TRAF6/NF-κB p65 pathway. Data shows that the CD137 expression can be stimulated by TNF-α in a time-dependent manner in mouse VSMCs. …”
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Balancing inflammation: the specific roles of serum amyloid A proteins in sterile and infectious diseasese by Tirthankar Mohanty, Katarina Miličević, Henri Göthert, Andreas Tillmann, Médea Padra, Praveen Papareddy, Heiko Herwald

“…Mechanistically, SAA proteins augment NF-κB signaling, driving pro and anti-inflammatory mediator production. SAA-/- mice carrying a deletion of the Saa1, Saa2, Saa3, and Saa4 serum amyloid A genes have better survival rates in sterile sepsis but are more prone to bacterial sepsis than their SAA+/+ counterparts, emphasizing their dual functionality in immune regulation. …”
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Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda by Bryan Ramirez Reyes, Shelby Madden, Kimberly A. Meyer, Brenden Bartsch, Austin P. Wright, David A. Constant, Timothy J. Nice

“…Neonatal homeostatic IFN-λ responses are independent of microbiota and pervasively distributed among IECs, distinguishing them from the homeostatic responses of adult mice. Developmental differences in homeostatic IFN-stimulated gene signatures of the intestine are regulated by maturation during the suckling-to-weanling transition, which includes reduced expression of Prdm1 by mature IECs. …”
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Neural recordings can differentiate between spontaneously metastasizing melanomas and melanomas with low metastatic potential. by Jay Shiralkar, Tiana Anthony, Grant A McCallum, Dominique M Durand

“…We performed daily neural recordings from male and female mice bearing orthotopic metastasizing- melanomas and melanomas with low metastatic poential, derived from B16-F10 and B16-F1 cells, respectively. …”
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Renal Urotensin II System Plays Roles in the Regulation of Blood Pressure in Dahl Salt-Resistant Rat by Fei Wu, Guanjong Chen, Aihua Zhang, Yang Yu, Minhua Fan, Chaoshu Tang

“…The Dahl salt-sensitive (SS) and SR rats and UII receptor gene knocked out (KO) mice were placed on a high-salt diet. Renal tissues were performed for the expression of UII in Dahl groups. …”
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IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING by Xue Zeng, Xiaosong Li, Yundong Zhang, Chaoxia Cao, Qin Zhou

“…Finally, anti-PD-L1 treatment in mice showed that blockade of PD-L1 significantly reversed tumor immune escape mediated by IL6-induced EVs. …”
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Existence of Neural Stem Cells in Mouse Spleen by Koichi Tomita, Hiroshi Ishikawa

“…In this study, we sought to identify possible neural stem cells in the mouse spleen. The spleens of ICR mice were removed and small specimens were incubated in Dulbecco’s modified Eagle’s medium with Nutrient Mixture F-12 containing either 10% fetal bovine serum (FBS), 20% FBS, 10% neonate bovine serum, or 10% fetal calf serum. …”
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Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation by Shuang Lin, Shanshan Dai, Jiahui Lin, Xiaohe Liang, Weiqi Wang, Weijian Huang, Bozhi Ye, Xia Hong

“…Our study investigated that hypertrophy and fibrosis can be induced after being treated with Ang II in cardiomyocytes (H9c2 cells and primary rat cardiomyocytes) and C57BL/6J mice. The anti-inflammatory drug oridonin could effectively attenuate the degree of cardiac remodeling both in vivo and vitro by inhibiting GSDMD, a key protein of intracellular inflammation which can further activate kinds of inflammation factors such as IL-1β and IL-18. …”
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Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity by Niko Komin, Mahsa Moein, Mark H. Ellisman, Alexander Skupin

“…Here we revisit our previously published data on the strong temperature dependence of Ca2+ signals in both cultured primary astrocytes and astrocytes in acute brain slices of mice. We apply multiscale modeling to test the hypothesis that the temperature dependent [Ca2+]i spiking is mainly caused by the increased activity of the sarcoendoplasmic reticulum ATPases (SERCAs) that remove Ca2+ from the cytosol into the endoplasmic reticulum. …”
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Noncoding RNAs Associated with PPARs in Etiology of MAFLD as a Novel Approach for Therapeutics Targets by Fatemeh Kazeminasab, Maryam Baharlooie, Kamran Ghaedi

“…We performed pathway enrichment analysis of total mRNAs based on KEGG repository data to screen the most potential pathways in the liver of MAFLD human subjects and mice model, and analyzed pathway interconnections via ClueGO. …”
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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…Afterwards, GV and TPM 6 were tested in a topical formulation in mice infected with L. (L.) amazonensis leading to elimination of parasite burdens at the site of lesion/infection. …”
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Shielding the Gut: Ghrelin and Ferrostatin-1’s Protective Role Against Sepsis-Induced Intestinal Ferroptosis by Qiliang Hou, Zhimin Dou, Lei Zhu, Bin Li

“…<b>Methods:</b> This study evaluates the therapeutic efficacy of intraperitoneal ghrelin (80 μg/kg) and Ferrostatin-1 (5 mg/kg) using a cecal ligation and puncture (CLP) model in C57BL/6 mice to determine their potential in alleviating sepsis-induced intestinal damage. …”
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